Axel H Schonthal

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90089 9094, USA
    Anticancer Agents Med Chem 10:450-61. 2010
  2. ncbi request reprint Targeting endoplasmic reticulum stress for cancer therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Front Biosci (Schol Ed) 4:412-31. 2012
  3. pmc Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I
    Simmy Thomas
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e65695. 2013
  4. pmc Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
    A H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Br J Cancer 97:1465-8. 2007
  5. ncbi request reprint Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Neurosurg Focus 20:E21. 2006
  6. doi request reprint Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Lett 275:163-9. 2009
  7. ncbi request reprint Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs
    Axel H Schonthal
    University of Southern California, Department of Molecular Microbiology and Immunology, 2011 Zonal Avenue, HMR 405, Los Angeles, California, CA 90089 9094, USA
    Expert Opin Investig Drugs 17:197-208. 2008
  8. ncbi request reprint Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response
    Axel H Schonthal
    Keck School of Medicine, University of Southern California, 2011 Zonal Ave HMR 405, Los Angeles, CA 90089, USA
    Curr Pharm Des 17:2428-38. 2011
  9. doi request reprint Adverse effects of concentrated green tea extracts
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Nutr Food Res 55:874-85. 2011
  10. ncbi request reprint Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin
    Vinay Gupta
    Department of Pathology, K Norris Jr Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Neurosurg Focus 20:E20. 2006

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90089 9094, USA
    Anticancer Agents Med Chem 10:450-61. 2010
    ..Several COX-2 independent targets will be presented, and it will be discussed how DMC has helped to delineate their relevance for the surmised COX-2 independent tumoricidal effects of celecoxib...
  2. ncbi request reprint Targeting endoplasmic reticulum stress for cancer therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Front Biosci (Schol Ed) 4:412-31. 2012
    ..The principles of this promising new approach to cancer therapy, as well as representative ER stress-aggravating compounds, will be presented in this review...
  3. pmc Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I
    Simmy Thomas
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e65695. 2013
    ....
  4. pmc Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
    A H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Br J Cancer 97:1465-8. 2007
    ..This review presents the recently emerged direct non-COX-2 targets of celecoxib and their proposed role in mediating this drug's antitumour effects...
  5. ncbi request reprint Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Neurosurg Focus 20:E21. 2006
    ..In this summary, the implications of recent findings with DMC will be presented and discussed...
  6. doi request reprint Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Lett 275:163-9. 2009
    ..This mini-review will describe the yin-yang principle of ERS and autophagy, and will present newly recognized approaches to pharmacologically exploit these mechanisms for improved antitumor outcomes...
  7. ncbi request reprint Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs
    Axel H Schonthal
    University of Southern California, Department of Molecular Microbiology and Immunology, 2011 Zonal Avenue, HMR 405, Los Angeles, California, CA 90089 9094, USA
    Expert Opin Investig Drugs 17:197-208. 2008
    ..In this review, the authors present the status of preclinical development of anticancer analogs of celecoxib that are COX-2 inactive, with an emphasis on 2,5-dimethyl-celecoxib (DMC) and OSU-03012...
  8. ncbi request reprint Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response
    Axel H Schonthal
    Keck School of Medicine, University of Southern California, 2011 Zonal Ave HMR 405, Los Angeles, CA 90089, USA
    Curr Pharm Des 17:2428-38. 2011
    ....
  9. doi request reprint Adverse effects of concentrated green tea extracts
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Nutr Food Res 55:874-85. 2011
    ....
  10. ncbi request reprint Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin
    Vinay Gupta
    Department of Pathology, K Norris Jr Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Neurosurg Focus 20:E20. 2006
    ..The chemotherapeutic agent temozolomide has demonstrated antitumor activity in patients with recurrent malignant glioma. Because responses are not enduring and recurrence is nearly universal, further improvements are urgently needed...
  11. doi request reprint Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib
    Adel Kardosh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90089 9094, USA
    Cancer Res 68:843-51. 2008
    ..We propose that this novel drug combination should receive further evaluation as a potentially effective anticancer therapy...
  12. doi request reprint Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature
    Jenilyn J Virrey
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Mol Cancer Ther 9:631-41. 2010
    ..In vitro and in vivo analyses confirmed that DMC has antivascular activity. Considering that DMC targets both tumor cells and tumor-associated ECs, this agent is a promising anticancer drug...
  13. ncbi request reprint Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo
    Adel Kardosh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90089 9094, USA
    Cancer Biol Ther 4:571-82. 2005
    ....
  14. ncbi request reprint Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress
    Hee Yeon Cho
    Department of Molecular Microbiology and Immunology, University of Southern California, 2011 Zonal Ave, Los Angeles, CA 90089 9094, USA
    Cancer Lett 282:87-97. 2009
    ....
  15. doi request reprint Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors
    Encouse B Golden
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9094, USA
    Blood 113:5927-37. 2009
    ..Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of BZM and suggest that consumption of green tea products may be contraindicated during cancer therapy with BZM...
  16. doi request reprint Glioma-associated endothelial cells are chemoresistant to temozolomide
    Jenilyn J Virrey
    Department of Pathology, Keck School of Medicine, University of Southern California, Hoffman Medical Research Building 315, Los Angeles, CA 90033, USA
    J Neurooncol 95:13-22. 2009
    ..Our findings show that temozolomide has no apparent effect on the glioma vascular microenvironment. Thus combination therapy with anti-vascular agents may enhance temozolomide effectiveness as glioma therapeutic protocol...
  17. ncbi request reprint Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors
    Simmy Thomas
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Lett 325:63-71. 2012
    ..e. compounds that lead to ER stress aggravation) should be further explored for potential therapy of otherwise difficult-to-treat TNBC...
  18. doi request reprint Perillyl alcohol for the treatment of temozolomide-resistant gliomas
    Hee Yeon Cho
    Departments of Neurosurgery and Pathology, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Mol Cancer Ther 11:2462-72. 2012
    ..Our data show that POH is an effective anti-glioma cytotoxic agent for TMZ-resistant gliomas when administered intranasally...
  19. pmc Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells
    Jenilyn J Virrey
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cancer Res 6:1268-75. 2008
    ..Our findings provide the proof of principle that targeting GRP78 will sensitize the tumor vasculature to chemotherapeutic drugs, thus enhancing the efficacy of these drugs in combination therapy for glioma treatment...
  20. ncbi request reprint HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
    Peter Pyrko
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 67:10920-8. 2007
    ..Because ER stress has also been reported as the mechanism for insulin resistance and diabetes, our ER stress model of PI function may also explain why these drugs may induce insulin resistance as one of their most common side effects...
  21. ncbi request reprint Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib
    Adel Kardosh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, USA
    Blood 106:4330-8. 2005
    ....
  22. doi request reprint Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2
    Szu Ting Chen
    Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089 9094, USA
    Leuk Res 34:250-3. 2010
    ..Together, these results indicate that celecoxib's cytotoxic effects on Raji lymphoma cells do not involve the inhibition of COX-2...
  23. ncbi request reprint Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib
    Peter Pyrko
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA
    Mol Cancer Ther 6:1262-75. 2007
    ..We propose that it might be worthwhile to further evaluate the potential of DMC as a non-coxib alternative to celecoxib for anticancer purposes...
  24. ncbi request reprint Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib
    Adel Kardosh
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Ave, HMR 405, Los Angeles, CA 90089 9094, USA
    J Biomed Sci 14:647-62. 2007
    ..In addition, our data introduce celecoxib as a drug with increased cytotoxicity against hypoxic tumor cells...
  25. ncbi request reprint Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone
    Martina Blumenthal
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USA
    Mol Carcinog 38:160-9. 2003
    ..Taken together, our data indicated that progesterone was able to suppress the transformed phenotype of ovarian tumor cells. This observation could serve to explain progesterone's alleged protective effect in ovarian carcinogenesis...
  26. ncbi request reprint The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    Peter Pyrko
    Department of Pathology, and University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 67:9809-16. 2007
    ....
  27. doi request reprint Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models
    Thomas C Chen
    Department of Neurosurgery, Keck School of Medicine, University of Southern California USC, Los Angeles, CA, USA
    Cancer Lett 302:100-8. 2011
    ..Thus, ER stress-regulatory components affect the chemotherapeutic response of glioblastoma cells to treatment with temozolomide, and inclusion of EGCG is able to increase the therapeutic efficacy of this DNA-damaging agent...
  28. ncbi request reprint The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model
    Peter Pyrko
    Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Neurosurg 103:526-37. 2005
    ..To translate these in vitro findings into clinical settings, the authors examined the effect of contortrostatin on glioma progression in a rodent model...
  29. doi request reprint Noscapine inhibits tumor growth in TMZ-resistant gliomas
    Niyati Jhaveri
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, United States
    Cancer Lett 312:245-52. 2011
    ..Using the intracranial xenograft model, we showed that noscapine increased survival of animals with TMZ-resistant gliomas. Thus noscapine can provide an alternative therapeutic approach for the treatment of TMZ-resistant gliomas...
  30. ncbi request reprint Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines
    Adel Kardosh
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USA
    Cancer Biol Ther 3:55-62. 2004
    ....
  31. pmc COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro
    Huan Ching Chuang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, USA
    Mol Cancer 7:38. 2008
    ....
  32. ncbi request reprint Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines
    Ashish Anshu
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9094, USA
    Biochem Pharmacol 82:600-9. 2011
    ....
  33. ncbi request reprint Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin
    Stephanie Schmitmeier
    Kenneth Norris Jr Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Neurosurgery 57:141-53; discussion 141-53. 2005
    ....
  34. doi request reprint Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
    Natasha Sharma
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, United States
    Cancer Lett 326:143-54. 2012
    ....
  35. pmc Increased survivin expression confers chemoresistance to tumor-associated endothelial cells
    Jenilyn J Virrey
    Departments of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Ave, HMR 315A, Los Angeles, CA 90033, USA
    Am J Pathol 173:575-85. 2008
    ..Our studies demonstrate that targeting survivin may be an effective approach to chemosensitization and anti-vascular therapy for brain tumors...
  36. pmc Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo
    Peter Pyrko
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, USA
    Mol Cancer 5:19. 2006
    ..However, the molecular components that are involved in mediating these drugs' apoptosis-stimulatory consequences are incompletely understood...
  37. ncbi request reprint Celecoxib transiently inhibits cellular protein synthesis
    Peter Pyrko
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
    Biochem Pharmacol 75:395-404. 2008
    ....
  38. ncbi request reprint Potential misidentification of cyclooxygenase-2 by Western blot analysis and prevention through the inclusion of appropriate controls
    Yen Ting Liu
    Department of Molecular Microbiology and Immunology, University of Southern California, 2011 Zonal Ave, HMR 405, Los Angeles, CA 90089 9094, USA
    Mol Biotechnol 34:329-35. 2006
    ..Here, we present some of these pitfalls and suggest the inclusion of appropriate controls to unequivocally identify COX-2 protein levels...
  39. doi request reprint Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation
    Weijun Wang
    Department of Neurosurgery, University of Southern California, Los Angeles, California, USA
    J Neurosurg 114:689-94. 2011
    ..Thus the capacity of CPT-11 to be converted to the active SN38 intratumorally in gliomas was addressed...
  40. ncbi request reprint Inhibition of tumor cell growth by Triton X-100 through specific effects on cell-cycle-regulatory components
    Esther R Picache
    Department of Molecular Microbiology and Immunology, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089 9094, USA
    J Biomed Sci 11:95-103. 2004
    ..Taken together, our results provide a molecular basis for the antiproliferative effects of the Triton detergent, namely its differential effects on various parts of the cell cycle machinery...
  41. ncbi request reprint Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas
    Vinay Gupta
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosurg 106:455-62. 2007
    ..The authors have investigated the effects of the topoisomerase I inhibitor irinotecan (CPT-11) on primary meningioma cultures and a malignant meningioma cell line in vitro and in vivo...
  42. ncbi request reprint Efficacy of celecoxib in the treatment of CNS lymphomas: an in vivo model
    Weijun Wang
    Department of Neurosurgery, University of Southern California, Los Angeles, California 90033, USA
    Neurosurg Focus 21:E14. 2006
    ..Recently, it has been demonstrated that the selective cyclooxygenase- 2 inhibitor celecoxib (Celebrex), can block the growth of lymphoma cells in vitro...
  43. doi request reprint Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib
    Angela Ferrario
    The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cancer Lett 304:33-40. 2011
    ..Our results also suggest that celecoxib mediated enhancement of PDT may involve both COX-2 dependent and independent mechanisms...
  44. ncbi request reprint Glioma-associated endothelial cells show evidence of replicative senescence
    Christiana Charalambous
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Exp Cell Res 313:1192-202. 2007
    ....
  45. ncbi request reprint Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer
    Leah M Backhus
    Department of Cardiothoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
    J Thorac Cardiovasc Surg 130:1406-12. 2005
    ....
  46. ncbi request reprint A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo
    Thomas C Chen
    Authors Affiliations Departments of Neurosurgery, Pathology, Molecular Microbiology and Immunology, and Pharmaceutical Sciences, University of Southern California, Los Angeles, California
    Mol Cancer Ther 13:1181-93. 2014
    ..At the same time, T-P seemed to be well tolerated by the animals. Thus, T-P may have potential as a novel therapy for brain-targeted breast cancer metastases...
  47. ncbi request reprint The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway
    Dominique T Nguyen
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Biol Med 41:1225-39. 2006
    ..We suggest that the formation of THIF may mediate the cellular actions of genistein in tumorigenic breast epithelial cells via the activation of signaling through p38...
  48. ncbi request reprint Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity
    Hong Zhou
    Department of Pathology, USC Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Cancer Biol Ther 1:300-6. 2002
    ..We conclude that P4 inhibits cell cycle activity in ovarian epithelial tumors, in part via down-regulation of the cdkl/cyclin B complex. This inhibitory effect may have therapeutic utility against ovarian epithelial tumors...
  49. pmc Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
    Vanessa M Yu
    Department of Pathology, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Int J Cancer 130:2495-504. 2012
    ..This may be particularly relevant to cancers that have a near tetraploid/polyploid number of chromosomes...
  50. doi request reprint Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
    Axel H Schonthal
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem Pharmacol 85:653-66. 2013
    ..g., CHOP/GADD153). This review will discuss the principle of pharmacological ER stress aggravation, and will present preclinical models with promise for cancer therapeutic applications...
  51. ncbi request reprint Measuring cyclin-dependent kinase activity
    Axel H Schonthal
    Department of Molecular Biology and Biochemistry and K Norris Jr Comprehenisve Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, USA
    Methods Mol Biol 281:105-24. 2004
    ..Here, I describe the execution of this in vitro kinase activity assay as well as appropriate controls that need to be considered for the proper evaluation of the results...
  52. ncbi request reprint The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells
    Thomas C Chen
    LAC USC Medical Center, Department of Neurosurgery, Pathology, University of Southern California, 1200 N State St, Suite 5046, Los Angeles, CA 90033, USA
    Cancer Biol Ther 1:268-76. 2002
    ..As we observe this effect with other glioma cell cultures as well, our results suggest that rolipram could prove useful as a novel differentiating agent with both cytostatic and cytotoxic potential in the treatment of malignant gliomas...
  53. ncbi request reprint EphB4 provides survival advantage to squamous cell carcinoma of the head and neck
    Rizwan Masood
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 119:1236-48. 2006
    ..Expression of EphB4 in HNSCC tumor cells confers survival and invasive properties, and thereby provides a strong rationale for targeting EphB4 as novel therapy for HNSCC...
  54. pmc Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis
    Sandra A S Johnson
    Department of Biochemistry and Molecular Biology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    Mol Cell Biol 23:3043-51. 2003
    ..We conclude that TBP may be a critical component in dysregulated signaling that occurs downstream of genetic lesions that cause tumors...