R W Schrier

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi request reprint Optimal care of autosomal dominant polycystic kidney disease patients
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nephrology (Carlton) 11:124-30. 2006
  2. ncbi request reprint Water and sodium retention in edematous disorders: role of vasopressin and aldosterone
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Med 119:S47-53. 2006
  3. doi request reprint The science behind hyponatremia and its clinical manifestations
    Robert W Schrier
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacotherapy 31:9S-17S. 2011
  4. ncbi request reprint Renin-Angiotensin-aldosterone system in autosomal dominant polycystic kidney disease
    Oleksandra Tkachenko
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C 281 1270 East 19th RC2 7th floor Room 7001, Aurora, Colorado, 80045, USA
    Curr Hypertens Rev 9:12-20. 2013
  5. doi request reprint Hyponatraemia: more than just a marker of disease severity?
    Robert W Schrier
    University of Colorado School of Medicine, 12700 East 19th Avenue C281, Aurora, CO 80045, USA
    Nat Rev Nephrol 9:37-50. 2013
  6. doi request reprint Use of diuretics in heart failure and cirrhosis
    Robert W Schrier
    Division of Renal Diseases and Hypertension, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Semin Nephrol 31:503-12. 2011
  7. pmc Diagnostic value of urinary sodium, chloride, urea, and flow
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:1610-3. 2011
  8. doi request reprint Dilemmas in human and rat pregnancy: proposed mechanisms relating to arterial vasodilation
    R W Schrier
    University of Colorado Denver, Aurora, CO 80045, USA
    J Neuroendocrinol 22:400-6. 2010
  9. ncbi request reprint Interpretation of renal volume in autosomal dominant polycystic kidney disease and relevant clinical implications
    Amirali Masoumi
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Iran J Kidney Dis 5:1-8. 2011
  10. doi request reprint Fluid administration in critically ill patients with acute kidney injury
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Room 7001, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 5:733-9. 2010

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Optimal care of autosomal dominant polycystic kidney disease patients
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nephrology (Carlton) 11:124-30. 2006
    ....
  2. ncbi request reprint Water and sodium retention in edematous disorders: role of vasopressin and aldosterone
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Med 119:S47-53. 2006
    ..These agents have been found to increase solute-free water excretion in patients with water-retaining, hyponatremic edema as well as in experimental animals...
  3. doi request reprint The science behind hyponatremia and its clinical manifestations
    Robert W Schrier
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacotherapy 31:9S-17S. 2011
    ..Determination of the serum sodium concentration is the most direct measure of hyponatremia. The vasopressin V(2)-receptor antagonists are effective aquaretic agents and correct hyponatremia in several hyponatremic disorders...
  4. ncbi request reprint Renin-Angiotensin-aldosterone system in autosomal dominant polycystic kidney disease
    Oleksandra Tkachenko
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C 281 1270 East 19th RC2 7th floor Room 7001, Aurora, Colorado, 80045, USA
    Curr Hypertens Rev 9:12-20. 2013
    ....
  5. doi request reprint Hyponatraemia: more than just a marker of disease severity?
    Robert W Schrier
    University of Colorado School of Medicine, 12700 East 19th Avenue C281, Aurora, CO 80045, USA
    Nat Rev Nephrol 9:37-50. 2013
    ..Such an approach must involve prospective randomized studies in different groups of patients with hyponatraemia, including those with advanced heart failure, those with cirrhosis, patients with cancer, and the elderly...
  6. doi request reprint Use of diuretics in heart failure and cirrhosis
    Robert W Schrier
    Division of Renal Diseases and Hypertension, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Semin Nephrol 31:503-12. 2011
    ..This review discusses the beneficial and potentially deleterious effects of diuretic use in patients with cardiac failure and cirrhosis...
  7. pmc Diagnostic value of urinary sodium, chloride, urea, and flow
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:1610-3. 2011
    ..The present brief review discusses the various aspects of the correct interpretation of urinary electrolytes, solute excretion, and urine flow in the setting of a rising serum creatinine concentration...
  8. doi request reprint Dilemmas in human and rat pregnancy: proposed mechanisms relating to arterial vasodilation
    R W Schrier
    University of Colorado Denver, Aurora, CO 80045, USA
    J Neuroendocrinol 22:400-6. 2010
    ..The present study proposes potential mechanisms relating to systemic arterial vasodilation to explain some of the apparent dilemmas of pregnancy...
  9. ncbi request reprint Interpretation of renal volume in autosomal dominant polycystic kidney disease and relevant clinical implications
    Amirali Masoumi
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Iran J Kidney Dis 5:1-8. 2011
    ..Recent developments on diagnostic modalities and criteria of the ADPKD are also discussed...
  10. doi request reprint Fluid administration in critically ill patients with acute kidney injury
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Room 7001, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 5:733-9. 2010
    ....
  11. doi request reprint Early intervention in acute kidney injury
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Avenue, Research 2, Aurora, CO 80045, USA
    Nat Rev Nephrol 6:56-9. 2010
    ..Thus, agents that have exclusive effects on renal hemodynamics and tubular function, or the intrarenal infusion of short-acting agents that do not have systemic effects, need to be considered in future studies for the prevention of AKI...
  12. doi request reprint Systemic arterial vasodilation, vasopressin, and vasopressinase in pregnancy
    Robert W Schrier
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Am Soc Nephrol 21:570-2. 2010
    ..Because desmopressin is already deaminated at the N-terminal, it is resistant to the effect of vasopressinase and therefore is the treatment of choice for transient diabetes insipidus of pregnancy...
  13. doi request reprint Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome
    Robert W Schrier
    Department of Medicine, University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 5:1132-40. 2010
    ..The effect of aldosterone in metabolic syndrome is also discussed in this review...
  14. doi request reprint Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado Denver, Denver, Colorado, USA
    J Am Soc Nephrol 20:1888-93. 2009
    ....
  15. pmc Role of vasopressin and vasopressin receptor antagonists in type I cardiorenal syndrome
    Robert W Schrier
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Denver, Colo, USA
    Blood Purif 27:28-32. 2009
    ..The effect of V2 receptor antagonists to correct hyponatremia in heart failure patients appears to be quite safe. However, to date no effect on mortality has been demonstrated...
  16. ncbi request reprint Chronic NOS inhibition reverses systemic vasodilation and glomerular hyperfiltration in pregnancy
    M A Cadnapaphornchai
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 280:F592-8. 2001
    ..These findings suggest a role for endothelial damage and decreased NO in the pathogenesis of preeclampsia...
  17. ncbi request reprint Pathogenesis and management of sodium and water retention in cardiac failure and cirrhosis
    R W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Semin Nephrol 21:157-72. 2001
    ....
  18. ncbi request reprint Treating high-risk diabetic hypertensive patients with comorbid conditions
    R W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 36:S10-7. 2000
    ..Angiotensin II (Ang II) receptor blockers (ARBs), which attenuate the deleterious effects of the RAS via blockade of the Ang II subtype 1 receptor, may also be beneficial. Clinical trials are under way to evaluate this possibility...
  19. ncbi request reprint A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome
    R W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, USA
    Kidney Int 53:1111-7. 1998
    ....
  20. ncbi request reprint Temporal relationships between hormonal and hemodynamic changes in early human pregnancy
    A B Chapman
    Department of Medicine, University of Colorado Health Sciences Center, St Louis, Missouri, USA
    Kidney Int 54:2056-63. 1998
    ..We hypothesize that systemic and renal hemodynamic changes occur early, prior to the presence of the fetal-placental unit...
  21. ncbi request reprint Water-losing and water-retaining states: role of water channels and vasopressin receptor antagonists
    R W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Heart Dis 3:210-4. 2001
    ..This review examines the roles of central vasopressin synthesis and release and collecting duct vasopressin V2 receptor and aquaporin-2 water channel regulation in water-losing and water-retaining states...
  22. ncbi request reprint Systemic hemodynamic, neurohormonal, and renal effects of a steady-state infusion of human brain natriuretic peptide in patients with hemodynamically decompensated heart failure
    W T Abraham
    Department of Medicine, University of Colorado School of Medicine, Denver
    J Card Fail 4:37-44. 1998
    ..However, the systemic hemodynamic, neurohormonal, and renal effects of hBNP have been incompletely studied in human heart failure...
  23. ncbi request reprint Diuretics versus angiotensin-converting enzyme inhibitors in autosomal dominant polycystic kidney disease
    T Ecder
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colo, USA
    Am J Nephrol 21:98-103. 2001
    ..This result will need to be further examined in a randomized study...
  24. ncbi request reprint Pathophysiology of sodium and water retention in heart failure
    M A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Cardiology 96:122-31. 2001
    ....
  25. ncbi request reprint Polyuria of thyrotoxicosis: downregulation of aquaporin water channels and increased solute excretion
    W Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Kidney Int 72:1088-94. 2007
    ....
  26. ncbi request reprint Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium
    K Lelamali
    Department of Medicine, University of Colorado, Health Sciences Center, Denver, Colorado 80262, USA
    J Cell Physiol 188:337-42. 2001
    ..These data demonstrating inhibition of leukocyte adhesion to endotoxin-treated endothelium suggest that peroxynitrite or NO may exert a beneficial effect during sepsis...
  27. ncbi request reprint Epidemiological study of kidney survival in autosomal dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 63:678-85. 2003
    ....
  28. ncbi request reprint Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model
    Iram Zafar
    University of Colorado School of Medicine, 4200 East Ninth Ave, B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 293:F854-9. 2007
    ..An enhancement of these protective interventions in this autosomal dominant PKD model was not demonstrated with the combined treatment...
  29. ncbi request reprint Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on blood pressure and the kidney
    Joshua M Thurman
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Med 114:588-98. 2003
    ..The purpose of this paper is to review the mechanisms of action of these two classes of medication, as well as the experimental and clinical evidence that they slow the progression of renal disease...
  30. ncbi request reprint From finch to fish to man: role of aquaporins in body fluid and brain water regulation
    R W Schrier
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
    Neuroscience 129:897-904. 2004
    ....
  31. ncbi request reprint Pathophysiology of renal fluid retention
    R W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Kidney Int Suppl 67:S127-32. 1998
    ..V2 receptor antagonists reverse the water retention and down-regulate AQP-2 water channels...
  32. ncbi request reprint Impaired fibrinolytic activity in type II diabetes: correlation with urinary albumin excretion and progression of renal disease
    M Kamgar
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    Kidney Int 69:1899-903. 2006
    ..5 vs 72.3%, P < 0.07) in the diabetic patients with more impaired fibrinolysis and greater UAE. Thus a prospective, randomized clinical trial in type II diabetes with PAI-1 inhibitors is needed...
  33. ncbi request reprint Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions
    A Wangsiripaisan
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Kidney Int 59:932-40. 2001
    ..The present in vitro results indicate the importance of oligosaccharide residues in mediating the effect of the THP on gel formation and potential cast formation in ATN...
  34. ncbi request reprint Effect of kappa opioid agonist RU 51599 on osmotic and non-osmotic stimulated arginine vasopressin release and gene regulation in small cell lung carcinoma cells
    J K Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Neuropeptides 31:423-9. 1997
    ..These results indicate, therefore, that RU 51599 suppresses AVP secretion by inhibition at the step of AVP release during osmotic and non-osmotic stimulation but does not affect the AVP gene transcription level in the SCLC cells...
  35. pmc Prospective change in renal volume and function in children with ADPKD
    Melissa A Cadnapaphornchai
    Department of Radiology, The Children s Hospital, University of Colorado School of Medicine, Aurora, Colorado, Aurora, Colorado, USA
    Clin J Am Soc Nephrol 4:820-9. 2009
    ..Autosomal dominant polycystic kidney disease (ADPKD) is a progressive hereditary disorder affecting children and young adults. Early intervention may be necessary to significantly affect the long-term consequences of this disease...
  36. ncbi request reprint Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B178, Denver, CO 80262, USA
    Kidney Int 61:1086-97. 2002
    ..The current study evaluated the effect of intensive versus moderate diastolic blood pressure (DBP) control on diabetic vascular complications in 480 normotensive type 2 diabetic patients...
  37. pmc Magnetic resonance imaging of kidney and cyst volume in children with ADPKD
    Melissa A Cadnapaphornchai
    Department of Pediatrics, PKD Research Group, University of Colorado Denver, and Department of Radiology, The Children s Hospital, 13001 East 17th Place, Box C283, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 6:369-76. 2011
    ..However, no studies have examined the utility of MRI for serial assessment of kidney and cyst volume in children with ADPKD...
  38. ncbi request reprint Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial
    Edward P Havranek
    Division of Cardiology, University of Colorado Health Sciences Center, Department of Medicine, Denver, USA
    Am Heart J 145:993-8. 2003
    ..Serial decline in electrocardiographic voltage in patients with increased left ventricular mass has been associated with a lower risk of cardiovascular events...
  39. pmc Oral tolvaptan is safe and effective in chronic hyponatremia
    Tomas Berl
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
    J Am Soc Nephrol 21:705-12. 2010
    ..In conclusion, prolonged administration of tolvaptan maintains an increased serum sodium with an acceptable margin of safety...
  40. doi request reprint Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease
    Berenice Y Reed
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Kidney Int 79:128-34. 2011
    ..Thus, the correlation between angiogenic growth factors with both renal and cardiac disease severity is compatible with a possible role for angiogenesis in the early progression of disease in ADPKD...
  41. pmc Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Kidney Int 74:1192-6. 2008
    ..These findings show that an increase in LVMI may be detected earlier than an increase in renal volume in children with ADPKD and borderline hypertension, suggesting that close monitoring of cardiac status is indicated in these children...
  42. ncbi request reprint Design and baseline characteristics of participants in the study of antihypertensive therapy in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD)
    Melissa A Cadnapaphornchai
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Contemp Clin Trials 26:211-22. 2005
    ..Baseline demographic and laboratory data for the study groups are reported. Results of this study could significantly impact the standard of care for management of ADPKD in this population...
  43. ncbi request reprint No effect of angiotensin-converting enzyme gene polymorphism on disease progression and left ventricular hypertrophy in autosomal dominant polycystic kidney disease
    Tevfik Ecder
    University of Colorado School of Medicine, Denver, Colo 80262, USA
    Am J Nephrol 23:466-70. 2003
    ..Also, the association between ACE gene polymorphism and the occurrence of left ventricular hypertrophy (LVH) has not been investigated in patients with ADPKD...
  44. ncbi request reprint Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone
    J G Abdallah
    Division of Nephrology and Hypertension, University of Colorado School of Medicine and Veterans Administration Medical Center, Denver, Colorado, USA
    J Am Soc Nephrol 12:1335-41. 2001
    ..A portion of the furosemide effect can be prevented by blockade of mineralocorticoid receptors...
  45. ncbi request reprint Treating hypertension in the elderly
    R W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Geriatr Cardiol 10:355-65. 2001
    ..Drugs with a convenient dosing schedule, minimal side effects, and the ability to impact comorbid conditions are important considerations in the treatment of hypertension in the elderly...
  46. ncbi request reprint Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
    M Knotek
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 59:2243-9. 2001
    ..The present study tested the hypothesis that the role of TNF in endotoxic renal failure is mediated by iNOS-derived NO...
  47. ncbi request reprint Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 283:F583-7. 2002
    ....
  48. pmc Diagnosis and management of hyponatremia in acute illness
    Robert W Schrier
    Division of Renal Disease and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Opin Crit Care 14:627-34. 2008
    ....
  49. ncbi request reprint Relationship between urinary albumin excretion and left ventricular mass with mortality in patients with type 2 diabetes
    Niloofar Nobakhthaghighi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin J Am Soc Nephrol 1:1187-90. 2006
    ..62 +/- 114.11; P = 0.0003) than nonsurvivors. The results indicate that patients with type 2 diabetes and increased UAE should be evaluated for increased LVM as an important and potentially reversible cardiovascular risk factor...
  50. ncbi request reprint Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome
    Alireza Abdollah Shamshirsaz
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, 80262, USA
    Kidney Int 68:2218-24. 2005
    ..The natural history of autosomal-dominant polycystic kidney disease (ADPKD) has not been well described in children and infants...
  51. doi request reprint Role of AQP1 in endotoxemia-induced acute kidney injury
    Weidong Wang
    Department of Medicine, Division of Renal Diseases and Hypertension, Univ of Colorado Health Sciences Center, 4200 East 9Ave, Box B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 294:F1473-80. 2008
    ..Thus the polyuria in AQP1-KO mice does not protect against endotoxemia-induced acute kidney injury but rather absence of AQP1 predisposed to enhanced endotoximic renal injury...
  52. ncbi request reprint Comparison of ARF after myeloablative and nonmyeloablative hematopoietic cell transplantation
    Chirag R Parikh
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 45:502-9. 2005
    ..The present study compares the incidence of ARF between patients undergoing concurrent myeloablative and nonmyeloablative HCT in the same period at the same institution...
  53. ncbi request reprint Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia
    Robert W Schrier
    University of Colorado, Denver, USA
    N Engl J Med 355:2099-112. 2006
    ..We investigated whether tolvaptan, an orally active vasopressin V(2)-receptor antagonist that promotes aquaresis--excretion of electrolyte-free water--might be of benefit in hyponatremia...
  54. ncbi request reprint Divergent effects of acute and chronic ethanol exposure on contraction and Ca2+ mobilization in cultured vascular smooth muscle cells
    V A Briner
    Department of Medicine, University of Colorado School of Medicine, Denver 80262
    Am J Hypertens 6:268-75. 1993
    ..05) and the rise in cytosolic free Ca2+ ([Ca2+]i) (P < .01). In contrast, chronic ethanol-treated VSMC enhanced IP3 formation (P < .05) and the rise in [Ca2+]i (P < .01) in response to AVP.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi request reprint Pathogenesis of sodium and water retention in cardiac failure
    R W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Ren Fail 20:773-81. 1998
    ..Tailored specific selective inhibition of these neurohumoral systems, perhaps in combination, may enable more effective treatment of cardiac failure...
  56. ncbi request reprint Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules
    C L Edelstein
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    J Am Soc Nephrol 10:1940-9. 1999
    ..Thus, although the role of caspases in apoptotic cell death is well established, this study provides new evidence that caspases contribute to necrotic cell death as well...
  57. ncbi request reprint Gibbs memorial lecture. Unifying hypothesis of body fluid volume regulation: implications for cardiac failure and cirrhosis
    R W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Mt Sinai J Med 68:350-61. 2001
    ..The understanding of the pathogenesis of sodium and water retention in cardiac failure and cirrhosis has led to therapies that favorably affect the morbidity and mortality of these patients...
  58. ncbi request reprint Effect of intensive blood pressure control with valsartan on urinary albumin excretion in normotensive patients with type 2 diabetes
    Raymond O Estacio
    University of Colorado Health Sciences Center, Denver, Colorado 80203, USA
    Am J Hypertens 19:1241-8. 2006
    ..Diabetes is the most common cause of renal failure in the United States, and data regarding the effects of aggressive blood pressure (BP) therapy in normotensive patients with type 2 diabetes are inadequate...
  59. ncbi request reprint Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism
    Yung Chang Chen
    Univ of Colorado School of Medicine, 4200 E Ninth Ave, Box C293, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 289:F672-8. 2005
    ..The impairment of maximal solute-free water excretion in HT rats, however, appears also to involve diminished distal fluid delivery...
  60. pmc Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease
    Yunxia Tao
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Renal Box C281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:6954-9. 2005
    ....
  61. doi request reprint A case of tuberous sclerosis complex that progressed to end-stage renal disease
    Mohammad Sarraf
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Nat Clin Pract Nephrol 5:172-6. 2009
    ..A 31-year-old woman with tuberous sclerosis complex presented with a 1 week history of subjective fever, chills, rigors, poor appetite and dizziness...
  62. ncbi request reprint Characteristics of hypertension in young adults with autosomal dominant polycystic kidney disease compared with the general U.S. population
    Catherine L Kelleher
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Hypertens 17:1029-34. 2004
    ..Therefore, standard screening (serum creatinine and urinalysis) of young individuals with unexplained hypertension to exclude renal parenchymal disease would rarely detect ADPKD...
  63. pmc Role of vasopressin and aldosterone in pulmonary arterial hypertension: A pilot study
    Shweta Bansal
    Division of Renal Disease and Hypertension, University of Colorado Denver, Aurora, Colorado, USA
    Contemp Clin Trials 30:392-9. 2009
    ....
  64. ncbi request reprint Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol Renal Physiol 284:F532-7. 2003
    ..Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia...
  65. doi request reprint Molecular mechanisms of clinical concentrating and diluting disorders
    Robert W Schrier
    University of Colorado Health Sciences Center, Denver, CO, USA
    Prog Brain Res 170:539-50. 2008
    ..Vasopressin-resistant downregulation of aquaporin 2 expression has also been described as a factor in impaired urinary concentration...
  66. ncbi request reprint The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 64:1792-9. 2003
    ..The present study was undertaken to examine the role of parental hypertension in the occurrence of hypertension in 475 ADPKD offspring...
  67. ncbi request reprint Earlier diagnosis of autosomal dominant polycystic kidney disease: importance of family history and implications for cardiovascular and renal complications
    Matthew Taylor
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 46:415-23. 2005
    ..We hypothesized that advances in knowledge of and potential interventions for ADPKD have led to increased use of family history screening...
  68. ncbi request reprint Hyponatremia treatment guidelines 2007: expert panel recommendations
    Joseph G Verbalis
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
    Am J Med 120:S1-21. 2007
    ..This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists...
  69. ncbi request reprint Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
    J Am Coll Cardiol 47:1-8. 2006
    ....
  70. ncbi request reprint Role of glucocorticoid hormones in arginine vasopressin gene regulation
    J K Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochem Biophys Res Commun 289:1252-6. 2001
    ..In conclusion, the data presented here support a central mechanism to explain, at least in part, the nonosmotic increase in AVP with glucocorticoid deficiency...
  71. ncbi request reprint Effect of primary polydipsia on aquaporin and sodium transporter abundance
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Am J Physiol Renal Physiol 285:F965-71. 2003
    ..We conclude that the impaired urinary concentrating ability associated with primary POLY in rats is due to impaired osmotic equilibration in the collecting duct that is mediated primarily by decreased AQP-2 protein abundance...
  72. pmc Interaction between vasopressin and angiotensin II in vivo and in vitro: effect on aquaporins and urine concentration
    Weidong Wang
    University of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Renal Physiol 299:F577-84. 2010
    ..Studies in collecting duct cells were confirmatory...
  73. pmc Cancer therapy and renal injury
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 110:743-5. 2002
  74. doi request reprint Renal ultrasonographic evaluation in children at risk of autosomal dominant polycystic kidney disease
    Berenice Reed
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, CO, USA
    Am J Kidney Dis 56:50-6. 2010
    ..To date, there are no criteria for diagnosing autosomal dominant polycystic kidney disease (ADPKD) in at-risk children 15 years or younger...
  75. ncbi request reprint Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study
    Godela M Fick-Brosnahan
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 39:1127-34. 2002
    ..50) for both men and women. We conclude that renal volume and rate of renal volume growth may be useful markers for disease progression in early stages of ADPKD when GFR is preserved...
  76. ncbi request reprint Caspases, Bcl-2 proteins and apoptosis in autosomal-dominant polycystic kidney disease
    Tevfik Ecder
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 61:1220-30. 2002
    ..The Han:Sprague-Dawley (SPRD) rat model closely resembles human ADPKD and presents an opportunity to investigate the apoptotic pathway in the pathogenesis of this disease...
  77. ncbi request reprint Congenital renal agenesis: case-control analysis of birth characteristics
    Chirag R Parikh
    Division of Nephrology, Department of Preventive Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 39:689-94. 2002
    ..This condition appears to have a multifactorial cause, with a combination of genetic and environmental factors. Further research is needed to show a better understanding of these risk factors...
  78. ncbi request reprint Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Health Sciences Center C283, 4200 E Ninth Avenue, Denver, CO 80262, USA
    J Am Soc Nephrol 15:1023-8. 2004
    ..The mean length of follow-up was 9.8 yr (median, 9.7 yr). These findings have important health care and economic implications in following patients with ADPKD...
  79. ncbi request reprint Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial
    Robert W Schrier
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Nat Clin Pract Nephrol 3:428-38. 2007
    ..Analysis of the results of 5 years of follow-up revealed a highly significant correlation of all-cause and cardiovascular mortality with left ventricular mass and severity of albuminuria...
  80. ncbi request reprint Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency
    Weidong Wang
    Div of Renal Diseases and Hypertension, Univ of Colorado Health Sciences Center, 4200 East 9th Ave, Box B173, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 290:F1135-42. 2006
    ..OPC-31260 reversed upregulation and apical trafficking of AQP2 and pAQP2 in association with improved urinary diluting capacity and increased water excretion after oral water loading...
  81. pmc CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation
    Claudia R Amura
    Division of Gastroenterology, Department of Medicine, University of Colorado Health Sciences Center, Box B 146, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 294:C786-96. 2008
    ..An upstream element between -272 and -1,481 bp allowed for the stress-induced increase in IL-8 transcription. These studies support the hypothesis that CXCR2 signaling promotes ADPKD liver cyst growth...
  82. pmc Variation in age at ESRD in autosomal dominant polycystic kidney disease
    Berenice Y Reed
    Department of Medicine, Division of Renal Diseases and Hypertension, American Indian and Alaska Native Program, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 51:173-83. 2008
    ..We evaluated variation in age at end-stage renal disease (ESRD) in ADPKD families for evidence of anticipation...
  83. ncbi request reprint The sea within us: disorders of body water homeostasis
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Department of Medicine, 4200 East Ninth Avenue B173, Denver, CO 80262, USA
    Curr Opin Investig Drugs 8:304-11. 2007
    ..The relationship between osmotic and non-osmotic regulation of antidiuretic hormone (arginine vasopressin) release is discussed...
  84. doi request reprint Pulmonary hypertension, right ventricular failure, and kidney: different from left ventricular failure?
    Robert W Schrier
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Clin J Am Soc Nephrol 3:1232-7. 2008
    ....
  85. ncbi request reprint Clinical update on renal aquaporins
    Yung Chang Chen
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biol Cell 97:357-71. 2005
    ..The present article reviews current knowledge regarding the function and dysfunction of renal aquaporins in disorders of water metabolism...
  86. doi request reprint Serum phosphorus and cardiovascular mortality in type 2 diabetes
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado at Denver, Health Sciences Center, Denver, CO 80262, USA
    Am J Med 122:380-6. 2009
    ....
  87. doi request reprint Cardiorenal syndrome in acute decompensated heart failure
    Mohammad Sarraf
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 4:2013-26. 2009
    ....
  88. ncbi request reprint Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  89. ncbi request reprint Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  90. ncbi request reprint Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
    Yunxia Tao
    Division of Renal Diseases and Hypertension, University of ColoradoHealth Sciences Center, Denver, CO, USA
    J Am Soc Nephrol 16:46-51. 2005
    ..In summary, in a rat model of PKD, rapamycin treatment (1) decreases proliferation in cystic and noncystic tubules, (2) markedly inhibits renal enlargement and cystogenesis, and (3) prevents the loss of kidney function...
  91. pmc Vasopressin and aquaporin 2 in clinical disorders of water homeostasis
    Robert W Schrier
    Division of Renal Diseases and Hypertension School of Medicine, Department of Medicine, University of Colorado at Denver Health Sciences Center, Denver, CO 80262 3706, USA
    Semin Nephrol 28:289-96. 2008
    ..Vasopressin-resistant down-regulation of aquaporin 2 expression has also been described as a factor in impaired urinary concentration...
  92. pmc Glomerular hyperfiltration and renal progression in children with autosomal dominant polycystic kidney disease
    Imed Helal
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 6:2439-43. 2011
    ..The purpose of this study was to determine whether glomerular hyperfiltration (GH) occurring early in autosomal dominant polycystic kidney disease (ADPKD) is indicative of more rapid disease progression in children...
  93. pmc Molecular mechanisms of angiotensin II stimulation on aquaporin-2 expression and trafficking
    Chunling Li
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Renal Physiol 300:F1255-61. 2011
    ..ANG II-induced AQP2 expression involves cAMP, PKC, PKA, and calmodulin signaling pathways via V2 and AT(1) receptors...
  94. doi request reprint The use of vasopressin receptor antagonists in hyponatremia
    Elwaleed A Elhassan
    Division of Renal Diseases and Hypertension, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Expert Opin Investig Drugs 20:373-80. 2011
    ..These vasopressin receptor antagonists work by increasing electrolyte-free water excretion and thus raising serum sodium concentration...