Research Topics
Genomes and Genes | Geert W Schmid-SchönbeinSummaryAffiliation: University of California Country: USA Publications
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Publications
Biomechanics of microcirculatory blood perfusionG W Schmid-Schonbein
Department of Bioengineering and Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
Annu Rev Biomed Eng 1:73-102. 1999..The application of biomechanical analysis of the microcirculation is starting to focus on diseases. The field is rich with problems of high significance...- A new hypothesis for microvascular inflammation in shock and multiorgan failure: self-digestion by pancreatic enzymesGeert W Schmid-Schönbein
Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
Microcirculation 12:71-82. 2005.... - Analysis of inflammationGeert W Schmid-Schönbein
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093 0412, USA
Annu Rev Biomed Eng 8:93-131. 2006..The inflammatory cascade offers a large number of opportunities for development of quantitative models that describe various aspects of human diseases... - The primary valves in the initial lymphatics during inflammationPatrick M Lynch
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
Lymphat Res Biol 5:3-10. 2007..Thus, the opening dimension of the primary valves and their ability to prevent reflux into the interstitium during inflammation were investigated... 
2008 Landis Award lecture. Inflammation and the autodigestion hypothesisGeert W Schmid-Schönbein
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
Microcirculation 16:289-306. 2009..The evidence suggests that uncontrolled proteolytic and lipolytic enzyme activity may trigger the mechanism for tissue injury. The significance of such mechanisms remain to be explored in human diseases...- The second valve system in lymphaticsGeert W Schmid-Schönbein
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
Lymphat Res Biol 1:25-9; discussion 29-31. 2003..The primary valves, in conjunction with the secondary valves, provide a mechanism that facilitates the unidirectional flow during periodic compression and expansion of initial lymphatics... - New advances in the understanding of the pathophysiology of chronic venous insufficiencyG W Schmid-Schonbein
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla 92093 0412, USA
Angiology 52:S27-34. 2001.... - Mechanisms for cell activation and its consequences for biorheology and microcirculation: Multi-organ failure in shockG W Schmid-Schonbein
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA, USA
Biorheology 38:185-201. 2001..Our current evidence suggests that pancreatic digestive enzymes and tissue enzymes may play a central role in humoral activator production... - Microvascular endothelial cell death and rarefaction in the glucocorticoid-induced hypertensive ratC J Vogt
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093 0412, USA
Microcirculation 8:129-39. 2001..Microvascular rarefaction, which has been shown in human and animal hypertension, may result from increased endothelial cell apoptosis... - Pancreatic enzymes and microvascular cell activation in multiorgan failureG W Schmid-Schonbein
Department of Bioengineering, University of California, San Diego, La Jolla 92093 0412, USA
Microcirculation 8:5-14. 2001..The evidence suggests that pancreatic enzymes in the ischemic intestine may attack several tissue components and generate cellular activators that are associated with multiorgan dysfunction in physiological shock... - Biomechanical aspects of the auto-digestion theoryGeert W Schmid-Schönbein
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, CA, 92093 0412, USA
Mol Cell Biomech 5:83-95. 2008..The hypothesis that multi-organ failure in shock may be due an auto-digestion process by pancreatic enzymes is ready to be tested in a variety of shock conditions... - Pancreatic protease inhibition during shock attenuates cell activation and peripheral inflammationFlorian Fitzal
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, Microcirculation Laboratory, University of California, La Jolla, Calif, USA
J Vasc Res 39:320-9. 2002..These results indicate that intestinal pancreatic protease inhibition significantly attenuates intestinal ischemia-induced shock by reducing SIRS and gut injury... - Regulation of CD18 expression on neutrophils in response to fluid shear stressShunichi Fukuda
Department of Bioengineering and The Whitaker Institute for Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093 0412, USA
Proc Natl Acad Sci U S A 100:13152-7. 2003..The evidence suggests that physiological levels of fluid shear cause release of cysteine protease(s) including cathepsin B, leading to cleavage of the extracellular domain of CD18 molecules and possible membrane detachment... - Receptor cleavage and P-selectin-dependent reduction of leukocyte adhesion in the spontaneously hypertensive ratAngela Y Chen
Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093 0412, USA
J Leukoc Biol 92:183-94. 2012..The impaired ability of SHR leukocytes to reduce rolling velocity upon inflammatory stimulation led to fewer firmly adhered leukocytes to the endothelium as a contributor to immune suppression... - Improvement in early symptoms of shock by delayed intestinal protease inhibitionFlorian Fitzal
Microcirculation Laboratory, Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, USA
Arch Surg 139:1008-16. 2004..Herein we examine the effectiveness of delayed intestinal protease inhibition during reperfusion after SMAO... - Early capillary no-reflow during low-flow reperfusion after hind limb ischemia in the ratFlorian Fitzal
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, CA, USA
Ann Plast Surg 49:170-80. 2002..Instead, endothelial cell and/or tissue swelling in combination with luminal obstruction and leukocyte plugging may be responsible for the early capillary no-reflow phenomenon... - Pseudopod projection and cell spreading of passive leukocytes in response to fluid shear stressMark F Coughlin
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
Biophys J 87:2035-42. 2004..This behavior may contribute to cell spreading on endothelium and other cells as well as to transendothelial migration of leukocytes in the microcirculation... - An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertensionEdward D Tran
Department of Bioengineering, the Whitaker Institute for Biomedical Engineering Ulniversity of California San Diego, La Jolla 92093 0412, USA
Microcirculation 14:793-804. 2007..The objective of this study was to examine the early phase of endothelial apoptosis and capillary blood flow in the spontaneously hypertensive rat (SHR) and the normotensive Wistar-Kyoto (WKY) rat... - Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wallMarisol Chang
Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
Shock 37:297-305. 2012..This study demonstrates that disruption of the mucosal epithelial barrier within minutes of intestinal ischemia allows entry of fully activated pancreatic digestive proteases across the intestinal barrier triggering autodigestion... - A journey with Tony Hugli up the inflammatory cascade towards the auto-digestion hypothesisGeert W Schmid-Schönbein
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, 9500 Gilman Drive 0412 La Jolla, CA 92093 0412, USA
Int Immunopharmacol 7:1845-51. 2007..The auto-digestion hypothesis is in line with the century old observation that the intestine plays a special role on shock - indeed it is the organ for digestion. Auto-digestion may be the prize to pay for life-long nutrition... - Acute venous occlusion enhances matrix metalloprotease activity: Implications on endothelial dysfunctionTom Alsaigh
Department of Bioengineering, The Institute for Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
Microvasc Res 81:108-16. 2011..We conclude that venous pressure elevation increases enzymatic activity which may contribute to inflammation and endothelial dysfunction associated with this disease by influencing critical surface receptors... - Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venulesTakanori Yasu
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Int J Cardiol 98:245-52. 2005..To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature... - Pancreatic enzymes generate cytotoxic mediators in the intestineAlexander H Penn
Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Shock 27:296-304. 2007..Cytotoxicity was significantly increased after digestion of food by luminal fluid compared with luminal fluid or undigested food. These results indicate the presence of a previously unknown mechanism for hemorrhagic necrosis in shock... - Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shockErik B Kistler
Department of Anesthesiology and Critical Care, University of California, San Diego, CA 92093, USA
Shock 38:262-7. 2012..Digestive enzymes and their products, if allowed to penetrate the gut wall, may trigger multiorgan failure and death... - Enhanced matrix metalloproteinase activity in the spontaneously hypertensive rat: VEGFR-2 cleavage, endothelial apoptosis, and capillary rarefactionEdward D Tran
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, Calif 92093 0412, USA
J Vasc Res 47:423-31. 2010..These results suggest elevated plasma MMP activities may cleave VEGFR-2, resulting in endothelial apoptosis and capillary rarefaction in the SHR... - Recoil and stiffening by adherent leukocytes in response to fluid shearMark F Coughlin
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California at San Diego, La Jolla, California, USA
Biophys J 94:1046-51. 2008..This initial shear stress response may be particularly important in facilitating leukocyte attachment under sustained fluid shear stress by the flowing blood in the microcirculation... - Intraluminal pancreatic serine protease activity, mucosal permeability, and shock: a reviewJose A Acosta
University of California San Diego School of Medicine, San Diego, CA, USA
Shock 26:3-9. 2006..We further hypothesize how these enzymes and/or their products may ultimately contribute to multiorgan failure and death... - Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophilsHainsworth Y Shin
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093 0412 USA
J Cell Physiol 214:528-36. 2008.... - De-activation of neutrophils in suspension by fluid shear stress: a requirement for erythrocytesYutaka Komai
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Ann Biomed Eng 33:1375-86. 2005..These results suggest that erythrocytes play an important role in neutrophil de-activation by reducing the superoxide level in plasma. Shear stress, rather than shear rate, is the key determinant that regulates neutrophil de-activation... - Characterization of two classes of pancreatic shock factors: functional differences exhibited by hydrophilic and hydrophobic shock factorsWilliam J Kramp
La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
Shock 20:356-62. 2003.... 
Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swineHubert D Kim
Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
J Trauma 68:1078-83. 2010..The objective of this study was to determine whether enteroclysis with NM would improve the clinical outcomes in swine after hemorrhagic shock and intestinal hypoperfusion...- The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteinsAlexander H Penn
Dept of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 294:H1779-92. 2008..Breakdown of free fatty acid binding proteins by proteases causes release of free fatty acids to act as powerful cytotoxic mediators... - Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndromeRyan S Friese
Department of Bioengineering, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0838, USA
Circ Cardiovasc Genet 5:430-40. 2012.... - Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in ratsAngelina E Altshuler
Department of Bioengineering, The Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California, United States of America
PLoS ONE 7:e32672. 2012..Proteases, including pancreatic proteases, may be shock mediators and potential targets for therapy in shock... - Enhancement of glucocorticoid and mineralocorticoid receptor density in the microcirculation of the spontaneously hypertensive ratFrank A DeLano
Microcirculation Laboratory, Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, 9500 Gilman Dr, University of California San Diego, La Jolla, CA 92093, USA
Microcirculation 11:69-78. 2004..As background, this study was designed to examine the distribution of the glucocorticoid and mineralocorticoid receptors in a microvascular network... - Matrix metalloproteinase activity causes VEGFR-2 cleavage and microvascular rarefaction in rat mesenteryEdward D Tran
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093 0412, USA
Microcirculation 18:228-37. 2011..These results spatially link MMP-induced VEGFR-2 cleavage and rarefaction in the mesentery of the SHR and thus support the hypothesis that MMPs serve as regulators of microvascular dysfunction in hypertension... - Therapeutic management of chronic venous insufficiency: microcirculation as a targetJ J Bergan
University of California San Diego, La Jolla 92037, USA
Microcirculation 7:S23-8. 2000..Currently, surgical attack is focused on correction of the sources of venous hypertension, but it is felt that this provides a crude method that hopefully wil be replaced by more precise pharmacological interventions... - Receptor cleavage reduces the fluid shear response in neutrophils of the spontaneously hypertensive ratAngela Y Chen
Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 0412, USA
Am J Physiol Cell Physiol 299:C1441-9. 2010..These results suggest that proteolytic cleavage of the FPR may interfere with normal fluid shear-induced pseudopod retractions in SHR neutrophils... - Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the ratHenrique S Rosario
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
Am J Pathol 164:1707-16. 2004..This process represents a powerful in vivo pathophysiological mechanism for trypsin-induced MMP-9 activation and is likely to play a central role in the development of acute intestinal inflammation and shock... - Fluid stresses on the membrane of migrating leukocytesSusan S Su
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
Ann Biomed Eng 36:298-307. 2008.... - Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cellsRafi Mazor
Department of Bioengineering, The Institute of Engineering in Medicine, Veterans Affairs Medical Center, San Diego, California, USA
J Biol Chem 288:598-607. 2013..These results suggest a mechanism by which MMP-1 may prime or sensitize endothelial cell functions... - An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavageGeert W Schmid-Schönbein
Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
Curr Hypertens Rep 14:88-96. 2012..This work may open the opportunity for reassessment of old interventions and development of new interventions to manage hypertension and its comorbidities... - Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertensionJohn J Bergan
Department of Surgery, University of California San Diego, 9850 Genesee, La Jolla, CA 92037, USA
J Vasc Surg 47:183-92. 2008..Reflux of blood through incompetent venous valves is a major cause of the venous hypertension that underlies clinical manifestations of chronic venous disease, including varicose veins, lipodermatosclerosis, and venous ulcers... - Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal diseaseRyan S Friese
Department of Medicine, University of California, San Diego, CA, USA
Clin Exp Hypertens 31:521-33. 2009..Our results suggest discrete patterns of MMP overexpression in hypertension, with MMP-9 elevated early, and MMP-2 and MMP-10 linked to target organ damage... - Nuclear factor kappa B and matrix metalloproteinase induced receptor cleavage in the spontaneously hypertensive ratKwan I Sharon Wu
Department of Bioengineering, Institute for Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
Hypertension 57:261-8. 2011..These results suggest NFκB is an important transcription factor in the SHR and may be involved in the enhanced MMP activity and, consequently, receptor cleavage... - Systematic polymorphism discovery after genome-wide identification of potential susceptibility loci in a hereditary rodent model of human hypertensionRyan S Friese
Department of Bioengineering, University of California at San Diego, USA
Blood Press 20:222-31. 2011..Our method for candidate gene identification is portable and can be applied to microarray data from any tissue, in any disease model with a QTL database... - Whole blood assay for elastase, chymotrypsin, matrix metalloproteinase-2, and matrix metalloproteinase-9 activityRoy B Lefkowitz
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0448, USA
Anal Chem 82:8251-8. 2010..Thus, these new substrates demonstrate broad applicability toward clinically relevant detection of important disease-relevant proteases... - Proteinase activity and receptor cleavage: mechanism for insulin resistance in the spontaneously hypertensive ratFrank A DeLano
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla CA 92093 0412, USA
Hypertension 52:415-23. 2008..The results suggest that elevated MMP activity leads to proteolytic cleavage of membrane receptors in the SHR, eg, cleavage of the insulin receptor-binding domain associated with insulin resistance... - Discontinuous expression of endothelial cell adhesion molecules along initial lymphatic vessels in mesentery: the primary valve structureWalter L Murfee
Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093, USA
Lymphat Res Biol 5:81-9. 2007..The objective of this study was to evaluate the expression pattern of adhesion molecules at endothelial cell junctions in an adult initial lymphatic network... - Whole blood assay for trypsin activity using polyanionic focusing gel electrophoresisRoy B Lefkowitz
Department of Bioengineering, University of California, San Diego, CA 92093 0448, USA
Electrophoresis 31:2442-51. 2010..This straightforward technique now allows for the rapid measurement of clinically relevant levels of trypsin activity in microliter volumes of whole blood, providing a useful tool for the development of novel point-of-care diagnostics... - Orbital response indicates nasal pungency: analysis of biomechanical strain on the skinA A Jalowayski
Chemosensory Perception Laboratory, Department of Surgery Otolaryngology, University of California, San Diego, La Jolla, California, USA
Chem Senses 26:1005-13. 2001..Comparison with psychophysical data showed that the strain became evident at concentrations just detectable as pungent. Maximum strain measured on the skin shows promise as an objective index of pungency... - A mechanism for erythrocyte-mediated elevation of apparent viscosity by leukocytes in vivo without adhesion to the endotheliumB P Helmke
Department of Bioengineering, University of California, San Diego, La Jolla 92093 0412, USA
Biorheology 35:437-48. 1998..Thus, leukocytes influence the whole organ resistance in skeletal muscle to a significant degree only in the presence of erythrocytes... - Severe intestinal ischemia can trigger cardiovascular collapse and sudden death via a parasympathetic mechanismAlexander H Penn
Department of Bioengineering, The Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
Shock 36:251-62. 2011.... - Fluid shear attenuates endothelial pseudopodia formation into the capillary lumenIsgard S Hueck
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California 92093 0412, USA
Microcirculation 15:531-42. 2008..To examine mechanotransduction mechanisms, we investigated in vivo the hemodynamic conditions in capillaries that control endothelial pseudopod formation... - Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verificationRyan S Friese
Department of Bioengineering, University of California, La Jolla, CA 92093 0838, USA
Physiol Genomics 40:195-207. 2010..The Chga KO may constitute a unique model for studying the relationship between the CHGA locus and disease phenotypes of the metabolic syndrome... - An electrophoretic method for the detection of chymotrypsin and trypsin activity directly in whole bloodRoy B Lefkowitz
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0448, USA
Electrophoresis 31:403-10. 2010..Thus, the new charge changing peptide substrates enable a simple electrophoretic assay format for the measurement of degradative enzyme activity, which is an important step toward the development of novel point-of-care diagnostics... - Mechanisms in experimental venous valve failure and their modification by Daflon 500 mgL Pascarella
Department of Surgery University of California San Diego, La Jolla, CA, USA
Eur J Vasc Endovasc Surg 35:102-10. 2008..To characterize the acute response of the vein wall to venous hypertension and associated altered fluid shear stress and to test the effect of micronized purified flavonoid fraction (MPFF, Daflon 500), on this response... - Mechanotransduction in leukocyte activation: a reviewAyako Makino
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0412, USA
Biorheology 44:221-49. 2007..We describe a disease model with chronic hypertension that suffers from an attenuated fluid shear-response with far reaching implications for microvascular blood flow... - Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shockFrank A DeLano
Department of Bioengineering, The Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Sci Transl Med 5:169ra11. 2013.... - An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesisGeert W Schmid-Schönbein
Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 92093 0412, USA
Conf Proc IEEE Eng Med Biol Soc 2012:3114-5. 2012..The consequence of autodigestion is multiorgan failure. We discuss the possibility to block the digestive enzymes in acute forms of shock as a potential therapeutic intervention... - Digested formula but not digested fresh human milk causes death of intestinal cells in vitro: implications for necrotizing enterocolitisAlexander H Penn
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA
Pediatr Res 72:560-7. 2012..We hypothesized that after lipase digestion, formula, but not fresh breast milk, contains levels of unbound free fatty acids (FFAs) that are cytotoxic to intestinal cells... - Enhanced DNA fragmentation in the thymus of spontaneously hypertensive ratsH Suzuki
Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol 276:H2135-40. 1999..Thus increased DNA fragmentation represents one of the mechanisms associated with thymic atrophy, a feature that reflects immune suppression in SHR... - Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear StressAngelina E Altshuler
Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 0412
Cell Mol Bioeng 5:82-91. 2012..Under shear, however, glucose uptake for protease-treated BAECs was greater than untreated controls. In conclusion, protease activity in plasma alters the exofacial membrane components of ECs and may interfere with mechanotransduction... - Transport processes in biomedical systems: a roadmap for future research directionsGeert W Schmid-Schönbein
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, California, USA
Ann Biomed Eng 33:1136-41. 2005..Most central is the expanded integration of fundamental transport sciences into the understanding of living systems and the great potential of patient specific modeling in designing a broad array of medical procedures... - Causes of telengiectasias, reticular veins, and varicose veinsLuigi Pascarella
Whitaker Institute of Biomedical Engineering, Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA 92093-0412, USA
Semin Vasc Surg 18:2-4. 2005..Telangiectasias, reticular veins, and true varicose veins appear to be a consequence of the changes induced by venous hypertension and sheer stress...
Research Grants
- Microvascular Injury and Pancreatic Enzyme ProductsGEERT SCHMID SCHOENBEIN; Fiscal Year: 2005..Understanding the trigger mechanisms for inflammation in shock will lead to new treatment modalities in man. ..
- STRUCTURE AND FUNCTION OF THE MICROCIRCULATIONGEERT SCHMID SCHOENBEIN; Fiscal Year: 2006..These studies serve to delineate mechanisms for the expression of key inflammatory mediators in hypertensive microvessels as a basis for development of new interventions against the injurious aspects of this syndrome. ..
- 2006 Molecular Mechanisms in Lymphatic Function & Disease Gordon ConferenceGEERT SCHMID SCHOENBEIN; Fiscal Year: 2006..The conference plays an essential role in the advancement of lymphology and development of a new understanding of lymphatic diseases and treatments. ..
- STRUCTURE AND FUNCTION OF MICROCIRCULATIONGEERT SCHMID SCHOENBEIN; Fiscal Year: 2007..The research program serves the first time to unify a diverse set of pathogenic mechanisms in the SHR under one mechanistic hypothesis and at the same time open the opportunity for new therapeutic approaches. ..
- STRUCTURE AND FUNCTION OF MICROCIRCULATIONGEERT SCHMID SCHOENBEIN; Fiscal Year: 2009..The research program serves the first time to unify a diverse set of pathogenic mechanisms in the SHR under one mechanistic hypothesis and at the same time open the opportunity for new therapeutic approaches. ..
- STRUCTURE AND FUNCTION OF MICROCIRCULATIONGEERT W SCHMID SCHOENBEIN; Fiscal Year: 2010..The research program serves the first time to unify a diverse set of pathogenic mechanisms in the SHR under one mechanistic hypothesis and at the same time open the opportunity for new therapeutic approaches. ..
- STRUCTURE/FUNCTION OF THE MICROCIRCULATIOMGEERT SCHMID SCHOENBEIN; Fiscal Year: 2001..Such a program will serve to clarify the pathogenesis of hypertension and is expected to stimulate the design of novel approaches for interventions. ..
- STRUCTURE AND FUNCTION OF THE MICROCIRCULATIONGEERT SCHMID SCHOENBEIN; Fiscal Year: 1993....
- STRUCTURE AND FUNCTION OF MICROCIRCULATIONGEERT SCHMID SCHOENBEIN; Fiscal Year: 1991..This type of approach should enable us to evaluate the effectiveness of current therapeutic interventions and to identify potentially new departures...
- Digestive Enzymes and Microvascular Inflammation in ShockGEERT W SCHMID SCHOENBEIN; Fiscal Year: 2010..This research will provide essential information for development of a new intervention against multi-organ failure by transient blockade of the pancreatic digestive enzymes. ..