Heath D Schmidt

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
  2. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
  3. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
  4. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
  6. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
  7. pmc Deep Brain Stimulation of the Nucleus Accumbens Shell Attenuates Cocaine Reinstatement through Local and Antidromic Activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 33:14446-54. 2013
  8. pmc A negative regulator of MAP kinase causes depressive behavior
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 16:1328-32. 2010
  9. pmc Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models
    Heath D Schmidt
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA
    Neuropsychopharmacology 35:2378-91. 2010
  10. pmc Stimulation of mGluR5 in the Accumbens Shell Promotes Cocaine Seeking by Activating PKC Gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 33:14160-9. 2013

Collaborators

Detail Information

Publications12

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
    ..Taken together, these results suggest that cocaine priming-induced reinstatement of drug seeking is mediated in part by a serial polysynaptic limbic subcircuit encompassing the mPFC, PPTg/LDT and VTA...
  2. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
    ..Identifying epigenetic signatures that define psychostimulant addiction may lead to novel, efficacious treatments for drug craving and relapse...
  3. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
    ..Together, these studies highlight the need to develop a biomarker panel for depression that aims to profile diverse peripheral factors that together provide a biological signature of MDD subtypes as well as treatment response...
  4. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
    ....
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
    ....
  6. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
    ..It is possible; therefore, that increased phosphorylation of CaMKII and GluA1 following acute cocaine is a compensatory mechanism in the DL striatum...
  7. pmc Deep Brain Stimulation of the Nucleus Accumbens Shell Attenuates Cocaine Reinstatement through Local and Antidromic Activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 33:14446-54. 2013
    ....
  8. pmc A negative regulator of MAP kinase causes depressive behavior
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 16:1328-32. 2010
    ..These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions...
  9. pmc Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models
    Heath D Schmidt
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA
    Neuropsychopharmacology 35:2378-91. 2010
    ..Taken together, these results indicate that peripheral/serum BDNF may not only represent a biomarker of MDD, but also have functional consequences on molecular signaling substrates, neurogenesis, and behavior...
  10. pmc Stimulation of mGluR5 in the Accumbens Shell Promotes Cocaine Seeking by Activating PKC Gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 33:14160-9. 2013
    ..Moreover, the endocytosis of shell GluA2-containing AMPARs during cocaine seeking may depend on interactions with PKCγ and PICK1. ..
  11. doi request reprint Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1187:35-75. 2010
    ..Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction...
  12. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
    ....