C SCHONEICH

Summary

Affiliation: University of Kansas
Country: USA

Publications

  1. ncbi request reprint Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Biochim Biophys Acta 1703:111-9. 2005
  2. ncbi request reprint Selective Cu2+/ascorbate-dependent oxidation of alzheimer's disease beta-amyloid peptides
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Ann N Y Acad Sci 1012:164-70. 2004
  3. ncbi request reprint Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Am Chem Soc 125:13700-13. 2003
  4. ncbi request reprint CU(II)-catalyzed oxidation of Alzheimer's disease beta-amyloid peptide and related sequences: remarkably different selectivities of neurotoxic betaAP1-40 and non-toxic betaAP40-1
    C SCHONEICH
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Cell Mol Biol (Noisy-le-grand) 49:753-61. 2003
  5. ncbi request reprint Proteomics in gerontological research
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Exp Gerontol 38:473-81. 2003
  6. ncbi request reprint Cu(II)-catalyzed oxidation of beta-amyloid peptide targets His13 and His14 over His6: Detection of 2-Oxo-histidine by HPLC-MS/MS
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence 66047, USA
    Chem Res Toxicol 15:717-22. 2002
  7. ncbi request reprint Redox processes of methionine relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Arch Biochem Biophys 397:370-6. 2002
  8. ncbi request reprint Characterization of the metal-binding site of bovine growth hormone through site-specific metal-catalyzed oxidation and high-performance liquid chromatography-tandem mass spectrometry
    Susan W Hovorka
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Anal Biochem 300:206-11. 2002
  9. ncbi request reprint Mechanisms of metal-catalyzed oxidation of histidine to 2-oxo-histidine in peptides and proteins
    C SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    J Pharm Biomed Anal 21:1093-7. 2000
  10. ncbi request reprint Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat
    C SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Mech Ageing Dev 107:221-31. 1999

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Biochim Biophys Acta 1703:111-9. 2005
    ....
  2. ncbi request reprint Selective Cu2+/ascorbate-dependent oxidation of alzheimer's disease beta-amyloid peptides
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Ann N Y Acad Sci 1012:164-70. 2004
    ....
  3. ncbi request reprint Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Am Chem Soc 125:13700-13. 2003
    ....
  4. ncbi request reprint CU(II)-catalyzed oxidation of Alzheimer's disease beta-amyloid peptide and related sequences: remarkably different selectivities of neurotoxic betaAP1-40 and non-toxic betaAP40-1
    C SCHONEICH
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Cell Mol Biol (Noisy-le-grand) 49:753-61. 2003
    ..The significantly different characteristic of betaAP1-40 and betaAP40-1 with regard to metal catalyzed processes may be related to the differences in the neurotoxic properties of these sequences...
  5. ncbi request reprint Proteomics in gerontological research
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Exp Gerontol 38:473-81. 2003
    ..The instrumental tools of proteomics offer great potential for molecular studies of biological aging. This article reviews specific applications and emerging concepts of proteomics, which are or can be applied to aging research...
  6. ncbi request reprint Cu(II)-catalyzed oxidation of beta-amyloid peptide targets His13 and His14 over His6: Detection of 2-Oxo-histidine by HPLC-MS/MS
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence 66047, USA
    Chem Res Toxicol 15:717-22. 2002
    ....
  7. ncbi request reprint Redox processes of methionine relevant to beta-amyloid oxidation and Alzheimer's disease
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Arch Biochem Biophys 397:370-6. 2002
    ..Additional support for a potential catalytic role of an oxygen-containing functional group comes from numerous studies with organic model sulfides...
  8. ncbi request reprint Characterization of the metal-binding site of bovine growth hormone through site-specific metal-catalyzed oxidation and high-performance liquid chromatography-tandem mass spectrometry
    Susan W Hovorka
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Anal Biochem 300:206-11. 2002
    ..This result is supported by a previously predicted tertiary structure of bGH and compared with the location of metal-binding His residues of human growth hormone...
  9. ncbi request reprint Mechanisms of metal-catalyzed oxidation of histidine to 2-oxo-histidine in peptides and proteins
    C SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    J Pharm Biomed Anal 21:1093-7. 2000
    ..For predicting the susceptibility of His residues in proteins it is important to understand in detail how protein sequence and conformation control the mechanisms of His oxidation to 2-oxo-His, reviewed in this paper...
  10. ncbi request reprint Age-related chemical modification of the skeletal muscle sarcoplasmic reticulum Ca-ATPase of the rat
    C SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Mech Ageing Dev 107:221-31. 1999
    ..Peroxynitrite selectively nitrated the tyrosine residues of the SERCA2a isoform even in the presence of an excess of SERCA1. Thus, peroxynitrite may be responsible for the age-dependent modification of the SR Ca-ATPase in vivo...
  11. ncbi request reprint Selective oxidation of Zn2+ -insulin catalyzed by Cu2+
    Vikram Sadineni
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 96:1844-7. 2007
    ..8 microM Zn2+ were exposed to 8 microM Cu2+ and 50 microM ascorbate for 90 min. The Cu2+ -catalyzed oxidation mainly targeted the B chain of INS, where the two histidine residues are located...
  12. ncbi request reprint Redox properties of Met(35) in neurotoxic beta-amyloid peptide. A molecular modeling study
    Dariusz Pogocki
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Chem Res Toxicol 15:408-18. 2002
    ....
  13. pmc Fluorogenic tagging of protein 3-nitrotyrosine with 4-(aminomethyl)benzene sulfonate in tissues: a useful alternative to Immunohistochemistry for fluorescence microscopy imaging of protein nitration
    V S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA
    Free Radic Biol Med 53:1877-85. 2012
    ....
  14. ncbi request reprint Biological aging does not lead to the accumulation of oxidized Cu,Zn-superoxide dismutase in the liver of F344 rats
    E Ghezzo-Schöneich
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Free Radic Biol Med 30:858-64. 2001
    ..Therefore, our data do not confirm an earlier hypothesis that oxidatively modified Cu,Zn-SOD protein accumulates in the liver of aged F344 rats...
  15. ncbi request reprint Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging
    Jaroslaw Kanski
    University of Kansas, Department of Pharmaceutical Chemistry, 2099 Constant Ave, Lawrence, KS 66047, USA
    Am J Physiol Heart Circ Physiol 288:H371-81. 2005
    ..Possibly the oxidative modifications of the identified proteins contribute to the age-dependent degeneration and functional decline of heart proteins...
  16. ncbi request reprint Protein modification in aging: an update
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Exp Gerontol 41:807-12. 2006
    ....
  17. doi request reprint Selective fluorogenic derivatization of 3-nitrotyrosine and 3,4-dihydroxyphenylalanine in peptides: a method designed for quantitative proteomic analysis
    Victor S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA
    Methods Enzymol 441:19-32. 2008
    ..The methodology can be expanded to other substituted benzylamines, which carry functional groups for affinity enrichment...
  18. ncbi request reprint Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging
    Giridharan Gokulrangan
    Department of Pharmaceutical Chemistry, University of Lawrence, Kansas 66047, USA
    J Neurochem 100:1494-504. 2007
    ....
  19. ncbi request reprint Reactive oxygen species and biological aging: a mechanistic approach
    C SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Exp Gerontol 34:19-34. 1999
    ..Complexation of calmodulin to calmodulin-binding proteins and protein turnover are additional parameters likely contributing to the accumulation of specifically modified calmodulin...
  20. ncbi request reprint Characterization of the metal-binding site of human prolactin by site-specific metal-catalyzed oxidation
    Vikram Sadineni
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA
    Anal Biochem 358:208-15. 2006
    ..This result shows the similarity of hPRL to human growth hormone (hGH), a member of the same family as hPRL, where the MBS is composed of His18, His21, and Glu174...
  21. ncbi request reprint Mass spectrometry of protein modifications by reactive oxygen and nitrogen species
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Free Radic Biol Med 41:1507-20. 2006
    ....
  22. ncbi request reprint Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry
    Victor S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Exp Gerontol 41:407-16. 2006
    ..Our data show a correlation of age-dependent 3-NT accumulation with Ph-b inactivation...
  23. ncbi request reprint Protein nitration in biological aging: proteomic and tandem mass spectrometric characterization of nitrated sites
    Jaroslaw Kanski
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    Methods Enzymol 396:160-71. 2005
    ..Some examples for the MS/MS analysis of nitrated peptides obtained from aging rat heart and skeletal muscle are provided, such as nitration of Tyr105 of the mitochondrial electron-transfer flavoprotein and Tyr14 of creatine kinase...
  24. pmc Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry
    Sung Jung Hong
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA
    Exp Gerontol 42:639-51. 2007
    ..The post-translational modification of these cytoskeletal proteins may provide some rationale for the age-dependent functional decline of the heart...
  25. ncbi request reprint Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging
    Elena S Dremina
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    J Neurochem 93:1262-71. 2005
    ..The putative mechanism of nitric oxide synthase (NOS) activity regulation by the level of caveolin expression and raft protein-protein interactions is discussed...
  26. ncbi request reprint Proteomic approach to aging research
    Victor S Sharov
    University of Kansas, Pharmaceutical Chemistry Department, Lawrence, KS 66047, USA
    Expert Rev Proteomics 4:309-21. 2007
    ..Specific attention is paid to the illustrations of successful applications of proteomic technologies and potential applications of new proteomic concepts to biogerontological studies...
  27. ncbi request reprint High sensitivity of Zn2+ insulin to metal-catalyzed oxidation: detection of 2-oxo-histidine by tandem mass spectrometry
    Susan W Hovorka
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Pharm Res 19:530-7. 2002
    ....
  28. pmc Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: selective protein oxidation during biological aging
    Victor S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Biochem J 394:605-15. 2006
    ..Our data show an age-dependent loss of cysteine residues (approx. 2.8 mol of cysteine/mol of SERCA1), which may be partially responsible for the age-dependent decrease in the specific Ca2+-ATPase activity (by 40%)...
  29. ncbi request reprint Potential role of methionine sulfoxide in the inactivation of the chaperone GroEL by hypochlorous acid (HOCl) and peroxynitrite (ONOO-)
    Hui Koon Khor
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047 3729, USA
    J Biol Chem 279:19486-93. 2004
    ..The high sensitivity of GroEL toward HOCl and ONOO(-) suggests that this protein may be a target for bacterial killing by phagocytes...
  30. ncbi request reprint Oxidative inactivation of purified plasma membrane Ca2+-ATPase by hydrogen peroxide and protection by calmodulin
    Asma Zaidi
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    Biochemistry 42:12001-10. 2003
    ..Preincubation of PMCA with CaM protected the enzyme from undergoing this conformational change...
  31. ncbi request reprint Computational characterization of sulfur-cxygen-bonded sulfuranyl radicals derived from alkyl- and (carboxyalkyl)thiopropionic acids: evidence for sigma-type radicals
    Dariusz Pogocki
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Org Chem 67:1526-35. 2002
    ..Characteristic optical absorption bands, vibrational frequencies, and hyperfine coupling tensors are evaluated to facilitate the identification of such radicals by time-resolved UV, IR, and ESR spectroscopy...
  32. ncbi request reprint Age-dependent oxidation and aggregation of ZnT-1: a role for metal catalyzed oxidation?
    Vikram Sadineni
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA
    Exp Gerontol 42:1130-6. 2007
    ..The latter would be consistent with the known propensity of metal-binding proteins to suffer MCO...
  33. ncbi request reprint Thiyl radical reaction with amino acid side chains: rate constants for hydrogen transfer and relevance for posttranslational protein modification
    Thomas Nauser
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Chem Res Toxicol 17:1323-8. 2004
    ....
  34. pmc Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function?
    Victor S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Arch Biochem Biophys 484:155-66. 2009
    ....
  35. ncbi request reprint Mass spectrometry in aging research
    CHRISTIAN SCHONEICH
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Mass Spectrom Rev 24:701-18. 2005
    ..Selected examples will show both the power and also current limitations of the respective techniques. Experimental results and strategies are discussed in view of current theories of the aging process...
  36. pmc Synthesis of sulfonamide- and sulfonyl-phenylboronic acid-modified silica phases for boronate affinity chromatography at physiological pH
    Xiaobao Li
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA
    Anal Biochem 372:227-36. 2008
    ..5). Mono-, di-, and triphosphates of adenosine were also separated at pH 6.0. Hence, the new boronate solid phase offers efficient affinity separation and purification of cis-diol-containing molecules under rather mild pH conditions...
  37. ncbi request reprint Selective site-specific fenton oxidation of methionine in model peptides: evidence for a metal-bound oxidant
    Dawn R Dufield
    Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, USA
    J Pharm Sci 93:1122-30. 2004
    ....
  38. ncbi request reprint Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry
    Jaroslaw Kanski
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA
    J Biol Chem 280:24261-6. 2005
    ..The latter experiments demonstrate that the in vitro exposure of an isolated protein to peroxynitrite may not always be a good model to mimic protein nitration in vivo...
  39. ncbi request reprint Proteomic identification of age-dependent protein nitration in rat skeletal muscle
    Jaroslaw Kanski
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA
    Free Radic Biol Med 35:1229-39. 2003
    ....
  40. doi request reprint Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion
    Olivier Mozziconacci
    Department of Pharmaceutical Chemistry, 2095 Constant Avenue, University of Kansas, Lawrence, Kansas 66047, USA
    J Phys Chem B 114:6751-62. 2010
    ....
  41. doi request reprint Photolysis of an intrachain peptide disulfide bond: primary and secondary processes, formation of H2S, and hydrogen transfer reactions
    Olivier Mozziconacci
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Phys Chem B 114:3668-88. 2010
    ..An important photolytic product is H(2)S, which is highly relevant for the production and storage of protein pharmaceuticals, where H(2)S can catalyze disulfide scrambling and protein degradation...
  42. ncbi request reprint Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and alpha C-H bonds in insulin: control of selectivity by secondary structure
    Olivier Mozziconacci
    Department of Pharmaceutical Chemistry, 2095 Constant Avenue, University of Kansas, Lawrence, Kansas 66047, USA
    J Phys Chem B 112:15921-32. 2008
    ..This feature has important consequences for protein stability under conditions of oxidative stress and/or protein production in pharmaceutical biotechnology...
  43. doi request reprint Peptide cysteine thiyl radicals abstract hydrogen atoms from surrounding amino acids: the photolysis of a cystine containing model peptide
    Olivier Mozziconacci
    The Department of Pharmaceutical Chemistry, 2095 Constant Avenue, University of Kansas, Lawrence, Kansas 66047, USA
    J Phys Chem B 112:9250-7. 2008
    ....
  44. pmc Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA)
    Elena S Dremina
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    Biochem J 383:361-70. 2004
    ....
  45. ncbi request reprint Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds
    Thomas Nauser
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    Chem Res Toxicol 16:1056-61. 2003
    ..The rate constants for hydrogen abstraction at thymine C5-CH(3) were compared to those with benzylic substrates, toluenesulfonic acid, and benzyl alcohol...
  46. ncbi request reprint Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides
    Elena S Dremina
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Chem Res Toxicol 20:1462-9. 2007
    ..Our data demonstrate a potential role of peptide- and protein-derived peroxides as important mediators of oxidative stress in vivo, which may cause a selective oxidation of Cys residues leading to inactivation of membrane proteins...
  47. ncbi request reprint Oxidative degradation of a sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrone in aqueous/organic cosolvent mixtures
    Susan W Hovorka
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Pharm Res 19:538-45. 2002
    ....
  48. ncbi request reprint Two-dimensional separation of the membrane protein sarcoplasmic reticulum Ca-ATPase for high-performance liquid chromatography-tandem mass spectrometry analysis of posttranslational protein modifications
    Victor S Sharov
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Anal Biochem 308:328-35. 2002
    ..At molar ratios of nitrotyrosine to protein of 0.23 we confirmed by LC-MS/MS the nitration of predominantly Tyr(122) in the SERCA1 sequence...
  49. ncbi request reprint Reactions of aliphatic thiyl radicals in the solid state: photoisomerization of trans-4,5-dihydroxy-1,2-dithiacyclohexane and oxidation of dithiothreitol
    Lorena B Barrón
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, KS 66047, USA
    J Phys Chem A 109:9241-8. 2005
    ....
  50. ncbi request reprint Solid-state photodegradation of bovine somatotropin (bovine growth hormone): evidence for tryptophan-mediated photooxidation of disulfide bonds
    Brian L Miller
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Pharm Sci 92:1698-709. 2003
    ..Our results show a novel mechanism for Trp-mediated photodegradation of protein disulfide bonds via formation of a pair of thiyL radicals followed by addition of molecular oxygen...
  51. ncbi request reprint Thiyl radicals abstract hydrogen atoms from the (alpha)C-H bonds in model peptides: absolute rate constants and effect of amino acid structure
    Thomas Nauser
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Am Chem Soc 125:2042-3. 2003
    ..However, the correlation of rate constants with BDEs is poor. Rather, these reactions may be controlled by conformation and dynamic flexibility around the (alpha)C-H bonds...