Heath D Schmidt

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
  2. pmc Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14160-9. 2013
  3. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
  4. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
  6. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
  7. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
  8. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
  9. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
  10. doi request reprint Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1187:35-75. 2010

Collaborators

Detail Information

Publications16

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
    ..Taken together, these results suggest that cocaine priming-induced reinstatement of drug seeking is mediated in part by a serial polysynaptic limbic subcircuit encompassing the mPFC, PPTg/LDT and VTA...
  2. pmc Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14160-9. 2013
    ..Moreover, the endocytosis of shell GluA2-containing AMPARs during cocaine seeking may depend on interactions with PKCγ and PICK1. ..
  3. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
    ..Identifying epigenetic signatures that define psychostimulant addiction may lead to novel, efficacious treatments for drug craving and relapse...
  4. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
    ..Together, these studies highlight the need to develop a biomarker panel for depression that aims to profile diverse peripheral factors that together provide a biological signature of MDD subtypes as well as treatment response...
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
    ....
  6. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
    ....
  7. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
    ....
  8. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
    ..It is possible; therefore, that increased phosphorylation of CaMKII and GluA1 following acute cocaine is a compensatory mechanism in the DL striatum...
  9. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
    ....
  10. doi request reprint Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1187:35-75. 2010
    ..Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction...
  11. doi request reprint Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 20:285-96. 2015
    ..Furthermore, stimulation of mGluR1 and mGluR5 in the accumbens core may regulate cocaine seeking, in part, through activation of PKCγ. ..
  12. pmc A negative regulator of MAP kinase causes depressive behavior
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 16:1328-32. 2010
    ..These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions...
  13. pmc Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models
    Heath D Schmidt
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA
    Neuropsychopharmacology 35:2378-91. 2010
    ..Taken together, these results indicate that peripheral/serum BDNF may not only represent a biomarker of MDD, but also have functional consequences on molecular signaling substrates, neurogenesis, and behavior...
  14. pmc Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats
    Blake A Kimmey
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:539-51. 2014
    ..Collectively, these results indicate that increased extracellular acetylcholine levels are sufficient to attenuate nicotine taking and seeking in rats and that these effects are not due to adverse malaise symptoms such as nausea. ..
  15. doi request reprint Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats
    Leonardo A Guercio
    Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 S 31st Street, Philadelphia, PA 19104, USA
    Behav Brain Res 281:125-30. 2015
    ..Together, these results indicate that DBS of the accumbens shell disrupts cue-induced reinstatement associated with both a drug and a natural reinforcer. ..
  16. doi request reprint Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats
    Alycia M Lee
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 125 South 31st Street, TRL Building, Rm 2214, Philadelphia, PA 19104, United States
    Behav Brain Res 274:168-75. 2014
    ..Taken together, these findings suggest that ABT-089 and ABT-107 do not affect nicotine consumption, but may reduce the likelihood that a smoking lapse will lead to relapse. ..