Heath D Schmidt

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
  2. pmc Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14160-9. 2013
  3. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
  4. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
  6. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
  7. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
  8. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
  9. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
  10. doi request reprint Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1187:35-75. 2010

Collaborators

Detail Information

Publications12

  1. pmc The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Neurosci 30:1358-69. 2009
    ..Taken together, these results suggest that cocaine priming-induced reinstatement of drug seeking is mediated in part by a serial polysynaptic limbic subcircuit encompassing the mPFC, PPTg/LDT and VTA...
  2. pmc Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14160-9. 2013
    ..Moreover, the endocytosis of shell GluA2-containing AMPARs during cocaine seeking may depend on interactions with PKCγ and PICK1. ..
  3. pmc Epigenetics and psychostimulant addiction
    Heath D Schmidt
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cold Spring Harb Perspect Med 3:a012047. 2013
    ..Identifying epigenetic signatures that define psychostimulant addiction may lead to novel, efficacious treatments for drug craving and relapse...
  4. pmc Functional biomarkers of depression: diagnosis, treatment, and pathophysiology
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 36:2375-94. 2011
    ..Together, these studies highlight the need to develop a biomarker panel for depression that aims to profile diverse peripheral factors that together provide a biological signature of MDD subtypes as well as treatment response...
  5. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
    ....
  6. pmc Epigenetic inheritance of a cocaine-resistance phenotype
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Neurosci 16:42-7. 2013
    ....
  7. pmc Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation
    Fair M Vassoler
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:14446-54. 2013
    ....
  8. pmc Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats
    Samantha L White
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 1102a, Philadelphia, PA 19104, USA
    Neurosci Lett 537:71-6. 2013
    ..It is possible; therefore, that increased phosphorylation of CaMKII and GluA1 following acute cocaine is a compensatory mechanism in the DL striatum...
  9. pmc Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake
    Elizabeth G Mietlicki-Baase
    Translational Neuroscience Program, Department of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:1685-97. 2013
    ....
  10. doi request reprint Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
    Heath D Schmidt
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1187:35-75. 2010
    ..Therefore, we also outline the progress and prospects of glutamate modulators for the treatment of cocaine addiction...
  11. pmc A negative regulator of MAP kinase causes depressive behavior
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 16:1328-32. 2010
    ..These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions...
  12. pmc Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models
    Heath D Schmidt
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA
    Neuropsychopharmacology 35:2378-91. 2010
    ..Taken together, these results indicate that peripheral/serum BDNF may not only represent a biomarker of MDD, but also have functional consequences on molecular signaling substrates, neurogenesis, and behavior...