Linda Schuler

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo
    Kathleen A O'Leary
    Department of Comparative Biosciences, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706
    Endocrinology 154:4483-92. 2013
  2. pmc Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer
    Lisa M Arendt
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Dr, Madison, WI 53706, USA
    Breast Cancer Res 13:R11. 2011
  3. pmc Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer
    Linda A Schuler
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Cancer Prev Res (Phila) 3:1365-70. 2010
  4. ncbi request reprint Prolactin receptor heterogeneity: processing and signalling of the long and short isoforms during development
    L A Schuler
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, U S A
    Biochem Soc Trans 29:52-6. 2001
  5. ncbi request reprint Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL
    Matthew D Schroeder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 144:5300-7. 2003
  6. ncbi request reprint PRL activates the cyclin D1 promoter via the Jak2/Stat pathway
    Jennifer L Brockman
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 16:774-84. 2002
  7. pmc Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells
    Jennifer H Gutzman
    Molecular and Environmental Toxicology Program, University of Wisconsin, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 18:3064-75. 2004
  8. pmc Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter
    Jennifer L Brockman
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Mol Cell Endocrinol 239:45-53. 2005
  9. ncbi request reprint Increasing sex and ethnic/racial diversity of researchers in aging: some promising strategies at the postdoctoral level
    Molly Carnes
    Department of Medicine, University of Wisconsin Center for Women s Health Research, 700 Regent Street, Madison, WI 53715, USA
    J Am Geriatr Soc 54:980-5. 2006
  10. doi request reprint Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells
    Kristopher C Carver
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Mol Cancer Res 6:634-43. 2008

Research Grants

Collaborators

  • Ameae M Walker
  • Hallgeir Rui
  • Lori Bakken
  • Gloria E Sarto
  • ANTHONY AUGER
  • Susan E Hankinson
  • Arthur Buckley
  • Charles V Clevenger
  • Lisa M Arendt
  • Kristopher C Carver
  • Debra E Rugowski
  • Matthew D Schroeder
  • Jennifer H Gutzman
  • Timothy M Piazza
  • Juu Chin Lu
  • Jennifer L Brockman
  • Kathleen A O'Leary
  • Teresa A Rose-Hellekant
  • Maria Jose Garcia-Barchino
  • Molly Carnes
  • Jyoti J Watters
  • Eric P Sandgren
  • Cristina M Karp
  • Fatou Jallow
  • Ruth Sullivan
  • Kerstin W Sinkevicius
  • Geoffrey L Greene
  • Tara A Grafwallner-Huseth
  • Tara L Grafwallner-Huseth
  • Lindsay C Evans
  • Stephanie J Lent
  • Sarah E Nikolai
  • Kristin K Miller
  • MingYu Zhang
  • Donna J Buckley
  • Huiqui Pan
  • Kennedy Gilchrist
  • Ger J Strous
  • Jaime Symowicz
  • Patricia Scott

Detail Information

Publications26

  1. pmc Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo
    Kathleen A O'Leary
    Department of Comparative Biosciences, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706
    Endocrinology 154:4483-92. 2013
    ..In light of the high expression of PRL receptors in ERα+ cancers, understanding the actions of PRL and cross talk with other oncogenic factors and ERα itself has important implications for therapeutic strategies. ..
  2. pmc Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer
    Lisa M Arendt
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Dr, Madison, WI 53706, USA
    Breast Cancer Res 13:R11. 2011
    ..To evaluate their relationship to clinical tumors, we determined phenotypic relationships among these carcinomas, other murine models of breast cancer, and features of luminal tumors in women...
  3. pmc Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer
    Linda A Schuler
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    Cancer Prev Res (Phila) 3:1365-70. 2010
    ..Understanding the mechanisms underlying this programming can lead to the identification of risk factors and sensitive developmental windows, enabling improved prevention and treatment strategies for this devastating disease...
  4. ncbi request reprint Prolactin receptor heterogeneity: processing and signalling of the long and short isoforms during development
    L A Schuler
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, U S A
    Biochem Soc Trans 29:52-6. 2001
    ..Our studies reveal the importance of the JAK/STAT (Janus kinase/signal transduction and activators of transcription) pathway, and the complexity of prolactin signalling to this promoter...
  5. ncbi request reprint Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL
    Matthew D Schroeder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 144:5300-7. 2003
    ..These studies support the utility of this mutant as a PRL antagonist to proliferative signals in mammary epithelial cells, including a potential role in breast cancer therapeutics...
  6. ncbi request reprint PRL activates the cyclin D1 promoter via the Jak2/Stat pathway
    Jennifer L Brockman
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 16:774-84. 2002
    ..These data suggest that cyclin D1 may be a target gene for PRL in normal lobuloalveolar development, as well as in the development and/or progression of mammary cancer...
  7. pmc Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells
    Jennifer H Gutzman
    Molecular and Environmental Toxicology Program, University of Wisconsin, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 18:3064-75. 2004
    ..These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease...
  8. pmc Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter
    Jennifer L Brockman
    Department of Comparative Biosciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Mol Cell Endocrinol 239:45-53. 2005
    ..This suggests a role for Oct-1 in PRL-dependent control of cyclin D1 transcription...
  9. ncbi request reprint Increasing sex and ethnic/racial diversity of researchers in aging: some promising strategies at the postdoctoral level
    Molly Carnes
    Department of Medicine, University of Wisconsin Center for Women s Health Research, 700 Regent Street, Madison, WI 53715, USA
    J Am Geriatr Soc 54:980-5. 2006
  10. doi request reprint Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells
    Kristopher C Carver
    Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
    Mol Cancer Res 6:634-43. 2008
    ..Together, these data indicate that strong cooperative cross talk between prolactin and IGF-I augments biological processes associated with neoplastic progression, with implications for therapeutic strategies...
  11. ncbi request reprint Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells
    Jennifer H Gutzman
    Department of Comparative Biosciences, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 88:69-77. 2004
    ..This model will allow investigation of endogenous hPRL in mammary epithelial cells and will enable further dissection of PRL effects on other hormone signaling pathways to determine the role of PRL in breast cancer...
  12. pmc Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells
    Kristopher C Carver
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:8003-12. 2010
    ..Together, these findings describe a novel mechanism of cross-talk between PRL and IGF-I in breast cancer cells, with implications for our understanding of tumor progression and potential therapeutic strategies...
  13. pmc Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos
    Jennifer H Gutzman
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
    Mol Endocrinol 19:1765-78. 2005
    ..The enhanced AP-1 activity resulting from the interaction of these hormones may increase expression of many target genes that are critical for oncogenesis and may contribute to neoplastic progression...
  14. ncbi request reprint PRL modulates cell cycle regulators in mammary tumor epithelial cells
    Matthew D Schroeder
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Mol Endocrinol 16:45-57. 2002
    ..This model system will enable further molecular dissection of the pathways involved in PRL-induced proliferation, increasing our understanding of this hormone and its interactions with other factors in normal and pathogenic processes...
  15. pmc SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells
    Timothy M Piazza
    Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Mol Endocrinol 23:202-12. 2009
    ....
  16. pmc Prolactin potentiates transforming growth factor alpha induction of mammary neoplasia in transgenic mice
    Lisa M Arendt
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Am J Pathol 168:1365-74. 2006
    ....
  17. pmc Prolactin drives estrogen receptor-alpha-dependent ductal expansion and synergizes with transforming growth factor-alpha to induce mammary tumors in males
    Lisa M Arendt
    Cellular and Molecular Biology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Am J Pathol 172:194-202. 2008
    ..Activation of ER-alpha is one mechanism by which PRL may contribute to breast cancer and points to other therapeutic strategies for male patients...
  18. pmc Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cells
    Juu Chin Lu
    Department of Comparative Biosciences, University of Wisconsin Madison, Wisconsin 53706, USA
    J Biol Chem 280:33909-16. 2005
    ..Our findings described a new potential mediator of prolactin action and a novel mechanism whereby proteasomes modulate cellular processes...
  19. doi request reprint Transgenic models to study actions of prolactin in mammary neoplasia
    Lisa M Arendt
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    J Mammary Gland Biol Neoplasia 13:29-40. 2008
    ..These studies highlight the utility of these models to decipher the interplay between prolactin and other oncogenic factors in breast cancer, with implications for preventative and therapeutic strategies...
  20. pmc Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice
    Teresa A Rose-Hellekant
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Oncogene 22:4664-74. 2003
    ..These studies provide a mouse model of hormonally dependent breast cancer, and, perhaps most strikingly, a model in which some neoplasms retain ERalpha, as occurs in the human disease...
  21. pmc Complex prolactin crosstalk in breast cancer: new therapeutic implications
    Kristopher C Carver
    Cellular and Molecular Biology Program, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Cell Endocrinol 307:1-7. 2009
    ..We discuss the potential benefit of PRL/PRLR-targeted therapy in combination with established therapies and implications for de novo and acquired resistance to treatment...
  22. pmc Prolactin-growth factor crosstalk reduces mammary estrogen responsiveness despite elevated ERalpha expression
    Lisa M Arendt
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Am J Pathol 174:1065-74. 2009
    ..These findings provide insight into the interactions of PRL with growth factors during mammary oncogenesis and suggest combinatorial approaches that may result in improved therapeutic efficacy...
  23. ncbi request reprint Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways
    Juu Chin Lu
    Endocrinology Reproductive Physiology Program, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 16:2515-27. 2002
    ..These studies define the basis of cellular trafficking of PRLR isoforms and increase our understanding of control of target cell responsiveness by PRL...
  24. pmc Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes
    Lisa M Arendt
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Endocrinol 203:99-110. 2009
    ..Mammary pERK1/2 and pAkt, but not phosphorylated Stat5, were markedly elevated by local PRL. Together, these findings indicate that PRL employs multiple mechanisms to promote mammary tumorigenesis...
  25. ncbi request reprint Identification of HRPAP20: a novel phosphoprotein that enhances growth and survival in hormone-responsive tumor cells
    Cristina M Karp
    College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 64:1016-25. 2004
    ..05). We conclude that HRPAP20 is a phosphoprotein that is required for proliferation and survival of hormone-dependent tumor cells...
  26. pmc The role of prolactin in mammary carcinoma
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocr Rev 24:1-27. 2003
    ..These findings indicate that antagonists of PRL/PRL receptor interaction or PRL receptor-associated signal transduction may be of considerable utility in the treatment of human breast cancer...

Research Grants13

  1. MAMMARY PROLACTIN PRODUCTION AND BREAST CANCER
    Linda Schuler; Fiscal Year: 2005
    ..These studies will increase our understanding of how these factors may cooperate in the pathogenesis of mammary neoplasia, and design of clinically useful approaches. ..
  2. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2005
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..
  3. MAMMARY PROLACTIN PRODUCTION AND BREAST CANCER
    Linda Schuler; Fiscal Year: 2004
    ..These studies will increase our understanding of how these factors may cooperate in the pathogenesis of mammary neoplasia, and design of clinically useful approaches. ..
  4. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2004
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..
  5. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2003
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..
  6. MAMMARY PROLACTIN PRODUCTION AND BREAST CANCER
    Linda Schuler; Fiscal Year: 2003
    ..These studies will increase our understanding of how these factors may cooperate in the pathogenesis of mammary neoplasia, and design of clinically useful approaches. ..
  7. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2006
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..