John Schetz

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Allosteric modulation of dopamine receptors
    John A Schetz
    Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mini Rev Med Chem 5:555-61. 2005
  2. ncbi request reprint A prototypical Sigma-1 receptor antagonist protects against brain ischemia
    John A Schetz
    Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1181:1-9. 2007
  3. ncbi request reprint Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function
    Christina Z Floresca
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Recept Signal Transduct Res 24:207-39. 2004
  4. pmc An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones
    Ivan T Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 79107, USA
    Eur J Pharmacol 578:123-36. 2008

Research Grants

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Allosteric modulation of dopamine receptors
    John A Schetz
    Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mini Rev Med Chem 5:555-61. 2005
    ..Different types of allosteric modulation of dopamine receptors are discussed as well as the significance of such modulation in the control of normal biological processes and in the treatment of disease...
  2. ncbi request reprint A prototypical Sigma-1 receptor antagonist protects against brain ischemia
    John A Schetz
    Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1181:1-9. 2007
    ....
  3. ncbi request reprint Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function
    Christina Z Floresca
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Recept Signal Transduct Res 24:207-39. 2004
    ..Molecular determinants that mediate the D4/D2-selectivity of many extremely D4-selective 1,4-DAP ligands, include a nonconserved cluster of bulky amino acids at the TM2/TM3 interface (positions 2.61, 3.28 and 3.29)...
  4. pmc An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones
    Ivan T Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 79107, USA
    Eur J Pharmacol 578:123-36. 2008
    ..The antidepressant fluvoxamine, the drug of abuse methamphetamine, and the neurosteroid progesterone were amongst the many ligands whose interactions with the sigma(1) receptor were confirmed with our screening assay...

Research Grants8

  1. NEUROLEPTIC SPACER LENGTH GOVERNS MOLECULAR RECOGNITION
    John Schetz; Fiscal Year: 2009
    ....
  2. NEUROLEPTIC SPACER LENGTH GOVERNS MOLECULAR RECOGNITION
    John Schetz; Fiscal Year: 2002
    ..Only positions 2.53, 2.60, 2.62, and 2.64 on serotonin receptors will be considered, because these are the only positions in TMS2 that are believed to be facing the binding pocket and that have different amino acids for the two subtypes...