F A Schmitt

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project
    F A Schmitt
    Sanders Brown Center on Aging Alzheimer s Disease Research Center, Department of Neurology, University of Kentucky Medical Center, Lexington 40536, USA
    Gerontologist 41:716-22. 2001
  2. ncbi request reprint "Preclinical" AD revisited: neuropathology of cognitively normal older adults
    F A Schmitt
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, Department of Neurology, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 55:370-6. 2000
  3. pmc Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:1805-13. 2010
  4. ncbi request reprint Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 53:1391-6. 1999
  5. pmc Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
  6. ncbi request reprint Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task
    C D Smith
    Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroimaging 11:165-70. 2001
  7. ncbi request reprint Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging Spectrometry Center Davis Mills Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    J Neuroimaging 15:271-7. 2005
  8. ncbi request reprint Critical decline in fine motor hand movements in human aging
    C D Smith
    Department of Neurology, Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, USA
    Neurology 53:1458-61. 1999
  9. pmc Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Dement Geriatr Cogn Disord 26:187-92. 2008
  10. ncbi request reprint Modelling mini mental state examination changes in Alzheimer's disease
    M S Mendiondo
    Center on Aging, 101 Sanders Brown Building, University of Kentucky, Lexington, KY 40536, USA
    Stat Med 19:1607-16. 2000

Detail Information

Publications23

  1. ncbi request reprint Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project
    F A Schmitt
    Sanders Brown Center on Aging Alzheimer s Disease Research Center, Department of Neurology, University of Kentucky Medical Center, Lexington 40536, USA
    Gerontologist 41:716-22. 2001
    ..Within research settings, encouraging participant recruitment of friends or family members would likely increase tissue acquisition rates...
  2. ncbi request reprint "Preclinical" AD revisited: neuropathology of cognitively normal older adults
    F A Schmitt
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, Department of Neurology, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 55:370-6. 2000
    ..To classify neuropathologic alterations in the brains of nondemented older adults using current sets of criteria for AD...
  3. pmc Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:1805-13. 2010
    ....
  4. ncbi request reprint Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 53:1391-6. 1999
    ..To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness...
  5. pmc Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
    ..Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation...
  6. ncbi request reprint Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task
    C D Smith
    Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroimaging 11:165-70. 2001
    ..No category differences in activation strength in the left temporal lobe were observed. The authors conclude that visual semantic operations may involve visual association cortex in the right temporal lobe in women...
  7. ncbi request reprint Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging Spectrometry Center Davis Mills Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    J Neuroimaging 15:271-7. 2005
    ..The authors sought to determine whether known alterations of brain function in normal individuals who are at high risk for Alzheimer's disease (AD) worsen or stay the same after a significant interval of time...
  8. ncbi request reprint Critical decline in fine motor hand movements in human aging
    C D Smith
    Department of Neurology, Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, USA
    Neurology 53:1458-61. 1999
    ..Slowing of motor movements in human aging is a well-known occurrence, but its biologic basis is poorly understood. Reliable quantitation may refine observations of this phenomenon to better aid research on this entity...
  9. pmc Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Dement Geriatr Cogn Disord 26:187-92. 2008
    ..Comparative analysis of subjects with mild cognitive impairment (MCI) diagnosed in a primary research setting and those seen in a tertiary care memory disorders clinic...
  10. ncbi request reprint Modelling mini mental state examination changes in Alzheimer's disease
    M S Mendiondo
    Center on Aging, 101 Sanders Brown Building, University of Kentucky, Lexington, KY 40536, USA
    Stat Med 19:1607-16. 2000
    ..Such estimations of disease course are useful when comparing different populations for both clinical and research purposes...
  11. ncbi request reprint Modeling the time-course of Alzheimer dementia
    J W Ashford
    Department of Psychiatry, Sanders Brown Center on Aging, University of Kentucky, 101 Sanders Brown Building, Lexington, KY 40536 0230, USA
    Curr Psychiatry Rep 3:20-8. 2001
    ..Rate of progression and confidence intervals require at least two successive measurements. Rate of progression measures can be used to support diagnosis and to investigate disease-course-modifying therapies...
  12. ncbi request reprint Brain structural alterations before mild cognitive impairment
    C D Smith
    MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536
    Neurology 68:1268-73. 2007
    ..To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease (AD)...
  13. ncbi request reprint Risk factors for transitions from normal to mild cognitive impairment and dementia
    R J Kryscio
    Sanders Brown Center on Aging, University of Kentucky, KY, USA
    Neurology 66:828-32. 2006
    ..To identify risk factors associated with transitions from cognitively normal to various forms of mild cognitive impairment (MCI) and then from MCI into early dementia with death as a competing state...
  14. ncbi request reprint Promoting interactions with basic scientists and clinicians: summary of the panel session
    F A Schmitt
    Department of Neurology and Center on Aging, Room 101, Sanders Brown Building, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Stat Med 19:1463-8. 2000
    ....
  15. ncbi request reprint Evidence of increased oxidative damage in subjects with mild cognitive impairment
    J N Keller
    Department of Anatomy, University of Kentucky, Lexington 40536 0230, USA
    Neurology 64:1152-6. 2005
    ..To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD)...
  16. ncbi request reprint Short-term neuropsychological outcome following Gamma Knife radiosurgery for arteriovenous malformations: a preliminary report
    L X Blonder
    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, USA
    Appl Neuropsychol 6:181-6. 1999
    ..After treatment, 2 AVMs disappeared, 4 decreased slightly in size, and 4 remained unchanged. We conclude that Gamma Knife radiotherapy in this sample of patients was neither detrimental nor beneficial to neuropsychological functioning...
  17. ncbi request reprint Women at risk for AD show increased parietal activation during a fluency task
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 58:1197-202. 2002
    ..A recent study has shown increased parietal activation in high-risk subjects during a paired associates recall task, which the authors postulated might overlap activation typically observed in verbal fluency...
  18. ncbi request reprint Acceleration of HIV dementia with methamphetamine and cocaine
    A Nath
    Department of Neurology, University of Kentucky, Lexington 40526-0284, USA
    J Neurovirol 7:66-71. 2001
    ..Careful attention and analysis to histories of remote non-injecting drug abuse may help substantiate our hypothesis...
  19. ncbi request reprint Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    S W Scheff
    Sanders Brown Center on Aging and Alzheimer Disease Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    Neurology 68:1501-8. 2007
    ....
  20. ncbi request reprint Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex
    F A Schmitt
    Department of Neurology, University of Kentucky Medical Center, Lexington 40536 0084
    N Engl J Med 319:1573-8. 1988
    ..The results of this study suggest HIV-associated cognitive abnormalities may be partially ameliorated after the administration of zidovudine...
  21. ncbi request reprint Sleep-disordered breathing in healthy aged persons: two- and three-year follow-up
    B A Phillips
    Department of Medicine, University of Kentucky, Lexington 40536-0084
    Sleep 17:411-5. 1994
    ..We conclude that moderate levels of sleep-disordered breathing in an otherwise asymptomatic healthy geriatric patient should probably not be considered pathologic in the short term...
  22. ncbi request reprint Self report on sleep symptoms in older adults: correlates of daytime sleepiness and health
    F A Schmitt
    University of Kentucky, College of Medicine, Sanders-Brown Center on Aging, Lexington, Kentucky 40536-0084, USA
    Sleep 19:59-64. 1996
    ..Even as a subjective self-report measure, snoring readily predicts self-reported problems with daytime sleepiness...
  23. ncbi request reprint Sleep-disordered breathing in healthy aged persons: one-year follow-up of daytime sequelae
    D T Berry
    Department of Psychology, Sanders-Brown Center on Aging, University of Kentucky, Lexington 40506-0044
    Sleep 12:211-5. 1989
    ..When combined with other recent data, these results raise the possibility that SDB exerts an insidious pathological influence on the health and daytime functioning of otherwise healthy older persons...