Thomas Schilling

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain
    Lei Zhang
    Department of Mathematics, University of California, Irvine, CA 92697 3875, USA
    Mol Syst Biol 8:613. 2012
  2. pmc Dynamics and precision in retinoic acid morphogen gradients
    Thomas F Schilling
    Center for Complex Biological Systems, University of California, Irvine, CA 92697 2280, United States
    Curr Opin Genet Dev 22:562-9. 2012
  3. pmc Fishing for the signals that pattern the face
    Thomas F Schilling
    Department of Developmental and Cell Biology, 4462 Natural Sciences II, University of California, Irvine, CA 92697 2300, USA
    J Biol 8:101. 2009
  4. pmc FishNet: an online database of zebrafish anatomy
    Robert J Bryson-Richardson
    The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney, 2010, Australia
    BMC Biol 5:34. 2007
  5. ncbi request reprint Considering the zebrafish in a comparative context
    Thomas F Schilling
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Exp Zool B Mol Dev Evol 308:515-22. 2007
  6. ncbi request reprint Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest
    T F Schilling
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Dev Biol 231:201-16. 2001
  7. ncbi request reprint AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 132:3127-38. 2005
  8. pmc Origins of anteroposterior patterning and Hox gene regulation during chordate evolution
    T F Schilling
    Department of Developmental and Cell Biology, 5210 Bio Sci II, University of California, Irvine, CA 92697 2300, USA
    Philos Trans R Soc Lond B Biol Sci 356:1599-613. 2001
  9. ncbi request reprint Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, California, USA
    Dev Dyn 229:87-98. 2004
  10. ncbi request reprint lockjaw encodes a zebrafish tfap2a required for early neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 130:5755-68. 2003

Collaborators

Detail Information

Publications28

  1. pmc Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain
    Lei Zhang
    Department of Mathematics, University of California, Irvine, CA 92697 3875, USA
    Mol Syst Biol 8:613. 2012
    ..This finding suggests a novel noise attenuation mechanism that relies on intracellular noise to induce switching and coordinate cellular decisions during developmental patterning...
  2. pmc Dynamics and precision in retinoic acid morphogen gradients
    Thomas F Schilling
    Center for Complex Biological Systems, University of California, Irvine, CA 92697 2280, United States
    Curr Opin Genet Dev 22:562-9. 2012
    ....
  3. pmc Fishing for the signals that pattern the face
    Thomas F Schilling
    Department of Developmental and Cell Biology, 4462 Natural Sciences II, University of California, Irvine, CA 92697 2300, USA
    J Biol 8:101. 2009
    ....
  4. pmc FishNet: an online database of zebrafish anatomy
    Robert J Bryson-Richardson
    The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney, 2010, Australia
    BMC Biol 5:34. 2007
    ....
  5. ncbi request reprint Considering the zebrafish in a comparative context
    Thomas F Schilling
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Exp Zool B Mol Dev Evol 308:515-22. 2007
    ..Studies of the zebrafish in phylogenetic context provide an opportunity for synergy between communities using these two fundamentally different approaches...
  6. ncbi request reprint Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest
    T F Schilling
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Dev Biol 231:201-16. 2001
    ..Thus, consistent with models implicating hox expression in control of segmental identity, plasticity in hox expression correlates with plasticity in final cell fate...
  7. ncbi request reprint AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 132:3127-38. 2005
    ....
  8. pmc Origins of anteroposterior patterning and Hox gene regulation during chordate evolution
    T F Schilling
    Department of Developmental and Cell Biology, 5210 Bio Sci II, University of California, Irvine, CA 92697 2300, USA
    Philos Trans R Soc Lond B Biol Sci 356:1599-613. 2001
    ....
  9. ncbi request reprint Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, California, USA
    Dev Dyn 229:87-98. 2004
    ..Developmental Dynamics 229:87-98, 2004...
  10. ncbi request reprint lockjaw encodes a zebrafish tfap2a required for early neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 130:5755-68. 2003
    ..These studies demonstrate that low is required for early steps in neural crest development and suggest that tfap2a is essential for the survival of a subset of neural crest derivatives...
  11. ncbi request reprint Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution
    Trevor L Hoffman
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2305, USA
    J Exp Zool B Mol Dev Evol 308:679-91. 2007
    ....
  12. ncbi request reprint Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:335-45. 2007
    ..Collectively, our results indicate that Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest...
  13. ncbi request reprint Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ....
  14. pmc Chemokine signaling controls endodermal migration during zebrafish gastrulation
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Science 322:89-92. 2008
    ..This process may have relevance to human gastrointestinal bifurcations and other organ defects...
  15. ncbi request reprint REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development
    Nikki Plaster
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 236:1891-904. 2007
    ..We present a model for RERE-dependent patterning in which tissue-specific transcriptional repression, by means of an REREa-HDAC complex, modulates growth factor signaling during embryogenesis...
  16. pmc Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches
    Angela Linville
    Department of Developmental and Cell Biology, Developmental Biology Center, University of California, Irvine, CA 92697, USA
    Dev Biol 325:60-70. 2009
    ..These studies reveal novel tissue-specific roles for RARs in controlling the competence and sensitivity of cells to respond to RA...
  17. pmc Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration
    Sarah Piloto
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 137:1981-90. 2010
    ..Similar processes probably occur in other cell types in which Wnt signaling promotes migration...
  18. pmc Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo
    Richard J White
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
    PLoS Biol 5:e304. 2007
    ..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner...
  19. ncbi request reprint Development of cartilage and bone
    Yashar Javidan
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697, USA
    Methods Cell Biol 76:415-36. 2004
  20. ncbi request reprint Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish
    Jochen Holzschuh
    Department of Developmental and Cell Biology, University of California, 5438 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3731-42. 2005
    ..Our results show that the endoderm regulates the differentiation of cranial sensory ganglia, which coordinates the cranial nerves with the segments that they innervate...
  21. ncbi request reprint Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain
    Angela Linville
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Dev Biol 270:186-99. 2004
    ..Thus, in addition to its role in determining rhombomere identities, RA plays a more direct role in the differentiation of subsets of branchiomotor neurons within the hindbrain...
  22. ncbi request reprint Requirement for endoderm and FGF3 in ventral head skeleton formation
    Nicolas B David
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, F 75230 Paris cedex 05, France
    Development 129:4457-68. 2002
    ..Together, our results reveal for the first time that the endoderm provides differential cues along the anteroposterior axis to control ventral head skeleton development and demonstrate that this function is mediated in part by Fgf3...
  23. ncbi request reprint The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans
    Tatjana Piotrowski
    National Institutes of Health, NICHD, LMG, Bldg 6B, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Development 130:5043-52. 2003
    ..Furthermore, we provide evidence for regulatory interactions between vgo/tbx1 and edn1 and hand2, genes that are implicated in the control of pharyngeal arch development and in the etiology of DGS...
  24. ncbi request reprint Cranial neural crest and development of the head skeleton
    Robert D Knight
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Sciences, University of Sheffield, South Yorkshire, UK
    Adv Exp Med Biol 589:120-33. 2006
    ..We highlight recent genetic studies of craniofacial development in zebrafish that have revealed new tissue interactions and show that the process of CNC development is highly conserved across the vertebrates...
  25. ncbi request reprint Molecular dissection of craniofacial development using zebrafish
    Pamela C Yelick
    The Forsyth Institute, Department of Cytokine Biology, and Harvard Forsyth Department of Oral Biology, 140 The Fenway, Boston, MA 02115, USA
    Crit Rev Oral Biol Med 13:308-22. 2002
    ..We discuss the potential impact of specialized mutagenesis screens and the future applications of this versatile, vertebrate developmental model system in the molecular dissection of craniofacial development...
  26. pmc Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones
    Will H Norton
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 132:645-58. 2005
    ....
  27. ncbi request reprint Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish
    David E Clouthier
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Kentucky 40292, USA
    Birth Defects Res C Embryo Today 72:190-9. 2004
    ....
  28. ncbi request reprint Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells
    David Stafford
    The Committee on Developmental Biology, The University of Chicago, 1027 East 57th Street, IL 60637, USA
    Development 133:949-56. 2006
    ..These findings suggest that RA will have important applications in the quest to induce islets from stem cells for therapeutic uses...

Research Grants22

  1. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2007
    ....
  2. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  3. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2006
    ....
  4. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2006
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  5. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2007
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  6. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  7. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2009
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  8. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ....
  9. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  10. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..abstract_text> ..
  11. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  12. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2002
    ..abstract_text> ..
  13. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2002
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  14. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2003
    ..abstract_text> ..
  15. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2003
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  16. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2004
    ..abstract_text> ..
  17. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2004
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  18. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..abstract_text> ..
  19. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas F Schilling; Fiscal Year: 2010
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..