Avner Schlessinger

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Comparison of human solute carriers
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California
    Protein Sci 19:412-28. 2010
  2. ncbi Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
  3. ncbi High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
  4. ncbi Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
  5. ncbi Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010
  6. ncbi ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011
  7. ncbi Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA
    Pharmacogenet Genomics 20:687-99. 2010
  8. ncbi Protein disorder--a breakthrough invention of evolution?
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California San Francisco, CA, USA
    Curr Opin Struct Biol 21:412-8. 2011
  9. ncbi Function of human Rh based on structure of RhCG at 2.1 A
    Franz Gruswitz
    Department of Biochemistry and Biophysics, S412C Genentech Hall, Center for the Structure of Membrane Proteins, and Membrane Protein Expression Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:9638-43. 2010
  10. ncbi Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010

Collaborators

Detail Information

Publications10

  1. ncbi Comparison of human solute carriers
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California
    Protein Sci 19:412-28. 2010
    ..The classification scheme will inform future attempts directed at modeling the structures of the solute carriers, a prerequisite for describing the substrate specificities of the individual families...
  2. ncbi Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
    ..The observations highlight the utility of virtual screening against a comparative model, even when the target shares less than 30% sequence identity with its template structure and no known ligands in the primary binding site...
  3. ncbi High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
    ..Our combined approach may be useful for characterizing interactions between small molecules and other membrane proteins, as well as for describing substrate specificities in other protein families...
  4. ncbi Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
    ..3 to 3.0 μM. One of the new ligands from the homology model screen was optimized for affinity to 81 nM. The feasibility of docking screens against modeled GPCRs more generally is considered...
  5. ncbi Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010
    ..This study suggests that nonsynonymous variants of OCT1 in Chinese and Japanese populations may affect the differential response to metformin...
  6. ncbi ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011
    ..org/modeval), the PCSS server for predicting which peptides bind to a given protein (http://salilab.org/pcss) and the FoXS server for calculating and fitting Small Angle X-ray Scattering profiles (http://salilab.org/foxs)...
  7. ncbi Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA
    Pharmacogenet Genomics 20:687-99. 2010
    ....
  8. ncbi Protein disorder--a breakthrough invention of evolution?
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California San Francisco, CA, USA
    Curr Opin Struct Biol 21:412-8. 2011
    ..We need new advanced computational methods to study this new milestone in the advance of protein biology...
  9. ncbi Function of human Rh based on structure of RhCG at 2.1 A
    Franz Gruswitz
    Department of Biochemistry and Biophysics, S412C Genentech Hall, Center for the Structure of Membrane Proteins, and Membrane Protein Expression Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:9638-43. 2010
    ..Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG, RhD, and RhCE...
  10. ncbi Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010
    ..Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures...