M R Schiller

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions
    Martin R Schiller
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06019 4301, USA
    J Biol Chem 281:18774-86. 2006
  2. ncbi request reprint Genes expressed in the mouse pituitary corticotrope AtT-20/D-16v tumor cell line
    M R Schiller
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, Connecticut, USA
    Pituitary 3:141-52. 2000
  3. pmc Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin
    Martin R Schiller
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Exp Cell Res 314:2674-91. 2008
  4. ncbi request reprint Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity
    Martin R Schiller
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3401, USA
    Exp Cell Res 307:402-17. 2005
  5. ncbi request reprint Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link
    Martin R Schiller
    Department of Neuroscience and Partnership for Excellence in Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 4301, USA
    Cell Signal 18:1834-43. 2006
  6. ncbi request reprint Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
    Peter Penzes
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 37:263-74. 2003
  7. pmc Critical role for Kalirin in nerve growth factor signaling through TrkA
    Kausik Chakrabarti
    University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave, Farmington, CT 06030 4301, USA
    Mol Cell Biol 25:5106-18. 2005
  8. ncbi request reprint A neuroendocrine-specific protein localized to the endoplasmic reticulum by distal degradation
    M R Schiller
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 270:26129-38. 1995
  9. ncbi request reprint High-throughput phosphotyrosine profiling using SH2 domains
    Kazuya Machida
    Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell 26:899-915. 2007
  10. pmc Viral infection and human disease--insights from minimotifs
    Krishna Kadaveru
    University of Connecticut Health Center, Department of Molecular, Microbial, and Structural Biology, Biological Systems Modeling Group, 263 Farmington Ave, Farmington, CT, 06030 3305, USA
    Front Biosci 13:6455-71. 2008

Research Grants

  1. REGULATORY MECHANISMS OF KALIRIN'S GEF1 DOMAIN
    Martin Schiller; Fiscal Year: 2006
  2. Building motif lexicons
    Martin Schiller; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions
    Martin R Schiller
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06019 4301, USA
    J Biol Chem 281:18774-86. 2006
    ..This study establishes a novel molecular mechanism whereby intramolecular and intermolecular Kalirin SH3 domain/ligand interactions modulate GEF activity, a regulatory mechanism that is likely used by other RhoGEF family members...
  2. ncbi request reprint Genes expressed in the mouse pituitary corticotrope AtT-20/D-16v tumor cell line
    M R Schiller
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, Connecticut, USA
    Pituitary 3:141-52. 2000
    ..Nine completely novel cDNAs and 39 cDNAs homologous to known ESTs were also identified. A listing of other genes known to be expressed in AtT-20/D-16v cells is also provided...
  3. pmc Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin
    Martin R Schiller
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Exp Cell Res 314:2674-91. 2008
    ..We conclude that the Sec14p and N-terminal spectrin-like domains of Kalirin play critical roles in distinguishing the actions of full-length and Delta-Kalirin proteins...
  4. ncbi request reprint Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity
    Martin R Schiller
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3401, USA
    Exp Cell Res 307:402-17. 2005
    ..Together, our results indicate that Kal-GEF1 induces lamellipodia through activation of Pak, where GEF activity is not required. GEF-activity-independent effects on downstream targets may be a general property of RhoGEFs...
  5. ncbi request reprint Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link
    Martin R Schiller
    Department of Neuroscience and Partnership for Excellence in Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 4301, USA
    Cell Signal 18:1834-43. 2006
    ....
  6. ncbi request reprint Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
    Peter Penzes
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 37:263-74. 2003
    ..This novel signal transduction pathway may be critical for the regulation of the actin cytoskeleton controlling spine morphogenesis during development and plasticity...
  7. pmc Critical role for Kalirin in nerve growth factor signaling through TrkA
    Kausik Chakrabarti
    University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave, Farmington, CT 06030 4301, USA
    Mol Cell Biol 25:5106-18. 2005
    ..The interaction of TrkA with the pleckstrin homology domain of Kalirin may be one example of a general mechanism whereby receptor/Rho GEF pairings play an important role in receptor tyrosine kinase activation and signal transduction...
  8. ncbi request reprint A neuroendocrine-specific protein localized to the endoplasmic reticulum by distal degradation
    M R Schiller
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 270:26129-38. 1995
    ..The data implicate a novel ER localization mechanism for this neuroendocrine-specific luminal ER resident...
  9. ncbi request reprint High-throughput phosphotyrosine profiling using SH2 domains
    Kazuya Machida
    Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell 26:899-915. 2007
    ..These results demonstrate that high-throughput comprehensive SH2 profiling provides valuable mechanistic insights into tyrosine kinase signaling pathways...
  10. pmc Viral infection and human disease--insights from minimotifs
    Krishna Kadaveru
    University of Connecticut Health Center, Department of Molecular, Microbial, and Structural Biology, Biological Systems Modeling Group, 263 Farmington Ave, Farmington, CT, 06030 3305, USA
    Front Biosci 13:6455-71. 2008
    ..This system architecture allows viruses to exploit a motif, whereas the viability of the host is not affected by mutation of a single motif...
  11. pmc MimoSA: a system for minimotif annotation
    Jay Vyas
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave Farmington, CT 06030 3305, USA
    BMC Bioinformatics 11:328. 2010
    ..Our recently proposed function and sequence syntax for minimotifs enables us to build a general tool that will facilitate structured annotation and management of minimotif data from the biomedical literature...
  12. pmc A proposed syntax for Minimotif Semantics, version 1
    Jay Vyas
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 3305 USA
    BMC Genomics 10:360. 2009
    ..With these two purposes in mind, the authors provide a proposed syntax for minimotif semantics primarily useful for functional annotation...
  13. ncbi request reprint Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms
    Victor May
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05404, USA
    J Neurosci 22:6980-90. 2002
    ..Thus Kalirin, acting via RhoG in a novel manner, plays a central role in establishing the morphological phenotypic diversity that is essential to the connectivity of the developing nervous system...
  14. ncbi request reprint Minimotif Miner: a tool for investigating protein function
    Sudha Balla
    Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Nat Methods 3:175-7. 2006
    ..Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1...
  15. ncbi request reprint RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose
    Guofeng Zhang
    Experimental Medicine Section, Oral Infection and Immunity Branch OIIB, National Institute of Dental and Craniofacial Research NIDCR, The National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    J Endocrinol 195:313-21. 2007
    ..We conclude that RESP18 is a luminal protein of DCVs and its expression is regulated by exposure to glucose...

Research Grants3

  1. REGULATORY MECHANISMS OF KALIRIN'S GEF1 DOMAIN
    Martin Schiller; Fiscal Year: 2006
    ..Understanding the mechanism by which the GEF domain of kalirin is controlled will provide a basis for future studies to determine the mechanisms by which kalirin controls neuronal morphology. ..
  2. Building motif lexicons
    Martin Schiller; Fiscal Year: 2007
    ..Addressing these limitations will vastly increase the utility of short motif prediction. ..