J O Schorge

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma
    Jayanthi S Lea
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Gynecol Oncol 91:558-62. 2003
  2. ncbi request reprint Adenocarcinoma of the cervix
    John O Schorge
    Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390, USA
    Curr Treat Options Oncol 5:119-27. 2004
  3. ncbi request reprint Management of low-risk gestational trophoblastic neoplasia in indigent women
    John O Schorge
    Southwestern Trophoblastic Disease Center, Division of Gynecologic Oncology, Dep of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390 9032, USA
    J Reprod Med 48:780-4. 2003
  4. ncbi request reprint Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    J Reprod Med 48:751-5. 2003
  5. ncbi request reprint Cervical adenocarcinoma survival among Hispanic and white women: a multicenter cohort study
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Obstet Gynecol 188:640-4. 2003
  6. ncbi request reprint Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    Clin Cancer Res 10:3474-8. 2004
  7. ncbi request reprint Germline BRCA1-2 mutations in non-Ashkenazi families with double primary breast and ovarian cancer
    J O Schorge
    Harold C Simmons Comprehensive Cancer Center and Familial Cancer Registry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Gynecol Oncol 83:383-7. 2001
  8. ncbi request reprint P16 as a molecular biomarker of cervical adenocarcinoma
    John O Schorge
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 190:668-73. 2004
  9. ncbi request reprint Fertility-sparing surgery in 101 women with adenocarcinoma in situ of the cervix
    Shawna L Bull-Phelps
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, J7 124, Dallas, TX 75390 9032, USA
    Gynecol Oncol 107:316-9. 2007
  10. ncbi request reprint Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry
    Bin Ye
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Clin Cancer Res 9:2904-11. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma
    Jayanthi S Lea
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Gynecol Oncol 91:558-62. 2003
    ..The purpose of this study was to identify poor prognostic factors of low-risk stage IB1 cervical adenocarcinoma..
  2. ncbi request reprint Adenocarcinoma of the cervix
    John O Schorge
    Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390, USA
    Curr Treat Options Oncol 5:119-27. 2004
    ..Patients with stage IIB to IVA disease should also receive primary radiation with weekly cisplatin. Management of recurrence should be individualized, depending on the location of disease and the type of previous therapy...
  3. ncbi request reprint Management of low-risk gestational trophoblastic neoplasia in indigent women
    John O Schorge
    Southwestern Trophoblastic Disease Center, Division of Gynecologic Oncology, Dep of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390 9032, USA
    J Reprod Med 48:780-4. 2003
    ..To identify the most effective dosing regimen for indigent patients with low-risk gestational trophoblastic neoplasia (GTN) at high risk of noncompliance...
  4. ncbi request reprint Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    J Reprod Med 48:751-5. 2003
    ..To conduct a surveillance trial after conization to prospectively determine the outcome of conservative management of adenocarcinoma in situ (AIS)...
  5. ncbi request reprint Cervical adenocarcinoma survival among Hispanic and white women: a multicenter cohort study
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Obstet Gynecol 188:640-4. 2003
    ..We compared the clinical outcome of cervical adenocarcinoma in Hispanic and white women to determine whether race was an independent predictor of survival...
  6. ncbi request reprint Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer
    John O Schorge
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    Clin Cancer Res 10:3474-8. 2004
    ..The purpose of this study was to test the hypothesis that OPN is a clinically useful adjunct to CA125 in detecting recurrent ovarian cancer...
  7. ncbi request reprint Germline BRCA1-2 mutations in non-Ashkenazi families with double primary breast and ovarian cancer
    J O Schorge
    Harold C Simmons Comprehensive Cancer Center and Familial Cancer Registry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Gynecol Oncol 83:383-7. 2001
    ..The purpose of this study was to determine the frequency and type of BRCA1-2 mutations in non-Ashkenazi families with at least one member having double primary breast and ovarian cancer...
  8. ncbi request reprint P16 as a molecular biomarker of cervical adenocarcinoma
    John O Schorge
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 190:668-73. 2004
    ..Cervical adenocarcinomas are increasing in incidence each year. The aim of this study was to identify a molecular biomarker to improve early detection...
  9. ncbi request reprint Fertility-sparing surgery in 101 women with adenocarcinoma in situ of the cervix
    Shawna L Bull-Phelps
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, J7 124, Dallas, TX 75390 9032, USA
    Gynecol Oncol 107:316-9. 2007
    ..The purpose of this study was to determine the outcomes of patients treated by this fertility-sparing strategy over an extended period of surveillance...
  10. ncbi request reprint Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry
    Bin Ye
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Clin Cancer Res 9:2904-11. 2003
    ..An antibody was generated from the synthesized peptide for quantitative validation in the cases and controls. CA125 was determined and compared with the same set of specimens...
  11. ncbi request reprint BRCA1-related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis
    J O Schorge
    Laboratory of Gynecologic Oncology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 60:1361-4. 2000
    ..013) than wild-type BRCA1 case subjects. We propose that the unique molecular pathogenesis of BRCA1-related PSCP may affect the ability of current methods to reliably prevent or detect this disease prior to metastasis...
  12. doi request reprint Evaluation of pemetrexed (Alimta, LY231514) as second line chemotherapy in persistent or recurrent carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group
    David Scott Miller
    University of Texas Southwestern Medical Center at Dallas, TX 75390 9032, USA
    Gynecol Oncol 110:65-70. 2008
    ..To estimate the anti-tumor activity of pemetrexed in patients with advanced or recurrent carcinoma of the cervix that failed on higher priority treatment protocols and to determine the nature and degree of toxicity...
  13. ncbi request reprint Postmolar surveillance at a trophoblastic disease center that serves indigent women
    Jennifer E Allen
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Southwestern Trophoblastic Disease Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    Am J Obstet Gynecol 188:1151-3. 2003
    ..The purpose of this study was to determine compliance with postmolar pregnancy surveillance in our indigent population...
  14. ncbi request reprint Aberrant p16 methylation is a biomarker for tobacco exposure in cervical squamous cell carcinogenesis
    Jayanthi S Lea
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Obstet Gynecol 190:674-9. 2004
    ..The purpose of this study was to determine the association between active tobacco exposure and aberrant p16 promoter methylation in primary cervical squamous cell cancer and high-grade squamous cervical dysplasia...
  15. ncbi request reprint Management of cervical adenocarcinoma in situ during pregnancy
    Robin A Lacour
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390 9032, USA
    Am J Obstet Gynecol 192:1449-51. 2005
    ..Few reports have described the treatment of this condition in gravid women. The purpose of this study was to review our collective experience managing cervical AIS during pregnancy...
  16. ncbi request reprint Management and outcomes for elderly women with vulvar cancer over time
    J A Rauh-Hain
    Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Boston, MA, USA
    BJOG 121:719-27; discussion 727. 2014
    ..To examine changes over time in survival and treatment for women diagnosed with vulvar squamous cell carcinoma included in the Surveillance, Epidemiology, and End Results (SEER) Program...
  17. ncbi request reprint Retrospective cohort study of surgical staging for ovarian low malignant potential tumors
    Shana N Wingo
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Am J Obstet Gynecol 194:e20-2. 2006
    ..The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors...
  18. ncbi request reprint Surgical staging of ovarian low malignant potential tumors
    Gautam G Rao
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obstet Gynecol 104:261-6. 2004
    ..The purpose of this study was to compare the outcome of surgically staged patients with low malignant potential tumors with those who were not staged...
  19. ncbi request reprint Duration of human chorionic gonadotropin surveillance for partial hydatidiform moles
    Isaac Lavie
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390 9032, USA
    Am J Obstet Gynecol 192:1362-4. 2005
    ..Partial hydatidiform moles infrequently progress to gestational trophoblastic neoplasia. The purpose of this study was to determine the optimal duration of human chorionic gonadotropin surveillance...
  20. ncbi request reprint Promoter hypermethylation profile of ovarian epithelial neoplasms
    Prakash B Makarla
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 11:5365-9. 2005
    ..The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis...
  21. ncbi request reprint Cytologic and biopsy findings leading to conization in adenocarcinoma in situ of the cervix
    Christine H Shin
    Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 100:271-6. 2002
    ..To investigate the utility of currently available screening tests in preoperatively detecting adenocarcinoma in situ of the cervix...
  22. ncbi request reprint Osteopontin as a potential diagnostic biomarker for ovarian cancer
    Jae Hoon Kim
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    JAMA 287:1671-9. 2002
    ..Analyses involving complementary DNA (cDNA) microarray data can be used to identify up-regulated genes in cancer cells, whose products may then be further validated as potential biomarkers...
  23. ncbi request reprint Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ
    Jayanthi S Lea
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Gynecol Oncol 87:129-32. 2002
    ..To determine if performing an endocervical curettage (ECC) at the time of conization is a useful diagnostic tool for predicting residual cervical adenocarcinoma in situ (AIS) among women who might wish to preserve their fertility...
  24. ncbi request reprint Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer
    Jae Hoon Kim
    Department of Obstetrics, Gynecology and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 9:4782-91. 2003
    ..090 in 26 normal women. This investigation has shown that the Ep-CAM autoantibody was found to be associated with ovarian cancer and suggested that future research assessing its clinical usefulness would be worthwhile...
  25. ncbi request reprint Early-stage cervical adenocarcinoma treated by surgical intent: the role of para-aortic lymph node dissection
    Jayanthi S Lea
    Division of Gynecologic Oncology, University of Texas Southwestern, Dallas, Texas 75390, USA
    Gynecol Oncol 84:285-8. 2002
    ..The purpose of this study was to further define the node of para-aortic lymph node dissection in early-stage cervical adenocarcinoma treated by surgical intent...
  26. ncbi request reprint Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women
    Asha Rathi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75930, USA
    Clin Cancer Res 8:3324-31. 2002
    ..The purpose of this research was to examine the DNA methylation profiles of primary sporadic ovarian cancers and ovarian tissues from high-risk women...
  27. ncbi request reprint Fertility-sparing surgery for ovarian low malignant potential tumors
    Gautam G Rao
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    Gynecol Oncol 98:263-6. 2005
    ..Conservative management usually involves leaving behind the uterus and contralateral adnexa to allow future childbearing. The purpose of this study was to determine the outcome of women treated with fertility-sparing surgery...
  28. ncbi request reprint Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix
    D M Boruta
    Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Gynecol Oncol 81:82-7. 2001
    ..01). CONCLUSION: NECC is a highly lethal variant of cervical cancer. The presence of lymph node metastases is the most important prognostic variable. Postoperative VAC or PE appears most likely to improve chances for survival...
  29. ncbi request reprint BRCA1 gene mutations in women with papillary serous carcinoma of the peritoneum
    C A Bandera
    Division of Gynecologic Oncology, The University of Pennsylvania Cancer Center, Philadelphia, USA
    Obstet Gynecol 92:596-600. 1998
    ..To compare BRCA1 mutations in papillary serous carcinoma of the peritoneum and papillary serous ovarian carcinoma...
  30. doi request reprint Secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer
    John O Schorge
    Division of Gynecologic Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Gynaecol Obstet 108:123-7. 2010
    ..To determine the risks and benefits of secondary cytoreductive surgery for recurrent platinum-sensitive ovarian cancer...
  31. doi request reprint Prognostic determinants in patients with stage IIIC and IV uterine papillary serous carcinoma
    J Alejandro Rauh-Hain
    Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Gynecol Oncol 119:299-304. 2010
    ..The aim of this study was to evaluate the survival impact of cytoreductive surgery and other prognostic determinants in patients with stage IIIC and IV uterine papillary serous carcinoma (UPSC)...
  32. doi request reprint Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
    Cristina M Contreras
    Department of Pathology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Cancer Res 68:759-66. 2008
    ..This study shows that Lkb1 plays an important role in the malignant transformation of endometrium and that Lkb1 loss promotes a highly invasive phenotype...
  33. doi request reprint Implications of EGFR inhibition in ovarian cancer cell proliferation
    Shawna L Bull Phelps
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Gynecol Oncol 109:411-7. 2008
    ..Targeted inhibition of EGFR via its tyrosine kinase domain is a successful treatment in lung cancer. Our objective was to correlate EGFR over-expression and growth inhibition, by EGF receptor inhibitors, in ovarian cancer...
  34. ncbi request reprint Stage IIB-IVB cervical adenocarcinoma: prognostic factors and survival
    Jayanthi S Lea
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Gynecol Oncol 84:115-9. 2002
    ..Few reports have described the outcome of patients with advanced cervical adenocarcinoma. The purpose of this study was to determine the prognostic factors and survival for patients with stage IIB-IVB disease...
  35. ncbi request reprint Gestational trophoblastic disease among Hispanic women: a 21-year hospital-based study
    Richard D Drake
    Southwestern Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Gynecol Oncol 103:81-6. 2006
    ..Few reports have described gestational trophoblastic disease (GTD) in this population. The purpose of this study was to determine the incidence of GTD at our public hospital which primarily serves the Hispanic population...
  36. ncbi request reprint BRCAPAP: feasibility of clinical BRCA testing on liquid-based cervical cytology: implications for biomarker development
    Carolyn Y Muller
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9073, USA
    Cancer Epidemiol Biomarkers Prev 13:1534-7. 2004
    ..The study was designed to test the feasibility that lower genital tract cytology is a compatible medium for robust germ line genetic analyses...
  37. ncbi request reprint Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas
    Colleen M Feltmate
    Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Cancer Res 11:7651-7. 2005
    ..The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin...
  38. ncbi request reprint ThinPrep detection of cervical and endometrial adenocarcinoma: a retrospective cohort study
    John O Schorge
    Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer 96:338-43. 2002
    ..The current study was performed to compare the accuracy of the ThinPrep trade mark Papanicoloau (Pap) test with that of the conventionally prepared Pap smear in detecting cervical and endometrial adenocarcinomas...
  39. pmc Somatic LKB1 mutations promote cervical cancer progression
    Shana N Wingo
    Division of Gynecologic Oncology, UT Southwestern Medical Center, Dallas, TX, USA
    PLoS ONE 4:e5137. 2009
    ..Furthermore, LKB1 status can be exploited clinically to predict disease recurrence...
  40. ncbi request reprint Transitional cell ovarian carcinoma in a BRCA1 mutation carrier
    Gautam G Rao
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obstet Gynecol 99:944-6. 2002
    ..BRCA1 mutation carriers are at high risk of developing epithelial ovarian cancer, but the transitional cell variant has not been previously reported in these patients...
  41. doi request reprint Use of a combination of approaches to identify and validate relevant tumor-associated antigens and their corresponding autoantibodies in ovarian cancer patients
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Division of Gynecology Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 14:764-71. 2008
    ..Indeed, many autoantibodies have recently been shown to correlate with cancer patient prognosis or to be suitable for detection of the disease...
  42. ncbi request reprint Simplifying the preevacuation testing strategy for patients with molar pregnancy
    Lynne M Knowles
    Southwestern Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    J Reprod Med 52:685-8. 2007
    ..To review our institution's preevacuation testing strategy for suspected molar pregnancy to determine whether a simplified approach might be indicated...
  43. ncbi request reprint Primary abdominal gestational choriocarcinoma
    Jennifer L Bailey
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Southwestern Trophoblastic Disease Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 102:988-90. 2003
    ..Gestational choriocarcinoma associated with ectopic pregnancy is an extremely infrequent event. Primary abdominal gestational choriocarcinoma has not been previously described...