M R Schiller
Affiliation: University of Connecticut Health Center
- Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactionsMartin R Schiller
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06019 4301, USA
J Biol Chem 281:18774-86. 2006..This study establishes a novel molecular mechanism whereby intramolecular and intermolecular Kalirin SH3 domain/ligand interactions modulate GEF activity, a regulatory mechanism that is likely used by other RhoGEF family members...
- Genes expressed in the mouse pituitary corticotrope AtT-20/D-16v tumor cell lineM R Schiller
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, Connecticut, USA
Pituitary 3:141-52. 2000..Nine completely novel cDNAs and 39 cDNAs homologous to known ESTs were also identified. A listing of other genes known to be expressed in AtT-20/D-16v cells is also provided...
- Autonomous functions for the Sec14p/spectrin-repeat region of KalirinMartin R Schiller
Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Exp Cell Res 314:2674-91. 2008..We conclude that the Sec14p and N-terminal spectrin-like domains of Kalirin play critical roles in distinguishing the actions of full-length and Delta-Kalirin proteins...
- Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activityMartin R Schiller
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3401, USA
Exp Cell Res 307:402-17. 2005..Together, our results indicate that Kal-GEF1 induces lamellipodia through activation of Pak, where GEF activity is not required. GEF-activity-independent effects on downstream targets may be a general property of RhoGEFs...
- Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the linkMartin R Schiller
Department of Neuroscience and Partnership for Excellence in Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 4301, USA
Cell Signal 18:1834-43. 2006....
- Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirinPeter Penzes
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Neuron 37:263-74. 2003..This novel signal transduction pathway may be critical for the regulation of the actin cytoskeleton controlling spine morphogenesis during development and plasticity...
- Critical role for Kalirin in nerve growth factor signaling through TrkAKausik Chakrabarti
University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave, Farmington, CT 06030 4301, USA
Mol Cell Biol 25:5106-18. 2005..The interaction of TrkA with the pleckstrin homology domain of Kalirin may be one example of a general mechanism whereby receptor/Rho GEF pairings play an important role in receptor tyrosine kinase activation and signal transduction...
- A neuroendocrine-specific protein localized to the endoplasmic reticulum by distal degradationM R Schiller
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 270:26129-38. 1995..The data implicate a novel ER localization mechanism for this neuroendocrine-specific luminal ER resident...
- High-throughput phosphotyrosine profiling using SH2 domainsKazuya Machida
Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
Mol Cell 26:899-915. 2007..These results demonstrate that high-throughput comprehensive SH2 profiling provides valuable mechanistic insights into tyrosine kinase signaling pathways...
- Viral infection and human disease--insights from minimotifsKrishna Kadaveru
University of Connecticut Health Center, Department of Molecular, Microbial, and Structural Biology, Biological Systems Modeling Group, 263 Farmington Ave, Farmington, CT, 06030 3305, USA
Front Biosci 13:6455-71. 2008..This system architecture allows viruses to exploit a motif, whereas the viability of the host is not affected by mutation of a single motif...
- MimoSA: a system for minimotif annotationJay Vyas
Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave Farmington, CT 06030 3305, USA
BMC Bioinformatics 11:328. 2010..Our recently proposed function and sequence syntax for minimotifs enables us to build a general tool that will facilitate structured annotation and management of minimotif data from the biomedical literature...
- A proposed syntax for Minimotif Semantics, version 1Jay Vyas
Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 3305 USA
BMC Genomics 10:360. 2009..With these two purposes in mind, the authors provide a proposed syntax for minimotif semantics primarily useful for functional annotation...
- Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanismsVictor May
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05404, USA
J Neurosci 22:6980-90. 2002..Thus Kalirin, acting via RhoG in a novel manner, plays a central role in establishing the morphological phenotypic diversity that is essential to the connectivity of the developing nervous system...
- Minimotif Miner: a tool for investigating protein functionSudha Balla
Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Nat Methods 3:175-7. 2006..Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1...
- RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucoseGuofeng Zhang
Experimental Medicine Section, Oral Infection and Immunity Branch OIIB, National Institute of Dental and Craniofacial Research NIDCR, The National Institutes of Health NIH, Bethesda, Maryland 20892, USA
J Endocrinol 195:313-21. 2007..We conclude that RESP18 is a luminal protein of DCVs and its expression is regulated by exposure to glucose...
- REGULATORY MECHANISMS OF KALIRIN'S GEF1 DOMAINMartin Schiller; Fiscal Year: 2006..Understanding the mechanism by which the GEF domain of kalirin is controlled will provide a basis for future studies to determine the mechanisms by which kalirin controls neuronal morphology. ..