Madelyn R Schmidt

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes
    M R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    J Immunol 165:4112-9. 2000
  2. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
  3. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
  4. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
  5. pmc Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains
    Madelyn R Schmidt
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:11654-62. 2012
  6. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
  7. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
  8. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
  9. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
  10. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011

Collaborators

  • Leonard D Shultz
  • Rita Bottino
  • Ranjan Sen
  • Michael C Appel
  • Kevan C Herold
  • Robert T Woodland
  • Lori W McGinnes
  • Lisa J Giassi
  • Marie King
  • Dale L Greiner
  • Todd Pearson
  • Aldo A Rossini
  • Bruce A Woda
  • Craig B Thompson
  • Mark S Cabatingan
  • Trudy G Morrison
  • Gale Smith
  • Kathryn A Gravel
  • Michael J Massare
  • Evelyn A Kurt-Jones
  • Robert W Finberg
  • Casey J Fox
  • Massimo Trucco
  • Joseph Laning
  • Morey Kraus
  • Peter S Hammerman
  • Joseph T Opferman
  • Michael J Thompson
  • Mark A Atkinson
  • Stanley J Korsmeyer
  • Kristin Biber
  • Clive Wasserfall
  • David M Hilbert
  • Jean Leif

Detail Information

Publications10

  1. ncbi request reprint Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes
    M R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    J Immunol 165:4112-9. 2000
    ....
  2. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
    ..The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS...
  3. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
    ..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice...
  4. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
    ..Because BlyS is required for the normal homeostasis of all B cells, these data suggest a therapeutic strategy simultaneously inhibiting mTOR and Pim 2 could target pathogenic B cells...
  5. pmc Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains
    Madelyn R Schmidt
    Department of Microbiology and Physiological Systems Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:11654-62. 2012
    ..These results demonstrate that VLPs are effective in stimulating long-lived RSV-specific, T-cell-dependent neutralizing antibody-secreting cells and RSV-specific memory responses...
  6. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
    ..We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling...
  7. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
    ..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool...
  8. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
    ..In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory...
  9. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
    ..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...
  10. pmc Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins
    Lori W McGinnes
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Room S5 250, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:366-77. 2011
    ..These results suggest that these VLPs are effective RSV vaccines in mice, in contrast to other nonreplicating RSV vaccine candidates...