Todd E Scheetz

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes
    Eduardo R Macagno
    Division of Biological Sciences, University of California, San Diego, CA, USA
    BMC Genomics 11:407. 2010
  2. pmc High-throughput gene discovery in the rat
    Todd E Scheetz
    Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, Iowa 52242, USA
    Genome Res 14:733-41. 2004
  3. ncbi request reprint ESTprep: preprocessing cDNA sequence reads
    Todd E Scheetz
    Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, IA 52242, USA
    Bioinformatics 19:1318-24. 2003
  4. pmc Insights into a dinoflagellate genome through expressed sequence tag analysis
    Jeremiah D Hackett
    Department of Biological Sciences and Roy J, Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242, USA
    BMC Genomics 6:80. 2005
  5. pmc Prediction of cochlear implant performance by genetic mutation: the spiral ganglion hypothesis
    Robert W Eppsteiner
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Hear Res 292:51-8. 2012
  6. pmc A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci
    Todd E Scheetz
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e58657. 2013
  7. doi request reprint Prioritization of retinal disease genes: an integrative approach
    Alex H Wagner
    Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Mutat 34:853-9. 2013
  8. pmc AudioGene: predicting hearing loss genotypes from phenotypes to guide genetic screening
    Kyle R Taylor
    Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA
    Hum Mutat 34:539-45. 2013
  9. pmc 1274 full-open reading frames of transcripts expressed in the developing mouse nervous system
    Maria F Bonaldo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Genome Res 14:2053-63. 2004
  10. pmc Regulation of gene expression in the mammalian eye and its relevance to eye disease
    Todd E Scheetz
    Departments of Ophthalmology and Biomedical Engineering, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 103:14429-34. 2006

Collaborators

Detail Information

Publications57

  1. pmc Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes
    Eduardo R Macagno
    Division of Biological Sciences, University of California, San Diego, CA, USA
    BMC Genomics 11:407. 2010
    ..To begin to address this problem, we constructed whole embryo and adult central nervous system (CNS) EST libraries and created a clustered sequence database of the Hirudo transcriptome that is available to the scientific community...
  2. pmc High-throughput gene discovery in the rat
    Todd E Scheetz
    Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, Iowa 52242, USA
    Genome Res 14:733-41. 2004
    ..Complete information, including radiation hybrid mapping data, is also maintained locally at http://genome.uiowa.edu/clcg.html. All of the sequences described in this article have been submitted to the dbEST division of the NCBI...
  3. ncbi request reprint ESTprep: preprocessing cDNA sequence reads
    Todd E Scheetz
    Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, IA 52242, USA
    Bioinformatics 19:1318-24. 2003
    ..These errors further complicate the automated identification of EST-related sequencing. A tool is required to prepare the data prior to advanced annotation processing and submission to public databases...
  4. pmc Insights into a dinoflagellate genome through expressed sequence tag analysis
    Jeremiah D Hackett
    Department of Biological Sciences and Roy J, Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242, USA
    BMC Genomics 6:80. 2005
    ..Previous analyses of these data have clarified plastid origin and here we study the gene content, annotate the ESTs, and analyze the genes that are putatively involved in DNA packaging...
  5. pmc Prediction of cochlear implant performance by genetic mutation: the spiral ganglion hypothesis
    Robert W Eppsteiner
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Hear Res 292:51-8. 2012
    ..As a corollary, we hypothesize that because genetic testing can identify sites of cochlear pathology, it may be useful in predicting CI performance...
  6. pmc A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci
    Todd E Scheetz
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e58657. 2013
    ..However, several yielded putative associations requiring validation. Our data suggest that POAG is more genetically complex than AMD, with no common risk alleles of large effect...
  7. doi request reprint Prioritization of retinal disease genes: an integrative approach
    Alex H Wagner
    Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Mutat 34:853-9. 2013
    ..The java source code, compiled binary, assembled feature vectors, and instructions are available online at https://github.com/ahwagner/PULP...
  8. pmc AudioGene: predicting hearing loss genotypes from phenotypes to guide genetic screening
    Kyle R Taylor
    Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA
    Hum Mutat 34:539-45. 2013
    ..As personalized genomic medicine becomes more common, AudioGene will be increasingly useful as a phenotypic filter to assess pathogenicity of variants identified by massively parallel sequencing...
  9. pmc 1274 full-open reading frames of transcripts expressed in the developing mouse nervous system
    Maria F Bonaldo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Genome Res 14:2053-63. 2004
    ..Importantly, we identified transcripts, among the 1274 full-ORF sequences, that are exclusively or predominantly expressed in brain and eye tissues, many of which encode yet uncharacterized proteins...
  10. pmc Regulation of gene expression in the mammalian eye and its relevance to eye disease
    Todd E Scheetz
    Departments of Ophthalmology and Biomedical Engineering, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 103:14429-34. 2006
    ..These data and analytical approaches can be used to facilitate the discovery of additional genes and regulatory elements involved in human eye disease...
  11. ncbi request reprint IDOCS: intelligent distributed ontology consensus system--the use of machine learning in retinal drusen phenotyping
    George Thomas
    Department of Computer Science, University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 48:2278-84. 2007
    ..To use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD)...
  12. ncbi request reprint Genome-wide identification of pseudogenes capable of disease-causing gene conversion
    Jared M Bischof
    Coordinated Laboratory for Computational Genomics, The University of Iowa, Iowa City, Iowa 52240, USA
    Hum Mutat 27:545-52. 2006
    ..All results and tools produced by this study are available for download at: http://genome.uiowa.edu/pseudogenes...
  13. doi request reprint Microarray mRNA expression profiling to study cystic fibrosis
    Shyam Ramachandran
    Interdisciplinary Program in Genetics, Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Methods Mol Biol 742:193-212. 2011
    ..We also outline novel strategies for experimental design and data analysis, and describe some powerful gene and pathway discovery tools...
  14. pmc Computational quantification of complex fundus phenotypes in age-related macular degeneration and Stargardt disease
    Gwenole Quellec
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 52:2976-81. 2011
    ....
  15. pmc Cell of origin strongly influences genetic selection in a mouse model of T-ALL
    Katherine E Berquam-Vrieze
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA
    Blood 118:4646-56. 2011
    ..These findings have broad implications for the genetic analysis of human cancers as well as the production of mouse models of cancer...
  16. pmc Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11)
    Annie P Chiang
    Department of Electrical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 103:6287-92. 2006
    ....
  17. pmc Exon-level expression profiling of ocular tissues
    Alex H Wagner
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Exp Eye Res 111:105-11. 2013
    ..Known tissue-specific genes were examined and they demonstrated correspondence of expression with the representative ocular tissues. The estimated gene and exon level abundances are available online at the Ocular Tissue Database...
  18. pmc Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa
    Budd A Tucker
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 108:E569-76. 2011
    ....
  19. doi request reprint Association of a novel mutation in the retinol dehydrogenase 12 (RDH12) gene with autosomal dominant retinitis pigmentosa
    John H Fingert
    Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Ophthalmol 126:1301-7. 2008
    ..To identify the gene causing retinitis pigmentosa (RP) in an autosomal dominant pedigree...
  20. doi request reprint Computational identification of operon-like transcriptional loci in eukaryotes
    Kishore Nannapaneni
    Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USA
    Comput Biol Med 43:738-43. 2013
    ..elegans and some instances in Drosophila. We identify several candidate operons in Drosophila melanogaster of which two have been subsequently molecularly validated...
  21. pmc Analysis of ASB10 variants in open angle glaucoma
    John H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 21:4543-8. 2012
    ..These data suggest that non-synonymous mutations in ASB10 do not cause Mendelian forms of POAG...
  22. ncbi request reprint Transcript annotation prioritization and screening system (TrAPSS) for mutation screening
    Brian M O'Leary
    Coordinated Laboratory for Computational Genomics, University of Iowa, Iowa City, IA 52242, USA
    J Bioinform Comput Biol 5:1155-72. 2007
    ..g. conserved protein functional domains) so as to prioritize candidate genes...
  23. ncbi request reprint Large-scale gene discovery in human airway epithelia reveals novel transcripts
    Todd E Scheetz
    Department of Pediatrics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 17:69-77. 2004
    ..This UniGene set should be useful for studies of pulmonary diseases involving the airway epithelium including cystic fibrosis, respiratory infections and asthma. It also provides a reagent for large-scale expression profiling...
  24. pmc Differential gene expression in human conducting airway surface epithelia and submucosal glands
    Anthony J Fischer
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 40:189-99. 2009
    ..This study illustrates the power of LCM in defining the roles of specific anatomic features in airway biology and may be useful in examining how disease states alter transcriptional programs in the conducting airways...
  25. pmc Integration site choice of a feline immunodeficiency virus vector
    Yubin Kang
    Program in Gene Therapy, Department of Pediatrics, University of Iowa, Iowa City, 52242, 52242, USA
    J Virol 80:8820-3. 2006
    ..FIV integration preferences are more similar to those of primate lentiviruses and distinct from those of Moloney murine leukemia virus, avian sarcoma leukosis virus, and foamy virus...
  26. pmc Copy number variations on chromosome 12q14 in patients with normal tension glaucoma
    John H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 20:2482-94. 2011
    ..However, animal studies will be necessary to rule out a role for the other duplicated or neighboring genes...
  27. pmc Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors
    Benjamin T Brett
    Center for Bioinformatics and Computational Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e24668. 2011
    ..Overall, this method will facilitate ongoing efforts to decipher the genetic complexity of the human cancer genome by providing more accurate comparative information from Sleeping Beauty models of cancer...
  28. pmc Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia
    Audra A Winder
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Respir Res 10:96. 2009
    ..The recognition of microbial molecular patterns via toll-like receptors (TLRs) is critical for mucosal defenses...
  29. ncbi request reprint CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia
    Joseph Zabner
    Department of Internal Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 289:L545-53. 2005
    ..Overall, the results indicate that CFTR dysfunction has little direct impact on airway epithelial gene expression in samples grown under these conditions...
  30. doi request reprint A knowledge-based approach to predict intragenic deletions or duplications
    Krishna R Kalari
    Department of Biomedical Engineering, Center for Bioinformatics and Computational Biology, University of Iowa, Iowa, USA
    Bioinformatics 24:1975-9. 2008
    ..We have developed a novel computational system, SPeeDD (system to prioritize deletions or duplications) that utilizes machine learning techniques to predict likely candidate regions that delete or duplicate exon(s) within a gene...
  31. pmc Selection of Phototransduction Genes in Homo sapiens
    Mark Christopher
    Institute for Vision Research, University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 54:5489-96. 2013
    ..We investigated the evidence of recent positive selection in the human phototransduction system at single nucleotide polymorphism (SNP) and gene level...
  32. pmc Advancing genetic testing for deafness with genomic technology
    A Eliot Shearer
    Department of Otolaryngology Head and Neck Surgery, Molecular Otolaryngology and Renal Research Labs, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Med Genet 50:627-34. 2013
    ....
  33. doi request reprint Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and Senior-Loken syndrome
    Edwin M Stone
    Department of Ophthalmology and Visual Sciences, The University of Iowa, 375 Newton Rd, 4111 MERF, Iowa City, IA 52242, USA
    Arch Ophthalmol 129:81-7. 2011
    ..To investigate whether mutations in NPHP5 can cause Leber congenital amaurosis (LCA) without early-onset renal disease...
  34. pmc Genome-wide analysis of copy number variants in age-related macular degeneration
    Kacie J Meyer
    Interdisciplinary Genetics Program, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 129:91-100. 2011
    ..These and other candidate genes highlighted by this study deserve further scrutiny as sources of genetic risk for AMD...
  35. pmc The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia
    Alejandro A Pezzulo
    Department of Internal Medicine, Univ of Iowa, Iowa City, 52242, USA
    Am J Physiol Lung Cell Mol Physiol 300:L25-31. 2011
    ..We describe a high level of similarity between cells of tracheal and bronchial origin within and between different human donors, which suggests a very robust expression profile that is specific to airway cells...
  36. ncbi request reprint First exons and introns--a survey of GC content and gene structure in the human genome
    Krishna R Kalari
    Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, IA 52242, USA
    In Silico Biol 6:237-42. 2006
    ..This study provides insight into the structure of eukaryotic genes. These results confirm and expand the previously identified regulatory potential of first exons and introns...
  37. ncbi request reprint Migration of the plastid genome to the nucleus in a peridinin dinoflagellate
    Jeremiah D Hackett
    Department of Biological Sciences and Center for Comparative Genomics, The University of Iowa, Iowa City, IA 52242, USA
    Curr Biol 14:213-8. 2004
    ..tamarense. The plastid-targeted genes have red and green algal origins. These results highlight the unique position of dinoflagellates as the champions of plastid gene transfer to the nucleus among photosynthetic eukaryotes...
  38. pmc Eukaryotic operon-like transcription of functionally related genes in Drosophila
    Yehuda Ben-Shahar
    Howard Hughes Medical Institute, and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 104:222-7. 2007
    ..These data reveal eukaryotic operon-like transcription of functionally related genes in Drosophila. The results also suggest that operon-based transcription may be more common in eukaryotes than previously appreciated...
  39. ncbi request reprint Prioritizing regions of candidate genes for efficient mutation screening
    Terry A Braun
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 27:195-200. 2006
    ..These results suggest that prioritization strategies such as PAR can accelerate disease-gene identification through more efficient use of screening resources...
  40. pmc Identification and initial characterization of 6,000 expressed sequenced tags (ESTs) from rat normal-growing cartilage and swarm rat chondrosarcoma cDNA libraries
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    Iowa Orthop J 22:28-34. 2002
    ..It suggests that the biochemical characterization of growing cartilage and chondrosarcoma reported to date has only begun to describe the complexity of these tissues...
  41. pmc Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells
    S Scott Whitmore
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA
    Mol Vis 19:2274-97. 2013
    ..We investigated differential gene expression in samples of human retinal pigment epithelium (RPE) and choroid from early AMD and control maculas with exon-based arrays...
  42. pmc Swarm rat chondrosarcoma cells as an in vivo model: lung colonization and effects of tissue environment on tumor growth
    Jose A Morcuende
    Department of Orthopaedic Surgery and Rehabilitation University of Iowa 200 Hawkins Drive, Iowa City, IA 52242, USA
    Iowa Orthop J 32:46-53. 2012
    ..Identifying these interactions will lead to further understanding of chondrosarcoma and contribute to therapeutic targets in the future...
  43. ncbi request reprint Complement factor H polymorphism p.Tyr402His and cuticular Drusen
    Michael A Grassi
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA
    Arch Ophthalmol 125:93-7. 2007
    ..To determine the histidine frequency in patients with the cuticular drusen phenotype of age-related macular degeneration (AMD)...
  44. pmc Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing
    A Eliot Shearer
    Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 107:21104-9. 2010
    ..Massively parallel sequencing technologies provide sensitivity, specificity, and reproducibility at levels sufficient to perform genetic diagnosis of hearing loss...
  45. ncbi request reprint A comprehensive nonredundant expressed sequence tag collection for the developing Rattus norvegicus heart
    Jennifer J S Laffin
    Department of Pediatrics and Interdepartmental Genetics Graduate Program, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 17:245-52. 2004
    ..It is anticipated that such EST and cDNA clone resources will prove invaluable to gene expression studies aimed at the understanding of the molecular mechanisms underlying heart septation defects...
  46. pmc A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon
    Erin R Burnight
    1 Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA 2 Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA 3 Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Mol Ther Nucleic Acids 1:e50. 2012
    ..Molecular Therapy - Nucleic Acids (2012) 1, e50; doi:10.1038/mtna.2012.12; published online 16 October 2012...
  47. pmc Automated quantification of inherited phenotypes from color images: a twin study of the variability of optic nerve head shape
    Li Tang
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 51:5870-7. 2010
    ....
  48. pmc A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice
    Adam J Dupuy
    Department of Anatomy and Cell Biology, Center for Bioinformatics, Computational Biology and Biomedical Engineering, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Res 69:8150-6. 2009
    ..These novel alleles provide additional tools for the SB system and provide some insight into how this mutagenesis system can be manipulated to model cancer in mice...
  49. ncbi request reprint Gene expression profiling of potential PPARgamma target genes in mouse aorta
    Henry L Keen
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Physiol Genomics 18:33-42. 2004
    ....
  50. ncbi request reprint Isolation and characterization of autotrophic, hydrogen-utilizing, perchlorate-reducing bacteria
    Joshua D Shrout
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Appl Microbiol Biotechnol 67:261-8. 2005
    ..These bacteria used fumarate as an alternate electron acceptor, which is the first report of growth on an organic electron acceptor by perchlorate-reducing bacteria...
  51. pmc Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    Robert L Strausberg
    National Cancer Institute, Bethessda, MD 20892 2580, USA
    Proc Natl Acad Sci U S A 99:16899-903. 2002
    ..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)...
  52. pmc Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes-Vibrio fischeri light organ symbiosis
    Michael S Goodson
    Department of Medical Microbiology and Immunology, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Appl Environ Microbiol 71:6934-46. 2005
    ..Further investigations should elucidate the role of the Toll/NF-kappaB pathway in the initiation of the beneficial symbiosis between E. scolopes and Vibrio fischeri...
  53. pmc An annotated cDNA library of juvenile Euprymna scolopes with and without colonization by the symbiont Vibrio fischeri
    Carlene K Chun
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    BMC Genomics 7:154. 2006
    ..We report here the creation of a juvenile light-organ specific EST database...
  54. pmc The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
    Daniela S Gerhard
    Genome Res 14:2121-7. 2004
    ..Recently, a rat cDNA component was added to the project, and ongoing frog (Xenopus) and zebrafish (Danio) cDNA projects were expanded to take advantage of the high-throughput MGC pipeline...
  55. pmc High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence
    Anne E Kwitek
    Human and Molecular Genetics Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 14:750-7. 2004
    ..This new integrated RH map contains approximately 10 RH-mapped elements per Mb on the genome assembly, enabling the RH maps to serve as a scaffold for a variety of data visualization tools...
  56. ncbi request reprint Ethnic variation in AMD-associated complement factor H polymorphism p.Tyr402His
    Michael A Grassi
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Hum Mutat 27:921-5. 2006
    ..This study suggests that there are other yet unidentified genetic factors important in the pathogenesis of AMD that may mitigate the effects of c.1204T>C, p.Tyr402His variant...
  57. ncbi request reprint PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human
    Shu Hong Zhao
    Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Genomics 84:114-25. 2004
    ..Our data correct GenomeScan annotation of this region of the human genome and describe functional gene discovery in mammals not recognized in human EST projects...