Genomes and Genes
KRISTINA HILDEGARD SCHMIDT
Affiliation: University of South Florida
- Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome proteinKristina H Schmidt
Department of Biology, University of South Florida, 4202 E Fowler Avenue, SCA110, Tampa, FL 33620, USA
Mol Cell Biol 26:5406-20. 2006..The translocation structures observed suggest involvement of a dicentric intermediate and break-induced replication with multiple cycles of DNA template switching...
- Suppression of spontaneous genome rearrangements in yeast DNA helicase mutantsKristina H Schmidt
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 103:18196-201. 2006..These findings demonstrate that different nonreplicative helicases function at the interface between replication and repair to maintain genome integrity...
- Defects in DNA lesion bypass lead to spontaneous chromosomal rearrangements and increased cell deathKristina H Schmidt
Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA
Eukaryot Cell 9:315-24. 2010....
- Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicaseKristina H Schmidt
Ludwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, California 92093, USA
Mol Cell Biol 24:3213-26. 2004..These observations identify Rrm3 as a new member of a network of pathways, involving Sgs1 and Srs2 helicases and Mus81 endonuclease, suggested to act during repair of stalled replication forks...
- Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tagMarcus B Smolka
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA
Mol Cell Proteomics 4:1358-69. 2005....
- Saccharomyces cerevisiae RRM3, a 5' to 3' DNA helicase, physically interacts with proliferating cell nuclear antigenKristina H Schmidt
Ludwig Institute for Cancer Research, Cancer Center, and Department of Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0660, USA
J Biol Chem 277:45331-7. 2002..The results presented here suggest that the RRM3 helicase functions at the replication fork...
- Formation of complex and unstable chromosomal translocations in yeastKristina H Schmidt
Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, United States of America
PLoS ONE 5:e12007. 2010..These findings provide insight into eukaryotic genome instability, especially the formation of translocations and the sources of intraclonal heterogeneity, both of which are often associated with human cancers...
- Analysis of gross-chromosomal rearrangements in Saccharomyces cerevisiaeKristina H Schmidt
Ludwig Institute for Cancer Research, University of North Texas, Health Science Center, Fort Worth, USA
Methods Enzymol 409:462-76. 2006..This GCR analysis provides an effective tool for the assessment of the contribution by multiple cellular mechanisms to the maintenance of genome integrity...
- The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligaseSangeetha Vijayakumar
Radiation Oncology Research Laboratory, Department of Radiation Oncology and The Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201 1509, USA
Nucleic Acids Res 35:1624-37. 2007....