HARRY WILLIAM SCHROEDER

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
    Gregory C Ippolito
    Department of Microbiology, University of Alabama at Birmingham, SHEL 401, Birmingham, AL 35294, USA
    J Exp Med 203:1567-78. 2006
  2. pmc The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation
    Andre M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Exp Med 210:875-90. 2013
  3. pmc Absence of N addition facilitates B cell development, but impairs immune responses
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, USA
    Immunogenetics 63:599-609. 2011
  4. pmc DH and JH usage in murine fetal liver mirrors that of human fetal liver
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Immunogenetics 62:653-66. 2010
  5. pmc Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8
    Manda L Waldrep
    Allergy, Asthma and Immunology Clinic of Georgetown, Georgetown, Texas, USA
    BMC Med Genet 10:100. 2009
  6. pmc Structure and function of immunoglobulins
    Harry W Schroeder
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Allergy Clin Immunol 125:S41-52. 2010
  7. pmc Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production
    Harry W Schroeder
    Department of Medicine, University of Alabama at Birmingham, 35294 2182, USA
    Crit Rev Immunol 30:327-44. 2010

Research Grants

  1. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2007
  2. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2003
  3. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2003
  4. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
  5. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2001
  6. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2009
  7. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2001
  8. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2007
  9. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2006
  10. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2005

Collaborators

Detail Information

Publications8

  1. pmc Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
    Gregory C Ippolito
    Department of Microbiology, University of Alabama at Birmingham, SHEL 401, Birmingham, AL 35294, USA
    J Exp Med 203:1567-78. 2006
    ..Thus, violation of the conserved preference for tyrosine and glycine in D(H) RF1 alters CDR-H3 content and impairs B cell development and antibody production...
  2. pmc The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation
    Andre M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Exp Med 210:875-90. 2013
    ..The potential relevance of these findings for the rational design of vaccines is discussed...
  3. pmc Absence of N addition facilitates B cell development, but impairs immune responses
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, USA
    Immunogenetics 63:599-609. 2011
    ..TdT deficiency, which characterizes fetal lymphocytes, thus appears to facilitate filling both central and peripheral lymphoid compartments, but at the cost of altered responses to a broad set of antigens...
  4. pmc DH and JH usage in murine fetal liver mirrors that of human fetal liver
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Immunogenetics 62:653-66. 2010
    ..However, fetal liver usage of J(H)-proximal D(H)Q52 and D(H)-proximal J(H)2 was markedly greater than that of adult bone marrow. Thus, the early pattern of D(H) and J(H) usage in mouse feta liver mirrors that of human...
  5. pmc Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8
    Manda L Waldrep
    Allergy, Asthma and Immunology Clinic of Georgetown, Georgetown, Texas, USA
    BMC Med Genet 10:100. 2009
    ..Of 13 affected subjects, nine had inherited HLA *B8 and six had inherited HLA B44. This raised the possibility that TACI mutations might synergize with MHC class I alleles to enhance susceptibility to humoral immune deficiency...
  6. pmc Structure and function of immunoglobulins
    Harry W Schroeder
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Allergy Clin Immunol 125:S41-52. 2010
    ..Each class defines the IgM, IgG, IgA, IgD, and IgE isotypes. IgG can be split into 4 subclasses, IgG1, IgG2, IgG3, and IgG4, each with its own biologic properties, and IgA can similarly be split into IgA1 and IgA2...
  7. pmc Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production
    Harry W Schroeder
    Department of Medicine, University of Alabama at Birmingham, 35294 2182, USA
    Crit Rev Immunol 30:327-44. 2010
    ..This change in the repertoire variably affects antibody production and the development of specific B-cell subsets...

Research Grants20

  1. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2007
    ..abstract_text> ..
  2. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2003
    ..abstract_text> ..
  3. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2003
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..
  4. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ....
  5. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2001
    ..abstract_text> ..
  6. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2009
    ....
  7. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2001
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..
  8. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2007
    ....
  9. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2006
    ....
  10. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2005
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..
  11. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2004
    ..abstract_text> ..
  12. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2004
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..
  13. TCRb CDR3 and Susceptibility to Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2003
    ..These experiments will also shed light on the role of potentially abnormal TCR sequence in promoting lupus and other autoimmune diseases. ..
  14. IMMUNOGLOBULIN HCDR3 IN AUTOIMMUNE DISEASE
    Harry Schroeder; Fiscal Year: 2002
    ..abstract_text> ..
  15. DEVELOPMENT OF THE ANTIBODY REPERTOIRE
    Harry Schroeder; Fiscal Year: 2002
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..
  16. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ..g. antigen encased in liposomes or antigen displayed by pseudovirions) will facilitate the generation of antibodies that can bind the key MPER region of the HIV envelope protein in a way that will enable them to broadly neutralize HIV. ..