Christine E Schaner-Tooley
Affiliation: University of Virginia
- NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma proteinChristine E Schaner Tooley
Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Nature 466:1125-8. 2010..Knockdown of NRMT recapitulates the multi-spindle phenotype seen with methylation-defective RCC1 mutants, demonstrating the importance of alpha-N-methylation for normal bipolar spindle formation and chromosome segregation...
- N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosisTing Chen
Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine University of Virginia, Charlottesville, VA 22908 0577, USA
Nat Cell Biol 9:596-603. 2007..These data provide the first known function for N-terminal protein methylation...
- Regulation of RCC1 through N-terminal serine metnylationCHRISTINE SCHANER TOOLEY; Fiscal Year: 2007..Specific aim #2 will identify the methyltransferase responsible for the N-terminal serine methylation of RCC1. ..