H W Schroeder

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Regulation of the antibody repertoire through control of HCDR3 diversity
    H W Schroeder
    Department of Medicine, University of Alabama, Birmingham 35294 3300, USA
    Vaccine 16:1383-90. 1998
  2. ncbi request reprint Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)
    Douglas T Johnston
    University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
    Clin Immunol 119:346-50. 2006
  3. pmc Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes
    Jason M Link
    Department of Microbiology, Division of Developmental and Clinical Immunology, Wallace Tumor Institute 378, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Arthritis Res 4:80-3. 2002
  4. ncbi request reprint Similarity and divergence in the development and expression of the mouse and human antibody repertoires
    Harry W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, Wallace Tumor Institute 378, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Dev Comp Immunol 30:119-35. 2006
  5. pmc Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes
    H W Schroeder
    Department of Medicine, Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Mol Med 4:72-86. 1998
  6. ncbi request reprint The complex genetics of common variable immunodeficiency
    Harry W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Investig Med 52:90-103. 2004
  7. ncbi request reprint Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life
    H W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Blood 98:2745-51. 2001
  8. pmc Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
    H W Schroeder
    Department of Medicine, University of Alabama, Birmingham 35294
    Proc Natl Acad Sci U S A 87:6146-50. 1990
  9. pmc An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family
    T P Atkinson
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Hum Genet 69:791-803. 2001
  10. pmc A rapid and quantitative method for the evaluation of V gene usage, specificities and the clonal size of B cell repertoires
    A M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    J Immunol Methods 376:143-9. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Regulation of the antibody repertoire through control of HCDR3 diversity
    H W Schroeder
    Department of Medicine, University of Alabama, Birmingham 35294 3300, USA
    Vaccine 16:1383-90. 1998
    ..The precise role that this restriction of the HCDR3 might play in the development of immunocompetence in the human remains to be elucidated...
  2. ncbi request reprint Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)
    Douglas T Johnston
    University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
    Clin Immunol 119:346-50. 2006
    ..0001). Inheritance of HLA-B44 may yield susceptibility to recurrent sinopulmonary infection even in the presence of normal serum immunoglobulin levels...
  3. pmc Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes
    Jason M Link
    Department of Microbiology, Division of Developmental and Clinical Immunology, Wallace Tumor Institute 378, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Arthritis Res 4:80-3. 2002
    ....
  4. ncbi request reprint Similarity and divergence in the development and expression of the mouse and human antibody repertoires
    Harry W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, Wallace Tumor Institute 378, 1530 3rd Ave S, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Dev Comp Immunol 30:119-35. 2006
    ....
  5. pmc Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes
    H W Schroeder
    Department of Medicine, Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Mol Med 4:72-86. 1998
    ..In a search for the gene(s) in the major histocompatibility complex (MHC) that predispose to IgAD/CVID, we analyzed the extended MHC haplotypes present in a large family with 8 affected members...
  6. ncbi request reprint The complex genetics of common variable immunodeficiency
    Harry W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Investig Med 52:90-103. 2004
    ..First-degree family members of patients with CVID are at risk throughout their lives for the development of these diseases and should be monitored with a high index of suspicion...
  7. ncbi request reprint Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life
    H W Schroeder
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Blood 98:2745-51. 2001
    ..Antibody repertoire development appears to be endogenously controlled and adheres to an individualized developmental progression that probably contributes to the relative immaturity of the neonatal immune response...
  8. pmc Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
    H W Schroeder
    Department of Medicine, University of Alabama, Birmingham 35294
    Proc Natl Acad Sci U S A 87:6146-50. 1990
    ..These data support the hypothesis that VH3 gene segments play an essential role in the development of the immune response...
  9. pmc An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family
    T P Atkinson
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Hum Genet 69:791-803. 2001
    ..70 with marker D2S2328, and the peak three-point LOD score was 3.82. This is the first linkage assignment of a dominant locus for mucocutaneous candidiasis...
  10. pmc A rapid and quantitative method for the evaluation of V gene usage, specificities and the clonal size of B cell repertoires
    A M Vale
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    J Immunol Methods 376:143-9. 2012
    ....
  11. pmc Complement activation in factor D-deficient mice
    Y Xu
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 98:14577-82. 2001
    ..Kinetics of opsonization of Streptococcus pneumoniae by C3 fragments was much slower in factor D-deficient serum, suggesting a significant contribution of the alternative pathway to antibacterial host defense early after infection...
  12. pmc Membranous glomerulopathy in an adult patient with X-linked agammaglobulinemia receiving intravenous gammaglobulin
    L M Endo
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
    J Investig Allergol Clin Immunol 21:405-9. 2011
    ..Immune complex deposition in the subepithelial zone of glomerular capillaries can lead to membranous glomerulopathy...
  13. ncbi request reprint The J chain gene is transcribed during B and T lymphopoiesis in humans
    F E Bertrand
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA
    J Immunol 156:4240-4. 1996
    ..These results suggest that the J chain gene is transcriptionally active during early stages of both B cell and T cell differentiation, before the expression of their respective Ag receptors...
  14. ncbi request reprint Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors
    Ivaylo I Ivanov
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 174:7773-80. 2005
    ..08 +/- 0.03) to mild hydrophilic in fraction F (-0.17 +/- 0.02). Fundamental constraints on the sequence and structure of CDR-H3 are thus established before surface IgM expression...
  15. ncbi request reprint B-cell numbers in the blood of patients with non-HLA*B8 or non-HLA*B44 common variable immunodeficiency
    Douglas T Johnston
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
    Ann Allergy Asthma Immunol 98:163-7. 2007
    ..Genetic susceptibility to common variable immunodeficiency (CVID) has been linked to the inheritance of part or all of 2 extended major histocompatibility complex haplotypes: HLA*B8*DR3(17) and HLA*B44*DR7...
  16. ncbi request reprint A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function
    Robert L Schelonka
    Department of Pediatrics, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 175:6624-32. 2005
    ..Although limited to a repertoire specific to DFL16.1, the presence of a single DH gene segment of normal sequence was sufficient for development of normal numbers of mature B cells and for robust humoral immune function...
  17. ncbi request reprint Categorical selection of the antibody repertoire in splenic B cells
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1530, USA
    Eur J Immunol 37:1010-21. 2007
    ....
  18. pmc Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire
    Huan H Nguyen
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 81:9331-8. 2007
    ....
  19. ncbi request reprint Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's disease
    Jian Li
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Psychosom Med 69:551-9. 2007
    ..To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD)...
  20. ncbi request reprint Recognition reversal in a spineless scrounger
    Neil S Greenspan
    Nat Immunol 7:797-8. 2006
  21. pmc Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
    Gregory C Ippolito
    Department of Microbiology, University of Alabama at Birmingham, SHEL 401, Birmingham, AL 35294, USA
    J Exp Med 203:1567-78. 2006
    ..Thus, violation of the conserved preference for tyrosine and glycine in D(H) RF1 alters CDR-H3 content and impairs B cell development and antibody production...
  22. ncbi request reprint Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires
    Michael Zemlin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Immunol Res 26:265-78. 2002
    ....
  23. ncbi request reprint Despite extensive similarity in germline DH and JH sequence, the adult Rhesus macaque CDR-H3 repertoire differs from human
    Jason M Link
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, AL 35294 3300, USA
    Mol Immunol 42:943-55. 2005
    ..We conclude that the same mechanisms that refine and shape CDR-H3 diversity during ontogeny can also be used to fine tune and individualize species-specific antibody repertoires despite germline immunoglobulin sequence similarity...
  24. ncbi request reprint The Rhesus monkey immunoglobulin IGHD and IGHJ germline repertoire
    Jason M Link
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, AL 35294 3300, USA
    Immunogenetics 54:240-50. 2002
    ..The high degree of conservation between human and Rhesus IGHD and IGHJ genes supports the hypothesis that the germline repertoire encodes evolutionarily preferred antibody sequence as a result of selection for function...
  25. ncbi request reprint Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
    Michael Zemlin
    Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
    J Mol Biol 334:733-49. 2003
    ..This information may also be useful for the design of species-specific CDR-H3 sequences in synthetic antibody libraries...
  26. ncbi request reprint Antibody repertoire in a mouse with a simplified D(H) locus: the D-limited mouse
    Gregory C Ippolito
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Ann N Y Acad Sci 987:262-5. 2003
  27. ncbi request reprint Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families
    Damini Jawaheer
    Center for Genomics and Human Genetics, Manhasset, New York 11030, USA
    Arthritis Rheum 48:906-16. 2003
    ..A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) have been previously identified. The present study attempts to confirm these findings...
  28. ncbi request reprint Adult lupus-prone MRL/MpJ2+ mice express a primary antibody repertoire that differs in CDR-H3 length distribution and hydrophobicity from that expressed in the C3H parental strain
    Michael Zemlin
    Clinic for Neonatology and Neuropediatrics, Philipps Universitat Marburg, Deutschhausstr 12, 35037 Marburg, Germany
    Mol Immunol 42:789-98. 2005
    ..Dysregulation of the adult pre-B CDR-H3 antibody repertoire could be a contributing factor for the development of florid auto-immune disease in MRL/MpJ(2+) mice...