Marca Schuckit

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 36:1244-52. 2012
  2. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
  3. pmc Sex differences in how a low sensitivity to alcohol relates to later heavy drinking
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Drug Alcohol Rev 31:871-80. 2012
  4. pmc Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, California 92037, USA
    J Stud Alcohol Drugs 74:271-9. 2013
  5. pmc Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire
    Marc A Schuckit
    University of California, San Diego, Department of Psychiatry, 8950 Villa La Jolla Drive, Suite B 218, La Jolla, CA 92037, USA
    Drug Alcohol Depend 128:194-9. 2013
  6. pmc Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, California 92037, USA
    J Stud Alcohol Drugs 73:195-204. 2012
  7. pmc fMRI differences between subjects with low and high responses to alcohol during a stop signal task
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, 92037, USA
    Alcohol Clin Exp Res 36:130-40. 2012
  8. ncbi request reprint A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs
    Marc A Schuckit
    University of California San Diego, Department of Psychiatry 116A, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Alcohol Clin Exp Res 29:1921-7. 2005
  9. ncbi request reprint Autosomal linkage analysis for the level of response to alcohol
    Marc A Schuckit
    Department of Genetics and Neurology, The Carolina Center for Genome Sciences, Chapel Hill, NC, USA
    Alcohol Clin Exp Res 29:1976-82. 2005
  10. pmc Externalizing disorders in the offspring from the San Diego prospective study of alcoholism
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego and the VA San Diego Healthcare System, 3350 La Jolla, Village Drive, San Diego, CA 92161 2002, USA
    J Psychiatr Res 42:644-52. 2008

Research Grants

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 36:1244-52. 2012
    ..However, more definitive research on new paradigms is very expensive, and in the current economic climate, progress can be made by evaluating smaller pilot studies. This study describes one such approach...
  2. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
    ..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation...
  3. pmc Sex differences in how a low sensitivity to alcohol relates to later heavy drinking
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Drug Alcohol Rev 31:871-80. 2012
    ..While previous analyses of how LR relates to heavier drinking reported the process is similar in males and females, some potential sex differences have been identified. This difference is further explored in these analyses...
  4. pmc Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, California 92037, USA
    J Stud Alcohol Drugs 74:271-9. 2013
    ..We hypothesized that a longitudinal study that uses validated interviews with subjects and relatives and distinguishes between IDEs and alcohol-induced depressive episodes would reveal little evidence of a link between IDEs and AUDs...
  5. pmc Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire
    Marc A Schuckit
    University of California, San Diego, Department of Psychiatry, 8950 Villa La Jolla Drive, Suite B 218, La Jolla, CA 92037, USA
    Drug Alcohol Depend 128:194-9. 2013
    ..This paper reports the relationships among these two measures and how each related to both recent and future drinking quantities and problems across 15 years in 235 men...
  6. pmc Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, California 92037, USA
    J Stud Alcohol Drugs 73:195-204. 2012
    ..To accomplish this, we describe results from the first prospective evaluation of potential mediators of how an earlier low LR to alcohol relates to adverse alcohol outcomes in offspring from the San Diego Prospective Study (SDPS)...
  7. pmc fMRI differences between subjects with low and high responses to alcohol during a stop signal task
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, 92037, USA
    Alcohol Clin Exp Res 36:130-40. 2012
    ..While the low LR reflects, at least in part, a low brain response to alcohol, the physiological underpinnings of the low LR have only recently been addressed...
  8. ncbi request reprint A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs
    Marc A Schuckit
    University of California San Diego, Department of Psychiatry 116A, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Alcohol Clin Exp Res 29:1921-7. 2005
    ..While most studies support the influence of genes for this characteristic, no data to date have addressed how LR established from alcohol challenges performs in similarly aged subjects across generations...
  9. ncbi request reprint Autosomal linkage analysis for the level of response to alcohol
    Marc A Schuckit
    Department of Genetics and Neurology, The Carolina Center for Genome Sciences, Chapel Hill, NC, USA
    Alcohol Clin Exp Res 29:1976-82. 2005
    ..4 and 0.6, and efforts are being made to find genes related to this phenotype. This paper presents data from a family-based genome with linkage analysis focusing on alcohol challenge determinants of LR...
  10. pmc Externalizing disorders in the offspring from the San Diego prospective study of alcoholism
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego and the VA San Diego Healthcare System, 3350 La Jolla, Village Drive, San Diego, CA 92161 2002, USA
    J Psychiatr Res 42:644-52. 2008
    ..This paper evaluates these questions in well-educated families of alcoholics and controls...
  11. ncbi request reprint An evaluation of the level of response to alcohol, externalizing symptoms, and depressive symptoms as predictors of alcoholism
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, USA
    J Stud Alcohol 67:215-27. 2006
    ..This article evaluates the impact of these three intermediate phenotypes and additional domains in a structural equation model (SEM)...
  12. ncbi request reprint History is useful
    Marc Schuckit
    School of Medicine University of California, Alcohol Research Center Va San Diego Healthcare System, La Jolla, 92093, USA
    Addiction 101:641; discussion 644-5. 2006
  13. ncbi request reprint Relationships among the level of response to alcohol and the number of alcoholic relatives in predicting alcohol-related outcomes
    Marca Schuckit
    Department of Psychiatry University of California at San Diego and the VA San Diego Healthcare System, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 30:1308-14. 2006
    ..This study tests the hypotheses that there will be an inverse relationship between LR and FH and that LR will be a better predictor of the maximum quantity of alcohol consumed...
  14. ncbi request reprint Evaluation of a depression-related model of alcohol problems in 430 probands from the San Diego prospective study
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego and the VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Drug Alcohol Depend 82:194-203. 2006
    ..This paper describes a prospective study that evaluates a model of the role of depressive episodes in the development of alcohol-related problems, while controlling for substance-induced mood disorders...
  15. ncbi request reprint Performance of a self-report measure of the level of response to alcohol in 12- to 13-year-old adolescents
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, and the Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161 2002, USA
    J Stud Alcohol 66:452-8. 2005
    ..Because LR might change with increasing age and years of drinking, there is a need to measure this phenotype as early as possible in the drinking career...
  16. pmc The overlap in predicting alcohol outcome for two measures of the level of response to alcohol
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, VA San Diego Healthcare System, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 33:563-9. 2009
    ..3 to 0.4, up to 0.6. However, it is not clear how this correlation relates to the ability of each measure to predict alcohol outcomes. This paper evaluates that overlap...
  17. ncbi request reprint Evaluation of a level of response to alcohol-based structural equation model in adolescents
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, and the VA San Diego Healthcare System, San Diego, California 92161 2002, USA
    J Stud Alcohol 66:174-84. 2005
    ..The current analyses evaluate how LR functions within the context of a Social Information Processing Model, using 238 subjects aged 13 to 19 years from the Collaborative Study on the Genetics of Alcoholism (COGA)...
  18. ncbi request reprint Correlations among first-degree relatives for responses on the Self-Rating of the Effects of Alcohol Questionnaire in teenagers
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, USA
    J Stud Alcohol 66:62-5. 2005
    ..This article presents data regarding the familial nature of SRE-based scores among a sample of teenagers...
  19. ncbi request reprint Prospective evaluation of the four DSM-IV criteria for alcohol abuse in a large population
    Marc A Schuckit
    VA San Diego Healthcare System, University of California, San Diego, CA, USA
    Am J Psychiatry 162:350-60. 2005
    ....
  20. ncbi request reprint Testing the level of response to alcohol: social information processing model of alcoholism risk--a 20-year prospective study
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego and San Diego Veterans Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161 2002, USA
    Alcohol Clin Exp Res 28:1881-9. 2004
    ..An optimal understanding of how this intermediate phenotype relates to the AUD risk requires evaluation of the milieu in which LR operates, and this study tested an LR/social information processing model in adult men...
  21. ncbi request reprint Findings across subgroups regarding the level of response to alcohol as a risk factor for alcohol use disorders: a college population of women and Latinos
    Marc A Schuckit
    Veterans Affairs San Diego Healthcare System and the University of California Medical School, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 28:1499-508. 2004
    ..These analyses explored whether the differential rate of alcohol use disorders (AUDs) might reflect one genetically influenced phenotype related to alcoholism risk: the low level of response (LR) to alcohol...
  22. ncbi request reprint The search for genes contributing to the low level of response to alcohol: patterns of findings across studies
    Marc A Schuckit
    Veterans Affairs San Diego Healthcare System and the University of California San Diego School of Medicine, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 28:1449-58. 2004
    ..This article reviews data from animal and human studies regarding the LR to alcohol, searching for a convergence of results that might lead to the identification of relevant genes...
  23. ncbi request reprint Comorbidity between substance use disorders and psychiatric conditions
    Marc A Schuckit
    VA San Diego Healthcare System, San Diego, CA, USA
    Addiction 101:76-88. 2006
    ..To review information relevant to the question of whether substance-induced mental disorders exist and their implications...
  24. ncbi request reprint The empirical basis of substance use disorders diagnosis: research recommendations for the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V)
    Marc A Schuckit
    University of California, San Diego, Veterans Association Medical Center, San Diego, CA, USA
    Addiction 101:170-3. 2006
    ....
  25. ncbi request reprint An evaluation of the performance of the self-rating of the effects of alcohol questionnaire in 12- and 35-year-old subjects
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, California, USA
    J Stud Alcohol 67:841-50. 2006
    ..g., age, gender, and weight), as well as the number of items endorsed on the questionnaire...
  26. doi request reprint A prospective evaluation of how a low level of response to alcohol predicts later heavy drinking and alcohol problems
    Marc A Schuckit
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Am J Drug Alcohol Abuse 37:479-86. 2011
    ..This report attempts to offer a more straightforward description of the results from such a prospective model of how a lower LR at age 20 relates to alcohol outcomes at age 40...
  27. pmc Testing a level of response to alcohol-based model of heavy drinking and alcohol problems in 1,905 17-year-olds
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 35:1897-904. 2011
    ..This study evaluates a full LR-based model of risk in a large sample of adolescents from the United Kingdom...
  28. pmc Onset and course of alcoholism over 25 years in middle class men
    Marc A Schuckit
    University of California, San Diego, La Jolla, 92037, USA
    Drug Alcohol Depend 113:21-8. 2011
    ..However, few studies use multiple data points and detailed history spanning early adulthood to middle age. This study reports such data from 373 men in the San Diego Prospective Study...
  29. doi request reprint Comparing structural equation models that use different measures of the level of response to alcohol
    Marc A Schuckit
    Department of Psychiatry, UCSD School of Medicine, La Jolla, California 92093 0866, USA
    Alcohol Clin Exp Res 34:861-8. 2010
    ..However, few data are available regarding whether alcohol challenge-based and SRE-based LRs operate similarly in structural equation models (SEMs) that search for characteristics, which help to mediate how LR impacts alcohol outcomes...
  30. pmc An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 70:436-45. 2009
    ..This article presents the first full test of this LR-based model in young subjects from the Collaborative Study on the Genetics of Alcoholism (COGA)...
  31. ncbi request reprint An overview of genetic influences in alcoholism
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, VA San Diego Healthcare System, San Diego, CA 92161 2002, USA
    J Subst Abuse Treat 36:S5-14. 2009
    ....
  32. pmc The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects
    Marc A Schuckit
    Department of Psychiatry, VA San Diego Healthcare System University of California, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Alcohol Alcohol 43:641-6. 2008
    ..The current analyses evaluate the ability of SRE scores as determined at age 12 to predict heavier drinking and alcohol-related problems 2 years later in a sample from the United Kingdom...
  33. pmc The performance of elements of a 'level of response to alcohol'-based model of drinking behaviors in 13-year-olds
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, CA 92161 2002, USA
    Addiction 103:1786-92. 2008
    ..The goals of this paper are to evaluate whether drinking practices among peers mediates the relationship between a low level of response (LR) to alcohol and a person's heavier drinking and alcohol-related problems in 12-14-year-olds...
  34. ncbi request reprint Testing the level of response to alcohol-based model of heavy drinking and alcohol problems in offspring from the San Diego Prospective Study
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 69:571-9. 2008
    ..This article evaluates an LR-based model of drinking patterns in 113 drinking offspring, ages 12 to 24 years, from the San Diego Prospective Study...
  35. pmc The prognostic implications of DSM-IV abuse criteria in drinking adolescents
    Marc A Schuckit
    Department of Psychiatry 116A, University of California San Diego and the VA San Diego Healthcare System, San Diego, CA 92161 2002, USA
    Drug Alcohol Depend 97:94-104. 2008
    ..While future diagnostic manuals might alter the approach to abuse, it is worthwhile to evaluate the implications of the current definition that has been in place since 1994...
  36. doi request reprint Clinical implications of tolerance to alcohol in nondependent young drinkers
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego 92161 2002, USA
    Am J Drug Alcohol Abuse 34:133-49. 2008
    ..However, relatively few data are available on the clinical implications of tolerance in nondependent men and women...
  37. ncbi request reprint A comparison of factors associated with substance-induced versus independent depressions
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 68:805-12. 2007
    ....
  38. ncbi request reprint Patterns and correlates of drinking in offspring from the San Diego Prospective Study
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, and the VA San Diego Healthcare System, San Diego, CA 92161 2002, USA
    Alcohol Clin Exp Res 31:1681-91. 2007
    ....
  39. ncbi request reprint The ability of the Self-Rating of the Effects of Alcohol (SRE) Scale to predict alcohol-related outcomes five years later
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, and the Veterans Affairs San Diego Healthcare System, San Diego, CA 92161 2002, USA
    J Stud Alcohol Drugs 68:371-8. 2007
    ....
  40. ncbi request reprint Patterns of drug-related disorders in a prospective study of men chosen for their family history of alcoholism
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, USA
    J Stud Alcohol 65:613-20. 2004
    ..This study controls for several factors that might contribute to a propensity toward both alcohol and substance-related conditions in a prospective follow-up of middle-class men...
  41. ncbi request reprint Similarities in the clinical characteristics related to alcohol dependence in two populations
    Marc A Schuckit
    Department of Psychiatry, University of California San Diego and the San Diego Veterans Affairs Healthcare System, 92161 2002, USA
    Am J Addict 11:1-9. 2002
    ....
  42. ncbi request reprint The prevalence and clinical course of sedative-hypnotic abuse and dependence in a large cohort
    Marc A Schuckit
    Department of Psychiatry, VA San Diego Healthcare System, University of California San Diego, 92161 2002, USA
    Am J Drug Alcohol Abuse 28:73-90. 2002
    ....
  43. ncbi request reprint The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders
    M A Schuckit
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, and University of California, 92161 2002, USA
    J Stud Alcohol 61:827-35. 2000
    ....
  44. ncbi request reprint A comparison of correlates of DSM-IV alcohol abuse or dependence among more than 400 sons of alcoholics and controls
    M A Schuckit
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, and the University of California 92161 2002, USA
    Alcohol Clin Exp Res 25:1-8. 2001
    ..Alcohol dependence and abuse are defined as separate disorders. However, relatively few data are available about whether the same characteristics predict both syndromes...
  45. ncbi request reprint A preliminary evaluation of the potential usefulness of the diagnoses of polysubstance dependence
    M A Schuckit
    Department of Psychiatry, University of California, San Diego and Veterans Affairs San Diego Healthcare System, 92161 2002, USA
    J Stud Alcohol 62:54-61. 2001
    ..This article evaluates the prevalence and characteristics associated with PD in participants in a large collaborative study...
  46. ncbi request reprint A genome-wide search for genes that relate to a low level of response to alcohol
    M A Schuckit
    Department of Psychiatry, University of California, San Diego 92161 2002, USA
    Alcohol Clin Exp Res 25:323-9. 2001
    ..The genes that contribute to a low LR have not yet been identified...
  47. ncbi request reprint The clinical course of alcohol dependence associated with a low level of response to alcohol
    M A Schuckit
    University of California San Diego and Department of Psychiatry 116A, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    Addiction 96:903-10. 2001
    ..To evaluate the clinical course of specific alcohol-related life problems and the risk for dependence on illicit drugs in individuals with relatively low and high levels of response (LR) to alcohol earlier in life...
  48. ncbi request reprint Five-year clinical course associated with DSM-IV alcohol abuse or dependence in a large group of men and women
    M A Schuckit
    Department of Psychiatry, University of California, San Diego 92161 2002, USA
    Am J Psychiatry 158:1084-90. 2001
    ..The prognostic validity of the DSM-IV diagnoses of alcohol abuse and alcohol dependence was evaluated by examining the 5-year clinical course associated with those diagnoses in a large group of predominantly blue-collar men and women...
  49. ncbi request reprint Correlates of unpredicted outcomes in sons of alcoholics and controls
    M A Schuckit
    Department of Psychiatry, University of California, San Diego, and the Veterans Affairs San Diego Healthcare System, 92161 2002, USA
    J Stud Alcohol 62:477-85. 2001
    ..This article evaluates factors that might have contributed to unexpected outcomes, in a prospective study of sons of alcoholics and controls...
  50. ncbi request reprint Women who marry men with alcohol-use disorders
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 26:1336-43. 2002
    ..Our data were gathered as part of a prospective study of an original sample of 453 sons of alcoholics and controls who were originally selected as students or nonacademic staff at a university...
  51. ncbi request reprint Level of response to alcohol measured on the self-rating of the effects of alcohol questionnaire in a group of 40-year-old women
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego and the Veterans Affairs San Diego Healthcare System, San Diego, CA 92161 2002, USA
    Am J Drug Alcohol Abuse 29:191-201. 2003
    ..001), and related to recent nicotine use (0.23, p < 0.05). These data indicate the potential usefulness of the SRE as a measure of LR as a risk factor for alcoholism in relatively highly functioning middle-aged women...
  52. ncbi request reprint A 5-year prospective evaluation of DSM-IV alcohol dependence with and without a physiological component
    M A Schuckit
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Alcohol Clin Exp Res 27:818-25. 2003
    ..Few studies have determined the prognostic meaning of a history of a physiological component to DSM-IV alcohol dependence...
  53. ncbi request reprint Genetics of the risk for alcoholism
    M A Schuckit
    Veterans Affairs San Diego Healthcare System, CA 92161 2002, USA
    Am J Addict 9:103-12. 2000
    ..These findings are placed in the perspective of the impact that they are likely to have on both prevention and treatment efforts in the alcohol field...
  54. ncbi request reprint Changes over time in the self-reported level of response to alcohol
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego and the VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161 2002, USA
    Alcohol Alcohol 39:433-8. 2004
    ....
  55. ncbi request reprint The Self-Rating of the Effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism
    M A Schuckit
    Addiction 92:979-88. 1997
    ..A 12-question Self-Rating of the Effects (SRE) of alcohol form has been shown to correlate cross-sectionally with a designation of a low LR determined by alcohol challenges...
  56. ncbi request reprint A measure of the intensity of response to alcohol in a military population
    M A Schuckit
    University of California San Diego, 92161 2002, USA
    Am J Drug Alcohol Abuse 27:749-57. 2001
    ..These data also support the potential usefulness of the SRE both in identifying individuals likely to have more severe alcohol profiles and in educating individuals regarding their levels of risk for alcohol abuse and dependence...
  57. ncbi request reprint Correlates of externalizing symptoms in children from families of alcoholics and controls
    Marc A Schuckit
    Department of Psychiatry, University of California and the Veterans Affairs San Diego Healthcare System, San Diego, CA 92161 2002, USA
    Alcohol Alcohol 38:559-67. 2003
    ..This paper describes a new stage in the ongoing evaluation of the original families of sons of alcoholics and controls where we now focus on the relationships among relevant domains of functioning in their young sons and daughters...
  58. ncbi request reprint The five-year predictive validity of each of the seven DSM-IV items for alcohol dependence among alcoholics
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego, and the Veterans Affairs San Diego Healthcare System, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 26:980-7. 2002
    ..Information about the prognostic implications of a DSM-IV diagnosis of alcohol dependence is important to both clinicians and researchers. In this regard, only limited data are available on the performance of specific diagnostic items...
  59. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    ..Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism...
  60. ncbi request reprint Behavioral symptoms and psychiatric diagnoses among 162 children in nonalcoholic or alcoholic families
    M A Schuckit
    Department of Psychiatry, VA San Diego Healthcare System, CA 92161 2002, USA
    Am J Psychiatry 157:1881-3. 2000
    ..Many studies have not controlled for parental disorders other than alcoholism or for parents' socioeconomic status and general life functioning. The authors' goal was to conduct a study controlling for such factors...
  61. ncbi request reprint The 5-year clinical course of high-functioning men with DSM-IV alcohol abuse or dependence
    M A Schuckit
    Department of Psychiatry, VA Medical Center, VA San Diego Healthcare System, California 92121 2002, USA
    Am J Psychiatry 157:2028-35. 2000
    ..This study evaluated the ability of the DSM-IV categories of alcohol abuse and alcohol dependence to predict the onset and cessation of the 11 DSM-IV abuse/dependence criterion items...
  62. ncbi request reprint Mood and anxiety symptoms among 140 children from alcoholic and control families
    U W Preuss
    Department of Veterans Affairs, VA San Diego Healthcare System, University of California, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Drug Alcohol Depend 67:235-42. 2002
    ..The present evaluations assess the relationships of the family histories of alcohol use disorders and independent mood and anxiety disorders to internalizing symptoms in children of alcoholic and nonalcoholic subjects...
  63. ncbi request reprint A latent class analysis of antisocial personality disorder symptom data from a multi-centre family study of alcoholism
    K K Bucholz
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108 1334, USA
    Addiction 95:553-67. 2000
    ..To determine if there are subtypes of Antisocial Personality Disorder (ASPD), as manifested by distinctive symptom profiles or by associations with alcohol, other drug dependence or other psychiatric disorders...
  64. ncbi request reprint Comparison of 3190 alcohol-dependent individuals with and without suicide attempts
    U W Preuss
    Department of Veterans Affairs, VA San Diego Healthcare System, Department of Psychiatry, California 92161, USA
    Alcohol Clin Exp Res 26:471-7. 2002
    ..Suicidal behaviors are often seen in alcohol-dependent individuals. The aim of this study is to identify and confirm risk factors for suicide attempts in a large, family-based sample of alcoholics...
  65. ncbi request reprint Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
    H Begleiter
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, NY 11203, USA
    Electroencephalogr Clin Neurophysiol 108:244-50. 1998
    ....
  66. ncbi request reprint A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attempts
    U W Preuss
    Department of Psychiatry, University of California, San Diego 92161 2002, USA
    J Stud Alcohol 63:498-502. 2002
    ....
  67. ncbi request reprint The use of alcoholic subtype diagnoses in the U.S. Navy
    M A Schuckit
    Navy Medical Neuropsychiatric Research Unit, San Diego, California, USA
    Dis Nerv Syst 35:563-7. 1974
    ..It was concluded that from these perspectives the alcoholic subtype system of the DMS II adds little, if anything, beyond the basic diagnosis of alcoholism as outlined by the National Council on Alcoholism Criteria...
  68. ncbi request reprint Amnestic effects of intravenous diazepam in healthy young men
    R M Anthenelli
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093
    Am J Drug Alcohol Abuse 17:129-36. 1991
    ..The data expand our current understanding of the amnestic effects of benzodiazepines and suggest that patients abusing these drugs in large doses may develop profound degrees of memory impairment...
  69. ncbi request reprint A five-year prospective study of diagnostic orphans for alcohol use disorders
    M Y Eng
    Department of Psychiatry 116A, University of California, San Diego, and the Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, California 92161 2002, USA
    J Stud Alcohol 64:227-34. 2003
    ..These persons have been referred to as "diagnostic orphans." The aim of the analyses presented here is to further understanding about this potentially important group...
  70. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
    ..There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking...
  71. pmc Multiple-domain predictors of problematic alcohol use in young adulthood
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 69:649-59. 2008
    ..The goal of this study was to identify predictors of problematic young adult alcohol use...
  72. doi request reprint Level of response to alcohol within the context of alcohol-related domains: an examination of longitudinal approaches assessing changes over time
    Ryan S Trim
    Department of Psychiatry, University of California, and VA San Diego Healthcare System, San Diego, California, USA
    Alcohol Clin Exp Res 32:472-80. 2008
    ..This study evaluated whether a person's LR to alcohol predicted alcohol-related domains at multiple time-points and examined longitudinal relations among these domains in a sample of probands from the San Diego Prospective Study...
  73. ncbi request reprint Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093 0603, USA
    Neuropsychopharmacology 26:53-63. 2002
    ..These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction...
  74. ncbi request reprint Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Mol Genet 17:963-70. 2008
    ..Thus, variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease...
  75. ncbi request reprint The level of response to alcohol in daughters of alcoholics and controls
    Mimy Y Eng
    San Diego State University, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120, USA
    Drug Alcohol Depend 79:83-93. 2005
    ....
  76. ncbi request reprint Predictors and correlates of suicide attempts over 5 years in 1,237 alcohol-dependent men and women
    Ulrich W Preuss
    VA San Diego Healthcare System and the University of California, San Diego, CA, USA
    Am J Psychiatry 160:56-63. 2003
    ..Psychiatric comorbidity was examined in terms of a distinction between substance-induced and independent psychiatric disorders...
  77. ncbi request reprint Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 62:761-8. 2005
    ..Relapse is a common clinical problem in individuals with substance dependence. Previous studies have implicated a multifactorial process underlying relapse; however, the contribution of specific neural substrates has not yet been examined...
  78. ncbi request reprint Transitions to, and correlates of, suicidal ideation, plans, and unplanned and planned suicide attempts among 3,729 men and women with alcohol dependence
    Kenneth R Conner
    Center for the Study and Prevention of Suicide and the Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, New York 14620, USA
    J Stud Alcohol Drugs 68:654-62. 2007
    ....
  79. ncbi request reprint Searching for the full picture: structural equation modeling in alcohol research
    Marc A Schuckit
    Department of Psychiatry, University of California at San Diego and VA San Diego Healthcare System, San Diego, California 92161 2002, USA
    Alcohol Clin Exp Res 30:194-202. 2006
    ..This is followed by a description of the application of SEM to an affect-related model as discussed by John Kramer and Kathleen Bucholz. Finally, Kenneth Sher offers thoughts on how to place these findings into perspective...
  80. ncbi request reprint The validity of DSM-IV alcohol dependence: what do we know and what do we need to know?
    Deborah S Hasin
    Mailman School of Public Health, Division of Epidemiology, and College of Physicians and Surgeons, Department of Psychiatry of Columbia University, New York, NY 10032, USA
    Alcohol Clin Exp Res 27:244-52. 2003
    ..Marc Schuckit, as discussant for the symposium, placed the issues in perspective for the upcoming DSM-V...
  81. ncbi request reprint EEG alpha variants and alpha power in Hispanic American and white non-Hispanic American young adults with a family history of alcohol dependence
    Cindy L Ehlers
    Department of Neuropharmacology, The Scripps Research Institute CVN 14 TSRI, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 33:99-106. 2004
    ..Results of the current study confirm the presence of ethnic stratification in EEG alpha variants...
  82. ncbi request reprint Relationship of age of first drink to child behavioral problems and family psychopathology
    Samuel Kuperman
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 1057, USA
    Alcohol Clin Exp Res 29:1869-76. 2005
    ....
  83. ncbi request reprint Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism
    Laura Jean Bierut
    Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 26:208-13. 2002
    ..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...
  84. ncbi request reprint Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years
    Robert Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110 1026, USA
    Arch Gen Psychiatry 62:753-60. 2005
    ..A major criterion to validate diagnoses is stability over time...
  85. ncbi request reprint Ethnicity and psychiatric comorbidity among alcohol-dependent persons who receive inpatient treatment: African Americans, Alaska natives, Caucasians, and Hispanics
    Michie N Hesselbrock
    School of Social Work, University of Connecticut, West Hartford, Connecticut 06117 2698, USA
    Alcohol Clin Exp Res 27:1368-73. 2003
    ..Significant ethnic differences were found in relation to age of onset of alcohol and multiple substance dependence and psychiatric comorbidity. Ethnic differences were also noted with regard to the health care utilization...
  86. ncbi request reprint Level of response to alcohol and brain response during visual working memory
    Susan F Tapert
    Veterans Affairs San Diego Healthcare System, University of California San Diego, San Diego, California 92161, USA
    J Stud Alcohol 65:692-700. 2004
    ..This study examined neural correlates of the low level of response to alcohol using functional magnetic resonance imaging (FMRI) during a challenging visual working memory task...
  87. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  88. ncbi request reprint Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition
    Kevin A Jones
    Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA
    Int J Psychophysiol 53:75-90. 2004
    ..001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans...
  89. ncbi request reprint Should DSM-V include dimensional diagnostic criteria for alcohol use disorders?
    John E Helzer
    Health Behavior Research Center, University of Vermont Medical School, South Burlington, Vermont 05403, USA
    Alcohol Clin Exp Res 30:303-10. 2006
    ..The discussion is by Marc Schuckit, who was chair of the Substance Use disorders (SUD) Committee for DSM-IV and cochair of the international group of experts reviewing the SUD definitions for DSM-V...
  90. ncbi request reprint Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents
    Anne S Hinckers
    Department of Psychosomatics, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 60:282-7. 2006
    ..To date, all studies of relevant polymorphisms have been carried out in populations in the United States...
  91. ncbi request reprint The importance of a positive family history of alcoholism, parental rejection and emotional warmth, behavioral problems and peer substance use for alcohol problems in teenagers: a path analysis
    Sven Barnow
    Department of Psychiatry and Psychotherapy, Ernst Moritz Arndt University of Greifswald, Germany
    J Stud Alcohol 63:305-15. 2002
    ..Among 180 offspring, family history of alcoholism, parenting styles, behavioral and emotional problems, peer-group characteristics, feelings of self-esteem, behavioral problems and psychiatric comorbidity of the parents were examined...
  92. ncbi request reprint Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
    ..The perceived bitterness of PROP has also been associated with oral sensation and drinking behaviors...
  93. ncbi request reprint The relationship of behavioural undercontrol to alcoholism in higher-functioning adults
    Marc A Schuckit
    Department of Psychiatry, University of California, San Diego and the VA San Diego Healthcare System, San Diego, California 92161 2002, USA
    Drug Alcohol Rev 25:393-402. 2006
    ....
  94. ncbi request reprint Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians
    Nicole C E Duranceaux
    Department of Psychiatry, University of California, San Diego, California 92161, USA
    Alcohol Clin Exp Res 30:1470-8. 2006
    ..Variations in the ADH1B and ADH1C genes may influence the LR to alcohol by increasing levels of acetaldehyde during alcohol metabolism, although most data on this question come from Asian populations...
  95. pmc Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, California 92093 0603, USA
    Alcohol Clin Exp Res 30:1363-71. 2006
    ..A low level of response to alcohol is a major risk factor for the development of alcohol dependence, but neural correlates of this marker are unclear...
  96. ncbi request reprint Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task
    Ajayan Padmanabhapillai
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, SUNY, HSCB, Brooklyn, NY 11203, USA
    Int J Psychophysiol 62:262-71. 2006
    ..The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk...
  97. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  98. ncbi request reprint Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California at San Diego, La Jolla, 92093 0603, USA
    Biol Psychiatry 53:65-74. 2003
    ..This study examined whether the degree of success and the degree of predictability differentially affected MD's decision making...
  99. ncbi request reprint Comparison of psychiatric diagnoses from interview reports with those from best-estimate procedures
    Kathleen K Bucholz
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, Missouri 63110 1093, USA
    J Stud Alcohol 67:157-68. 2006
    ....
  100. ncbi request reprint Precontemplated and impulsive suicide attempts among individuals with alcohol dependence
    Kenneth R Conner
    Center for the Study and Prevention of Suicide and Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14620, USA
    J Stud Alcohol 67:95-101. 2006
    ..Some suicide attempts are precontemplated, whereas other attempts are impulsive. The purpose of this study was to compare characteristics and correlates of impulsive and precontemplated suicide attempts...
  101. ncbi request reprint The relationship between parental alcoholism and adolescent psychopathology: a systematic examination of parental comorbid psychopathology
    Christine McCauley Ohannessian
    Department of Individual and Family Studies, University of Delaware, Newark, DE 19716, USA
    J Abnorm Child Psychol 32:519-33. 2004
    ..These findings underscore the importance of considering parental comorbid psychopathology when examining the relationship between parental alcoholism and offspring adjustment...

Research Grants16

  1. LEVEL OF RESPONSE TO ALCOHOL AND BRAIN FUNCTIONING
    Marc A Schuckit; Fiscal Year: 2010
    ..The project will also expand our understanding of the neural substrates of the level of response to alcohol, a key risk factor for the development of alcohol dependence. ..
  2. LEVEL OF RESPONSE TO ALCOHOL AND BRAIN FUNCTIONING
    Marc Schuckit; Fiscal Year: 2007
    ..The project will also expand our understanding of the neural substrates of the level of response to alcohol, a key risk factor for the development of alcohol dependence. ..
  3. Prospective Study: Alcoholic & Control Family Offspring
    Marc Schuckit; Fiscal Year: 2007
    ..Our ultimate goal is to identify ways to prevent the escalation of drinking and associated problems in young populations. ..
  4. REACTIONS TO DEPRESSANTS IN SONS OF ALCS
    Marc Schuckit; Fiscal Year: 2003
    ....
  5. Prospective Study: Alcoholic & Control Family Offspring
    Marc A Schuckit; Fiscal Year: 2010
    ..Our ultimate goal is to identify ways to prevent the escalation of drinking and associated problems in young populations. ..