N Schuff

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
  2. pmc Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging
    N Schuff
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, and University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 20:279-85. 1999
  3. pmc Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 58:928-35. 2002
  4. pmc Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging
    N Schuff
    DVA Medical Center, San Francisco, California 94121, USA
    Magn Reson Med 45:899-907. 2001
  5. ncbi request reprint Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis
    N Schuff
    DVA Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California 94121, USA
    Magn Reson Med 45:513-6. 2001
  6. pmc Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
  7. pmc Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center (114M, University of California, San Francisco 94121, USA
    J Neurol Neurosurg Psychiatry 71:441-7. 2001
  8. pmc Magnetic resonance imaging and magnetic resonance spectroscopy in dementias
    Y Y Hsu
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco 94121, USA
    J Geriatr Psychiatry Neurol 14:145-66. 2001
  9. pmc Higher atrophy rate of entorhinal cortex than hippocampus in AD
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neurology 62:422-7. 2004
  10. pmc Atrophy rates of entorhinal cortex in AD and normal aging
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Neurology 60:481-6. 2003

Detail Information

Publications39

  1. pmc Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
    ....
  2. pmc Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging
    N Schuff
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, and University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 20:279-85. 1999
    ..Furthermore, because NAA is considered a marker of neurons, these results provide stronger support for neuron loss in the aging hippocampus than volume measurements by MRI alone...
  3. pmc Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 58:928-35. 2002
    ..MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging...
  4. pmc Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging
    N Schuff
    DVA Medical Center, San Francisco, California 94121, USA
    Magn Reson Med 45:899-907. 2001
    ..Furthermore, NAA and Cr changes correlated with age. In conclusion, regional and tissue differences of brain metabolites must be considered in addition to age-related changes when interpreting (1)H MRSI data...
  5. ncbi request reprint Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis
    N Schuff
    DVA Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California 94121, USA
    Magn Reson Med 45:513-6. 2001
    ..02) higher. This demonstrates that the metabolite ratio changes in ALS were due to NAA loss in the motor cortex (as expected) and Cho increase in the posterior internal capsule (not expected). Magn Reson Med 45:513-516, 2001...
  6. pmc Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
    ..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals...
  7. pmc Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center (114M, University of California, San Francisco 94121, USA
    J Neurol Neurosurg Psychiatry 71:441-7. 2001
    ..CONCLUSIONS: Volume reductions in the ERC and hippocampus may be early signs of AD pathology that can be measured using MRI...
  8. pmc Magnetic resonance imaging and magnetic resonance spectroscopy in dementias
    Y Y Hsu
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco 94121, USA
    J Geriatr Psychiatry Neurol 14:145-66. 2001
    ....
  9. pmc Higher atrophy rate of entorhinal cortex than hippocampus in AD
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neurology 62:422-7. 2004
    ....
  10. pmc Atrophy rates of entorhinal cortex in AD and normal aging
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Neurology 60:481-6. 2003
    ..To explore the atrophy rate of entorhinal cortex (ERC) in AD and normal aging and assess the value of rate measurement of ERC atrophy for classifying subjects with AD from cognitively normal (CN) control subjects...
  11. pmc Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Neurology 58:1635-41. 2002
    ..To determine the effects of subcortical ischemic vascular dementia (SIVD) and AD on entorhinal cortex (ERC) and hippocampus...
  12. pmc Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study
    R R Rule
    Department of Radiology, University of California, San Francisco, CA, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:141-9. 2004
    ....
  13. pmc Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects
    G C Chiang
    Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue M 391, San Francisco, CA 94143, USA
    Neurology 75:1976-81. 2010
    ..We also determined whether APOE2 carriers have less Alzheimer pathology as reflected by CSF biomarkers...
  14. pmc Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease
    G Fein
    Neurobehavioral Research, Inc, San Francisco, CA, USA
    Neurology 55:1626-35. 2000
    ..Hippocampal atrophy may result from a mixture of ischemic and degenerative pathologies. The cause of diffuse cortical atrophy is not known, but may be partially indexed by the severity of WMSH...
  15. ncbi request reprint Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis
    B J Soher
    Department of Radiology, University of California San Francisco, MR Unit 114M, DVA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Magn Reson Imaging 18:1159-65. 2000
    ..This approach was applied to data from optimized PRESS-SI and multi-slice spin-echo SI acquisitions, for which sample spectra and metabolite images are shown...
  16. ncbi request reprint Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability
    D Wiedermann
    Magnetic Resonance Unit of DVA Medical Center and Department of Radiology, University of California, San Francisco, USA
    Magn Reson Imaging 19:1073-80. 2001
    ..These findings indicate that voxel gray/white matter contributions, regional variations in metabolite concentrations, and reliability limitations must be considered when interpreting 1H MR spectra of the brain...
  17. pmc Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
    L L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Neurobiol Aging 31:368-77. 2010
    ....
  18. pmc Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
    A T Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, USA
    Neurology 67:1215-20. 2006
    ....
  19. ncbi request reprint Deformation tensor morphometry of semantic dementia with quantitative validation
    C Studholme
    Department of Radiology, U C S F, VAMC 114Q, San Francisco, CA 94121, USA
    Neuroimage 21:1387-98. 2004
    ..Additional lower significance findings (P < 0.05 permutation corrected) were detected in the left superior frontal gyrus, left orbital gyrus and left parietal lobe...
  20. ncbi request reprint Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia
    V A Cardenas
    Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, 4150 Clement Street 116R, San Francisco, CA 94121, USA
    Neurobiol Aging 24:537-44. 2003
    ....
  21. pmc Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Biol Psychiatry 50:952-9. 2001
    ..Furthermore, these metabolite changes seem to be better indicators of posttraumatic stress disorder pathology than volume losses...
  22. pmc MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    N Schuff
    Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    Brain 132:1067-77. 2009
    ....
  23. pmc Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS
    S G Mueller
    Center of Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, Department of Radiology, University of California San Francisco, San Francisco, CA 94121, USA
    NMR Biomed 19:655-68. 2006
    ..More research is needed to determine the value of other MR modalities, i.e. diffusion, perfusion and functional MRI and MR spectroscopy, for clinical trials with neuroprotective drugs...
  24. doi request reprint Imaging of mild cognitive impairment and early dementia
    N Schuff
    University of California, Center for Imaging of Neurodegenerative Diseases Veterans Affairs Medical Center, San Francisco, California, USA
    Br J Radiol 80:S109-14. 2007
    ..The strength and limitations of each modality for diagnosis of MCI, prediction of MCI outcome and assessment of drug efficacy will be discussed...
  25. pmc Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
    S G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 42:42-8. 2008
    ..The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD...
  26. pmc Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation
    C I Haupt
    Department of Radiology, University of California San Francisco, USA
    Magn Reson Med 35:678-87. 1996
    ..When applied together with optimized acquisition methods, this provides an effective procedure for imaging metabolite distributions in cerebral cortical surface regions...
  27. ncbi request reprint Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder
    R F Deicken
    Magnetic Resonance Unit, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Psychiatry Res 106:35-45. 2001
    ..Increased thalamic creatine bilaterally may represent altered cellular energy metabolism and is consistent with prior studies demonstrating changes in thalamic metabolism in mood disorders...
  28. doi request reprint White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance?
    G C Chiang
    Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, USA
    AJNR Am J Neuroradiol 33:1392-7. 2012
    ..The purpose of this study was to use diffusion tensor imaging to detect possible differences in white matter integrity between cognitively normal elderly apoE ε2 carriers and apoE ε3/ε3 controls...
  29. pmc Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T
    S G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs DVA Medical Center, Clement Street 4150, San Francisco, CA 94121, United States
    Neurobiol Aging 28:719-26. 2007
    ..In AD subjects, CA1 and subiculum were smaller than in age-matched controls. These preliminary findings suggest that measurement of hippocampal subfields may be helpful to distinguish between normal aging and AD...
  30. pmc Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging
    D J Meyerhoff
    Magnetic Resonance Unit, University of California San Francisco, San Francisco, CA, USA
    Addict Biol 4:405-19. 1999
    ....
  31. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  32. pmc Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment
    A L Boxer
    Memory and Aging Center, Department of Neurology, University of California at San Francisco, 94143 1207, USA
    Neurology 61:1485-91. 2003
    ..To explore the structural neuroimaging correlates of visual constructive impairment in patients with mild to moderate Alzheimer disease (AD)...
  33. ncbi request reprint Evidence for altered cerebellar vermis neuronal integrity in schizophrenia
    R F Deicken
    Psychiatry Service, 116 N, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Psychiatry Res 107:125-34. 2001
    ....
  34. pmc Robust analysis of short echo time (1)H MRSI of human brain
    X P Zhu
    Department of Radiology, University of California San Francisco, San Francisco, CA 94121, USA
    Magn Reson Med 55:706-11. 2006
    ..Back-to-back MRSI studies on 10 healthy volunteers showed that mean spectra markedly improved reliability of brain metabolite measurements, most notably for myo-inositol, as compared to regression methods...
  35. ncbi request reprint Patterns of brain atrophy in frontotemporal dementia and semantic dementia
    H J Rosen
    Department of Neurology, UCSF Memory and Aging Center, Univeristy of California, San Francisco, 94143 1207, USA
    Neurology 58:198-208. 2002
    ..To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD)...
  36. pmc Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI
    J Suhy
    Department of Radiology, University of California at San Francisco, USA
    Neurology 58:773-9. 2002
    ....
  37. pmc Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 59:867-73. 2002
    ..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
  38. pmc Longitudinal volumetric MRI change and rate of cognitive decline
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neurology 65:565-71. 2005
    ..To examine how baseline and change of volumetric MRI relate to cognitive decline in older individuals...
  39. pmc Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging
    A A Maudsley
    Department of Radiology, MR Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    NMR Biomed 19:492-503. 2006
    ....