Gina Schatteman

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice
    G C Schatteman
    Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52245, USA
    J Clin Invest 106:571-8. 2000
  2. ncbi request reprint Biology of bone marrow-derived endothelial cell precursors
    Gina C Schatteman
    Integrative Physiology FH412, Univ of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 292:H1-18. 2007
  3. ncbi request reprint Old bone marrow cells inhibit skin wound vascularization
    Gina C Schatteman
    Department of Exercise Science FH412, University of Iowa, Iowa City, Iowa 52242, USA
    Stem Cells 24:717-21. 2006
  4. ncbi request reprint CD34- blood-derived human endothelial cell progenitors
    M Harraz
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    Stem Cells 19:304-12. 2001
  5. ncbi request reprint CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds
    E Sivan-Loukianova
    Department of Exercise Science, University of Iowa, Iowa City, IA 52242, USA
    J Vasc Res 40:368-77. 2003
  6. ncbi request reprint Angiogenesis: new insights and therapeutic potential
    R J Tomanek
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City 52242, USA
    Anat Rec 261:126-35. 2000
  7. ncbi request reprint The chemokine (C-X-C motif) receptor 4 inhibitor AMD3100 accelerates blood flow restoration in diabetic mice
    C Jiao
    Integrative Physiology FH412, University of Iowa, Iowa, IA 52242, USA
    Diabetologia 49:2786-9. 2006
  8. pmc Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry
    M J Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 1109, USA
    Proc Natl Acad Sci U S A 98:8018-23. 2001
  9. ncbi request reprint Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing
    Vesna Stepanovic
    Department of Exercise Science FH406, University of Iowa, Iowa City, IA 52242 1111, USA
    Circ Res 92:1247-53. 2003
  10. ncbi request reprint Differential healing activities of CD34+ and CD14+ endothelial cell progenitors
    Ola Awad
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, USA
    Arterioscler Thromb Vasc Biol 26:758-64. 2006

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice
    G C Schatteman
    Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52245, USA
    J Clin Invest 106:571-8. 2000
    ..Our findings suggest that CD34(+) cells may be a useful tool for therapeutic angiogenesis in diabetics...
  2. ncbi request reprint Biology of bone marrow-derived endothelial cell precursors
    Gina C Schatteman
    Integrative Physiology FH412, Univ of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 292:H1-18. 2007
    ....
  3. ncbi request reprint Old bone marrow cells inhibit skin wound vascularization
    Gina C Schatteman
    Department of Exercise Science FH412, University of Iowa, Iowa City, Iowa 52242, USA
    Stem Cells 24:717-21. 2006
    ..Our data suggest that bone marrow-derived cells may be poor candidates for therapeutic use in older patients and could actually harm them...
  4. ncbi request reprint CD34- blood-derived human endothelial cell progenitors
    M Harraz
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    Stem Cells 19:304-12. 2001
    ..However, incorporation of these cells requires co-injection with CD34+ cells, indicating that leukocyte-leukocyte interactions may play a critical role in governing angioblast behavior in vivo...
  5. ncbi request reprint CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds
    E Sivan-Loukianova
    Department of Exercise Science, University of Iowa, Iowa City, IA 52242, USA
    J Vasc Res 40:368-77. 2003
    ..These findings indicate that blood-derived progenitors may have therapeutic potential in the treatment of skin lesions in the setting of diabetes, and give insights into how bone marrow cells exert their effects on neovascularization...
  6. ncbi request reprint Angiogenesis: new insights and therapeutic potential
    R J Tomanek
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City 52242, USA
    Anat Rec 261:126-35. 2000
    ..Anat Rec (New Anat) 261:126-135, 2000...
  7. ncbi request reprint The chemokine (C-X-C motif) receptor 4 inhibitor AMD3100 accelerates blood flow restoration in diabetic mice
    C Jiao
    Integrative Physiology FH412, University of Iowa, Iowa, IA 52242, USA
    Diabetologia 49:2786-9. 2006
    ....
  8. pmc Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry
    M J Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 1109, USA
    Proc Natl Acad Sci U S A 98:8018-23. 2001
    ..This finding could pose a significant clinical challenge in targeting tumor cells that may masquerade as circulating endothelial cells or other embryonic-like stem cells...
  9. ncbi request reprint Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing
    Vesna Stepanovic
    Department of Exercise Science FH406, University of Iowa, Iowa City, IA 52242 1111, USA
    Circ Res 92:1247-53. 2003
    ..Additionally, we observed little incorporation of injected cells into wound structures, suggesting that improved healing is mediated through mechanisms other than direct differentiation and incorporation of the cells...
  10. ncbi request reprint Differential healing activities of CD34+ and CD14+ endothelial cell progenitors
    Ola Awad
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, USA
    Arterioscler Thromb Vasc Biol 26:758-64. 2006
    ..We compared the ability of primitive and monocytic endothelial cell progenitors to stimulate vascular growth and healing in diabetes and investigated potential molecular mechanisms through which the cells mediate their in vivo effects...
  11. ncbi request reprint Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination
    Mary J C Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
    Cancer Res 62:665-8. 2002
    ....
  12. ncbi request reprint Obese diabetic mouse environment differentially affects primitive and monocytic endothelial cell progenitors
    Ola Awad
    Department of Anatomy, University of Iowa, Iowa City, IA 52242, USA
    Stem Cells 23:575-83. 2005
    ..These data suggest that therapies involving prECPs or stem-like cells in diabetic patients may be inadvisable at this time...
  13. ncbi request reprint Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs
    Gina C Schatteman
    Department of Exercise Science, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Top Dev Biol 64:141-80. 2004
    ..Finally, the use of bone marrow cells as therapeutic tools will be addressed...
  14. ncbi request reprint Non-classical mechanisms of heart repair
    Gina C Schatteman
    Department of Exercise Science, University of Iowa, Iowa City, IA 52242, USA
    Mol Cell Biochem 264:103-17. 2004
    ..What remains to be deciphered is the physiological importance of the mechanisms...
  15. ncbi request reprint Epidermal cells accelerate the restoration of the blood flow in diabetic ischemic limbs
    Chunhua Jiao
    Department of Exercise Science, The University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 117:1055-63. 2004
    ..Finally, because epidermal cells are readily accessible and expandable, they appear to be ideally suited for use as a non-viral gene delivery therapy...
  16. ncbi request reprint Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors
    Chunlin Wang
    Department of Exercise Science, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Heart Circ Physiol 286:H1985-93. 2004
    ..to the angiogenic factors basic fibroblast growth factor (FGF-2), vascular endothelial cell growth factor-A165, and erythropoietin while inducing EC progenitor death in the presence of transforming growth factor-beta1 in vitro..
  17. ncbi request reprint In vivo and in vitro properties of CD34+ and CD14+ endothelial cell precursors
    Gina C Schatteman
    University of Iowa, Iowa City, IA, 52242, USA
    Adv Exp Med Biol 522:9-16. 2003
  18. ncbi request reprint Hemangioblasts, angioblasts, and adult endothelial cell progenitors
    Gina C Schatteman
    University of Iowa, Department of Exercise Science, Iowa City, Iowa 52242, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:13-21. 2004
    ..Hence, there is great hope that either alone, in combination with angiogenic factors, or as gene therapy vectors, we can harness these cells to treat ischemic and vascular diseases in the relatively near future...
  19. ncbi request reprint Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry
    Elisabeth A Seftor
    Department of Anatomy and Cell Biology, The University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242 1109, USA
    Crit Rev Oncol Hematol 44:17-27. 2002
    ....

Research Grants15

  1. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina Schatteman; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This work could lead to better treatment of heart attacks, strokes, and burns as well as prevention of chronic ulcers, particularly in people who are obese and those with diabetes. ..
  2. Role of Adult Angioblasts in Vascular Maintenance
    Gina Schatteman; Fiscal Year: 2006
    ..abstract_text> ..
  3. ENDOTHELIAL & KERATINOCYTE STEM CELLS IN WOUND HEALING
    Gina Schatteman; Fiscal Year: 2004
    ..We will also investigate whether diabetes affects the incorporation of these labeled cells into different skin components. ..
  4. ADULT ANGIOBLASTS AND VASCULAR MAINTENANCE
    Gina Schatteman; Fiscal Year: 2000
    ..We will also investigate the involvement of angioblasts in retinal vascularization to assess the possibility that anti-angioblast therapy may be an effective means of inhibiting proliferative retinopathy. ..
  5. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This work could lead to better treatment of heart attacks, strokes, and burns as well as prevention of chronic ulcers, particularly in people who are obese and those with diabetes. ..