Nina Felice Schor

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The Scholarly Project Initiative: introducing scholarship in medicine through a longitudinal, mentored curricular program
    Nina Felice Schor
    Division of Child Neurology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Acad Med 80:824-31. 2005
  2. ncbi request reprint Child neurology: a trilogy
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA
    Neurology 66:613. 2006
  3. ncbi request reprint Brain Mets: a poem in three voices
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA
    Neurology 66:457. 2006
  4. ncbi request reprint Building a division of child neurology: a tribute to Michael J. Painter, MD
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh, 3706 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Child Neurol 18:127-30. 2003
  5. ncbi request reprint The p75 neurotrophin receptor in human development and disease
    Nina Felice Schor
    Department of Pediatrics, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Prog Neurobiol 77:201-14. 2005
  6. ncbi request reprint Brain imaging and prophylactic therapy in children with migraine: recommendations versus reality
    Nina Felice Schor
    Division of Child Neurology, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pediatr 143:776-9. 2003
  7. ncbi request reprint Exploiting oxidative stress and signaling in chemotherapy of resistant neoplasms
    N F Schor
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, USA
    Biochemistry (Mosc) 69:38-44. 2004
  8. ncbi request reprint Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells
    Chaohua Yan
    Division of Child Neurology, The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Brain Res Mol Brain Res 139:225-34. 2005
  9. doi request reprint p75NTR-dependent modulation of cellular handling of reactive oxygen species
    Zhiping Mi
    Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
    J Neurochem 110:295-306. 2009
  10. ncbi request reprint Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2
    Zhiping Mi
    Division of Child Neurology, Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh of UPMC, PA 15213, USA
    Cancer Chemother Pharmacol 57:357-67. 2006

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The Scholarly Project Initiative: introducing scholarship in medicine through a longitudinal, mentored curricular program
    Nina Felice Schor
    Division of Child Neurology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Acad Med 80:824-31. 2005
    ..The block as a whole includes traditional lectures, small-group laboratory and problem-based sessions, and mentored independent study components...
  2. ncbi request reprint Child neurology: a trilogy
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA
    Neurology 66:613. 2006
  3. ncbi request reprint Brain Mets: a poem in three voices
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA
    Neurology 66:457. 2006
  4. ncbi request reprint Building a division of child neurology: a tribute to Michael J. Painter, MD
    Nina F Schor
    Division of Child Neurology, University of Pittsburgh, Children s Hospital of Pittsburgh, 3706 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Child Neurol 18:127-30. 2003
    ....
  5. ncbi request reprint The p75 neurotrophin receptor in human development and disease
    Nina Felice Schor
    Department of Pediatrics, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Prog Neurobiol 77:201-14. 2005
    ....
  6. ncbi request reprint Brain imaging and prophylactic therapy in children with migraine: recommendations versus reality
    Nina Felice Schor
    Division of Child Neurology, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pediatr 143:776-9. 2003
    ..Study design A retrospective review of the records of 106 consecutive patients referred to an academic children's hospital headache clinic...
  7. ncbi request reprint Exploiting oxidative stress and signaling in chemotherapy of resistant neoplasms
    N F Schor
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, USA
    Biochemistry (Mosc) 69:38-44. 2004
    ....
  8. ncbi request reprint Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells
    Chaohua Yan
    Division of Child Neurology, The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Brain Res Mol Brain Res 139:225-34. 2005
    ..These studies provide evidence that the pro-apoptotic effects of p75NTR in PC12 cells are related to the upregulation of cholesterol biosynthetic enzymes and consequent increased cholesterol biosynthesis...
  9. doi request reprint p75NTR-dependent modulation of cellular handling of reactive oxygen species
    Zhiping Mi
    Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
    J Neurochem 110:295-306. 2009
    ..In addition, decreased de novo GSH synthesis and increased GSH consumption are observed in p75NTR-deficient cells. These findings indicate that p75NTR regulates cellular handling of ROS to effect a survival response to oxidative stress...
  10. ncbi request reprint Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2
    Zhiping Mi
    Division of Child Neurology, Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh of UPMC, PA 15213, USA
    Cancer Chemother Pharmacol 57:357-67. 2006
    ..These results definitively demonstrate the requirement for caspase-3, cleavable Bcl-2, and available sulfhydryl groups (separate from those required for NCS activation) in potentiation of NCS-induced apoptosis by Bcl-2...
  11. ncbi request reprint TrkA as a life and death receptor: receptor dose as a mediator of function
    Chaohua Yan
    The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 62:4867-75. 2002
    ..This difference may mediate their differential survival after exposure to NGF...
  12. ncbi request reprint Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation
    Zhiping Mi
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15213, USA
    Brain Res 1112:46-55. 2006
    ..In conclusion, the present study describes a novel function of Bcl-2 in regulating cell shape through reduced ERK activation...
  13. ncbi request reprint Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice
    Travis Unger
    Department of Psychiatry, University of Pittsburgh School of Medicine, E1453 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 13:1041-51. 2005
    ....
  14. ncbi request reprint Bcl-2 mediates induction of neural differentiation
    Ye Liang
    Pediatric Center for Neuroscience and Division of Child Neurology, University and Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Oncogene 22:5515-8. 2003
    ..Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling...
  15. ncbi request reprint p75-nerve growth factor as an antiapoptotic complex: independence versus cooperativity in protection from enediyne chemotherapeutic agents
    Chaohua Yan
    The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Pharmacol 61:710-9. 2002
    ..e., TrkA independent or TrkA facilitatory) are responsible for NGF-mediated protection from enediyne-induced apoptosis...
  16. ncbi request reprint P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1
    Zeljka Korade Mirnics
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurobiol Dis 20:969-85. 2005
    ....
  17. ncbi request reprint Presenilin-1-dependent transcriptome changes
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1571-8. 2005
    ..The opposite directionality of these changes in transcript levels must be a function of APP and/or APP derivatives...
  18. ncbi request reprint The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress
    Yulia Y Tyurina
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Aging Cell 4:187-96. 2005
    ....
  19. ncbi request reprint Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease
    Qinghua Liang
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biochem Pharmacol 70:1371-81. 2005
    ..Adjunctive use of polynitroxylated albumin enhances the in vitro and in vivo effects of TEMPOL...
  20. ncbi request reprint Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain
    Zeljka Korade
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, PA, United States
    Neurobiol Aging 28:1522-31. 2007
    ..The unexpected localization of cholesterogenic enzymes in adult neurons suggests that at least some adult neurons retain the ability to synthesize cholesterol...
  21. ncbi request reprint p75NTR enhances PC12 cell tumor growth by a non-receptor mechanism involving downregulation of cyclin D2
    Melinda D Fritz
    Department of Pediatrics, University of Pittsburgh, PA, USA
    Exp Cell Res 312:3287-97. 2006
    ....
  22. pmc Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress
    Christopher A Ingraham
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Cell Res 315:3532-42. 2009
    ..Inhibition of JNK phosphorylation by SP600125 also resulted in increased resistance to 6-OHDA, suggesting that TrkA signaling underlies the susceptibility of these cells to oxidant stress...
  23. ncbi request reprint Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2
    Ye Liang
    The Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Mol Pharmacol 61:142-9. 2002
    ..Caspase 3-mediated Bcl-2 cleavage therefore plays an important role in the potentiation by Bcl-2 of NCS-induced apoptosis...
  24. ncbi request reprint The supportive academic environment: ingredients for success
    Nina F Schor
    Division of Child Neurology and Pediatric Center for Neuroscience, Department of Pediatrics, University and Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Neurol 29:370-3. 2003
    ..Painter in the careers of his residents, fellows, and faculty throughout more than two decades as Chief of the Division of Child Neurology at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh...
  25. ncbi request reprint Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Brain Res 1093:71-82. 2006
    ..Thus, we conclude that both peroxidase and cyclooxygenase half-cycles of COX-2-catalyzed reactions are essential for COX-2-dependent activation of 6-OHDA oxidation, oxygen radical production, oxidative stress, and cytotoxicity...
  26. ncbi request reprint Prevention of catecholaminergic oxidative toxicity by 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl and its recycling complex with polynitroxylated albumin, TEMPOL/PNA
    Ariella Weinberg
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 1012:13-21. 2004
    ..PNA enhances the therapeutic index of TEMPOL, and the recycling antioxidant that results from their adjunctive administration may prove useful in disorders involving oxidative stress...
  27. doi request reprint Reflections: neurology and the humanities. Developmental arrest
    Nina F Schor
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Neurology 71:1038. 2008
  28. pmc Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons
    Marc W Halterman
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Neurosci 38:125-37. 2008
    ..These data indicate that the pathologic response in cortical neurons induced by hypoxia involves both the loss of c/EBP-beta-mediated survival signals and activation of pro-death pathways originating from the endoplasmic reticulum...
  29. pmc Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy
    Danny Rogers
    Departments of Pediatrics, Neurology and Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY, USA
    Cancer Chemother Pharmacol 62:699-706. 2008
    ..To identify and mathematically model molecular predictors of response to the enediyne chemotherapeutic agent, neocarzinostatin, in nervous system cancer cell lines...

Research Grants1