Research Topics
| Mitchell SchnallSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
MRI detection of distinct incidental cancer in women with primary breast cancer studied in IBMC 6883Mitchell D Schnall
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Surg Oncol 92:32-8. 2005..We report on the rate of MRI and mammography detection of foci of distinct incidental cancer in a prospective, multi center trial involving 426 women with confirmed breast cancer at 15 institutions in the US, Canada, and Germany...
Imaging in breast cancer: magnetic resonance imagingConstance D Lehman
Department of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, WA, USA
Breast Cancer Res 7:215-9. 2005..Both the potential benefits and harms need to be evaluated to guide optimal use of this imaging modality in select patient populations...- Primer on imaging technologies for cancerMitchell Schnall
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Clin Oncol 24:3225-33. 2006..In addition, each modality has specific challenges related to reliable quantitation that are important to appreciate... - Diagnostic architectural and dynamic features at breast MR imaging: multicenter studyMitchell D Schnall
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 238:42-53. 2006..To prospectively determine the prevalence and predictive value of three-dimensional (3D) and dynamic breast magnetic resonance (MR) imaging and contrast material kinetic features alone and as part of predictive diagnostic models... - Phase I trial of combretastatin a-4 phosphate with carboplatinJoshua H Bilenker
University of Pennsylvania Cancer Center, University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA
Clin Cancer Res 11:1527-33. 2005..Preclinical evidence of synergy led to a phase I trial employing combretastatin A-4 phosphate (CA4P), a novel tubulin-binding antivascular drug, in combination with carboplatin... - Changes in the surgical management of patients with breast carcinoma based on preoperative magnetic resonance imagingIsabelle Bedrosian
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 98:468-73. 2003..Preoperative breast MRI studies may be particularly useful in surgical planning for and management of patients with lobular carcinoma... - MRI-guided diffuse optical spectroscopy of malignant and benign breast lesionsVasilis Ntziachristos
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
Neoplasia 4:347-54. 2002..It is foreseen that the technique can play a major role in functional activation studies of brain and muscle as well... - Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for dSandip Basu
Division of Nuclear Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cancer 112:995-1000. 2008.... - Breast MR imaging in the diagnostic settingMitchell Schnall
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Magn Reson Imaging Clin N Am 14:329-37, vi. 2006..Optimized MR imaging technique; careful mammography, ultrasound, and MR imaging correlation; and adherence to interpretation guidelines are important to avoid false-negative diagnoses... - De-enhancing the dynamic contrast-enhanced breast MRI for robust registrationYuanjie Zheng
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Med Image Comput Comput Assist Interv 10:933-41. 2007..Also, the effects of tumor shrinking in the conventional registration algorithms can be effectively avoided by our registration algorithm... - Screening women at high risk for breast cancer with mammography and magnetic resonance imagingConstance D Lehman
Department of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, Washington 98109 1023, USA
Cancer 103:1898-905. 2005..The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer... - Dual time point 18F-FDG PET imaging detects breast cancer with high sensitivity and correlates well with histologic subtypesAyse Mavi
Department of Radiology, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
J Nucl Med 47:1440-6. 2006..The changes that are noted in SUVs in dual time point imaging vary depending on the histopathologic type of primary breast cancer... 
Degree of tumor FDG uptake correlates with proliferation index in triple negative breast cancerJulia Tchou
Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
Mol Imaging Biol 12:657-62. 2010..We therefore performed a pilot study to test if FDG uptake correlated with proliferation index in women with triple negative cancer...- Segmentation and classification of breast tumor using dynamic contrast-enhanced MR imagesYuanjie Zheng
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Med Image Comput Comput Assist Interv 10:393-401. 2007..High accuracy of the proposed framework is a direct consequence of this two pronged approach, which is validated through experiments yielding, for instance, an area of 0.97 under the ROC curve... - Initial clinical experience with contrast-enhanced digital breast tomosynthesisSara C Chen
Department of Radiology, Hospital of the University of Pennsylvania, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
Acad Radiol 14:229-38. 2007.... - MR imaging evaluation of cancer extent: is there clinical relevance?Mitchell Schnall
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Magn Reson Imaging Clin N Am 14:379-81, vii. 2006..The evolution of BCT to include more targeted radiation therapy and ablation should place an even larger emphasis on accurate tumor localization and has the potential to allow BCT to become more prevalent and effective... - Pulmonary ventilation and perfusion scanning using hyperpolarized helium-3 MRI and arterial spin tagging in healthy normal subjects and in pulmonary embolism and orthotopic lung transplant patientsDavid A Lipson
Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 47:1073-6. 2002..Blood perfusion information may be obtained during the same examination using the AST technique. The sequential application of these imaging methods provides a novel tool for studying V/Q relationships... - Abdominal imaging at 4 T MR system: a preliminary resultHidemasa Uematsu
Department of Radiology, University of Pennsylvania Medical Center, 3600 Science Center, Suite 370, 3600 Market Street, Philadelphia, PA 19104 2649, USA
Eur J Radiol 47:161-3. 2003..95 times higher than those at 1.5 T. In conclusion, abdominal MR imaging at 4 T was feasible. Furthermore, abdominal MR imaging at 4 T was superior to that at 1.5 T in qualitative and quantitative analyses... - Added cancer yield of MRI in screening the contralateral breast of women recently diagnosed with breast cancer: results from the International Breast Magnetic Resonance Consortium (IBMC) trialConstance D Lehman
Department of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
J Surg Oncol 92:9-15; discussion 15-6. 2005..To estimate the added cancer yield of magnetic resonance imaging (MRI) over mammography in the contralateral breast of patients with a recent diagnosis of breast cancer... - MR imaging-guided 9-gauge vacuum-assisted core-needle breast biopsy: initial experienceSusan G Orel
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 238:54-61. 2006..To perform magnetic resonance (MR) imaging-compatible vacuum-assisted 9-gauge core-needle biopsy of suspicious enhancing breast lesions identified at MR imaging... - High frame-rate simultaneous bilateral breast DCE-MRILawrence Dougherty
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 57:220-5. 2007..In 11 of these cases there was a significant finding in the contralateral breast. DCE images of both breasts can be acquired simultaneously, resulting in high-resolution images as well as rapid sampling of the contrast kinetics... - Dynamic contrast-enhanced magnetic resonance imaging for assessing tumor vascularity and vascular effects of targeted therapies in renal cell carcinomaMark A Rosen
Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Cancer Res 13:770s-776s. 2007..DCE-MRI can be used to monitor the vascular changes induced by such therapies. Future efforts must be directed to standardizing image acquisition and analysis techniques to quantify tumor vascular responses... - Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening studyConstance D Lehman
Department of Radiology, University of Washington Medical Center, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3 200, Seattle, WA 98109 1023, USA
Radiology 244:381-8. 2007..To prospectively determine cancer yield, callback and biopsy rates, and positive predictive value (PPV) of mammography, magnetic resonance (MR) imaging, and ultrasonography (US) in women at high risk for breast cancer... - Relationship of breast magnetic resonance imaging to outcome after breast-conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situLawrence J Solin
Department of Radiation Oncology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Clin Oncol 26:386-91. 2008..To determine the relationship of breast magnetic resonance imaging (MRI) to outcome after breast-conservation treatment (BCT) with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ... - Prostate MR imaging at 3T with a longitudinal array endorectal surface coil and phased array body coilDavid Y Kim
Department of Radiology, Weill Cornell Medical College, New York, New York, USA
J Magn Reson Imaging 27:1327-30. 2008..To demonstrate the feasibility of using a double loop phased array endorectal coil combined with a phased array body coil to image the prostate at 3T... - Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomographyRegine Choe
University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:024020. 2009..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT... - Multimodality screening of high-risk women: a prospective cohort studySusan P Weinstein
University of Pennsylvania Health System, Radiology, 1 Silverstein Bldg, 3400 Spruce St, Philadelphia, PA, USA
J Clin Oncol 27:6124-8. 2009.... - Computer aided automatic detection of malignant lesions in diffuse optical mammographyDavid R Busch
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Phys 37:1840-9. 2010..The methodology is tested in a population of 35 biopsy-confirmed malignant lesions... - Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site studyBritton Chance
University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104 6059, USA
Acad Radiol 12:925-33. 2005.... - Methods for modeling and predicting mechanical deformations of the breast under external perturbationsFred S Azar
Department of Bioengineering, University of Pennsylvania, 120 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
Med Image Anal 6:1-27. 2002..The results show that it is possible to create a deformable model of the breast based on finite elements with non-linear material properties, capable of modeling and predicting breast deformations in a clinically useful amount of time... - Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 TeslaJiongjiong Wang
Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Magn Reson Imaging 22:1-7. 2004..ASL images, either with or without subtraction of the control, provide a robust alternative to blood oxygenation level dependant (BOLD) methods for activation imaging in regions of high static field inhomogeneity... - A modified logistic model to describe gadolinium kinetics in breast tumorsPeter J Moate
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA
Magn Reson Imaging 22:467-73. 2004..The advantages of this heuristic model compared to commonly used compartmental modeling approaches are discussed... - Breast conservation treatment for patients presenting with axillary lymphadenopathy from presumed primary breast cancer: the role of breast magnetic resonance imaging for stagingChanghu Chen
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Breast Cancer 3:219-22. 2002..These 3 cases illustrate the potential for breast conservation treatment for patients presenting with axillary adenopathy from a presumed primary breast cancer but without either mammographic or breast MRI findings... - Breast MR imagingMitchell D Schnall
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Radiol Clin North Am 41:43-50. 2003..Despite all of the progress made over the past years, however, there is still a significant amount of work ahead before a clear understanding of how this technique will affect the health care of women is obtained... - MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary resultsSteven G Lee
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 226:773-8. 2003..To investigate the role of screening magnetic resonance (MR) imaging in the detection of synchronous contralateral breast cancer in patients with newly diagnosed breast cancer... - Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinomaKeith T Flaherty
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 7:496-501. 2008..Sorafenib is a novel RAF and VEGF receptor tyrosine kinase inhibitor. We conducted this study to (a) determine if sorafenib is anti-angiogenic, and (b) to relate anti-angiogenic effect to outcome... - Frequency of malignancy seen in probably benign lesions at contrast-enhanced breast MR imaging: findings from ACRIN 6667Susan P Weinstein
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, 1 Silverstein Building, Philadelphia, PA 19104, USA
Radiology 255:731-7. 2010.... - STEP: spatiotemporal enhancement pattern for MR-based breast tumor diagnosisYuanjie Zheng
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Phys 36:3192-204. 2009..The experimental results for the proposed features exhibit superior performance, when compared to the existing approaches, with the area under the ROC curve approaching 0.97... - Improving parenchyma segmentation by simultaneous estimation of tissue property T1 map and group-wise registration of inversion recovery MR breast imagesYe Xing
Dept of Bioengineering, University of Pennsylvania, PA 19104, USA
Med Image Comput Comput Assist Interv 11:342-50. 2008..By iteratively performing E-step and R-step, we can simultaneously obtain better results for T1 map estimation, T1 map based segmentation, group-wise registration, and finally parenchyma segmentation... - Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flowJames P Stevenson
University of Pennsylvania, 16 Penn Tower, 3400 Spruce St, Philadelphia, PA 19104, USA
J Clin Oncol 21:4428-38. 2003..The present study investigated escalating doses of CA4P administered intravenously to patients with advanced cancer... - Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 TeslaJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
Magn Reson Med 48:242-54. 2002..5T functional data, with reduced fractional perfusion signal change and increased intersubject variability. Possible reasons for these experimental results, including susceptibility effects and physiological noise, are discussed... - Optimal post-contrast timing of breast MR image acquisition for architectural feature analysisLinda White Nunes
MCP Hahnemann University, Hahnemann University Hospital, Department of Radiologic Sciences, Philadelphia, Pennsylvania 19102, USA
J Magn Reson Imaging 16:42-50. 2002..If any time period is less optimal, it is that of our first run, performed between 0-90 seconds after contrast injection... - A direct comparison of signal behavior between 4.0 and 1.5 T: a phantom studyHidemasa Uematsu
Department of Radiology, University of Pennsylvania Medical Center, 3600 Market Street, Suite 370, Philadelphia, PA 19104-2649, USA
Eur J Radiol 45:154-9. 2003..5 T in the range of Gd concentration expected during clinical use. CONCLUSION: Higher magnetic fields benefit CNRs as well as SNRs. These advantages may lead to a high resolution imaging and reduction of scan time... - Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesionsIsabelle Bedrosian
Department of Surgery, University of Pennsylvania, 4 Silverstein, HUP, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Surg Oncol 9:457-61. 2002..These otherwise occult sites of disease can be appropriately biopsied with MRI needle-localization techniques... - FDG PET positive lymph nodes are highly predictive of metastasis in breast cancerRakesh Kumar
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Nucl Med Commun 27:231-6. 2006..The patients with higher grade of tumour, larger size and higher number of axillary lymph nodes may be considered for FDG PET scan for axillary staging... - Outcome after treatment of patients with mammographically occult, magnetic resonance imaging-detected breast cancer presenting with axillary lymphadenopathyChanghu Chen
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Clin Breast Cancer 5:72-7. 2004.... - The ACR imaging network: a retrospective on 5 years of conducting multicenter trials in radiology and plans for the futureBruce J Hillman
Department of Radiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Am Coll Radiol 1:346-50. 2004..The results of ACRIN trials will improve the appropriateness of the use of imaging and benefit both those with cancer and those who are concerned that they might have the disease... - Effect of breast magnetic resonance imaging on the clinical management of women with early-stage breast carcinomaGayle F Tillman
Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Clin Oncol 20:3413-23. 2002..0089). CONCLUSIONS: Breast MRI alters the clinical management for a sizable fraction of women with early-stage breast cancer and appears to offer clinically useful information for determining optimal local treatment... - Outcome of MRI-guided breast biopsyBoo Kyung Han
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
AJR Am J Roentgenol 191:1798-804. 2008..The objective of our study was to investigate the outcome of MRI-guided breast biopsy as a function of the indication for MRI and the MRI features of the lesions... - MRI before reexcision surgery in patients with breast cancerJanie M Lee
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
AJR Am J Roentgenol 182:473-80. 2004..All patients underwent contrast-enhanced MRI before further surgery and subsequently underwent either reexcision lumpectomy or mastectomy with histopathologic correlation... - Estimation of the content of fat and parenchyma in breast tissue using MRI T1 histograms and phantomsRaymond C Boston
School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kenneth Square, PA 19348, USA
Magn Reson Imaging 23:591-9. 2005..Using this method, the composition of the breast tissue in the study population was as follows: fat 69.9+/-22.9% and parenchyma 30.1+/-22.9%... - MRI evaluation of the contralateral breast in women with recently diagnosed breast cancerConstance D Lehman
University of Washington Medical Center, Seattle, WA 98109, USA
N Engl J Med 356:1295-303. 2007.... - Imaging and cancer: research strategy of the American College of Radiology Imaging NetworkDenise R Aberle
Department of Radiology of the University of California, Los Angeles, USA
Radiology 235:741-51. 2005..This article details ACRIN's research strategy according to disease site through the year 2007... - Magnetic resonance imaging of the breast prior to biopsyDavid A Bluemke
Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 292:2735-42. 2004..Breast magnetic resonance imaging (MRI) has been shown to have high sensitivity for cancer detection and is increasingly used following mammography to evaluate suspicious breast lesions... - Clinical utility of endorectal MRI in determining PSA outcome for patients with biopsy Gleason score 7, PSA <or=10, and clinically localized prostate cancerGeorge C Cheng
Joint Center for Radiation Therapy, Harvard Medical School, Cambridge, MA, USA
Int J Radiat Oncol Biol Phys 55:64-70. 2003..The clinical utility of the pretreatment prostrate-specific antigen (PSA) level (<or=10 and >10 ng/mL) and endorectal MRI (erMRI) stage (T3 vs. T2) to stratify PSA outcome after RP in these patients was evaluated... - The Translational Research Working Group developmental pathway for image-based assessment modalitiesGary S Dorfman
Weill Cornell Medical College, New York, New York, USA
Clin Cancer Res 14:5678-84. 2008..The IM pathway also forms a framework to identify opportunities to address current barriers and is expected to adapt and evolve as the field advances... - American College of Radiology Imaging Network: future clinical trialsBruce J Hillman
Radiology 227:631-2. 2003 - Quantifying the impact of seminal vesicle invasion identified using endorectal magnetic resonance imaging on PSA outcome after radiation therapy for patients with clinically localized prostate cancerPaul L Nguyen
Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 59:400-5. 2004..Consideration should be given to combining EBRT with hormonal therapy in these patients... - High-sensitivity blood-based detection of breast cancer by multi photon detection diagnostic proteomicsAndrzej K Drukier
BioTraces Inc, 12455 Sunrise Valley Dr, Herndon, Virginia 20171, USA
J Proteome Res 5:1906-15. 2006..The methods developed for selection, application, and evaluation of very high sensitivity biomarker panels are expected to have general relevance for diagnostic proteomics... - Workshop on imaging science development for cancer prevention and preemptionGary J Kelloff
NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
Cancer Biomark 3:1-33. 2007..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
Research Grants
- Evaluation of Multi Modality Breast ImagingMitchell Schnall; Fiscal Year: 2006..These will then be utilized to develop cost-effective strategies for clinical applications of multi-modality breast imaging. ..
- Research track radiology residencyMitchell Schnall; Fiscal Year: 2007....