Robert E Schoen

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    N Engl J Med 366:2345-57. 2012
  2. doi request reprint Colorectal cancers not detected by screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 75:612-20. 2012
  3. ncbi request reprint Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
    Gastroenterology 131:1683-9. 2006
  4. ncbi request reprint Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 129:464-75. 2005
  5. ncbi request reprint Results of repeat sigmoidoscopy 3 years after a negative examination
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:41-8. 2003
  6. pmc Utilization of surveillance colonoscopy in community practice
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Medical Center, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2582, USA
    Gastroenterology 138:73-81. 2010
  7. pmc Flexible sigmoidoscopy in the randomized prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial: added yield from a second screening examination
    Joel L Weissfeld
    UPMC Cancer Pavilion POB II, Pittsburgh, PA 15232, USA
    J Natl Cancer Inst 104:280-9. 2012
  8. ncbi request reprint Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial
    Joel L Weissfeld
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 97:989-97. 2005
  9. doi request reprint Physicians encouraging colorectal screening: a randomized controlled trial of enhanced office and patient management on compliance with colorectal cancer screening
    Bruce S Ling
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Arch Intern Med 169:47-55. 2009
  10. pmc Likelihood of missed and recurrent adenomas in the proximal versus the distal colon
    Adeyinka O Laiyemo
    Department of Medicine, Howard University College of Medicine, Washington, DC, USA
    Gastrointest Endosc 74:253-61. 2011

Collaborators

Detail Information

Publications67

  1. pmc Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    N Engl J Med 366:2345-57. 2012
    ..The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer incidence and mortality...
  2. doi request reprint Colorectal cancers not detected by screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 75:612-20. 2012
    ....
  3. ncbi request reprint Yield of advanced adenoma and cancer based on polyp size detected at screening flexible sigmoidoscopy
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvani 15213 2582, USA
    Gastroenterology 131:1683-9. 2006
    ..To examine the yield at colonoscopy when a given size lesion is observed, we assessed the yield of advanced adenoma and cancer at colonoscopy based on the size of the abnormality detected at flexible sigmoidoscopy (FSG)...
  4. ncbi request reprint Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 129:464-75. 2005
    ..We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer...
  5. ncbi request reprint Results of repeat sigmoidoscopy 3 years after a negative examination
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:41-8. 2003
    ..The necessary frequency of endoscopic colorectal cancer screening after a negative examination is uncertain...
  6. pmc Utilization of surveillance colonoscopy in community practice
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Medical Center, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2582, USA
    Gastroenterology 138:73-81. 2010
    ..The burden and cost of surveillance colonoscopy are significant. The aim of this study was to examine the use of surveillance colonoscopy on a community-wide basis...
  7. pmc Flexible sigmoidoscopy in the randomized prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial: added yield from a second screening examination
    Joel L Weissfeld
    UPMC Cancer Pavilion POB II, Pittsburgh, PA 15232, USA
    J Natl Cancer Inst 104:280-9. 2012
    ..We report outcomes from the PLCO screening FSG program and evaluate the increased yield produced by a second FSG...
  8. ncbi request reprint Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial
    Joel L Weissfeld
    University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 97:989-97. 2005
    ..Here we report findings from the baseline screening flexible sigmoidoscopy examination...
  9. doi request reprint Physicians encouraging colorectal screening: a randomized controlled trial of enhanced office and patient management on compliance with colorectal cancer screening
    Bruce S Ling
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Arch Intern Med 169:47-55. 2009
    ..Colorectal cancer screening is underused. Our objective was to evaluate methods for promoting colorectal cancer screening in primary care practice...
  10. pmc Likelihood of missed and recurrent adenomas in the proximal versus the distal colon
    Adeyinka O Laiyemo
    Department of Medicine, Howard University College of Medicine, Washington, DC, USA
    Gastrointest Endosc 74:253-61. 2011
    ..Colonoscopy may be less efficacious in reducing colorectal cancer mortality in the proximal compared with the distal colon. A greater likelihood for missed and recurrent adenomas in the proximal colon may contribute to this phenomenon...
  11. pmc Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities
    Adeyinka O Laiyemo
    Department of Medicine, Howard University College of Medicine, Howard University Cancer Center, Washington, DC 20060, USA
    J Natl Cancer Inst 102:538-46. 2010
    ..It is unclear whether the disproportionately higher incidence and mortality from colorectal cancer among blacks compared with whites reflect differences in health-care utilization or colorectal cancer susceptibility...
  12. pmc Short- and long-term risk of colorectal adenoma recurrence among whites and blacks
    Adeyinka O Laiyemo
    Department of Medicine, Howard University Hospital, Washington, DC, USA
    Gastrointest Endosc 77:447-54. 2013
    ..It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility...
  13. pmc Factors associated with inadequate colorectal cancer screening with flexible sigmoidoscopy
    Adeyinka O Laiyemo
    Division of Gastroenterology, Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
    Cancer Epidemiol 36:395-9. 2012
    ....
  14. pmc Factors associated with the risk of adenoma recurrence in distal and proximal colon
    Adeyinka O Laiyemo
    Division of Gastroenterology, Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
    Digestion 87:141-6. 2013
    ..Colonoscopy may be less effective in preventing cancer in the proximal colon. We evaluated whether risk factors for adenoma recurrence exhibit differential effect on adenoma recurrence by colon subsite...
  15. ncbi request reprint Using the transtheoretical model to stage screening behavior for colorectal cancer
    Jeanette M Trauth
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Health Educ Behav 30:322-36. 2003
    ..This study appears to be one of the first applications of this theory to understanding CRC screening behavior in a community intervention...
  16. pmc Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study
    Keith Leung
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Gastrointest Endosc 71:111-7. 2010
    ..Despite regular colonoscopy, interval colorectal cancer (CRC) may occur. Long-term studies examining CRC rates in patients with previous colonoscopy are lacking...
  17. doi request reprint The natural history of aberrant crypt foci
    Robert E Schoen
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 67:1097-102. 2008
    ..Aberrant crypt foci (ACF) are the putative precursors to colorectal adenomas and may be useful as biomarkers. Knowledge of their natural history is essential to understanding their potential utility...
  18. ncbi request reprint Relationship of visceral adipose tissue to recurrence of adenomatous polyps
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 99:687-93. 2004
    ..The aim of this investigation was to determine whether VAT is associated with recurrence of adenomatous polyps, the precursor to colorectal cancer...
  19. pmc Applying a natural language processing tool to electronic health records to assess performance on colonoscopy quality measures
    Ateev Mehrotra
    Departments of Medicine and Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gastrointest Endosc 75:1233-9.e14. 2012
    ..Natural language processing (NLP) is a field of computer science in which programs are trained to extract relevant information from text reports in an automated fashion...
  20. ncbi request reprint Adherence to repeat screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    Joel L Weissfeld
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer 94:2569-76. 2002
    ..In the current prospective study, the authors used adherence to repeat testing to assess the acceptability of screening flexible sigmoidoscopy...
  21. ncbi request reprint A population-based, community estimate of total colon examination: the impact on compliance with screening for colorectal cancer
    Robert E Schoen
    Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 97:446-51. 2002
    ..In a population-based survey we determined the prevalence and validated the self-reporting of TCE and assessed its impact on compliance with screening...
  22. ncbi request reprint Informed decision-making and colorectal cancer screening: is it occurring in primary care?
    Bruce S Ling
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15213, USA
    Med Care 46:S23-9. 2008
    ..The degree to which providers communicate the information necessary to prepare patients for participation in this process is not known...
  23. ncbi request reprint Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women
    Robert E Schoen
    Departments of Epidemiology, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Cancer Epidemiol Biomarkers Prev 11:581-6. 2002
    ..The lack of association between obesity and the IGF-1 axis suggests that the IGF-1 axis is not a likely mediator between VAT and disease...
  24. ncbi request reprint Analysis of colorectal cancer occurrence during surveillance colonoscopy in the dietary Polyp Prevention Trial
    Ajay Pabby
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastrointest Endosc 61:385-91. 2005
    ..Systematic evaluation of CRC detected after colonoscopy could identify ways to improve the quality and the outcome of colonoscopy...
  25. ncbi request reprint Nuclear matrix protein alterations associated with colon cancer metastasis to the liver
    Gisela Brunagel
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    Clin Cancer Res 8:3039-45. 2002
    ..These were compared with colon cancer NMP patterns, along with several primary cell systems and lines...
  26. ncbi request reprint Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps
    Gisela Brunagel
    Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    J Cell Biochem 91:365-74. 2004
    ..CC3 and CC4 are expressed earlier in the evolution of adenomatous polyps. Development of an assay to these proteins may serve as a new method for early detection of colorectal cancer...
  27. ncbi request reprint Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer
    Manimalha Balasubramani
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cancer Res 66:763-9. 2006
    ..These results suggest an involvement of hnRNP F and CKB in colorectal cancer. Additionally, they suggest that hnRNP F is a potential marker for colorectal cancer progression...
  28. ncbi request reprint Surveillance after positive and negative colonoscopy examinations: issues, yields, and use
    Robert E Schoen
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 98:1237-46. 2003
    ..Studies that examine the need and the needed timing of subsequent surveillance are essential to containing costs for screening as well as to informing the public better about what endoscopic screening can and cannot accomplish...
  29. pmc MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study
    Takashi Kimura
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Prev Res (Phila) 6:18-26. 2013
    ..g., high levels of MDSC) might already exist in some individuals, suggesting an even earlier premalignant stage or preselection of nonimmunosuppressed patients for prophylactic vaccination...
  30. ncbi request reprint Identification of calreticulin as a nuclear matrix protein associated with human colon cancer
    Gisela Brunagel
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    J Cell Biochem 89:238-43. 2003
    ..The aim of this study was to confirm the identity of the protein as calreticulin as well as to evaluate the localization of calreticulin in the nuclear matrix of colon cancer tissue...
  31. pmc Humoral immune response to abnormal MUC1 in subjects with colorectal adenoma and cancer
    Ann Willman Silk
    University of Pittsburgh, School of Medicine and Clinical Scientist Training Program, Pittsburgh, PA 15232, United States
    Mol Immunol 47:52-6. 2009
    ..045 OD vs. 0.030 OD; p=0.017). Our data support further studies into the potential role of anti-MUC1 immunity in preventing progression of premalignant colon lesions to colon cancer...
  32. pmc Relationship between detection of adenomas by flexible sigmoidoscopy and interval distal colorectal cancer
    Shari S Rogal
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Gastroenterol Hepatol 11:73-8. 2013
    ..We evaluated the relationship between the rate of adenoma detection by flexible sigmoidoscopy and interval distal colorectal cancer...
  33. ncbi request reprint Aberrant crypt foci: what we know and what we need to know
    Akshay K Gupta
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:526-33. 2007
    ..Studies of reproducibility, interobserver variability, and continuity over time to validate ACF as a clinical end point are required. ACF hold promise as a biomarker for colorectal carcinoma, but additional study is needed...
  34. ncbi request reprint Functional imaging of a colon polyp
    Jaideep Behari
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Gastrointest Endosc 61:733. 2005
  35. ncbi request reprint Noninvasive testing for colorectal cancer: a review
    Daniel L Ouyang
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Am J Gastroenterol 100:1393-403. 2005
    ....
  36. ncbi request reprint The case for population-based screening for colorectal cancer
    Robert E Schoen
    Division of Gastroenterology, Pennsylvania University Hospital, Pittsburgh 15213 2582, USA
    Nat Rev Cancer 2:65-70. 2002
    ..Fuelled by new research, market opportunities and increased recognition of individual risk, screening for colorectal cancer is becoming a recommended procedure, but controversy about how best to implement widespread screening remains...
  37. ncbi request reprint Gastric polyposis in familial juvenile polyposis
    Sergio M Crespo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 66:821-2; discussion 822. 2007
  38. pmc PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice
    Wei Qiu
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    J Clin Invest 121:1722-32. 2011
    ..These results indicate that PUMA induction contributes to the pathogenesis of colitis by promoting IEC apoptosis and suggest that PUMA inhibition may be an effective strategy to promote mucosal healing in patients with UC...
  39. doi request reprint Supplementation with oral vs. intravenous iron for anemia with IBD or gastrointestinal bleeding: is oral iron getting a bad rap?
    Sumera Rizvi
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Gastroenterol 106:1872-9. 2011
    ..The use of a low starting dose of oral iron, such as one ferrous sulfate tablet per day, for treatment of iron deficiency is worth considering...
  40. ncbi request reprint Association of physical activity and visceral adipose tissue in older women and men
    Steven E Riechman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obes Res 10:1065-73. 2002
    ..However, few investigations used computed tomography (CAT) scanning for precise measures of abdominal fat...
  41. ncbi request reprint Cancer in inflammatory bowel disease. An evidence-based analysis and guide for physicians and patients
    Rupam Sharan
    Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Gastroenterol Clin North Am 31:237-54. 2002
    ..With respect to CD, the evidence suggests that patients with extensive colonic involvement of long duration carry a similar risk of colorectal cancer to patients with UC and should be considered candidates for surveillance colonoscopy...
  42. ncbi request reprint Pro: should screening colonoscopy be performed on an 88-yr-old healthy patient?
    Robert E Schoen
    Department of Medicine and Epidemiology, University of Pittsburgh Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 101:1713-5; discussion 1717-8. 2006
  43. pmc Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
    Wei Qiu
    University of Pittsburgh Cancer Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 107:20027-32. 2010
    ..These results suggest that effective chemoprevention of colon cancer by NSAIDs lies in the elimination of stem cells that are inappropriately activated by oncogenic events through induction of apoptosis...
  44. ncbi request reprint Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis
    Eduardo Siqueira
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 56:40-7. 2002
    ..Brush cytology and serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9 [CA19-9]) have been used to diagnose cholangiocarcinoma, but there are few data comparing their effectiveness...
  45. doi request reprint Management of persistent gastric bleeding in a patient with Glanzmann's thrombasthenia
    Suzanne Bakdash
    Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hematol 83:411-5. 2008
  46. pmc Association between telephone activity and features of patients with inflammatory bowel disease
    Claudia Ramos-Rivers
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Clin Gastroenterol Hepatol 12:986-94.e1. 2014
    ....
  47. pmc Developing a natural language processing application for measuring the quality of colonoscopy procedures
    Henk Harkema
    Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Med Inform Assoc 18:i150-6. 2011
    ..Routine measurement of quality is limited by the costs of manual review of free-text patient charts. Our goal was to develop a natural language processing (NLP) application to measure colonoscopy quality...
  48. ncbi request reprint Identification of nuclear matrix protein alterations associated with human colon cancer
    Gisela Brunagel
    Department of Urology, Division of Gastroenterology, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Cancer Res 62:2437-42. 2002
    ..In addition, the functional characterization of these proteins and their early detection through the generation of NMP antibodies could significantly impact on the understanding of cancer progression and its diagnosis...
  49. ncbi request reprint Attenuated familial adenomatous polyposis: a case report with mixed features and review of genotype-phenotype correlation
    Diana N Ionescu
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Arch Pathol Lab Med 129:1401-4. 2005
    ..Differences in the APC mutation sites alone cannot completely account for intrafamilial and interfamilial variation in the polyposis phenotypes...
  50. doi request reprint Evaluation of colon cancer-specific antigen 2 as a potential serum marker for colorectal cancer
    Eddy S Leman
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Cancer Res 14:1349-54. 2008
    ..CCSA-2 is a distinct novel colon cancer marker identified using focused proteomics...
  51. ncbi request reprint Hemochromatosis gene mutations and distal adenomatous colorectal polyps
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:158-63. 2005
    ..These results do not support a relationship between HFE heterozygosity and risk of advanced distal adenoma...
  52. ncbi request reprint Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:152-7. 2005
    ..02). In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers...
  53. ncbi request reprint Variability in flexible sigmoidoscopy performance among examiners in a screening trial
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 3:792-7. 2005
    ..In 2 European trials, wide variability across examiners in FSG performance was noted. We report on the performance of examiners in the US randomized trial: the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
  54. ncbi request reprint Predictors of advanced proximal neoplasia in persons with abnormal screening flexible sigmoidoscopy
    Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7346, USA
    Clin Gastroenterol Hepatol 1:103-10. 2003
    ..The relationship between distal and proximal colonic findings is uncertain. Thus, there is no consensus on which findings on screening flexible sigmoidoscopy should trigger colonoscopy...
  55. ncbi request reprint Adenomatous polyp recurrence and physical activity in the Polyp Prevention Trial (United States)
    Lisa H Colbert
    National Institute on Aging, Bethesda, MD, USA
    Cancer Causes Control 13:445-53. 2002
    ..To examine prospectively the association between physical activity and adenomatous polyp recurrence...
  56. ncbi request reprint Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004
    ..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk...
  57. ncbi request reprint The management of small polyps found by virtual colonoscopy: results of a decision analysis
    Chin Hur
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Gastroenterol Hepatol 5:237-44. 2007
    ..Decision-analytic techniques were used to compare the outcomes of 2 management strategies for smaller (6-9 mm) polyps discovered by CTC...
  58. ncbi request reprint Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:546-52. 2004
    ..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer...
  59. doi request reprint Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma
    Ulrike Peters
    Public Health Science, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1144-54. 2008
    ..We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor...
  60. ncbi request reprint Prevalence of isolated advanced proximal neoplasia
    Robert E Schoen
    Arch Intern Med 163:2103; author reply 2103-4. 2003
  61. ncbi request reprint Calcium intake and colorectal adenoma in a US colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Clin Nutr 80:1358-65. 2004
    ..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis...
  62. ncbi request reprint Re: Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study
    Robert E Schoen
    J Natl Cancer Inst 95:830-1; author reply 831. 2003
  63. ncbi request reprint Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:1965-70. 2007
    ..No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma...
  64. ncbi request reprint Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers
    Eddy S Leman
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:5600-5. 2007
    ..ROC curves for CCSA-3 and CCSA-4 reveal an area under the curve of 0.94 (95% CI, 0.90-0.98%). In these initial analyses, CCSA-3 and CCSA-4 show promise as potential serum markers for detection of colorectal cancer and advanced adenomas...
  65. ncbi request reprint Insulin resistance-related genes and advanced left-sided colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:703-8. 2007
    ....
  66. ncbi request reprint Tobacco smoking and colorectal hyperplastic and adenomatous polyps
    Bu Tian Ji
    National Cancer Institute, 6120 Executive Boulevard, EPS 8120, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:897-901. 2006
    ..In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions...
  67. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
    ..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...