Research Topics
Genomes and Genes
| Trenton R SchoebSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Pneumonia in BALB/c Rag2-/- mice used in a CD45RB(high) T-cell transfer model of inflammatory bowel diseaseT R Schoeb
Department of Genetics, University of Alabama, Birmingham, AL 35294, USA
Vet Pathol 45:427-9. 2008..with an unusually aggressive inflammatory response related to the experimental procedure and possibly to the BALB/c genetic background...- Commentary: further comments on Mycoplasma pulmonis and lymphoma in bioassays of ratsT R Schoeb
UAB Department of Genetics, Birmingham, AL 35294, USA
Vet Pathol 48:420-6. 2011..5%) occurred within the first 104 weeks of the studies, showing that occurrence of such lesions was not due to appearance in rats surviving beyond that interval... - Mycoplasma pulmonis and lymphoma in bioassays in ratsT R Schoeb
UAB Department of Genetics, 724 Kaul Human Genetics Building, 720 S 20th Street, Birmingham, AL 35294, USA
Vet Pathol 46:952-9. 2009..pulmonis disease and that lesions of the disease were interpreted as lymphoma... 
Clinical and necropsy findings associated with increased mortality among American alligators of Lake Griffin, FloridaTrenton R Schoeb
Division of Comparative Medicine, Department of Pathobiology, University of Florida College of Veterinary Medicine, Gainesville, Florida 32611, USA
J Wildl Dis 38:320-37. 2002..The cause or causes have not yet been identified...- Diagnostic exercise: papulovesicular dermatitis in rhesus macaques (Macaca mulatta)T R Schoeb
Department of Genetics, Univeresity of Alabama at Birmingham, Birmingham, AL 35294, USA
Vet Pathol 45:592-4. 2008..Simian varicella virus was identified as the cause by polymerase chain reaction analysis and serologic testing... 
p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitisDaniel C Bullard
Department of Microbiology, University of Alabama at Birmingham, 845 19th Street S, Birmingham, AL 35294, USA
Am J Pathol 170:2001-8. 2007..Our results indicate that expression of p150/95 is critical on both T cells as well as other leukocytes for the development of demyelinating disease and may represent a novel therapeutic target for multiple sclerosis...- Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitisTing Feng
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:1321-32. 2010..Collectively, our data demonstrate that induction of colitis requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation... - Homozygous carnitine palmitoyltransferase 1b (muscle isoform) deficiency is lethal in the mouseShaonin Ji
Department of Genetics, University of Alabama at Birmingham, USA
Mol Genet Metab 93:314-22. 2008..38% male CPT-1b+/- mice, and 33% female vs. 8% male CPT-1b+/+ mice). Therefore, lethality of homozygous CPT-1b deficiency in the mice is consistent with paucity of human cases... - Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitisXianzhen Hu
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mol Immunol 47:1692-700. 2010..Furthermore, our findings suggest that these isoforms may also play key roles in controlling the development of inflammatory diseases such as multiple sclerosis, possibly through differential engagement with ICAM-1 ligands such as Mac-1... - Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complementJuling Zhou
Department of Medicine, University of Alabama at Birmingham, USA
J Am Soc Nephrol 23:1161-71. 2012.... - Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in miceCharles O Elson
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Gastroenterology 132:2359-70. 2007..Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17 (Th17) that can mediate chronic inflammation. This study was performed to define the role of IL-23 and Th17 cells in chronic colitis in mice... - Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteriaRajatava Basu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Immunity 37:1061-75. 2012..These findings establish Th22 cells as an important component of mucosal antimicrobial host defense... - Critical role for P-glycoprotein expression in hematopoietic cells in the FVB.Mdr1a(-/-) model of colitisElizabeth M Staley
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35243 2182, USA
J Pediatr Gastroenterol Nutr 53:666-73. 2011.... - Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytesShayne C Barlow
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int Immunol 16:345-51. 2004..These mice may therefore be useful in identifying potential mechanisms of pathogenesis and genetic predisposition in human inflammatory skin diseases... - Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone miceXiaodong He
Department of Genetics, University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
J Immunol 177:8748-56. 2006.... - Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insultsElizabeth M Staley
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35243 2182, USA
Inflamm Bowel Dis 15:684-96. 2009.... - Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitisDaniel C Bullard
Department of Genetics, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA
J Immunol 178:851-7. 2007.... - Renal CD14 expression correlates with the progression of cystic kidney diseaseJuling Zhou
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Kidney Int 78:550-60. 2010..But the association was significant when the analysis was confined to males. Clearly more studies need to be done to evaluate the utility of CD14 as a marker for outcomes in ADPKD... - Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutationDan Wang
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mol Genet Metab 99:62-71. 2010..This new mouse will provide an important tool to investigate therapeutic approaches for MPS I-H that cannot be addressed using current MPS I-H animal models... - Role of epidermal primary cilia in the homeostasis of skin and hair folliclesMandy J Croyle
Department of Cell Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
Development 138:1675-85. 2011..Collectively, these data indicate that epidermal primary cilia may function in stress responses and epidermal homeostasis involving pathways other than those typically associated with primary cilia... - Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitisDaniel C Bullard
Department of Genetics, University of Alabama at Birmingham, 35294, USA
J Immunol 175:6327-33. 2005..Our results indicate that Mac-1 expression is critical on both phagocytic cells and T cells for the development of demyelinating disease... - Murine P-glycoprotein deficiency alters intestinal injury repair and blunts lipopolysaccharide-induced radioprotectionElizabeth M Staley
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
Radiat Res 178:207-16. 2012.... - Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathyAiling Lu
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Pathol 178:2573-86. 2011.... - Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatusJessica L Werner
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 182:4938-46. 2009..fumigatus challenge was Dectin-1 dependent, and that neutralization of IL-17 significantly impaired A. fumigatus clearance. Collectively, these results support a requisite role for Dectin-1 in in vivo defense against A. fumigatus... - A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiotaYingzi Cong
Departments of Medicine and Microbiology, Pediatric Dentistry, and Genetics, University of Alabama at Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 106:19256-61. 2009..We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota... - Transforming growth factor-beta induces development of the T(H)17 lineagePaul R Mangan
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
Nature 441:231-4. 2006..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages... - Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouseLara R Nyman
Department of Genetics, University of Alabama at Birmingham, USA
Mol Genet Metab 86:179-87. 2005..Although the homozygous mutants were not viable, we did find some aspects of haploinsufficiency in the CPT-1a +/- mutants, which will make them an important mouse model for studying the role of CPT-1a in human disease... - Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in miceTrenton R Schoeb
University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
Arthritis Rheum 64:4114-24. 2012..This study was undertaken to determine the functions of eNOS in the initiation and progression of vasculitic lesion formation... - Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuRCrystal Wheeler
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Neuroimmunol 246:34-7. 2012..Ovariectomy prior to EAE induction abrogated the protective effect. Our findings support a role for the astrocyte and posttranscriptional regulation in hormonally-mediated attenuation of EAE... - G2E3 is a dual function ubiquitin ligase required for early embryonic developmentWilliam S Brooks
Department of Cell Biology, University of Alabama, Birmingham, Alabama 35233, USA
J Biol Chem 283:22304-15. 2008..In adult animals, the most intense staining is found in Purkinje cell bodies and cells lining the ductus deferens. In summary, G2E3 is a dual function ubiquitin ligase essential for prevention of apoptosis in early embryogenesis... - Detection by microsatellite analysis of early embryonic mortality in an alligator population in FloridaDavid S Rotstein
College of Veterinary Medicine, Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610, USA
J Wildl Dis 38:160-5. 2002.... - Association of Mycoplasma arthritidis mitogen with lethal toxicity but not with arthritis in miceWenyi Luo
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
Infect Immun 76:4989-98. 2008..The degree of mitogenic activity correlated with lethal toxicity in DBA/2J mice. In contrast, histopathological studies detected no correlation between MAM production and the severity of arthritis induced in DBA/2J and CBA/J mice... - Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasiaKyoko Kojima
Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Res 67:8121-30. 2007..This indicates that Smad4 is dispensable for normal pancreatic development but is critical for at least partial suppression of multiple Kras(G12D)-dependent disease-associated phenotypes... - Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthmaAmy Pastva
Departments of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 172:4520-6. 2004..Potential exists, therefore, for the amelioration of asthma-associated chronic airway inflammation through the use of aerobic exercise training as a non-drug therapeutic modality... - Exacerbation of murine respiratory mycoplasmosis by sialodacryoadenitis virus infection in gnotobiotic F344 ratsT R Schoeb
Department of Comparative Medicine, School of Medicine, University of Alabama, Birmingham, AL
Vet Pathol 24:392-9. 1987.... - Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseasesTrenton R Schoeb
Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0024, USA
Inflamm Bowel Dis 18:1558-65. 2012.... - ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptorZhongyu Liu
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 286:39654-62. 2011.... - Preclinical evaluation of a genetically engineered herpes simplex virus expressing interleukin-12James M Markert
Department of Surgery, Division of Neurosurgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA
J Virol 86:5304-13. 2012..nancymae lymphocytes in vitro. We conclude that the safety and preclinical efficacy of M002 warrants the advancement of a Δγ(1)34.5 virus expressing IL-12 to phase I clinical trials for patients with recurrent malignant glioma... - Gizzard shad thiaminase activity and its effect on the thiamine status of captive American alligators Alligator mississippiensisJ Perran Ross
Department of Wildlife Conservation and Ecology, University of Florida, Post Office Box 110430, Gainesville, Florida 32611, USA
J Aquat Anim Health 21:239-48. 2009..We conclude that the thiaminase activity in gizzard shad is high enough to cause thiamine deficiency in wild alligators when shad are a major part of their diet... - Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted miceRavi J Tolwani
Department of Genetics, University of Alabama, Birmingham, Alabama, USA
PLoS Genet 1:e23. 2005..The MCAD-deficient mouse reproduced important aspects of human MCAD deficiency and is a valuable model for further analysis of the roles of fatty acid oxidation and pathogenesis of human diseases involving fatty acid oxidation... - Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cellsChia Wei Chang
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
Stem Cells 27:1042-9. 2009..These results suggest that a single, polycistronic "hit and run" vector can safely and effectively reprogram adult dermal fibroblasts into iPS cells... - The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and menJonathan M Lehman
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Dev Dyn 237:1960-71. 2008.... - Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouseMichal Mrug
Department of Medicine, University of Alabama at Birmingham, 740 Kaul Human Genetics Building, 720 20th Street South, Birmingham, AL 35294, USA
J Am Soc Nephrol 16:905-16. 2005..Therefore, the positional candidate gene, Kif12, fulfills the major criteria for QTL gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene... - Psoriasiform dermatitis susceptibility in Itgb2(tm1Bay) PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe diseaseShayne C Barlow
Department of Genomics and Pathobiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Pathol 163:197-202. 2003..The susceptibility allele can act in either a heterozygous or homozygous state, dependent on the level of CD18 expression... - Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidantsMartin Leustik
Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35205 3703, USA
Am J Physiol Lung Cell Mol Physiol 295:L733-43. 2008..These findings suggest that Cl(2) inhalation damages both airway and alveolar epithelial tissues and that resulting effects were ameliorated by prophylactic administration of low-molecular-weight antioxidants... - Pathology of experimental mycoplasmosis in American alligatorsD R Brown
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611, USA
J Wildl Dis 37:671-9. 2001..Mycoplasma were not cultured at any time point from those alligators. The findings confirm that M. alligatoris can cause fulminant inflammatory disease and rapid death of alligators... - Detection of Mycoplasma pulmonis in cilia-associated respiratory bacillus isolates and in respiratory tracts of rats by nested PCRT R Schoeb
Department of Pathobiology, University of Florida, Gainesville 32610, USA
J Clin Microbiol 35:1667-70. 1997..pulmonis, and that M. pulmonis is present in all but four CAR bacillus isolates in our collection that were from naturally infected rats; the four isolates that were exceptions were obtained from rats from a single colony... - Respiratory diseases of rodentsT R Schoeb
Division of Comparative Medicine, Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
Vet Clin North Am Exot Anim Pract 3:481-96, vii. 2000..Features of the respiratory diseases of these four commonly encountered species are reviewed, including causes; clinical signs; diagnostic procedures; preventive measures; and, where appropriate, therapies... - Experimental inoculation of broad-nosed caimans (Caiman latirostris) and Siamese crocodiles (Crocodylus siamensis) with Mycoplasma alligatorisG W Pye
Department of Small Animal Clinical Services, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
J Zoo Wildl Med 32:196-201. 2001..Other species of crocodilians may be susceptible to infection with M. alligatoris, and this organism should be considered when the rapid onset of clinical signs of pneumonia, polyarthritis, pericarditis, and death occur... - Detection of antibodies to a pathogenic mycoplasma in American alligators (Alligator mississippiensis), broad-nosed Caimans (Caiman latirostris), and Siamese crocodiles (Crocodylus siamensis)D R Brown
Department of Pathobiology, University of Florida, Gainesville, Florida 32611-0880, USA
J Clin Microbiol 39:285-92. 2001..alligatoris. The ELISA may be used to monitor exposure to the lethal pathogen M. alligatoris among captive, repatriated, and wild crocodilian species... - Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and ratsAnh-Hue T Tu
Department of Genomics and Pathobiology, University of Alabama at Birmingham, 35294-0019, USA
J Infect Dis 186:432-5. 2002..Specifically, the MAV1 lysogen 158L3-1 was more virulent than the nonlysogen strain 158 in DBA/2NCr, C3H/HeNCr, C3H/HeJ, and C3Smn.CB17-Prkdc(scid)/J mice, as well as in LEW rats... - The upper and lower respiratory tracts differ in their requirement of IFN-gamma and IL-4 in controlling respiratory mycoplasma infection and diseaseMatthew D Woolard
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
J Immunol 172:6875-83. 2004..Our studies demonstrate that the upper and lower respiratory tracts are separate and distinct in their cytokine requirements for generating immunity against mycoplasma infection... - Pathology, physiologic parameters, tissue contaminants, and tissue thiamine in morbid and healthy central Florida adult American alligators (Alligator mississippiensis)Dale C Honeyfield
U S Geological Survey, Leetown Science Center, Northern Appalachian Research Laboratory, 176 Straight Run Road, Wellsboro, Pennsylvania 16901, USA
J Wildl Dis 44:280-94. 2008..The consumption of thiaminase-positive gizzard shad (Dorosoma cepedianum) is thought to have been the cause of the low tissue thiamine and resulting mortalities... - An evaluation of biomarkers of reproductive function and potential contaminant effects in Florida largemouth bass ( Micropterus salmoidesfloridanus) sampled from the St. Johns RiverMaria S Sepúlveda
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
Sci Total Environ 289:133-44. 2002..It is clear that additional studies are needed to evaluate the potential impact of these reproductive changes in populations of Florida largemouth bass inhabiting the St. Johns River... - Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune diseaseChristopher G Kevil
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Am J Pathol 165:609-16. 2004..These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE... - RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammationAmy Pastva
Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294-0005, USA
Brain Behav Immun 19:413-22. 2005..Together, these results suggest that GR nuclear translocation and NF-kappaB activation play roles in mediating the anti-inflammatory effects of exercise in allergen-mediated lung pathology... - Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in miceYong Woo Jung
Department of Pathology, University of Alabama at Birmingham, 35294 2170, USA
Am J Pathol 168:1425-34. 2006..Our findings demonstrate the importance of both antigen and endotoxin acting in a synergistic manner in the development of airway inflammation... - Proteinuria of nonautoimmune origin in wild-type FVB/NJ miceShannon M Maier
Arthritis and Immunology Program, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Comp Med 57:255-66. 2007..We propose that mapping of genetic polymorphisms that are responsible for these traits in FVB/NJ mice may lead to increased understanding of mild nephrotic syndromes including MCNS and other proteinurias... - Comparison of methods for detection of pinworms in mice and ratsJ Camille Effler
College of Veterinary Medicine, Auburn University, Auburn, AL, USA
Lab Anim (NY) 37:210-5. 2008..Though the different methods yielded comparable efficacy overall, the authors recommend using more than one type of test to increase detection potential...
Research Grants
- COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAININGTrenton Schoeb; Fiscal Year: 2006..abstract_text> ..