Morris Schambelan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel
    Morris Schambelan
    University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA
    J Acquir Immune Defic Syndr 31:257-75. 2002
  2. pmc Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers
    Grace A Lee
    Department of Medicine, University of California, San Francisco, California, USA
    AIDS 21:2183-90. 2007
  3. pmc Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance
    Madhu N Rao
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 95:4361-6. 2010
  4. pmc Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteers
    Steven A Taylor
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 55:361-4. 2010
  5. pmc Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers
    Grace A Lee
    Department of Medicine, University of California, San Francisco, California, USA
    Clin Infect Dis 43:658-60. 2006
  6. pmc The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative men
    Grace A Lee
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 52:246-8. 2009
  7. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
  8. pmc The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    Kathleen Mulligan
    Department of Medicine, University of California, San Francisco, USA
    J Clin Endocrinol Metab 94:1137-44. 2009
  9. pmc The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study
    Joan C Lo
    Div of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA
    Clin Infect Dis 39:732-5. 2004
  10. ncbi request reprint Indinavir increases glucose production in healthy HIV-negative men
    Jean Marc Schwarz
    Department of Medicine, University of California, San Francisco, CA, USA
    AIDS 18:1852-4. 2004

Research Grants

Detail Information

Publications35

  1. ncbi request reprint Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel
    Morris Schambelan
    University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA
    J Acquir Immune Defic Syndr 31:257-75. 2002
    ..These recommendations were developed to guide physicians actively involved in HIV care in the management of metabolic complications that occur primarily within the context of potent antiretroviral therapy...
  2. pmc Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers
    Grace A Lee
    Department of Medicine, University of California, San Francisco, California, USA
    AIDS 21:2183-90. 2007
    ..Some HIV protease inhibitors (PIs) have been shown to induce insulin resistance in vitro but the degree to which specific PIs affect insulin sensitivity in humans is less well understood...
  3. pmc Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance
    Madhu N Rao
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 95:4361-6. 2010
    ..Treatment with GH decreases visceral adiposity but worsens glucose metabolism. IGF-I, which mediates many of the effects of GH, improves insulin sensitivity in HIV-negative individuals...
  4. pmc Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteers
    Steven A Taylor
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 55:361-4. 2010
    ..Boosting dose ritonavir (100-200 mg) is the most commonly prescribed PI, yet its effects on glucose metabolism have not been described in the absence of another PI...
  5. pmc Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers
    Grace A Lee
    Department of Medicine, University of California, San Francisco, California, USA
    Clin Infect Dis 43:658-60. 2006
    ..Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect...
  6. pmc The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative men
    Grace A Lee
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 52:246-8. 2009
    ..The effects of different HIV protease inhibitors (PIs) on peripheral insulin resistance have been described, but less is known about their effects on insulin suppression of endogenous glucose production (EGP)...
  7. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
    ....
  8. pmc The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    Kathleen Mulligan
    Department of Medicine, University of California, San Francisco, USA
    J Clin Endocrinol Metab 94:1137-44. 2009
    ..Leptin deficiency is associated with dyslipidemia and insulin resistance in animals and humans with lipoatrophy; leptin replacement ameliorates these abnormalities...
  9. pmc The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study
    Joan C Lo
    Div of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA
    Clin Infect Dis 39:732-5. 2004
    ..Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline...
  10. ncbi request reprint Indinavir increases glucose production in healthy HIV-negative men
    Jean Marc Schwarz
    Department of Medicine, University of California, San Francisco, CA, USA
    AIDS 18:1852-4. 2004
    ..During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production...
  11. doi request reprint Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection
    Rebecca Scherzer
    University of California, San Francisco, USA
    AIDS 25:1405-14. 2011
    ..Unintentional loss of weight and muscle due to aging and disease has been associated with increased mortality. Wasting and weight loss occur in HIV infection even in the modern era of effective antiretroviral therapy...
  12. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008
    ..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects...
  13. pmc The metabolic effects of lopinavir/ritonavir in HIV-negative men
    Grace A Lee
    Metabolism Section 111F, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    AIDS 18:641-9. 2004
    ..Therefore, we tested the effects of the PI combination lopinavir and ritonavir on glucose and lipid metabolism in HIV-negative subjects...
  14. pmc Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost
    Guilherme M Campos
    Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    J Gastrointest Surg 14:15-23. 2010
    ..Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown...
  15. ncbi request reprint Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial
    Donald I Abrams
    University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
    Ann Intern Med 139:258-66. 2003
    ..Cannabinoid use could potentially alter HIV RNA levels by two mechanisms: immune modulation or cannabinoid-protease inhibitor interactions (because both share cytochrome P-450 metabolic pathways)...
  16. pmc Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle
    Umesh B Masharani
    Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e19878. 2011
    ..These stress kinases are activated through various mechanisms related to lipid oversupply locally in insulin target tissues and in various adipose depots...
  17. ncbi request reprint The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infection
    Joan C Lo
    Department of Medicine, University of California San Francisco, CA, USA
    Clin Infect Dis 41:1335-40. 2005
    ..We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance...
  18. pmc Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study
    Giorgos K Sakkas
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 4:e4605. 2009
    ..The objective of this study was to determine whether creatine supplementation augments the effects of PRT on muscle strength, energetics, and body composition in HIV-infected patients...
  19. pmc Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men
    Madhu N Rao
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    AIDS Res Treat 2012:103072. 2012
    ..This result suggests that fat distribution may modify the relationship between leptin and bone density...
  20. pmc Regional adipose tissue and elevations in serum aminotransferases in HIV-infected individuals
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 48:169-76. 2008
    ..Obesity is associated with hepatic steatosis, and ALT is a marker of steatosis in the general population...
  21. ncbi request reprint Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    AIDS 16:1103-11. 2002
    ..To determine whether treatment with growth hormone (GH) enhances thymopoiesis in individuals infected with HIV-1...
  22. ncbi request reprint Effects of recombinant human growth hormone on fat distribution in patients with human immunodeficiency virus-associated wasting
    Viva W Tai
    Department of Medicine, University of California, San Francisco, USA
    Clin Infect Dis 35:1258-62. 2002
    ..Treatment with a pharmacologic dose of GH (0.1 mg/kg/day) resulted in significant and sustained increases in lean body mass and losses of fat in both the trunk and appendicular regions...
  23. pmc Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T
    Xiaojuan Li
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA 94107, USA
    Magn Reson Imaging 26:188-97. 2008
    ....
  24. ncbi request reprint Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial
    Kathleen Mulligan
    Department of Medicine, University of California, San Francisco, California 94110, USA
    J Clin Endocrinol Metab 92:563-70. 2007
    ..Reduced energy intake is a primary factor in HIV-associated wasting. Megestrol acetate (MA) stimulates appetite and weight gain. However, much of the weight gained is fat, possibly as a result of MA-induced hypogonadism...
  25. pmc Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement
    Melissa E Weinberg
    University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e14709. 2011
    ..Historically, the use of uridine as a therapeutic agent has been limited by poor bioavailability. A food supplement containing nucleosides, NucleomaxX®, has been reported to raise plasma uridine to supraphysiologic levels...
  26. pmc Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study
    Mustafa A Noor
    Department of Medicine, University of California, Berkeley, California, USA
    AIDS 16:F1-8. 2002
    ..We hypothesized that a single dose of the PI indinavir resulting in therapeutic plasma concentrations would acutely decrease insulin-stimulated glucose disposal in healthy human volunteers...
  27. doi request reprint Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone
    Jennifer Park-Sigal
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    J Bone Miner Res 28:700-8. 2013
    ..Although her bone pain resolved, hyperaldosteronism persisted...
  28. ncbi request reprint Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting
    Kathleen Mulligan
    Division of Endocrinology, San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA 94110, USA
    Int J Cardiol 85:151-9. 2002
    ....
  29. pmc Time- and exercise-dependent gene regulation in human skeletal muscle
    Alexander C Zambon
    Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94141, USA
    Genome Biol 4:R61. 2003
    ..Both exercise-induced remodeling and circadian rhythms rely on the transcriptional regulation of key genes...
  30. pmc The associations of regional adipose tissue with lipid and lipoprotein levels in HIV-infected men
    David Wohl
    AIDS Clinical Trials Unit, University of North Carolina, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 48:44-52. 2008
    ..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional adipose tissue depots and lipid levels is not defined...
  31. pmc Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women
    Judith Currier
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 48:35-43. 2008
    ..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described...
  32. ncbi request reprint HIV protease inhibitors increase adiponectin levels in HIV-negative men
    Grace A Lee
    J Acquir Immune Defic Syndr 36:645-7. 2004
  33. ncbi request reprint Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation
    Jean Marc Schwarz
    Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720 3104, USA
    J Clin Endocrinol Metab 87:942. 2002
    ..The combined implications of these positive and negative metabolic effects for cardiovascular disease risk remain unknown...
  34. pmc State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary
    Steven K Grinspoon
    Circulation 118:198-210. 2008
  35. pmc Development of appropriate coronary heart disease risk prediction models in HIV-infected patients
    Morris Schambelan
    Circulation 118:e48-53. 2008

Research Grants19

  1. Can IGF-I/IGFBP-3 Reverse Central Fat Accumulation?
    Morris Schambelan; Fiscal Year: 2005
    ..Should the results of this preliminary study be positive, they would provide a rationale for further studies of this agent, including a randomized, double-blind, placebo-controlled trial. ..
  2. Leptin Treatment of HIV-Associated Lipodystrophy
    Morris Schambelan; Fiscal Year: 2004
    ..To evaluate the effects of leptin on whole-body and regional fat and lean tissue distribution, we will also perform whole-body dual-energy X-ray (DEXA) scanning. ..
  3. ANABOLIC THERAPIES AND THEIR METABOLIC EFFECTS IN AIDS
    Morris Schambelan; Fiscal Year: 2002
    ..This study will address the mechanisms of HIV-induced wasting and investigate the role of two potential medical treatments. ..
  4. ANABOLIC THERAPIES AND THEIR METABOLIC EFFECTS IN AIDS
    Morris Schambelan; Fiscal Year: 1993
    ..In view of the pre-treatment differences in endogenous levels of testosterone, we hypothesize that the magnitude of the anabolic response might be even greater in women...
  5. Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV
    Morris Schambelan; Fiscal Year: 2006
    ....