Research Topics
| CHRISTOPH SCHREINERSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Auditory cortical plasticity-from synapse to perceptionCHRISTOPH SCHREINER
UCSF, 513 Parnassus Ave, San Francisco, CA 94044
J Acoust Soc Am 131:3442. 2012..Supported by NIH Grants DC02260 (to CES) and DC009635 (to RCF)...
Auditory cortex mapmaking: principles, projections, and plasticityChristoph E Schreiner
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, and Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0732, USA
Neuron 56:356-65. 2007..Here, we consider the implications of auditory cortical map organization and its plasticity and evaluate the complementary role of maps in representation and computation from an auditory perspective...- Modular organization of frequency integration in primary auditory cortexC E Schreiner
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, University of California, San Francisco 94143 0732, USA
Annu Rev Neurosci 23:501-29. 2000..This organization has implications for our understanding of psychophysical spectral integration measures such as the critical band and general cortical coding strategies... - Spatial distribution of responses to simple and complex sounds in the primary auditory cortexC E Schreiner
Coleman Laboratory, W M Keck Center for Integrative Neuroscience, Sloan Center for Theoretical Neurobiology, University of California at San Francisco 94143 0732, USA
Audiol Neurootol 3:104-22. 1998..The consequences of such a layout for the spatial and temporal coding of pure tones and speech sounds is illustrated and ramifications for the interpretation of far-field event-related potentials are discussed... - Temporal processing in cat primary auditory cortexC E Schreiner
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
Acta Otolaryngol Suppl 532:54-60. 1997..The results suggest a relationship between temporal effects that are expressed at quite different time scales. The results are discussed in relation to spatial representational properties and to coding in other sensory cortices... - Laminar fine structure of frequency organization in auditory midbrainC E Schreiner
W M Keck Center for Integrative Neuroscience, Sloan Center for Theoretical Neuroscience, Coleman Laboratory, University of California at San Francisco, 94143 0732, USA
Nature 388:383-6. 1997.... - Nonlinear spectrotemporal sound analysis by neurons in the auditory midbrainMonty A Escabi
W M Keck Center for Integrative Neuroscience and University of California San Francisco University of California Berkeley Joint Bioengineering Graduate Group, University of California, San Francisco, California 94143, USA
J Neurosci 22:4114-31. 2002..Our findings delineate rules for spectrotemporal integration in the ICC that cannot be accounted for by conventional linear-energy integration models... - Functional organization and hemispheric comparison of primary auditory cortex in the common marmoset (Callithrix jacchus)Bénédicte Philibert
Coleman Memorial Laboratory and W M Keck Center for Integrative Neuroscience, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California 94143 0732, USA
J Comp Neurol 487:391-406. 2005..The overall results indicate that the basic functional organization between hemispheres is similar but not identical... - Improved cortical entrainment to infant communication calls in mothers compared with virgin miceRobert C Liu
W M Keck Center for Integrative Neuroscience, University of California at San Francisco, 513 Parnassus Avenue, USA
Eur J Neurosci 23:3087-97. 2006..In the broader context, our data suggest that auditory cortical responses to communication sounds are plastic, and that communicative significance is correlated with an improved cortical representation... - Spectrotemporal receptive fields in the lemniscal auditory thalamus and cortexLee M Miller
W M Keck Center for Integrative Neuroscience, University of California Medical Center, San Francisco, CA 94143, USA
J Neurophysiol 87:516-27. 2002..By comparing simultaneously along multiple stimulus dimensions in both stations, these observations establish the global characteristics of the thalamocortical receptive field transformation... - Concurrent tonotopic processing streams in auditory cortexCharles C Lee
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Cereb Cortex 14:441-51. 2004..The global convergence of cells outside the targeted frequency domain in AI and AAF could contribute to context-dependent processing and to intracortical plasticity and reorganization... - Cooperative nonlinearities in auditory cortical neuronsCraig A Atencio
University of California, San Francisco University of California, Berkeley Bioengineering Graduate Group, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 58:956-66. 2008..The difference between the nonlinearities suggests different possible roles for the MIDs in auditory processing... - Tone-evoked excitatory and inhibitory synaptic conductances of primary auditory cortex neuronsAndrew Y Y Tan
Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
J Neurophysiol 92:630-43. 2004..Our data indicate that the interaction of synaptic excitation and inhibition shapes the time course and frequency tuning of the spike responses of AI neurons... - Spectrotemporal processing differences between auditory cortical fast-spiking and regular-spiking neuronsCraig A Atencio
Bioengineering Graduate Group, University of California, San Francisco, 94143, USA
J Neurosci 28:3897-910. 2008..These global functional differences between RSUs and FSUs suggest fundamental distinctions between putative excitatory and inhibitory interneurons that shape auditory cortical processing... - Laminar diversity of dynamic sound processing in cat primary auditory cortexCraig A Atencio
University of California Berkeley and San Francisco Joint Graduate Group in Bioengineering, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0732, USA
J Neurophysiol 103:192-205. 2010..AI layers that express differing modulation properties may serve distinct roles in the extraction of dynamic sound information, with the differing information specific to the targeted stations of each layer... - Improved stimulus representation by short interspike intervals in primary auditory cortexJonathan Y Shih
University of California, Berkeley, San Francisco Graduate Program in Bioengineering, CA, USA
J Neurophysiol 105:1908-17. 2011..This suggests that short-ISI events are especially suited to provide noise immunity and high-fidelity information transmission in AI... - Development of spectral and temporal response selectivity in the auditory cortexEdward F Chang
Coleman Memorial Laboratory, Department of Otolaryngology, W M Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143 0444, USA
Proc Natl Acad Sci U S A 102:16460-5. 2005..They were subsequently renormalized when animals were returned to standard housing conditions as adults... - Columnar connectivity and laminar processing in cat primary auditory cortexCraig A Atencio
Berkeley Bioengineering Graduate Group, University of California, Berkeley, California, United States of America
PLoS ONE 5:e9521. 2010..Though the structure of this microcircuit is known, we do not know how the functional connectivity between layers relates to laminar processing... - Frequency-modulation encoding in the primary auditory cortex of the awake owl monkeyCraig A Atencio
Bioengineering Graduate Group, University of California San Francisco, San Francisco, CA 94143 0732, USA
J Neurophysiol 98:2182-95. 2007..Last, the population distributions of FM responses in the awake owl monkey were similar to, although of longer temporal duration than, those in the anesthetized squirrel monkeys... - Spatial interaction between spectral integration and frequency gradient in primary auditory cortexKazuo Imaizumi
W M Keck Center for Integrative Neuroscience, Department of Otolaryngology, University of California San Francisco, San Francisco, CA 94143 0732, USA
J Neurophysiol 98:2933-42. 2007.... - Realignment of interaural cortical maps in asymmetric hearing lossSteven W Cheung
Coleman Memorial Laboratory and Keck Center for Integrative Neuroscience, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, California 94143 0342, USA
J Neurosci 29:7065-78. 2009..The findings document that plastic change in central processing of sound stimuli arriving from the nominally better hearing ear may account for progressive realignment of both interaural frequency and threshold maps... - A synaptic memory trace for cortical receptive field plasticityRobert C Froemke
Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA
Nature 450:425-9. 2007..This restricted period of disinhibition may be a fundamental mechanism for receptive field plasticity, and could serve as a memory trace for stimuli or episodes that have acquired new behavioural significance... - Plasticity in primary auditory cortex of monkeys with altered vocal productionSteven W Cheung
Coleman Memorial Laboratory and W M Keck Center for Integrative Neuroscience, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143 0342, USA
J Neurosci 25:2490-503. 2005..These findings suggest a previously unrecognized form of cortical plasticity that is specific to higher-order processes involved in the discrimination of more complex sounds, such as species-specific vocalizations... - Associative learning shapes the neural code for stimulus magnitude in primary auditory cortexDaniel B Polley
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, and Department of Otolaryngology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:16351-6. 2004.... - Columnar transformations in auditory cortex? A comparison to visual and somatosensory corticesJennifer F Linden
W M Keck Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143 0732, USA
Cereb Cortex 13:83-9. 2003..While such analogies could prove useful as guidelines for future research, the best hope for understanding auditory columnar transformations may lie instead with a more modality-specific, functional approach... - Neuronal responses in cat primary auditory cortex to electrical cochlear stimulation: IV. Activation pattern for sinusoidal stimulationMarcia W Raggio
Epstein Laboratory, Coleman Laboratory, Department of Otolaryngology, University of California at San Francisco, 94143 0732, USA
J Neurophysiol 89:3190-204. 2003.... - Spectrotemporal structure of receptive fields in areas AI and AAF of mouse auditory cortexJennifer F Linden
Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 90:2660-75. 2003.... - Topography and synaptic shaping of direction selectivity in primary auditory cortexLi I Zhang
Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
Nature 424:201-5. 2003..The spectral asymmetry of the synaptic TRFs co-varied with CF, as had direction selectivity and sideband asymmetry, and thus suggested a synaptic mechanism for the shaping of FM direction selectivity and its topographic ordering... - Reward-dependent plasticity in the primary auditory cortex of adult monkeys trained to discriminate temporally modulated signalsRalph E Beitel
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 100:11070-5. 2003..The results suggest behaviorally contingent inhibitory and excitatory processes that are modulated by the probability that a particular signal predicts a reward... - Spatial organization of frequency response areas and rate/level functions in the developing AIBen H Bonham
Department of Otolaryngology Head and Neck Surgery, and W M Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 91:841-54. 2004.... - Acoustic variability and distinguishability among mouse ultrasound vocalizationsRobert C Liu
Sloan Swartz Center for Theoretical Neuroscience, Department of Physiology, Box 0444, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
J Acoust Soc Am 114:3412-22. 2003.... - Functional architecture of auditory cortexHeather L Read
WM Keck Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143 0732, USA
Curr Opin Neurobiol 12:433-40. 2002..Taken together, these data show that the auditory cortex has common and unique functional substrates... - Short-term adaptation of auditory receptive fields to dynamic stimuliMark N Kvale
Department of Physiology, W M Keck Center for Integrative Neuroscience, Sloan Swartz Center for Theoretical Neurobiology, University of California, San Francisco, California 94143 0444, USA
J Neurophysiol 91:604-12. 2004.... - Modular functional organization of cat anterior auditory fieldKazuo Imaizumi
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, Department of Otolaryngology, University of California at San Francisco, 513 Parnassus Ave, Box 0732, San Francisco, CA 94143 0732, USA
J Neurophysiol 92:444-57. 2004..These physiological field differences are consistent with anatomical evidence of largely independent, concurrent thalamocortical projections in AI and AAF, which strongly suggest field-specific processing... - Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in miceHidemi Misawa
Department of Physiology, University of California at San Francisco, School of Medicine, San Francisco, California 94143 0444, USA
J Neurosci 22:10088-93. 2002..3 implicated in a familial form of juvenile febrile convulsions. Cloning the gene for audiogenic seizures in these mice may provide important insight into the fundamental mechanisms for developmentally regulated human epilepsy syndromes... - Encoding of temporal information by timing, rate, and place in cat auditory cortexKazuo Imaizumi
Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e11531. 2010..Diversity in local processing emphasis and distribution of different repetition rate codes across AAF may give rise to concurrent feed-forward processing streams that contribute differently to higher-order sound analysis... - Fine functional organization of auditory cortex revealed by Fourier optical imagingValery A Kalatsky
W. M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:13325-30. 2005.... - Hierarchical computation in the canonical auditory cortical circuitCraig A Atencio
University of California, San Francisco University of California, Berkeley Bioengineering Graduate Group, W M Keck Foundation Center for Integrative Neuroscience, and Coleman Memorial Laboratory, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:21894-9. 2009..The AI microcircuit provides a valid template for three independent hierarchical computation principles. Increases in processing complexity, STRF cooperativity, and nonlinearity correlate with the synaptic distance from granular layers... - Auditory thalamocortical transformation: structure and functionJeffery A Winer
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Trends Neurosci 28:255-63. 2005..Some physiological and anatomical bases for these differences are the subject of this review... - Representation of spectral and temporal envelope of twitter vocalizations in common marmoset primary auditory cortexSrikantan S Nagarajan
Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112 9458, USA
J Neurophysiol 87:1723-37. 2002..Neurophysiological data reflecting response sensitivity in AI to these forms of degradation closely parallel human psychophysical results on the intelligibility of degraded speech in quiet and noisy conditions... - Gabor analysis of auditory midbrain receptive fields: spectro-temporal and binaural compositionAnqi Qiu
Biomedical Engineering Program and Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269-2157, USA
J Neurophysiol 90:456-76. 2003.... - Functional organization of squirrel monkey primary auditory cortex: responses to frequency-modulation sweepsBenoit Godey
Laboratoire IDM, UPRES-EA 3192, , Rennes, France
J Neurophysiol 94:1299-311. 2005..Combinations of pure-tone and FM response parameters form 2 significant factors to account for response variations. These results are interpreted in the context of earlier FM investigations and neuronal encoding of dynamic sounds... - The contribution of spike threshold to acoustic feature selectivity, spike information content, and information throughputMonty A Escabi
Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 1157, USA
J Neurosci 25:9524-34. 2005..Such a constraint on the specificity and throughput creates a continuum in the neural code with two extreme forms of information transfer that likely serve complementary roles in the representation of the auditory environment... - Spectral integration plasticity in cat auditory cortex induced by perceptual trainingM Diane Keeling
North Island College, Courtenay, BC V9N 8N6, Canada
Exp Brain Res 184:493-509. 2008..By contrast, control animals that used the ripple spectra only in a lateralization task showed broader ripple transfer functions and narrower pure-tone tuning than naïve animals... - Naturalistic auditory contrast improves spectrotemporal coding in the cat inferior colliculusMonty A Escabi
Department of Electrical and Computer Engineering and Biomedical Engineering Program, University of Connecticut, Storrs, Connecticut 06269 2157, USA
J Neurosci 23:11489-504. 2003..This efficient use of logarithmic spectrotemporal modulations by auditory midbrain neurons reflects a neural adaptation to structural regularities in natural sounds and likely underlies human perceptual abilities...
Research Grants
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXChristoph E Schreiner; Fiscal Year: 2011..Once the normal functions are better understood, the detrimental consequences of hearing loss on these central mechanisms can be examined and may lead to the development of new therapeutic approaches to communicative disorders. ..
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXChristoph E Schreiner; Fiscal Year: 2010..Insight into these principles is crucial for understanding the flow of information in auditory cortex, the circuits for normal auditory processing and perceptual learning, and their contributions to auditory disorders. ..
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXCHRISTOPH SCHREINER; Fiscal Year: 2009..Insight into these principles is crucial for understanding the flow of information in auditory cortex, the circuits for normal auditory processing and perceptual learning, and their contributions to auditory disorders. ..
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXCHRISTOPH SCHREINER; Fiscal Year: 2007..Insight into these principles is crucial for understanding the flow of information in auditory cortex, the circuits for normal auditory processing and perceptual learning, and their contributions to auditory disorders. ..
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXCHRISTOPH SCHREINER; Fiscal Year: 2004..Specifically, the authors will measure the degree of correlation and synchrony between the responses in regions of similar bandwidth or binaural properties. ..
- AUDITORY AND SOMATOSENSORY CORTEXCHRISTOPH SCHREINER; Fiscal Year: 2004....
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXCHRISTOPH SCHREINER; Fiscal Year: 1999....