PATRICK DAVID SCHLOSS

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Stabilization of the murine gut microbiome following weaning
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
    Gut Microbes 3:383-93. 2012
  2. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
  3. pmc Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 75:7537-41. 2009
  4. pmc A high-throughput DNA sequence aligner for microbial ecology studies
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 4:e8230. 2009
  5. pmc The effects of alignment quality, distance calculation method, sequence filtering, and region on the analysis of 16S rRNA gene-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA
    PLoS Comput Biol 6:e1000844. 2010
  6. pmc Assessing and improving methods used in operational taxonomic unit-based approaches for 16S rRNA gene sequence analysis
    Patrick D Schloss
    Department of Microbiology and Immunology University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 77:3219-26. 2011
  7. doi request reprint Evaluating different approaches that test whether microbial communities have the same structure
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    ISME J 2:265-75. 2008
  8. pmc A statistical toolbox for metagenomics: assessing functional diversity in microbial communities
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    BMC Bioinformatics 9:34. 2008

Research Grants

Detail Information

Publications8

  1. pmc Stabilization of the murine gut microbiome following weaning
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
    Gut Microbes 3:383-93. 2012
    ..These results suggest a high degree of stability in the microbiome once the community reached the second state...
  2. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
    ....
  3. pmc Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 75:7537-41. 2009
    ..This analysis of more than 222,000 sequences was completed in less than 2 h with a laptop computer...
  4. pmc A high-throughput DNA sequence aligner for microbial ecology studies
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 4:e8230. 2009
    ..Furthermore, because the implementation is not connected to a specific database it is easy to generalize the method to reference alignments for any DNA sequence...
  5. pmc The effects of alignment quality, distance calculation method, sequence filtering, and region on the analysis of 16S rRNA gene-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA
    PLoS Comput Biol 6:e1000844. 2010
    ..Taken together, these results urge caution in the design and interpretation of analyses using pyrosequencing data...
  6. pmc Assessing and improving methods used in operational taxonomic unit-based approaches for 16S rRNA gene sequence analysis
    Patrick D Schloss
    Department of Microbiology and Immunology University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 77:3219-26. 2011
    ..The ability to quickly and accurately assign sequences to OTUs and then obtain taxonomic information for those OTUs will greatly improve OTU-based analyses and overcome many of the challenges encountered with phylotype-based methods...
  7. doi request reprint Evaluating different approaches that test whether microbial communities have the same structure
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    ISME J 2:265-75. 2008
    ..These findings demonstrate that when correctly employed, the current statistical toolbox has the ability to address specific ecological questions concerning the differences between microbial communities...
  8. pmc A statistical toolbox for metagenomics: assessing functional diversity in microbial communities
    Patrick D Schloss
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    BMC Bioinformatics 9:34. 2008
    ..In this study, we developed and applied a suite of tools to describe and compare the richness, membership, and structure of microbial communities using peptide fragment sequences extracted from metagenomic sequence data...

Research Grants1

  1. Identifying population-level variation in cross-sectional and longitudinal HMP st
    PATRICK DAVID SCHLOSS; Fiscal Year: 2010
    ..Therefore, the proposed research is relevant to the part of the NIH's mission related to fostering innovative research strategies that improve the nation's ability to prevent and treat disease. ..