Joseph A Schauerte

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Simultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of Abeta species on lipid bilayers
    Joseph A Schauerte
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biochemistry 49:3031-9. 2010
  2. ncbi Amyloid-beta membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity
    Pamela T Wong
    Department of Biological Chemistry, University of Michigan, 930 N University, Ann Arbor, MI 48109, USA
    J Mol Biol 386:81-96. 2009
  3. ncbi β-Amyloid (1-40) peptide interactions with supported phospholipid membranes: a single-molecule study
    Hao Ding
    Department of Biophysics, University of Michigan, Ann Arbor, MI, USA
    Biophys J 103:1500-9. 2012
  4. ncbi Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function
    Kathleen C Wisser
    Biophysics Research Division, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Biochem Biophys 432:58-70. 2004
  5. ncbi Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes
    Robin D Johnson
    Department of Biophysics, University of Michigan, Ann Arbor, MI, USA
    Biophys J 104:894-903. 2013
  6. ncbi Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding
    Timothy L Tapley
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:5557-62. 2009
  7. ncbi The triplet-state lifetime of indole in aqueous and viscous environments: significance to the interpretation of room temperature phosphorescence in proteins
    Christopher J Fischer
    Biophysics Research Program, Applied Physics Program, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
    J Am Chem Soc 124:10359-66. 2002
  8. ncbi The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain
    Chuan Yin Liu
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 277:18346-56. 2002

Collaborators

  • Richard Miller
  • Ari Gafni
  • Christopher J Fischer
  • Kathleen C Wisser
  • Duncan G Steel
  • Hao Ding
  • Robin D Johnson
  • Pamela T Wong
  • Timothy L Tapley
  • Chuan Yin Liu
  • Michael A Sutton
  • Cynthia J L Carruthers
  • John Christian Althaus
  • Chun Chieh Chang
  • Ursula Jakob
  • Julia Hupfeld
  • Jan L Körner
  • Madhuri T Barge
  • Edgar L Lee
  • James C A Bardwell
  • David T Burke
  • Andrzej Galecki
  • Shu Chen
  • Randal J Kaufman
  • Hetty N Wong

Detail Information

Publications8

  1. ncbi Simultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of Abeta species on lipid bilayers
    Joseph A Schauerte
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biochemistry 49:3031-9. 2010
    ..At higher concentrations, perhaps beyond physiologically relevant concentrations, larger extended and dynamic structures are found with large conductances (hundreds of picosiemens), suggesting a major disruption of the membrane...
  2. ncbi Amyloid-beta membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity
    Pamela T Wong
    Department of Biological Chemistry, University of Michigan, 930 N University, Ann Arbor, MI 48109, USA
    J Mol Biol 386:81-96. 2009
    ..The differences in Abeta behavior induced by membrane composition may have significant implications on the development and progression of AD as neuronal membrane composition is altered with age...
  3. ncbi β-Amyloid (1-40) peptide interactions with supported phospholipid membranes: a single-molecule study
    Hao Ding
    Department of Biophysics, University of Michigan, Ann Arbor, MI, USA
    Biophys J 103:1500-9. 2012
    ....
  4. ncbi Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function
    Kathleen C Wisser
    Biophysics Research Division, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Biochem Biophys 432:58-70. 2004
    ..Tissue specific differences in GAPDH stability may have significant consequences to these alternate functions during aging...
  5. ncbi Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes
    Robin D Johnson
    Department of Biophysics, University of Michigan, Ann Arbor, MI, USA
    Biophys J 104:894-903. 2013
    ..These results are intriguing in light of the increased Aβ42:Aβ40 ratios shown to correlate with familial Alzheimer's disease mutations...
  6. ncbi Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding
    Timothy L Tapley
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:5557-62. 2009
    ..These efficient adaptations help to explain how a very small protein is rapidly activated and can bind a broad range of substrate proteins in a purely pH-regulated manner...
  7. ncbi The triplet-state lifetime of indole in aqueous and viscous environments: significance to the interpretation of room temperature phosphorescence in proteins
    Christopher J Fischer
    Biophysics Research Program, Applied Physics Program, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
    J Am Chem Soc 124:10359-66. 2002
    ..The work is put in the context of room temperature phosphorescence studies of proteins...
  8. ncbi The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain
    Chuan Yin Liu
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 277:18346-56. 2002
    ..Interestingly, we demonstrated that the NLD forms stable dimers linked by intermolecular disulfide bridges. Our data support that the luminal domain represents a novel ligand-independent dimerization domain...