Tim Schallert

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
  2. pmc Behavioral tests for preclinical intervention assessment
    Timothy Schallert
    Department of Psychology, Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    NeuroRx 3:497-504. 2006
  3. ncbi request reprint Brain-dependent movements and cerebral-spinal connections: key targets of cellular and behavioral enrichment in CNS injury models
    Timothy Schallert
    Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
    J Rehabil Res Dev 40:9-17. 2003
  4. ncbi request reprint Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism?
    Tim Schallert
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA
    Phys Med Rehabil Clin N Am 14:S27-46. 2003
  5. ncbi request reprint Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats
    Martin T Woodlee
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
    Exp Neurol 191:310-7. 2005
  6. pmc Reduction of dopamine synaptic activity: degradation of 50-kHz ultrasonic vocalization in rats
    Michelle R Ciucci
    Department of Psychology, University of Texas at Austin, USA
    Behav Neurosci 123:328-36. 2009
  7. ncbi request reprint Experimental focal ischemic injury: behavior-brain interactions and issues of animal handling and housing
    Tim Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, USA
    ILAR J 44:130-43. 2003
  8. ncbi request reprint Forced nonuse in unilateral parkinsonian rats exacerbates injury
    Jennifer L Tillerson
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 22:6790-9. 2002
  9. pmc The vermicelli handling test: a simple quantitative measure of dexterous forepaw function in rats
    Rachel P Allred
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 170:229-44. 2008
  10. ncbi request reprint Early appearance of functional deficits after neonatal excitotoxic and hypoxic-ischemic injury: fragile recovery after development and role of the NMDA receptor
    Barbara T Felt
    Department of Pediatrics, University of Michigan, Ann Arbor, Mich, USA
    Dev Neurosci 24:418-25. 2002

Collaborators

Detail Information

Publications72

  1. ncbi request reprint CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  2. pmc Behavioral tests for preclinical intervention assessment
    Timothy Schallert
    Department of Psychology, Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    NeuroRx 3:497-504. 2006
    ..Finally, a useful new modification of the water maze that involves moving the platform from trial to trial within the target quadrant is reviewed, and its advantages over the standard version are discussed...
  3. ncbi request reprint Brain-dependent movements and cerebral-spinal connections: key targets of cellular and behavioral enrichment in CNS injury models
    Timothy Schallert
    Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
    J Rehabil Res Dev 40:9-17. 2003
    ....
  4. ncbi request reprint Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism?
    Tim Schallert
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA
    Phys Med Rehabil Clin N Am 14:S27-46. 2003
    ....
  5. ncbi request reprint Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats
    Martin T Woodlee
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
    Exp Neurol 191:310-7. 2005
    ..Unlike other tests, cross-midline placing methods can readily distinguish between severe stroke and severe parkinsonism in rats...
  6. pmc Reduction of dopamine synaptic activity: degradation of 50-kHz ultrasonic vocalization in rats
    Michelle R Ciucci
    Department of Psychology, University of Texas at Austin, USA
    Behav Neurosci 123:328-36. 2009
    ..Our findings suggest that the nigrostriatal dopamine pathway is involved to some extent in fine sensorimotor function that includes USV production and complexity...
  7. ncbi request reprint Experimental focal ischemic injury: behavior-brain interactions and issues of animal handling and housing
    Tim Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, USA
    ILAR J 44:130-43. 2003
    ..The timing and interaction of biological and motor therapies and the potential contribution of experience-dependent and drug-induced trophic factor expression are discussed...
  8. ncbi request reprint Forced nonuse in unilateral parkinsonian rats exacerbates injury
    Jennifer L Tillerson
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 22:6790-9. 2002
    ..This precipitated a severe and chronic loss of DA terminals and functional deficits. These results suggest decreased physical activity not only is a symptom of PD but also may act to potentiate the underlying degeneration...
  9. pmc The vermicelli handling test: a simple quantitative measure of dexterous forepaw function in rats
    Rachel P Allred
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 170:229-44. 2008
    ..Because of its ease of administration and sensitivity to lateralized impairments in skilled forepaw use, this measure may be useful in rat models of upper extremity impairment...
  10. ncbi request reprint Early appearance of functional deficits after neonatal excitotoxic and hypoxic-ischemic injury: fragile recovery after development and role of the NMDA receptor
    Barbara T Felt
    Department of Pediatrics, University of Michigan, Ann Arbor, Mich, USA
    Dev Neurosci 24:418-25. 2002
    ..Thus, timing of sensorimotor tests may influence their sensitivity for detection of focal neuropathology originating in the neonatal period...
  11. ncbi request reprint Behavioral tests after intracerebral hemorrhage in the rat
    Ya Hua
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    Stroke 33:2478-84. 2002
    ..The purpose of this study was to use a battery of sensorimotor function tests to examine the neurological effects of ICH in the rat and to examine which components of the hematoma are involved in generating those effects...
  12. ncbi request reprint An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate
    Sheila M Fleming
    Department of Psychology, Institute for Neuroscience, University of Texas, Austin, TX 78712, USA
    Behav Brain Res 156:201-13. 2005
    ..These data suggest that establishing a symptomatic threshold preclinically may help researchers evaluate potential treatments and model individual and group resistance to nigrostriatal insults...
  13. ncbi request reprint Mass-related traumatic tissue displacement and behavior: a screen for treatments that reduce [corrected] harm to bystander cells and recovery of function
    Hongyan Yang
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurotrauma 23:721-32. 2006
    ..This model may permit development of treatment strategies to alleviate brain mass effects, without disrupting neuroplasticity...
  14. ncbi request reprint Consequences of forced disuse of the impaired forelimb after unilateral cortical injury
    J Leigh Leasure
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Behav Brain Res 150:83-91. 2004
    ..Our results uphold the idea that mild rehabilitative training early after injury is beneficial, while either extreme overuse or complete disuse may disrupt functional recovery...
  15. ncbi request reprint Local fluorouracil chemotherapy interferes with neural and behavioral recovery after brain tumor-like mass compression
    Hongyan Yang
    Institute for Neuroscience, University of Texas at Austin, 1 University Station, Austin, TX 78712, USA
    Behav Brain Res 172:80-9. 2006
    ....
  16. doi request reprint Polyethylene glycol rapidly restores axonal integrity and improves the rate of motor behavior recovery after sciatic nerve crush injury
    Joshua M Britt
    Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurophysiol 104:695-703. 2010
    ..These and other data show that PEG-fusion not only rapidly restores physiological and morphological axonal continuity, but also more quickly improves behavioral recovery...
  17. ncbi request reprint Sensorimotor deficits associated with brain tumor progression and tumor-induced brain plasticity mechanisms
    Hongyan Yang
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 1 University Station, A8000, Austin, TX 78712, USA
    Exp Neurol 207:357-67. 2007
    ....
  18. ncbi request reprint Ischemic preconditioning procedure induces behavioral deficits in the absence of brain injury?
    Ya Hua
    Department of Neurosurgery, University of Michigan, R5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Neurol Res 27:261-7. 2005
    ..This would be consistent with data suggesting that brain injury can initiate mechanisms potentially favorable to neuroplasticity and neuroprotection...
  19. ncbi request reprint Using behavioral measurement to assess tumor progression and functional outcome after antiangiogenic treatment in mouse glioma models
    Hongyan Yang
    Institute for Neuroscience, Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Behav Brain Res 182:42-50. 2007
    ....
  20. pmc Qualitative changes in ultrasonic vocalization in rats after unilateral dopamine depletion or haloperidol: a preliminary study
    Michelle R Ciucci
    Department of Communication Sciences and Disorders, University of Texas, Austin, TX 78712, USA
    Behav Brain Res 182:284-9. 2007
    ..This study provides a foundation to examine the role of dopamine in sensorimotor processes underlying USV production and potentially to explore treatments for dopamine deficiency-related impaired vocal outcome...
  21. ncbi request reprint Protease-activated receptor-1 mediates protection elicited by thrombin preconditioning in a rat 6-hydroxydopamine model of Parkinson's disease
    Jason R Cannon
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 1116:177-86. 2006
    ..Further mechanistic studies on the actions of PAR-1 and PAR-4 as detrimental in experimental models of Parkinson's disease are warranted...
  22. doi request reprint Repeated intravenous amphetamine exposure: rapid and persistent sensitization of 50-kHz ultrasonic trill calls in rats
    Allison M Ahrens
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, TX 78712, USA
    Behav Brain Res 197:205-9. 2009
    ..It is possible that 50-kHz USV recordings could provide a potentially valuable behavioral measure of sensitization linked to enhanced incentive salience and increased tendency to self-administer drugs of abuse...
  23. ncbi request reprint Interruption of functional recovery by the NMDA glutamate antagonist MK801 after compression of the sensorimotor cortex: implications for treatment of tumors or other mass-related brain injuries
    Hongyan Yang
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 1 University Station, A8000, Austin, TX 78712, USA
    Exp Neurol 200:262-6. 2006
    ..It may be possible to use this model to develop interventions that maintain anti-cancer effects but with diminished harm to bystander tissue and brain plasticity...
  24. pmc Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke
    Jennifer M Plane
    University of Michigan Department of Neurology, Ann Arbor, MI 48109 2200, USA
    Exp Neurol 214:125-34. 2008
    ..Further study of the integration of adult-born neurons in the ischemic striatum is necessary to determine their restorative potential...
  25. pmc Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury
    Dunyue Lu
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurotrauma 24:1132-46. 2007
    ..These results suggest that statins may be candidates for treatment of TBI...
  26. pmc The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing
    Jason R Cannon
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, United States
    Behav Brain Res 183:161-8. 2007
    ..The ability of a second cannula insertion with saline infusion to increase dramatically deficits raises questions as to what role physical injury to already susceptible cells might play in the pathogenesis of some cases of PD...
  27. pmc Role of gender in outcome after traumatic brain injury and therapeutic effect of erythropoietin in mice
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Brain Res 1185:301-12. 2007
    ..In addition, the major gender propensity observed in the present study with mice after TBI without treatment is limited to sensorimotor deficits and cell proliferation...
  28. pmc Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats
    Barbara T Felt
    Center for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, 48109, USA
    Behav Brain Res 171:261-70. 2006
    ..We recently reported that rats with chronic perinatal IDA, had altered regional brain iron, monoamines, and sensorimotor skill emergence during early development...
  29. doi request reprint Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurosurg 109:510-21. 2008
    ..This study was designed to investigate the beneficial effects of recombinant human erythropoietin (rhEPO) treatment of traumatic brain injury (TBI) in mice...
  30. pmc Limb use and complex ultrasonic vocalization in a rat model of Parkinson's disease: deficit-targeted training
    Michelle R Ciucci
    Department of Psychology, University of Texas, 1 University Station A8000, Austin, TX 78712, USA
    Parkinsonism Relat Disord 14:S172-5. 2008
    ..These deficits in movement initiation and fine sensorimotor control are potential targets for early training interventions...
  31. pmc Repeated intravenous cocaine experience: development and escalation of pre-drug anticipatory 50-kHz ultrasonic vocalizations in rats
    Sean T Ma
    Department of Psychology and Institute for Neuroscience, University of Texas, Austin, TX 78712, USA
    Behav Brain Res 212:109-14. 2010
    ..USVs may be a useful model for specifically investigating the neural basis of drug anticipation and aid in developing and assessing new addiction treatment strategies for reducing craving and relapse...
  32. pmc Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit
    Yanlu Zhang
    Department of Neurosurgery, Henry Ford Health System, E and R Building, Room 3096, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Brain Res 1294:153-64. 2009
    ....
  33. pmc Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurosurg 113:598-608. 2010
    ..This efficacy study was designed to investigate traumatic brain injury (TBI) in rats treated with delayed erythropoietin (EPO) administered in a single dose compared with a triple dose...
  34. pmc Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Brain Res 1230:247-57. 2008
    ..This study demonstrates for the first time that EPOR null in the nervous system aggravates sensorimotor deficits, impairs cortical neurogenesis and reduces thalamic calcium precipitation after TBI...
  35. ncbi request reprint The interplay between behavior and neurodegeneration in rat models of Parkinson's disease and stroke
    Martin T Woodlee
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
    Restor Neurol Neurosci 22:153-61. 2004
    ..In addition, we stress the need to recognize the reciprocal influence that behavior and the brain can have upon each other...
  36. pmc Long-lasting neural and behavioral effects of iron deficiency in infancy
    Betsy Lozoff
    Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA
    Nutr Rev 64:S34-43; discussion S72-91. 2006
    ..Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function...
  37. doi request reprint Cocaine deprivation effect: cue abstinence over weekends boosts anticipatory 50-kHz ultrasonic vocalizations in rats
    Esther Y Maier
    College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas at Austin, TX 78712, USA
    Behav Brain Res 214:75-9. 2010
    ..The results may have clinical implications, in that intermittently avoiding cues or context may enhance drug cue salience and resistance to extinction...
  38. doi request reprint Alcohol-induced retrograde memory impairment in rats: prevention by caffeine
    Michael J Spinetta
    Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA
    Psychopharmacology (Berl) 201:361-71. 2008
    ..Animal models may help to understand the conditions under which incidental memories formed just before ethanol intoxication might be lost or become difficult to retrieve...
  39. pmc Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration
    Masanobu Okauchi
    Department of Neurosurgery, University of Michigan, Ann Arbor, Mich 48109 2200, USA
    Stroke 41:375-82. 2010
    ..Our previous study found that 50 mg/kg is an effective dose in aged rats. In the present study, we explored potential therapeutic time windows and optimal therapeutic durations...
  40. pmc Delayed transplantation of human marrow stromal cell-seeded scaffolds increases transcallosal neural fiber length, angiogenesis, and hippocampal neuronal survival and improves functional outcome after traumatic brain injury in rats
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202, USA
    Brain Res 1263:183-91. 2009
    ..hMSC-seeded scaffolds may be a new and effective way to improve neurological function after TBI...
  41. pmc Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor
    Ye Xiong
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurotrauma 27:205-15. 2010
    ..These data demonstrate that EPO significantly provides neuroprotection following TBI, even in the absence of EPOR in the neural cells, suggesting that its therapeutic benefits may be mediated through vascular protection...
  42. ncbi request reprint A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice
    Se Hoon Choi
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 156:182-93. 2006
    ..In this way one can assess whether the rodent is continuing to search in the older platform location (i.e., displaying a strategy-switching problem) or whether it has successfully adopted a new search strategy...
  43. ncbi request reprint Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Cereb Blood Flow Metab 24:487-94. 2004
    ..05). These findings suggest that the mouse ICH model is a reproducible and feasible model. These results also suggest that gender and complement C5 are factors affecting brain injury after ICH...
  44. ncbi request reprint Memory processes governing amphetamine-induced psychomotor sensitization
    Stephan G Anagnostaras
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 26:703-15. 2002
    ....
  45. ncbi request reprint Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model
    Jason R Cannon
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA
    Neurosci Lett 373:189-94. 2005
    ..This report presents the new finding that preconditioning (and TPC in particular) provides protection in a 6-OHDA PD model. Understanding the mechanisms involved in TPC-mediated protection may stimulate innovative therapeutic regimens...
  46. doi request reprint Systemic lipopolysaccharide plus MPTP as a model of dopamine loss and gait instability in C57Bl/6J mice
    Stefanie L Byler
    Texas Christian University, Department of Psychology, Fort Worth, TX, USA
    Behav Brain Res 198:434-9. 2009
    ..These data are consistent with the view that nigrostriatal dopamine neurons might succumb after time to multiple toxic agents that independently may have only a transient, adverse effect...
  47. ncbi request reprint Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    Dunyue Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurotrauma 22:1011-7. 2005
    ..These data suggest that EPO treatment initiated 1 day after TBI is neurorestorative by enhancing neurogenesis, as well as neuroprotective...
  48. ncbi request reprint Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury
    Dunyue Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosurg 101:813-21. 2004
    ..The authors tested the effect of atorvastatin on vascular changes after TBI...
  49. ncbi request reprint Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury
    Changsheng Qu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, USA
    J Neurosurg 103:695-701. 2005
    ..Note, however, that parallel studies have not been performed in female rats. Therefore, the authors tested the effect of atorvastatin on TBI in female rats...
  50. doi request reprint Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?
    Martin T Woodlee
    Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
    Exp Neurol 211:511-7. 2008
    ..The relevance of these findings for unilateral rat models of neurological disease is discussed...
  51. ncbi request reprint Long-term effects of experimental intracerebral hemorrhage: the role of iron
    Ya Hua
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Neurosurg 104:305-12. 2006
    ..In this study the authors examine the role of iron in brain atrophy and neurological deficits following ICH...
  52. ncbi request reprint Intracerebral hemorrhage in the iron-deficient rat
    Jie Shao
    Center for Human Growth and Development, University of Michigan, Ann Arbor, USA
    Stroke 36:660-4. 2005
    ....
  53. ncbi request reprint Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Neurosurg 100:672-8. 2004
    ..In the present study the authors investigate whether deferoxamine, an iron chelator, can reduce ICH-induced brain injury...
  54. ncbi request reprint Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage
    Jimin Wu
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 0532, USA
    Brain Res 953:45-52. 2002
    ..In conclusion, oxidative stress caused by components of the lysed erythrocytes contributes to the brain injury after ICH...
  55. ncbi request reprint Long-term effects of sequential cortical infarcts on scar size, brain volume and cognitive function
    Elena V Shanina
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Behav Brain Res 158:69-77. 2005
    ..The present study revealed a complex interaction of lesions in animals with sequential strokes associated with global reduction of brain volume and cognitive impairment indicating degenerative processes beyond the lesions itself...
  56. ncbi request reprint Motor enrichment and the induction of plasticity before or after brain injury
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neurochem Res 28:1757-69. 2003
    ..However, it is possible that, in the chronic stages after brain injury, a regimen of exercise would reactivate mechanisms of plasticity and thus enhance rehabilitation targeting residual functional deficits...
  57. ncbi request reprint Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF
    Ann D Cohen
    Department of Neurology and Center for Neuroscience, University of Pittsburgh, Philadelphia, USA
    J Neurochem 85:299-305. 2003
    ..These results suggest that preinjury forced limb-use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6-OHDA and that this may be due in part to neuroprotective effects of GDNF...
  58. ncbi request reprint A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia
    Li Zhang
    Department of Neurology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    J Neurosci Methods 117:207-14. 2002
    ..The data demonstrate that the corner test is a sensitive and objective test, which can be applied to evaluate long term functional outcome after stroke in the mouse...
  59. ncbi request reprint High-frequency stimulation of the subthalamic nucleus reverses limb-use asymmetry in rats with unilateral 6-hydroxydopamine lesions
    Li Hong Shi
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem NC, 27157, USA
    Brain Res 1013:98-106. 2004
    ..This study is consistent with the possibility that there can be beneficial effects of STN-DBS on behavioral impairments in unilateral DA-depleted rats and may suggest an appropriate rodent model for DBS study...
  60. ncbi request reprint Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine
    Isabella Anna Moroz
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, PQ, Canada
    Exp Neurol 189:78-93. 2004
    ..The potential role of amphetamine-induced endogenous neurotrophic factors in the behavioral sparing and normalization of basal extracellular DA levels observed after subsequent 6-OHDA lesions is discussed...
  61. ncbi request reprint Constraint-induced movement therapy
    James C Grotta
    Department of Neurology Stroke Program, University of Texas Houston Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Stroke 35:2699-701. 2004
    ..More acutely instituted constraint-induced movement therapy has both practical and theoretic risks and benefits that deserve further careful evaluation...
  62. ncbi request reprint Repetitive vibrissae-elicited forelimb placing before and immediately after unilateral 6-hydroxydopamine improves outcome in a model of Parkinson's disease
    Kristin K Anstrom
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Behav Brain Res 179:183-91. 2007
    ..Only the PRE+123 group showed significant sparing of TH-ir compared to the HANDLE group. These data suggest that extensive repetitive exposure to a sensorimotor task may provide therapeutic effects in an animal model of PD...
  63. ncbi request reprint Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone
    Chuan Sheng Zhao
    Department of Neuroscience and Neurology, University of Kuopio, Finland
    Behav Brain Res 160:260-6. 2005
    ..In conclusion, zopiclone was not detrimental and even seemed to improve behavioral outcome without affecting ischemic damage in aged rats subjected to cortical photothrombosis...
  64. ncbi request reprint Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats
    Chuan Sheng Zhao
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Behav Brain Res 156:85-94. 2005
    ..Galanthamine is not beneficial with respect to the histological or functional outcome in rats subjected to cortical photothrombosis...
  65. ncbi request reprint Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury
    Chuan Sheng Zhao
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Behav Brain Res 158:211-20. 2005
    ..The present study showed that an atypical neuroleptic, risperidone, acutely impairs behavioral performance, but does not affect histological or functional outcome in aged rats subjected to cortical photothrombosis...
  66. ncbi request reprint CNS-active drugs in aging population at high risk of cerebrovascular events: evidence from preclinical and clinical studies
    Chuan Sheng Zhao
    Department of Neurology, University of Kuopio, Kuopio, Finland
    Neurosci Biobehav Rev 32:56-71. 2008
    ..The neurobiological mechanisms affected by these drugs are discussed...
  67. ncbi request reprint Psychotropic medication and stroke outcome
    Chuan Sheng Zhao
    Am J Psychiatry 162:1026-7; author reply 1027-8. 2005
  68. ncbi request reprint Plasticity-associated molecular and structural events in the injured brain
    Kathy Keyvani
    Institute of Neuropathology, University of Muenster, Germany
    J Neuropathol Exp Neurol 61:831-40. 2002
    ..This knowledge might also shed light on other forms of brain plasticity, such as those involved in learning processes or ontogeny...
  69. ncbi request reprint Wheel-running modestly promotes functional recovery after a unilateral cortical lesion in rats
    Xiurong Zhao
    Department of Neurology, University of Texas, Medical School, Houston, TX 77030, USA
    Behav Neurol 16:41-9. 2005
    ..We aimed to determine whether early or delayed wheel-running (W) after a cortical lesion in rats influences functional recovery and protein expression involving synaptic plasticity...
  70. pmc Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats
    Kay L Ward
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Nutr 137:1043-9. 2007
    ..These novel data imply that alterations in the metabolite profile of the striatum likely influence later neural functioning in early iron deficiency...
  71. ncbi request reprint Animal models of neurological deficits: how relevant is the rat?
    M Angela Cenci
    Wallenberg Neuroscience Centre, Neurobiology Division, University of Lund, BMC A11, S 221 84 Lund, Sweden
    Nat Rev Neurosci 3:574-9. 2002
    ..Studies in rodents that emphasize careful behavioural analysis should continue to be developed as effective and inexpensive models that complement studies in primates...
  72. ncbi request reprint Forelimb use after focal cerebral ischemia in rats treated with an alpha 2-adrenoceptor antagonist
    Heli Karhunen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, Harjulante 1, 70211, Kuopio, Finland
    Pharmacol Biochem Behav 74:663-9. 2003
    ..05). The data suggest that noradrenergic manipulation does not significantly enhance recovery in a test that does not depend on practice following focal cerebral ischemia...