Research Topics
| Morris SchambelanSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panelMorris Schambelan
University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA
J Acquir Immune Defic Syndr 31:257-75. 2002..These recommendations were developed to guide physicians actively involved in HIV care in the management of metabolic complications that occur primarily within the context of potent antiretroviral therapy...
Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteersGrace A Lee
Department of Medicine, University of California, San Francisco, California, USA
AIDS 21:2183-90. 2007..Some HIV protease inhibitors (PIs) have been shown to induce insulin resistance in vitro but the degree to which specific PIs affect insulin sensitivity in humans is less well understood...- Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistanceMadhu N Rao
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 95:4361-6. 2010..Treatment with GH decreases visceral adiposity but worsens glucose metabolism. IGF-I, which mediates many of the effects of GH, improves insulin sensitivity in HIV-negative individuals... - Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteersSteven A Taylor
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 55:361-4. 2010..Boosting dose ritonavir (100-200 mg) is the most commonly prescribed PI, yet its effects on glucose metabolism have not been described in the absence of another PI... - Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteersGrace A Lee
Department of Medicine, University of California, San Francisco, California, USA
Clin Infect Dis 43:658-60. 2006..Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect... - Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjectsRebecca Scherzer
University of California, San Francisco, CA 94121, USA
Am J Clin Nutr 88:1088-96. 2008.... - The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemiaKathleen Mulligan
Department of Medicine, University of California, San Francisco, USA
J Clin Endocrinol Metab 94:1137-44. 2009..Leptin deficiency is associated with dyslipidemia and insulin resistance in animals and humans with lipoatrophy; leptin replacement ameliorates these abnormalities... - The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative menGrace A Lee
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 52:246-8. 2009..The effects of different HIV protease inhibitors (PIs) on peripheral insulin resistance have been described, but less is known about their effects on insulin suppression of endogenous glucose production (EGP)... - The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot studyJoan C Lo
Div of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA
Clin Infect Dis 39:732-5. 2004..Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline... - Indinavir increases glucose production in healthy HIV-negative menJean-Marc Schwarz
Department of Medicine, University of California, San Francisco, CA, USA
AIDS 18:1852-4. 2004..During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production... 
Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infectionRebecca Scherzer
University of California, San Francisco, USA
AIDS 25:1405-14. 2011..Unintentional loss of weight and muscle due to aging and disease has been associated with increased mortality. Wasting and weight loss occur in HIV infection even in the modern era of effective antiretroviral therapy...- Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjectsRebecca Scherzer
Northern California Institute for Research and Education, San Francisco, CA, USA
Am J Clin Nutr 87:1809-17. 2008..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects... - Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lostGuilherme M Campos
Department of Surgery, University of California San Francisco, San Francisco, CA, USA
J Gastrointest Surg 14:15-23. 2010..Altered gut and pancreatic hormone secretion may bolster resolution of insulin resistance after Roux-en-Y gastric bypass (RYGB), but the independent effects of weight loss and hormonal secretion on peripheral glucose disposal are unknown... - The metabolic effects of lopinavir/ritonavir in HIV-negative menGrace A Lee
Metabolism Section 111F, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
AIDS 18:641-9. 2004..Therefore, we tested the effects of the PI combination lopinavir and ritonavir on glucose and lipid metabolism in HIV-negative subjects... - Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trialDonald I Abrams
University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
Ann Intern Med 139:258-66. 2003..CONCLUSIONS: Smoked and oral cannabinoids did not seem to be unsafe in people with HIV infection with respect to HIV RNA levels, CD4+ and CD8+ cell counts, or protease inhibitor levels over a 21-day treatment... - Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscleUmesh B Masharani
Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e19878. 2011..These stress kinases are activated through various mechanisms related to lipid oversupply locally in insulin target tissues and in various adipose depots... - The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infectionJoan C Lo
Department of Medicine, University of California San Francisco, CA, USA
Clin Infect Dis 41:1335-40. 2005..We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance... - Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled studyGiorgos K Sakkas
Department of Medicine, University of California San Francisco, San Francisco, California, USA
PLoS ONE 4:e4605. 2009..The objective of this study was to determine whether creatine supplementation augments the effects of PRT on muscle strength, energetics, and body composition in HIV-infected patients... - Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected MenMadhu N Rao
Department of Medicine, University of California, San Francisco, CA 94143, USA
AIDS Res Treat 2012:103072. 2012..This result suggests that fat distribution may modify the relationship between leptin and bone density... - Regional adipose tissue and elevations in serum aminotransferases in HIV-infected individualsPhyllis C Tien
Department of Medicine, University of California, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 48:169-76. 2008..Obesity is associated with hepatic steatosis, and ALT is a marker of steatosis in the general population... - Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormoneLaura A Napolitano
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
AIDS 16:1103-11. 2002..CONCLUSION: GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults... - Effects of recombinant human growth hormone on fat distribution in patients with human immunodeficiency virus-associated wastingViva W Tai
Department of Medicine, University of California, San Francisco, USA
Clin Infect Dis 35:1258-62. 2002..Treatment with a pharmacologic dose of GH (0.1 mg/kg/day) resulted in significant and sustained increases in lean body mass and losses of fat in both the trunk and appendicular regions... - Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 TXiaojuan Li
Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA 94107, USA
Magn Reson Imaging 26:188-97. 2008.... - Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trialKathleen Mulligan
Department of Medicine, University of California, San Francisco, California 94110, USA
J Clin Endocrinol Metab 92:563-70. 2007..Reduced energy intake is a primary factor in HIV-associated wasting. Megestrol acetate (MA) stimulates appetite and weight gain. However, much of the weight gained is fat, possibly as a result of MA-induced hypogonadism... - Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplementMelissa E Weinberg
University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e14709. 2011..Historically, the use of uridine as a therapeutic agent has been limited by poor bioavailability. A food supplement containing nucleosides, NucleomaxX®, has been reported to raise plasma uridine to supraphysiologic levels... - Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled studyMustafa A Noor
Department of Medicine, University of California, Berkeley, California, USA
AIDS 16:F1-8. 2002..Our data are compatible with the hypothesis that an acute effect of indinavir on glucose disposal in humans is mediated by a direct blockade of GLUT-4 transporters... - Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wastingKathleen Mulligan
Division of Endocrinology, San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA 94110, USA
Int J Cardiol 85:151-9. 2002.... - Time- and exercise-dependent gene regulation in human skeletal muscleAlexander C Zambon
Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94141, USA
Genome Biol 4:R61. 2003.... - The associations of regional adipose tissue with lipid and lipoprotein levels in HIV-infected menDavid Wohl
AIDS Clinical Trials Unit, University of North Carolina, Chapel Hill, NC, USA
J Acquir Immune Defic Syndr 48:44-52. 2008..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional adipose tissue depots and lipid levels is not defined... - Regional adipose tissue and lipid and lipoprotein levels in HIV-infected womenJudith Currier
Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
J Acquir Immune Defic Syndr 48:35-43. 2008..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described... - HIV protease inhibitors increase adiponectin levels in HIV-negative menGrace A Lee
J Acquir Immune Defic Syndr 36:645-7. 2004 - Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulationJean Marc Schwarz
Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720 3104, USA
J Clin Endocrinol Metab 87:942. 2002..The combined implications of these positive and negative metabolic effects for cardiovascular disease risk remain unknown... - State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summarySteven K Grinspoon
Circulation 118:198-210. 2008 - Development of appropriate coronary heart disease risk prediction models in HIV-infected patientsMorris Schambelan
Circulation 118:e48-53. 2008
Research Grants
- Can IGF-I/IGFBP-3 Reverse Central Fat Accumulation?Morris Schambelan; Fiscal Year: 2005..Should the results of this preliminary study be positive, they would provide a rationale for further studies of this agent, including a randomized, double-blind, placebo-controlled trial. ..
- Leptin Treatment of HIV-Associated LipodystrophyMorris Schambelan; Fiscal Year: 2004..To evaluate the effects of leptin on whole-body and regional fat and lean tissue distribution, we will also perform whole-body dual-energy X-ray (DEXA) scanning. ..
- ANABOLIC THERAPIES AND THEIR METABOLIC EFFECTS IN AIDSMorris Schambelan; Fiscal Year: 2002..This study will address the mechanisms of HIV-induced wasting and investigate the role of two potential medical treatments. ..
- ANABOLIC THERAPIES AND THEIR METABOLIC EFFECTS IN AIDSMorris Schambelan; Fiscal Year: 1993..In view of the pre-treatment differences in endogenous levels of testosterone, we hypothesize that the magnitude of the anabolic response might be even greater in women...
- Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIVMorris Schambelan; Fiscal Year: 2006....