N Schuff

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Nonlinear time course of brain volume loss in cognitively normal and impaired elders
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases and VA Medical Center, San Francisco, CA, USA
    Neurobiol Aging 33:845-55. 2012
  2. ncbi Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
    Neuroimage 54:S62-8. 2011
  3. ncbi MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    N Schuff
    Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    Brain 132:1067-77. 2009
  4. ncbi Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging
    Norbert Schuff
    Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
    Alzheimers Dement 5:454-62. 2009
  5. ncbi Imaging of mild cognitive impairment and early dementia
    N Schuff
    University of California, Center for Imaging of Neurodegenerative Diseases Veterans Affairs Medical Center, San Francisco, California, USA
    Br J Radiol 80:S109-14. 2007
  6. ncbi Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 162:147-57. 2008
  7. ncbi An MRI substudy of a donepezil clinical trial in mild cognitive impairment
    Norbert Schuff
    Center for Imaging of Neurodegenerative Disease, Veterans Affairs Medical Center, 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Neurobiol Aging 32:2318.e31-41. 2011
  8. ncbi Potential role of high-field MRI for studies in Parkinson's disease
    Norbert Schuff
    Centre for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Mov Disord 24:S684-90. 2009
  9. ncbi Longitudinal volumetric MRI change and rate of cognitive decline
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neurology 65:565-71. 2005
  10. ncbi Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003

Detail Information

Publications45

  1. ncbi Nonlinear time course of brain volume loss in cognitively normal and impaired elders
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases and VA Medical Center, San Francisco, CA, USA
    Neurobiol Aging 33:845-55. 2012
    ..The approach has potential uses for early detection of AD and differentiation between stable and progressing MCI...
  2. ncbi Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
    Neuroimage 54:S62-8. 2011
    ..Structural, perfusion, and diffusion MRI together may provide a signature for a PTSD marker...
  3. ncbi MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    N Schuff
    Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    Brain 132:1067-77. 2009
    ....
  4. ncbi Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging
    Norbert Schuff
    Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
    Alzheimers Dement 5:454-62. 2009
    ....
  5. ncbi Imaging of mild cognitive impairment and early dementia
    N Schuff
    University of California, Center for Imaging of Neurodegenerative Diseases Veterans Affairs Medical Center, San Francisco, California, USA
    Br J Radiol 80:S109-14. 2007
    ..The strength and limitations of each modality for diagnosis of MCI, prediction of MCI outcome and assessment of drug efficacy will be discussed...
  6. ncbi Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 162:147-57. 2008
    ..NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction...
  7. ncbi An MRI substudy of a donepezil clinical trial in mild cognitive impairment
    Norbert Schuff
    Center for Imaging of Neurodegenerative Disease, Veterans Affairs Medical Center, 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Neurobiol Aging 32:2318.e31-41. 2011
    ..003) whole brain volumes. Although the primary MRI outcome measure was negative, the main secondary MRI outcome measure showed a positive result. These findings suggest a treatment effect of donepezil on brain atrophy in aMCI...
  8. ncbi Potential role of high-field MRI for studies in Parkinson's disease
    Norbert Schuff
    Centre for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Mov Disord 24:S684-90. 2009
    ....
  9. ncbi Longitudinal volumetric MRI change and rate of cognitive decline
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neurology 65:565-71. 2005
    ..To examine how baseline and change of volumetric MRI relate to cognitive decline in older individuals...
  10. ncbi Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
    ....
  11. ncbi Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
    ..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals...
  12. ncbi Atrophy rates of entorhinal cortex in AD and normal aging
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    Neurology 60:481-6. 2003
    ..93. CONCLUSION: ERC volume loss over time may be a better indicator for AD than cross-sectional measurements...
  13. ncbi Magnetic resonance imaging and magnetic resonance spectroscopy in dementias
    Y Y Hsu
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco 94121, USA
    J Geriatr Psychiatry Neurol 14:145-66. 2001
    ....
  14. ncbi Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study
    R R Rule
    Department of Radiology, University of California, San Francisco, CA, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:141-9. 2004
    ....
  15. ncbi Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center (114M, University of California, San Francisco 94121, USA
    J Neurol Neurosurg Psychiatry 71:441-7. 2001
    ..CONCLUSIONS: Volume reductions in the ERC and hippocampus may be early signs of AD pathology that can be measured using MRI...
  16. ncbi Higher atrophy rate of entorhinal cortex than hippocampus in AD
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neurology 62:422-7. 2004
    ..CONCLUSION: The finding in AD that the atrophy rate in the entorhinal cortex is higher than in the hippocampus is consistent with the view that AD pathology begins in the entorhinal cortex...
  17. ncbi Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
    A T Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, USA
    Neurology 67:1215-20. 2006
    ....
  18. ncbi Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging
    N Schuff
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, and University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 20:279-85. 1999
    ..Furthermore, because NAA is considered a marker of neurons, these results provide stronger support for neuron loss in the aging hippocampus than volume measurements by MRI alone...
  19. ncbi Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging
    N Schuff
    DVA Medical Center, San Francisco, California 94121, USA
    Magn Reson Med 45:899-907. 2001
    ..Furthermore, NAA and Cr changes correlated with age. In conclusion, regional and tissue differences of brain metabolites must be considered in addition to age-related changes when interpreting (1)H MRSI data...
  20. ncbi Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis
    N Schuff
    DVA Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California 94121, USA
    Magn Reson Med 45:513-6. 2001
    ..02) higher. This demonstrates that the metabolite ratio changes in ALS were due to NAA loss in the motor cortex (as expected) and Cho increase in the posterior internal capsule (not expected). Magn Reson Med 45:513-516, 2001...
  21. ncbi Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment
    A L Boxer
    Memory and Aging Center, Department of Neurology, University of California at San Francisco, 94143 1207, USA
    Neurology 61:1485-91. 2003
    ..To explore the structural neuroimaging correlates of visual constructive impairment in patients with mild to moderate Alzheimer disease (AD)...
  22. ncbi Deformation tensor morphometry of semantic dementia with quantitative validation
    C Studholme
    Department of Radiology, U C S F, VAMC 114Q, San Francisco, CA 94121, USA
    Neuroimage 21:1387-98. 2004
    ..Additional lower significance findings (P < 0.05 permutation corrected) were detected in the left superior frontal gyrus, left orbital gyrus and left parietal lobe...
  23. ncbi Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects
    G C Chiang
    Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue M 391, San Francisco, CA 94143, USA
    Neurology 75:1976-81. 2010
    ..We also determined whether APOE2 carriers have less Alzheimer pathology as reflected by CSF biomarkers...
  24. ncbi Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability
    D Wiedermann
    Magnetic Resonance Unit of DVA Medical Center and Department of Radiology, University of California, San Francisco, USA
    Magn Reson Imaging 19:1073-80. 2001
    ..These findings indicate that voxel gray/white matter contributions, regional variations in metabolite concentrations, and reliability limitations must be considered when interpreting 1H MR spectra of the brain...
  25. ncbi Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
    L L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Neurobiol Aging 31:368-77. 2010
    ....
  26. ncbi Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Neurology 58:1635-41. 2002
    ..CONCLUSIONS: The entorhinal cortex and hippocampus are less affected by subcortical ischemic vascular dementia than by AD...
  27. ncbi Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Biol Psychiatry 50:952-9. 2001
    ..Furthermore, these metabolite changes seem to be better indicators of posttraumatic stress disorder pathology than volume losses...
  28. ncbi Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis
    B J Soher
    Department of Radiology, University of California San Francisco, MR Unit 114M, DVA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Magn Reson Imaging 18:1159-65. 2000
    ..This approach was applied to data from optimized PRESS-SI and multi-slice spin-echo SI acquisitions, for which sample spectra and metabolite images are shown...
  29. ncbi Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease
    G Fein
    Neurobehavioral Research, Inc, San Francisco, CA, USA
    Neurology 55:1626-35. 2000
    ..Hippocampal atrophy may result from a mixture of ischemic and degenerative pathologies. The cause of diffuse cortical atrophy is not known, but may be partially indexed by the severity of WMSH...
  30. ncbi Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia
    V A Cardenas
    Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, 4150 Clement Street 116R, San Francisco, CA 94121, USA
    Neurobiol Aging 24:537-44. 2003
    ....
  31. ncbi Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS
    S G Mueller
    Center of Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, Department of Radiology, University of California San Francisco, San Francisco, CA 94121, USA
    NMR Biomed 19:655-68. 2006
    ..More research is needed to determine the value of other MR modalities, i.e. diffusion, perfusion and functional MRI and MR spectroscopy, for clinical trials with neuroprotective drugs...
  32. ncbi Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 59:867-73. 2002
    ..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
  33. ncbi Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
    S G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 42:42-8. 2008
    ..The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal subfields in AD...
  34. ncbi Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  35. ncbi Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder
    R F Deicken
    Magnetic Resonance Unit, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Psychiatry Res 106:35-45. 2001
    ..Increased thalamic creatine bilaterally may represent altered cellular energy metabolism and is consistent with prior studies demonstrating changes in thalamic metabolism in mood disorders...
  36. ncbi Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T
    S G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs DVA Medical Center, Clement Street 4150, San Francisco, CA 94121, United States
    Neurobiol Aging 28:719-26. 2007
    ..In AD subjects, CA1 and subiculum were smaller than in age-matched controls. These preliminary findings suggest that measurement of hippocampal subfields may be helpful to distinguish between normal aging and AD...
  37. ncbi Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging
    D J Meyerhoff
    Magnetic Resonance Unit, University of California San Francisco, San Francisco, CA, USA
    Addict Biol 4:405-19. 1999
    ....
  38. ncbi White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance?
    G C Chiang
    Center for Imaging of Neurodegenerative Diseases, Department of Veteran Affairs Medical Center, San Francisco, California, USA
    AJNR Am J Neuroradiol 33:1392-7. 2012
    ..The purpose of this study was to use diffusion tensor imaging to detect possible differences in white matter integrity between cognitively normal elderly apoE ε2 carriers and apoE ε3/ε3 controls...
  39. ncbi Evidence for altered cerebellar vermis neuronal integrity in schizophrenia
    R F Deicken
    Psychiatry Service, 116 N, Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Psychiatry Res 107:125-34. 2001
    ....
  40. ncbi Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 58:928-35. 2002
    ..MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging...
  41. ncbi Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI
    J Suhy
    Department of Radiology, University of California at San Francisco, USA
    Neurology 58:773-9. 2002
    ..CONCLUSION: Metabolite changes measured by (1)H MRSI may provide a surrogate marker of ALS that can aid detection of early disease and monitor progression and treatment response...
  42. ncbi Brain atrophy associated with baseline and longitudinal measures of cognition
    V A Cardenas
    San Francisco Veterans Affairs Medical Center, USA
    Neurobiol Aging 32:572-80. 2011
    ..These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals...
  43. ncbi Robust analysis of short echo time (1)H MRSI of human brain
    X P Zhu
    Department of Radiology, University of California San Francisco, San Francisco, CA 94121, USA
    Magn Reson Med 55:706-11. 2006
    ..Back-to-back MRSI studies on 10 healthy volunteers showed that mean spectra markedly improved reliability of brain metabolite measurements, most notably for myo-inositol, as compared to regression methods...
  44. ncbi Patterns of brain atrophy in frontotemporal dementia and semantic dementia
    H J Rosen
    Department of Neurology, UCSF Memory and Aging Center, Univeristy of California, San Francisco, 94143 1207, USA
    Neurology 58:198-208. 2002
    ..To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD)...
  45. ncbi Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging
    A A Maudsley
    Department of Radiology, MR Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    NMR Biomed 19:492-503. 2006
    ....