Matthias Schmuth

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
  2. pmc Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders
    Matthias Schmuth
    Department of Dermatology, University of California, VAMC Metabolism 111F, 4150 Clement Street, San Francisco, CA 94121, USA
    Adv Dermatol 23:231-56. 2007
  3. ncbi Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
  4. ncbi Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation
    Man Mao-Qiang
    Department of Dermatology, University of California, San Francisco and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:305-12. 2004
  5. ncbi Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation
    Mao Qiang Man
    Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:370-7. 2008
  6. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
  7. doi PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
  8. ncbi Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
  9. ncbi The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
  10. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009

Collaborators

Detail Information

Publications29

  1. doi Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer...
  2. pmc Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders
    Matthias Schmuth
    Department of Dermatology, University of California, VAMC Metabolism 111F, 4150 Clement Street, San Francisco, CA 94121, USA
    Adv Dermatol 23:231-56. 2007
  3. ncbi Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    Ashley J Fowler
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 120:246-55. 2003
    ..LXR activators could provide a new class of therapeutic agents for the treatment of cutaneous inflammatory disorders...
  4. ncbi Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation
    Man Mao-Qiang
    Department of Dermatology, University of California, San Francisco and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:305-12. 2004
    ..These observations suggest that thiazolidindiones and perhaps other PPAR-gamma activators maybe useful in the treatment of cutaneous disorders...
  5. ncbi Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation
    Mao Qiang Man
    Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:370-7. 2008
    ..Together, these results further demonstrate that PPARbeta/delta in the epidermis: (1) is required for permeability barrier homeostasis; (2) regulates keratinocyte proliferation; and (3) modulates cutaneous inflammation...
  6. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  7. doi PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
    ..These studies show that PPARdelta has a role in SC formation and permeability barrier development...
  8. ncbi Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
    ..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma...
  9. ncbi The effect of LXR activators on AP-1 proteins in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 123:41-8. 2004
    ..These results indicate that oxysterols induce specific AP-1 proteins, thereby activating involucrin, one of the genes required for epidermal differentiation...
  10. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    ..Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris...
  11. ncbi The regulation of permeability barrier homeostasis
    Kenneth R Feingold
    Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:1574-6. 2007
    ..Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis...
  12. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
    ..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
  13. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm...
  14. ncbi Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Dermatology Service 190, VA Medical Center, San Francisco, CA 94121, USA
    Curr Allergy Asthma Rep 9:265-72. 2009
    ..This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm...
  15. ncbi Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  16. ncbi Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis
    Laszlo G Komuves
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 118:25-34. 2002
    ..The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation...
  17. ncbi Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ....
  18. ncbi Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress
    Yoshikazu Uchida
    Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Lipid Res 43:1293-302. 2002
    ..Thus, SMase-induced stress initiates a response in keratinocytes that includes upregulation of GlcCer synthesis which may protect against the deleterious effects of excess Cer...
  19. ncbi Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome
    Jean Pierre Hachem
    Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
    J Invest Dermatol 126:1609-21. 2006
    ..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack...
  20. ncbi Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero
    Matthias Schmuth
    Departments of Medicine Dermatology, University of California San Francisco, California 94121, USA
    J Invest Dermatol 119:1298-303. 2002
    ..The transient and incomplete nature of the developmental delay, however, is consistent with regulation of the late stages of epidermal development by multiple factors...
  21. ncbi Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects
    Reinhard Ackerl
    Department of Molecular Cell Biology, Max F Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
    J Cell Sci 120:2435-43. 2007
    ..Our study explains the early lethality of plectin-deficient mice and provides a model to ablate plectin in adult animals which could be used for developing gene or pharmacological therapies...
  22. pmc Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia
    Daniel Spazierer
    Department of Molecular Cell Biology, Max F Perutz Laboratories, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    Mol Cell Biol 26:559-68. 2006
    ....
  23. ncbi Dropping lipids for epidermal defense
    Matthias Schmuth
    Department of Dermatology, University of Innsbruck, Austria
    J Invest Dermatol 121:xi. 2003
  24. ncbi A model system using tape stripping for characterization of Langerhans cell-precursors in vivo
    Sandra Holzmann
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:1165-74. 2004
    ..We conclude that this experimental system may serve as a valuable tool for the further characterization of LC-precursors and the conditions necessary for LC-immigration into the epidermis...
  25. ncbi Differential expression of fatty acid transport proteins in epidermis and skin appendages
    Matthias Schmuth
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 125:1174-81. 2005
    ..Together, these findings indicate that FATP are not only expressed by different cell types within the skin, but also that their localization is dynamically regulated during development...
  26. ncbi Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 39:650-4. 2007
    ..i. = 20-1,136)). We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles...
  27. ncbi Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function
    Sandrine Dubrac
    Department of Dermatology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Immunol 178:4362-72. 2007
    ..In conclusion, PPARalpha activation by endogenous ligands may provide a molecular signal that allows LC to remain in an immature state within the epidermis for extended periods of time despite minor environmental stimuli...
  28. ncbi Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris
    Robert Gruber
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Hum Genet 15:179-84. 2007
    ..In a control population from west-Austria a combined p.R501X and c.2282del4 carrier frequency of 6/110 (5.45%) was observed. We confirm that these FLG variants are common, but our results point to the existence of additional modifiers...
  29. ncbi (P)PARsing epidermal development
    Sandrine Dubrac
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 126:241-2. 2006
    ..5 to birth). In contrast, pharmacologic activation of PPAR-alpha inhibits proliferation and induces differentiation in mouse epidermis regardless of developmental stage. Thus, PPAR-alpha is an important regulator of epidermal homeostasis...