Research Topics
| S L SchantzSummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?S L Schantz
Institute for Environmental Studies, University of Illinois at Urbana Champaign 61801, USA
Neurotoxicol Teratol 18:217-27; discussion 229-76. 1996..Hopefully, several new studies that are currently underway will help to resolve the uncertainties regarding the risks of perinatal PCB exposure that have been created by the conflicting results of these early studies...- Effects of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learningS L Schantz
Institute for Environmental Studies and Neuroscience Program, University of Illinois at Urbana Champaign, 61801, USA
Neurotoxicol Teratol 18:305-13. 1996..Together these findings suggest that coplanar and ortho-substituted PCBs may have different mechanisms of action on the CNS... - Neuropsychological assessment of an aging population of Great Lakes fisheatersS L Schantz
Institute for Environmental Studies, University of Illinois at Urbana Champaign 61801, USA
Toxicol Ind Health 12:403-17. 1996..DDE concentrations predict the degree of behavioral dysfunction? and 3) If PCB exposure is related to behavioral outcomes, which class of PCB congeners, ortho-substituted or coplanar, are responsible for the cognitive and motor deficits?.. - Motor function in aging Great Lakes fisheatersS L Schantz
College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Environ Res 80:S46-S56. 1999..46). These findings suggest that PCB/DDE exposure from Great Lakes fish has not significantly impaired hand steadiness or visual-motor coordination in this sample of older adults... 
Impairments of memory and learning in older adults exposed to polychlorinated biphenyls via consumption of Great Lakes fishS L Schantz
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Environ Health Perspect 109:605-11. 2001..These results are consistent with previous research showing an association between in utero PCB exposure and impairments of memory during infancy and childhood...- Effects of PCB exposure on neuropsychological function in childrenSusan L Schantz
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Environ Health Perspect 111:357-576. 2003..More complete information on the health effects of various congeners or congener classes would allow more informed scientific and risk assessment decisions... - Cognitive effects of endocrine-disrupting chemicals in animalsS L Schantz
Department of Veterinary Biosciences and Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Environ Health Perspect 109:1197-206. 2001.... - Chronic estradiol replacement impairs performance on an operant delayed spatial alternation task in young, middle-aged, and old ratsVictor C Wang
Neuroscience Program and Department of Veterinary Sciences, University of Illinois at Urbana Champaign, USA
Horm Behav 56:382-90. 2009.... 
Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of respondingVictor C Wang
Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL, USA
Behav Neurosci 122:794-804. 2008..These data suggest that chronic estrogen exposure may impair rats' abilities on measures of executive function including working memory and response inhibition...- Effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on spatial and visual reversal learning in ratsJohn J Widholm
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
Neurotoxicol Teratol 25:459-71. 2003.... - Alterations in DRH and DRL performance in rats developmentally exposed to an environmental PCB mixtureHelen J K Sable
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802 USA
Neurotoxicol Teratol 28:548-56. 2006..Overall, exposure to this PCB mixture resulted in increased responding which was suggestive of a deficit in inhibitory control... - Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory controlJ J Widholm
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Toxicol Appl Pharmacol 174:188-98. 2001..e., associative deficit). These data provide new insights into the underlying behavioral mechanisms that may be responsible for the spatial learning deficits observed in PCB-exposed rodents and monkeys... - Tetrachlorodibenzo-p-dioxin exposure alters radial arm maze performance and hippocampal morphology in female AhR miceB E Powers
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA
Genes Brain Behav 4:51-9. 2005..It is hypothesized that the effect of TCDD exposure is AhR dependent and that TCDD may alter GABAergic activity in the hippocampus of female mice during development... - Auditory deficits in rats exposed to an environmental PCB mixture during developmentBrian E Powers
Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61802, USA
Toxicol Sci 89:415-22. 2006..Developmental exposure to PCBs may also result in subtle auditory impairments in humans, and if so, this may contribute to some of the cognitive deficits that have been observed in epidemiological studies... - Impact of dietary genistein and aging on executive function in ratsSteven L Neese
Department of Veterinary Sciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
Neurotoxicol Teratol 32:200-11. 2010.... - Motor impairment in rats exposed to PCBs and methylmercury during early developmentCindy S Roegge
Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Toxicol Sci 77:315-24. 2004..Our results demonstrate that the possibility of additive neurotoxic effects of PCBs and MeHg needs to be seriously considered... - Developmental exposure to PCBs and/or MeHg: effects on a differential reinforcement of low rates (DRL) operant task before and after amphetamine drug challengeHelen J K Sable
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Neurotoxicol Teratol 31:149-58. 2009.... - Contaminant profiles in Southeast Asian immigrants consuming fish from polluted waters in northeastern WisconsinSusan L Schantz
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
Environ Res 110:33-9. 2010..The pattern of exposure is somewhat different than patterns in other fish-eating populations, possibly due to use of Aroclor 1242 by the paper industry in this region... - Developmental exposure to PCBs, MeHg, or both: long-term effects on auditory functionBrian E Powers
Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Environ Health Perspect 117:1101-7. 2009..However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function... - Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley ratsClinton D Allred
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
Carcinogenesis 25:211-8. 2004..The data suggest that in an endogenous estrogen environment similar to that of a postmenopausal woman, dietary genistein can stimulate the growth of a mammary carcinogen MNU-induced estrogen-dependent mammary tumors... - Motor function following developmental exposure to PCBS and/or MEHGCindy S Roegge
Psychiatry Department, Duke University Medical Center, Box 3415 Bell Building, Durham, NC 27710, USA
Neurotoxicol Teratol 28:260-77. 2006..There is need for a better understanding of the interactive effects of PCBs and MeHg, especially in regard to motor function... - A longitudinal examination of factors related to changes in serum polychlorinated biphenyl levelsP Grace Tee
School of Public Health, University of Texas, Houston, Texas, USA
Environ Health Perspect 111:702-7. 2003..PCB levels were particularly elevated for males who were classified as fisheaters in 1980, which may reflect higher levels of sport-caught fish consumption compared with female fisheaters... - Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHgCindy S Roegge
Psychiatry Department, Duke University Medical Center, Durham, NC 27710, USA
Neurotoxicol Teratol 28:74-85. 2006.... - Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in ratsRobert E Lasky
Center for Clinical Research and Evidence Based Medicine, University of Texas Health Science Center at Houston Medical School, 6431 Fannin, MSB 2 104, Houston, Texas 77030 1503, USA
Toxicol Sci 68:458-64. 2002..In contrast, ABR latencies and amplitudes were not altered by A1254 exposure. These findings provide the first functional evidence supporting a cochlear site of damage in PCB-induced hearing loss... - Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fishPaul J Kostyniak
University at Buffalo, New York 14214, USA
Toxicol Sci 88:400-11. 2005..This illustrates that Aroclor mixtures are useful for formulating dosing solutions which closely approximate actual environmental exposures... - Delayed spatial alternation impairments in adult rats following dietary n-6 deficiency during developmentCindy S Roegge
Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61802, United States
Neurotoxicol Teratol 27:485-95. 2005..Thus, the observed delayed spatial alternation impairments in rats fed PO fish and fish oil are hypothesized to have resulted from the altered n-6/n-3 FA ratios... - Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in ratsJohn J Widholm
Department of Psychology, College of Charleston, Charleston, South Carolina 29424, USA
Toxicol Sci 82:577-89. 2004..The results from the current study indicate that combined exposure to PCBs and MeHg does not exacerbate the PCB- or MeHg-induced impairments on spatial alternation tasks...
Research Grants
- RESEARCH TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYSusan Schantz; Fiscal Year: 2007..Selection will be based on academic success, relevance of proposed research to Program goals and commitment to toxicology. This effort to recruit under-represented minorities will continue. ..
- PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in AnimalsSusan Schantz; Fiscal Year: 2006..As in the past, findings from these animal studies will guide the selection of outcome measures for use in the birth cohort. ..