Robert Schrier

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Developments in the management of autosomal dominant polycystic kidney disease
    Amirali Masoumi
    Department of Medicine, Health Sciences Center, University of Colorado School of Medicine Denver, CO 80262, USA
    Ther Clin Risk Manag 4:393-407. 2008
  2. ncbi Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
    J Am Coll Cardiol 47:1-8. 2006
  3. pmc Diagnosis and management of hyponatremia in acute illness
    Robert W Schrier
    Division of Renal Disease and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Opin Crit Care 14:627-34. 2008
  4. ncbi Comparison of renal injury in myeloablative autologous, myeloablative allogeneic and non-myeloablative allogeneic haematopoietic cell transplantation
    Robert W Schrier
    Department of Medicine, The University of Colorado School of Medicine, Denver, CO, USA
    Nephrol Dial Transplant 20:678-83. 2005
  5. ncbi From finch to fish to man: role of aquaporins in body fluid and brain water regulation
    R W Schrier
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
    Neuroscience 129:897-904. 2004
  6. ncbi Water and sodium retention in edematous disorders: role of vasopressin and aldosterone
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Med 119:S47-53. 2006
  7. ncbi Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  8. pmc Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 114:5-14. 2004
  9. ncbi Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Health Sciences Center C283, 4200 E Ninth Avenue, Denver, CO 80262, USA
    J Am Soc Nephrol 15:1023-8. 2004
  10. ncbi Optimal care of autosomal dominant polycystic kidney disease patients
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nephrology (Carlton) 11:124-30. 2006

Collaborators

Detail Information

Publications87

  1. pmc Developments in the management of autosomal dominant polycystic kidney disease
    Amirali Masoumi
    Department of Medicine, Health Sciences Center, University of Colorado School of Medicine Denver, CO 80262, USA
    Ther Clin Risk Manag 4:393-407. 2008
    ....
  2. ncbi Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
    J Am Coll Cardiol 47:1-8. 2006
    ....
  3. pmc Diagnosis and management of hyponatremia in acute illness
    Robert W Schrier
    Division of Renal Disease and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Opin Crit Care 14:627-34. 2008
    ....
  4. ncbi Comparison of renal injury in myeloablative autologous, myeloablative allogeneic and non-myeloablative allogeneic haematopoietic cell transplantation
    Robert W Schrier
    Department of Medicine, The University of Colorado School of Medicine, Denver, CO, USA
    Nephrol Dial Transplant 20:678-83. 2005
  5. ncbi From finch to fish to man: role of aquaporins in body fluid and brain water regulation
    R W Schrier
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
    Neuroscience 129:897-904. 2004
    ....
  6. ncbi Water and sodium retention in edematous disorders: role of vasopressin and aldosterone
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Med 119:S47-53. 2006
    ..These agents have been found to increase solute-free water excretion in patients with water-retaining, hyponatremic edema as well as in experimental animals...
  7. ncbi Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  8. pmc Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 114:5-14. 2004
    ..The clinical evaluation of ARF and implications for potential future therapies to decrease the high mortality are described...
  9. ncbi Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Health Sciences Center C283, 4200 E Ninth Avenue, Denver, CO 80262, USA
    J Am Soc Nephrol 15:1023-8. 2004
    ..The mean length of follow-up was 9.8 yr (median, 9.7 yr). These findings have important health care and economic implications in following patients with ADPKD...
  10. ncbi Optimal care of autosomal dominant polycystic kidney disease patients
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nephrology (Carlton) 11:124-30. 2006
    ....
  11. ncbi Body water homeostasis: clinical disorders of urinary dilution and concentration
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Am Soc Nephrol 17:1820-32. 2006
  12. ncbi Pentoxifylline protects against endotoxin-induced acute renal failure in mice
    Wei Wang
    Dept of Medicine, Univ of Colorado Health Sciences Center, 4200 East 9th Ave Box C 281, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 291:F1090-5. 2006
    ..0 +/- 7.6 mmHg.ml(-1).min(-1), P < 0.01). Thus pentoxifylline, an FDA-approved drug, protects against endotoxemia-related ARF and involves a decrease in serum TNF-alpha, IL-1beta, and NO as well as a decrease in renal iNOS and ICAM-1...
  13. ncbi Pulmonary hypertension, right ventricular failure, and kidney: different from left ventricular failure?
    Robert W Schrier
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Clin J Am Soc Nephrol 3:1232-7. 2008
    ....
  14. pmc Vasopressin and aquaporin 2 in clinical disorders of water homeostasis
    Robert W Schrier
    Division of Renal Diseases and Hypertension School of Medicine, Department of Medicine, University of Colorado at Denver Health Sciences Center, Denver, CO 80262 3706, USA
    Semin Nephrol 28:289-96. 2008
    ..Vasopressin-resistant down-regulation of aquaporin 2 expression has also been described as a factor in impaired urinary concentration...
  15. ncbi Aquaporin-related disorders of water homeostasis
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Drug News Perspect 20:447-53. 2007
    ....
  16. ncbi Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nat Clin Pract Nephrol 3:428-38. 2007
    ..Analysis of the results of 5 years of follow-up revealed a highly significant correlation of all-cause and cardiovascular mortality with left ventricular mass and severity of albuminuria...
  17. ncbi Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Renal Physiol 293:F1131-6. 2007
    ..This effect may be overridden by excessive activation of the renin-angiotensin system in renal-specific PGIs Tg mice...
  18. ncbi Decreased effective blood volume in edematous disorders: what does this mean?
    Robert W Schrier
    University of Colorado School of Medicine, Denver, CO 80262, USA
    J Am Soc Nephrol 18:2028-31. 2007
    ..The regulatory mechanisms that lead to increased sodium and water retention by the normal kidney are related to arterial underfilling, as a result of a decrease in cardiac output, arterial vasodilation, or both...
  19. ncbi The sea within us: disorders of body water homeostasis
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Department of Medicine, 4200 East Ninth Avenue B173, Denver, CO 80262, USA
    Curr Opin Investig Drugs 8:304-11. 2007
    ..The relationship between osmotic and non-osmotic regulation of antidiuretic hormone (arginine vasopressin) release is discussed...
  20. ncbi Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia
    Robert W Schrier
    University of Colorado, Denver, USA
    N Engl J Med 355:2099-112. 2006
    ..We investigated whether tolvaptan, an orally active vasopressin V(2)-receptor antagonist that promotes aquaresis--excretion of electrolyte-free water--might be of benefit in hyponatremia...
  21. ncbi The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 64:1792-9. 2003
    ..The present study was undertaken to examine the role of parental hypertension in the occurrence of hypertension in 475 ADPKD offspring...
  22. ncbi Treating high-risk diabetic hypertensive patients with comorbid conditions
    R W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 36:S10-7. 2000
    ..Angiotensin II (Ang II) receptor blockers (ARBs), which attenuate the deleterious effects of the RAS via blockade of the Ang II subtype 1 receptor, may also be beneficial. Clinical trials are under way to evaluate this possibility...
  23. ncbi Pathogenesis and management of sodium and water retention in cardiac failure and cirrhosis
    R W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Semin Nephrol 21:157-72. 2001
    ....
  24. ncbi Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B178, Denver, CO 80262, USA
    Kidney Int 61:1086-97. 2002
    ..The current study evaluated the effect of intensive versus moderate diastolic blood pressure (DBP) control on diabetic vascular complications in 480 normotensive type 2 diabetic patients...
  25. pmc Cancer therapy and renal injury
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 110:743-5. 2002
  26. ncbi Renal aquaporin water channels: from molecules to human disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box B178, Denver, CO 80262, USA
    Prog Biophys Mol Biol 81:117-31. 2003
    ..This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states...
  27. ncbi Pathophysiology of renal fluid retention
    R W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Kidney Int Suppl 67:S127-32. 1998
    ..V2 receptor antagonists reverse the water retention and down-regulate AQP-2 water channels...
  28. ncbi Cardiac and renal effects of standard versus rigorous blood pressure control in autosomal-dominant polycystic kidney disease: results of a seven-year prospective randomized study
    Robert Schrier
    Department of Medicine, Health Sciences Center, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Am Soc Nephrol 13:1733-9. 2002
    ..This finding has particular clinical importance because cardiovascular complications are the most common cause of death in ADPKD patients...
  29. ncbi Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure
    Wei Wang
    Dept of Medicine, Univ of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C 281, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 287:F1044-8. 2004
    ..59 +/- 0.16, n = 9 vs. 0.42 +/- 0.05, n = 6, P = not significant). In summary, eNOS knockout mice have increased RVR and are more susceptible to endotoxemic ARF than wild-type mice despite higher MAP...
  30. doi Ghrelin protects mice against endotoxemia-induced acute kidney injury
    Wei Wang
    Dept of Medicine, Univ of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 297:F1032-7. 2009
    ..Of particular importance was the suppression of TNF-alpha both in the circulation and kidney tissues. Thus, ghrelin may be a promising peptide in managing endotoxemia-induced AKI...
  31. doi Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262 0001, USA
    Am J Physiol Renal Physiol 294:F571-6. 2008
    ..Reactive oxygen species appear to be involved in this acute renal injury in Tg mice during endotoxemia...
  32. ncbi Role of heme oxygenase-1 in endotoxemic acute renal failure
    Brian Poole
    Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    Am J Physiol Renal Physiol 289:F1382-5. 2005
    ..The renal protection was associated with significantly improved systemic hemodynamics, less renal vasoconstriction, and a higher GFR...
  33. ncbi Intensive blood pressure control reduces the risk of cardiovascular events in patients with peripheral arterial disease and type 2 diabetes
    Philip S Mehler
    Internal Medicine at Denver Health and Hospitals, University of Colorado Health Sciences Center, Denver 80203, USA
    Circulation 107:753-6. 2003
    ..Peripheral arterial disease (PAD) and diabetes are both associated with a high risk of ischemic events, but the role of intensive blood pressure control in PAD has not been established...
  34. ncbi Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial
    Edward P Havranek
    Division of Cardiology, University of Colorado Health Sciences Center, Department of Medicine, Denver, USA
    Am Heart J 145:993-8. 2003
    ..Serial decline in electrocardiographic voltage in patients with increased left ventricular mass has been associated with a lower risk of cardiovascular events...
  35. doi Combination therapy with albumin and pentoxifylline protects against acute kidney injury during endotoxemic shock in mice
    Shweta Bansal
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ren Fail 31:848-54. 2009
    ..Thus, in endotoxemic shock, a multifactorial approach involving hemodynamic and anti-inflammatory effect may be necessary to decrease AKI...
  36. ncbi Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Am Soc Nephrol 15:645-9. 2004
    ..5 mg/kg). In summary, the previously reported increased susceptibility to LPS of ob/ob mice, compared with db/db mice, may be attributable at least in part to increased susceptibility to ARF...
  37. doi Molecular mechanisms of clinical concentrating and diluting disorders
    Robert W Schrier
    University of Colorado Health Sciences Center, Denver, CO, USA
    Prog Brain Res 170:539-50. 2008
    ..Vasopressin-resistant downregulation of aquaporin 2 expression has also been described as a factor in impaired urinary concentration...
  38. pmc Prospective change in renal volume and function in children with ADPKD
    Melissa A Cadnapaphornchai
    Department of Radiology, The Children s Hospital, University of Colorado School of Medicine, Aurora, Colorado, Aurora, Colorado, USA
    Clin J Am Soc Nephrol 4:820-9. 2009
    ..Autosomal dominant polycystic kidney disease (ADPKD) is a progressive hereditary disorder affecting children and young adults. Early intervention may be necessary to significantly affect the long-term consequences of this disease...
  39. ncbi Effect of intensive blood pressure control with valsartan on urinary albumin excretion in normotensive patients with type 2 diabetes
    Raymond O Estacio
    University of Colorado Health Sciences Center, Denver, Colorado 80203, USA
    Am J Hypertens 19:1241-8. 2006
    ..Diabetes is the most common cause of renal failure in the United States, and data regarding the effects of aggressive blood pressure (BP) therapy in normotensive patients with type 2 diabetes are inadequate...
  40. ncbi Epidemiological study of kidney survival in autosomal dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 63:678-85. 2003
    ....
  41. ncbi Albuminuria as a predictor of heart failure hospitalizations in patients with type 2 diabetes
    Melinda L Hockensmith
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    J Card Fail 10:126-31. 2004
    ..Heart failure (HF) occurs more frequently and is a significant cause of mortality in diabetic patients. The purpose of the current study is to ascertain risk factors that are predictive of HF hospitalizations in type 2 diabetic patients...
  42. doi Role of AQP1 in endotoxemia-induced acute kidney injury
    Weidong Wang
    Department of Medicine, Division of Renal Diseases and Hypertension, Univ of Colorado Health Sciences Center, 4200 East 9Ave, Box B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 294:F1473-80. 2008
    ..Thus the polyuria in AQP1-KO mice does not protect against endotoxemia-induced acute kidney injury but rather absence of AQP1 predisposed to enhanced endotoximic renal injury...
  43. ncbi Relationship between urinary albumin excretion and left ventricular mass with mortality in patients with type 2 diabetes
    Niloofar Nobakhthaghighi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin J Am Soc Nephrol 1:1187-90. 2006
    ..62 +/- 114.11; P = 0.0003) than nonsurvivors. The results indicate that patients with type 2 diabetes and increased UAE should be evaluated for increased LVM as an important and potentially reversible cardiovascular risk factor...
  44. ncbi No effect of angiotensin-converting enzyme gene polymorphism on disease progression and left ventricular hypertrophy in autosomal dominant polycystic kidney disease
    Tevfik Ecder
    University of Colorado School of Medicine, Denver, Colo 80262, USA
    Am J Nephrol 23:466-70. 2003
    ..Also, the association between ACE gene polymorphism and the occurrence of left ventricular hypertrophy (LVH) has not been investigated in patients with ADPKD...
  45. ncbi Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency
    Weidong Wang
    Div of Renal Diseases and Hypertension, Univ of Colorado Health Sciences Center, 4200 East 9th Ave, Box B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 290:F1135-42. 2006
    ..OPC-31260 reversed upregulation and apical trafficking of AQP2 and pAQP2 in association with improved urinary diluting capacity and increased water excretion after oral water loading...
  46. ncbi Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome
    Robert W Schrier
    Department of Medicine, University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 5:1132-40. 2010
    ..The effect of aldosterone in metabolic syndrome is also discussed in this review...
  47. doi Relation of reduction in urinary albumin excretion to ten-year cardiovascular mortality in patients with type 2 diabetes and systemic hypertension
    Raymond O Estacio
    Colorado Prevention Center, Denver, Colorado, USA
    Am J Cardiol 109:1743-8. 2012
    ....
  48. pmc Role of vasopressin and vasopressin receptor antagonists in type I cardiorenal syndrome
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Denver, Colo, USA
    Blood Purif 27:28-32. 2009
    ..The effect of V2 receptor antagonists to correct hyponatremia in heart failure patients appears to be quite safe. However, to date no effect on mortality has been demonstrated...
  49. ncbi Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats
    Chunling Li
    Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
    J Am Soc Nephrol 17:1657-64. 2006
    ..05), and cortex plus outer stripe of outer medulla NKCC2 (142+/-16 versus 100+/-9%; P<0.05). In conclusion, hyperosmolality, secondary to either glucose or NaCl, upregulated renal AQP2 and NKCC2 in vivo in BB rats...
  50. ncbi Evidence for bradykinin as a stimulator of thirst
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 286:F875-80. 2004
    ..Furthermore, this dipsogenic effect was reversed by antagonism of bradykinin, thus implicating this hormone in thirst regulation in the rat...
  51. pmc Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease
    Yunxia Tao
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Renal Box C281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:6954-9. 2005
    ....
  52. ncbi Acute renal failure after nonmyeloablative hematopoietic cell transplantation
    Chirag R Parikh
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Am Soc Nephrol 15:1868-76. 2004
    ..The data are also suggestive that ARF may contribute to mortality after nonmyeloablative HCT...
  53. ncbi Erythropoietin ameliorates renal dysfunction during endotoxaemia
    Amit Mitra
    University of Colorado Health Sciences Center, 4200 East 9th Ave Box C 281, Denver, CO 80262, USA
    Nephrol Dial Transplant 22:2349-53. 2007
    ..Since erythropoietin (EPO) has been demonstrated to possess anti-oxidant and anti-inflammatory properties, EPO may have therapeutic efficacy for treating ARF associated with endotoxaemia...
  54. ncbi Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism
    Yung Chang Chen
    Univ of Colorado School of Medicine, 4200 E Ninth Ave, Box C293, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 289:F672-8. 2005
    ..The impairment of maximal solute-free water excretion in HT rats, however, appears also to involve diminished distal fluid delivery...
  55. pmc The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP
    Miguel A Lanaspa
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado 80045, USA
    J Biol Chem 285:31694-703. 2010
    ..In conclusion, these data demonstrate that TonEBP is necessary for the regulation of AQP1 expression in the inner medulla of the kidney under hypertonic conditions...
  56. ncbi A case of tuberous sclerosis complex that progressed to end-stage renal disease
    Mohammad Sarraf
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Nat Clin Pract Nephrol 5:172-6. 2009
    ..A 31-year-old woman with tuberous sclerosis complex presented with a 1 week history of subjective fever, chills, rigors, poor appetite and dizziness...
  57. pmc Variation in age at ESRD in autosomal dominant polycystic kidney disease
    Berenice Y Reed
    Department of Medicine, Division of Renal Diseases and Hypertension, American Indian and Alaska Native Program, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 51:173-83. 2008
    ..We evaluated variation in age at end-stage renal disease (ESRD) in ADPKD families for evidence of anticipation...
  58. ncbi Rapid microalbuminuria screening in type 2 diabetes mellitus: simplified approach with Micral test strips and specific gravity
    Chirag R Parikh
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Nephrol Dial Transplant 19:1881-5. 2004
    ..The purpose of the present study is to evaluate Micral test strips in conjunction with a urine specific gravity determination as a rapid and accurate method for detecting microalbuminuria in type 2 diabetic patients...
  59. pmc Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history
    Berenice Reed
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver and Health Sciences Center, Aurora, CO 80014, USA
    Am J Kidney Dis 52:1042-50. 2008
    ..To confirm de novo sequence variants, we have undertaken clinical and genetic screening of affected offspring and their parents...
  60. pmc Role of vasopressin and aldosterone in pulmonary arterial hypertension: A pilot study
    Shweta Bansal
    Division of Renal Disease and Hypertension, University of Colorado Denver, Aurora, Colorado, USA
    Contemp Clin Trials 30:392-9. 2009
    ....
  61. doi Serum phosphorus and cardiovascular mortality in type 2 diabetes
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado at Denver, Health Sciences Center, Denver, CO 80262, USA
    Am J Med 122:380-6. 2009
    ....
  62. ncbi Identification and characterization of a novel hypertonicity-responsive element in the human aquaporin-1 gene
    Fuminori Umenishi
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochem Biophys Res Commun 292:771-5. 2002
    ..These data suggest that the transcription of the AQP1 by hypertonicity in renal cells is upregulated by the interaction with putative DNA binding proteins to a novel HRE located at -54 to -46 in the AQP1 gene...
  63. ncbi Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model
    Iram Zafar
    University of Colorado School of Medicine, 4200 East Ninth Ave, B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 293:F854-9. 2007
    ..An enhancement of these protective interventions in this autosomal dominant PKD model was not demonstrated with the combined treatment...
  64. ncbi Effect of primary polydipsia on aquaporin and sodium transporter abundance
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Am J Physiol Renal Physiol 285:F965-71. 2003
    ..We conclude that the impaired urinary concentrating ability associated with primary POLY in rats is due to impaired osmotic equilibration in the collecting duct that is mediated primarily by decreased AQP-2 protein abundance...
  65. ncbi Modifier genes play a significant role in the phenotypic expression of PKD1
    Pamela R Fain
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 67:1256-67. 2005
    ..There are significant familial phenotype differences; but it is not clear if this is due to differences in PKD1 mutations, differences in genetic background, or both...
  66. ncbi Design and baseline characteristics of participants in the study of antihypertensive therapy in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD)
    Melissa A Cadnapaphornchai
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Contemp Clin Trials 26:211-22. 2005
    ..Baseline demographic and laboratory data for the study groups are reported. Results of this study could significantly impact the standard of care for management of ADPKD in this population...
  67. ncbi Modulation of hypertonicity-induced aquaporin-1 by sodium chloride, urea, betaine, and heat shock in murine renal medullary cells
    Fuminori Umenishi
    Address correspondence to Dr Fuminori Umenishi, Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
    J Am Soc Nephrol 16:600-7. 2005
    ..Taken together, NaCl, urea, betaine, and heat shock that regulate hypertonicity-induced AQP1 expression are potentially important factors in urinary concentration and contribute to the steady-state level of AQP1 expression...
  68. ncbi Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome
    Alireza Abdollah Shamshirsaz
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, 80262, USA
    Kidney Int 68:2218-24. 2005
    ..The natural history of autosomal-dominant polycystic kidney disease (ADPKD) has not been well described in children and infants...
  69. ncbi Hypertonic induction of aquaporin-1 water channel independent of transcellular osmotic gradient
    Fuminori Umenishi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 325:595-9. 2004
    ..These results indicate that AQP1 expression is predominantly mediated by basolateral hypertonicity but a transcellular osmotic gradient is not necessary for its induction...
  70. ncbi Comparison of three methods to quantify urinary aquaporin-2 protein
    Fuminori Umenishi
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 62:2288-93. 2002
    ..Recently, we have established an enzyme-linked immunosorbent assay (ELISA) for quantitation of urinary AQP2. The purpose of our current study was to compare three different immunoassay methods for measurement of urinary AQP2...
  71. ncbi cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway
    Fuminori Umenishi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochim Biophys Acta 1758:1100-5. 2006
    ..These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway...
  72. ncbi Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene
    Fuminori Umenishi
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
    J Biol Chem 278:15765-70. 2003
    ..These data demonstrate that the activation of ERK, p38 kinase, and JNK pathways and the hypertonicity response element in the AQP1 promoter are involved in hypertonicity-induced AQP1 expression in mIMCD-3 cells...
  73. ncbi Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 283:F583-7. 2002
    ....
  74. ncbi Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on blood pressure and the kidney
    Joshua M Thurman
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Med 114:588-98. 2003
    ..The purpose of this paper is to review the mechanisms of action of these two classes of medication, as well as the experimental and clinical evidence that they slow the progression of renal disease...
  75. ncbi Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus
    Berhane Seyoum
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Diab Vasc Dis Res 3:197-201. 2006
    ..03). Multiple Cox regression analysis also showed low peak VO2 to be an independent factor. In conclusion, patients with type 2 diabetes mellitus with reduced peak VO2 during exercise have a greater tendency to develop future CVD events...
  76. ncbi Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cells
    Fuminori Umenishi
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 293:913-7. 2002
    ..These results indicate that RAs strongly stimulate the human AQP1 gene expression through the RARE and define a novel role in the regulation of erythropoiesis...
  77. ncbi Comparison of ARF after myeloablative and nonmyeloablative hematopoietic cell transplantation
    Chirag R Parikh
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 45:502-9. 2005
    ..The present study compares the incidence of ARF between patients undergoing concurrent myeloablative and nonmyeloablative HCT in the same period at the same institution...
  78. ncbi Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver, USA
    J Am Soc Nephrol 14:566-74. 2003
    ....
  79. ncbi Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  80. ncbi Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol Renal Physiol 284:F532-7. 2003
    ..Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia...
  81. ncbi Pathophysiological roles of arginine vasopressin and aquaporin-2 in impaired water excretion
    San E Ishikawa
    Department of Medicine, Jichi Medical School Omiya Medical Center, Saitama, Japan
    Clin Endocrinol (Oxf) 58:1-17. 2003
  82. ncbi Effect of mineralocorticoid deficiency on ion and urea transporters and aquaporin water channels in the rat
    Mamiko Ohara
    Department of Nephrology, Kameda Medical Center, Kamogawa City, Chiba, Japan
    Biochem Biophys Res Commun 299:285-90. 2002
    ..Maintenance of sodium balance and extracellular fluid volume is associated with normalization of these perturbations...
  83. ncbi Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients
    William T Abraham
    The Ohio State University Heart Center, Division of Cardiovascular Medicine, Columbus, Ohio 43210 1252, USA
    J Am Coll Cardiol 47:1615-21. 2006
    ..The purpose of this study was to examine the renal effects of a V2 receptor arginine vasopressin (AVP) antagonist in heart failure...
  84. ncbi Need to intervene in established acute renal failure
    Robert W Schrier
    J Am Soc Nephrol 15:2756-8. 2004
  85. pmc CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation
    Claudia R Amura
    Division of Gastroenterology, Department of Medicine, University of Colorado Health Sciences Center, Box B 146, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 294:C786-96. 2008
    ..An upstream element between -272 and -1,481 bp allowed for the stress-induced increase in IL-8 transcription. These studies support the hypothesis that CXCR2 signaling promotes ADPKD liver cyst growth...
  86. ncbi Renal dysfunction in allogeneic hematopoietic cell transplantation
    Chirag R Parikh
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Kidney Int 62:566-73. 2002
    ..We have previously shown an overall 21% incidence of severe acute renal failure in patients undergoing autologous HCT. The present study evaluated renal dysfunction in patients undergoing allogeneic HCT...
  87. ncbi Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study
    Godela M Fick-Brosnahan
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 39:1127-34. 2002
    ..50) for both men and women. We conclude that renal volume and rate of renal volume growth may be useful markers for disease progression in early stages of ADPKD when GFR is preserved...