Matthew A Schaller

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Epigenetic regulation of IL-12-dependent T cell proliferation
    Matthew Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Immunology, Nara Medical University, Nara, Japan and Dermatology Research, Almirall, S A, St Feliu de Llobregat, Spain
    J Leukoc Biol 98:601-13. 2015
  2. pmc Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    Matthew A Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 204:2925-34. 2007
  3. pmc Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1
    Matthew A Schaller
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e12172. 2010
  4. pmc A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation
    Matthew A Schaller
    University of Michigan, Ann Arbor, MI 48109, USA
    Am J Pathol 172:386-94. 2008
  5. doi request reprint TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung
    Amrita D Joshi
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Eur J Immunol 38:3436-49. 2008
  6. pmc CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC
    Lara E Kallal
    Department of Molecular and Cellular Pathology, The University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Immunol 40:1042-52. 2010
  7. pmc Inefficient lymph node sensitization during respiratory viral infection promotes IL-17-mediated lung pathology
    Lara E Kallal
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:4137-47. 2010
  8. ncbi request reprint MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection
    Brian D Rudd
    Department of Pathology, University of Michigan Medical School, 1301 Catherine, Ann Arbor, MI 48109, USA
    J Immunol 178:5820-7. 2007
  9. pmc The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth
    Karen A Cavassani
    Department of Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Blood 115:4403-11. 2010
  10. pmc TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
    Karen A Cavassani
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 205:2609-21. 2008

Collaborators

Detail Information

Publications24

  1. doi request reprint Epigenetic regulation of IL-12-dependent T cell proliferation
    Matthew Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Immunology, Nara Medical University, Nara, Japan and Dermatology Research, Almirall, S A, St Feliu de Llobregat, Spain
    J Leukoc Biol 98:601-13. 2015
    ..Together, our results demonstrate that the MLL1 gene plays a previously unrecognized but essential role in Th1 cell biology and furthermore, describes a novel pathway through which Mll1 expression is regulated. ..
  2. pmc Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    Matthew A Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 204:2925-34. 2007
    ..These data demonstrate that dll4-mediated Notch activation is one regulator of antiviral immunity...
  3. pmc Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1
    Matthew A Schaller
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e12172. 2010
    ..It has also been shown that Notch ligands have diverse functions during T cell activation. We chose to investigate the role of Notch ligands during the Th2 response...
  4. pmc A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation
    Matthew A Schaller
    University of Michigan, Ann Arbor, MI 48109, USA
    Am J Pathol 172:386-94. 2008
    ..Thus, these studies identify CCR1 as a potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease...
  5. doi request reprint TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung
    Amrita D Joshi
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Eur J Immunol 38:3436-49. 2008
    ..Thus, our data suggest that TLR3 has a major regulatory role during a Th2-driven granulomatous response as its absence enhanced immunopathology...
  6. pmc CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC
    Lara E Kallal
    Department of Molecular and Cellular Pathology, The University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Immunol 40:1042-52. 2010
    ..Our data suggest that blockade of the CCL20/CCR6 pathway provides an environment whereby the attenuated recruitment of cDC alters the balance of innate immune cells and mediates the efficient antiviral response to RSV...
  7. pmc Inefficient lymph node sensitization during respiratory viral infection promotes IL-17-mediated lung pathology
    Lara E Kallal
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:4137-47. 2010
    ..Thus, immune cell trafficking to secondary lymph nodes is necessary for appropriate cytokine responses to RSV as well as modulation of the local environment...
  8. ncbi request reprint MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection
    Brian D Rudd
    Department of Pathology, University of Michigan Medical School, 1301 Catherine, Ann Arbor, MI 48109, USA
    J Immunol 178:5820-7. 2007
    ..Taken together, our data indicate that MyD88-mediated pathways are essential for the least pathogenic responses to this viral pathogen through the regulation of important Th1-associated instructive signals...
  9. pmc The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth
    Karen A Cavassani
    Department of Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Blood 115:4403-11. 2010
    ..Together, these data show that the post septic immune system obstructs tumor immunosurveillance, in part, by augmented Treg expansion and function...
  10. pmc TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
    Karen A Cavassani
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 205:2609-21. 2008
    ..Collectively, these data show that TLR3 is a regulator of the amplification of immune response and serves an endogenous sensor of necrosis, independent of viral activation...
  11. pmc Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    Sumanta Mukherjee
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 182:7381-8. 2009
    ..Thus, facilitation of efficient T cell differentiation may depend upon the activation of T cells via specific notch ligand stimulation...
  12. pmc B cell antigen presentation promotes Th2 responses and immunopathology during chronic allergic lung disease
    Dennis M Lindell
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e3129. 2008
    ..While interaction with T cells clearly has implications for B cell function and differentiation, this study investigated the role that B cells have in shaping the T cell response during chronic allergic lung disease...
  13. pmc Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity
    Karen A Cavassani
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e65899. 2013
    ..e. nMuLi). Moreover, TLR3 activation enhanced the expression of phosphorylated JNK in APAP injured livers. Thus, the current study demonstrates that TLR3 activation contributes to APAP-induced hepatotoxicity...
  14. pmc The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection
    Kelsey E Sivick
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 184:2065-75. 2010
    ..These results show that IL-17A is a key mediator for the innate immune response to UTIs...
  15. pmc IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus
    Tine Demoor
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 189:5942-53. 2012
    ..Similarly, viral clearance was rescued upon restored IPS-1 signaling in either the nonimmune or the immune compartment. These data support a nonredundant function for IPS-1 in controlling RSV-induced inflammation and viral replication...
  16. ncbi request reprint Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection
    Brian D Rudd
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 176:1937-42. 2006
    ..Together, these studies highlight that although TLR3 may not be required for viral clearance, it is necessary to maintain the proper immune environment in the lung to avoid developing pathologic symptoms of disease...
  17. ncbi request reprint CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity
    Matthew A Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Eur J Immunol 35:2061-70. 2005
    ..Altogether, these studies highlight a role for CD8(+) T lymphocytes in the development of allergen-induced airway responses...
  18. doi request reprint Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notch
    Nicholas W Lukacs
    University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan 48109 200, USA
    Viral Immunol 21:115-22. 2008
    ..While these mechanisms are likely similar in most respiratory viral infections, this review will focus on findings with respiratory syncytial virus (RSV) infections...
  19. pmc Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology
    Bryan C Petersen
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Nat Med 18:751-8. 2012
    ..These data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population...
  20. ncbi request reprint Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changes
    Haitao Wen
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Leukoc Biol 83:439-46. 2008
    ....
  21. ncbi request reprint The chemokine CCL6 promotes innate immunity via immune cell activation and recruitment
    Ana L Coelho
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Immunol 179:5474-82. 2007
    ..Thus, CCL6 attenuates the immune failure during sepsis, in part, through a protective type 1-cytokine mediated mechanism...
  22. doi request reprint Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection
    Danielle N Kroetz
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 11:e1005338. 2015
    ..Collectively, these findings identify Setdb2 as a novel regulator of the immune system in acute respiratory viral infection. ..
  23. pmc Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma
    Mohammad Fallahi-Sichani
    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA
    PLoS Comput Biol 6:e1000778. 2010
    ..Ultimately, these modeling and experimental results can help identify new strategies for TB disease control/therapy...
  24. doi request reprint Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses
    Anna B Owczarczyk
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 and
    J Immunol 195:1637-46. 2015
    ..These data indicate that SIRT1 promotes DC activation associated with autophagy-mediated processes during RSV infection, thereby directing efficient antiviral immune responses. ..