Research Topics
Genomes and Genes | Matthew A SchallerSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammationMatthew A Schaller
University of Michigan, Ann Arbor, MI 48109, USA
Am J Pathol 172:386-94. 2008..Thus, these studies identify CCR1 as a potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease...- Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokinesMatthew A Schaller
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Exp Med 204:2925-34. 2007..These data demonstrate that dll4-mediated Notch activation is one regulator of antiviral immunity... - Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1Matthew A Schaller
Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 5:e12172. 2010..It has also been shown that Notch ligands have diverse functions during T cell activation. We chose to investigate the role of Notch ligands during the Th2 response... 
TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lungAmrita D Joshi
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
Eur J Immunol 38:3436-49. 2008..Thus, our data suggest that TLR3 has a major regulatory role during a Th2-driven granulomatous response as its absence enhanced immunopathology...- Inefficient lymph node sensitization during respiratory viral infection promotes IL-17-mediated lung pathologyLara E Kallal
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 185:4137-47. 2010..Thus, immune cell trafficking to secondary lymph nodes is necessary for appropriate cytokine responses to RSV as well as modulation of the local environment... - CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DCLara E Kallal
Department of Molecular and Cellular Pathology, The University of Michigan, Ann Arbor, MI 48109, USA
Eur J Immunol 40:1042-52. 2010..Our data suggest that blockade of the CCL20/CCR6 pathway provides an environment whereby the attenuated recruitment of cDC alters the balance of innate immune cells and mediates the efficient antiviral response to RSV... 
MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infectionBrian D Rudd
Department of Pathology, University of Michigan Medical School, 1301 Catherine, Ann Arbor, MI 48109, USA
J Immunol 178:5820-7. 2007..Taken together, our data indicate that MyD88-mediated pathways are essential for the least pathogenic responses to this viral pathogen through the regulation of important Th1-associated instructive signals...- The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growthKaren A Cavassani
Department of Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Blood 115:4403-11. 2010..Together, these data show that the post septic immune system obstructs tumor immunosurveillance, in part, by augmented Treg expansion and function... - TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory eventsKaren A Cavassani
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Exp Med 205:2609-21. 2008..Collectively, these data show that TLR3 is a regulator of the amplification of immune response and serves an endogenous sensor of necrosis, independent of viral activation... - B cell antigen presentation promotes Th2 responses and immunopathology during chronic allergic lung diseaseDennis M Lindell
Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 3:e3129. 2008..While interaction with T cells clearly has implications for B cell function and differentiation, this study investigated the role that B cells have in shaping the T cell response during chronic allergic lung disease... - Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activationSumanta Mukherjee
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 182:7381-8. 2009..Thus, facilitation of efficient T cell differentiation may depend upon the activation of T cells via specific notch ligand stimulation... - The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infectionKelsey E Sivick
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 184:2065-75. 2010..These results show that IL-17A is a key mediator for the innate immune response to UTIs... - Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infectionBrian D Rudd
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 176:1937-42. 2006..Together, these studies highlight that although TLR3 may not be required for viral clearance, it is necessary to maintain the proper immune environment in the lung to avoid developing pathologic symptoms of disease... - IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virusTine Demoor
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 189:5942-53. 2012..Similarly, viral clearance was rescued upon restored IPS-1 signaling in either the nonimmune or the immune compartment. These data support a nonredundant function for IPS-1 in controlling RSV-induced inflammation and viral replication... - Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notchNicholas W Lukacs
University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan 48109 200, USA
Viral Immunol 21:115-22. 2008..While these mechanisms are likely similar in most respiratory viral infections, this review will focus on findings with respiratory syncytial virus (RSV) infections... - CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivityMatthew A Schaller
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA
Eur J Immunol 35:2061-70. 2005..Altogether, these studies highlight a role for CD8(+) T lymphocytes in the development of allergen-induced airway responses... - Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathologyBryan C Petersen
Department of Pathology, University of Michigan, Ann Arbor, USA
Nat Med 18:751-8. 2012..These data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population... - Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changesHaitao Wen
University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
J Leukoc Biol 83:439-46. 2008.... - The chemokine CCL6 promotes innate immunity via immune cell activation and recruitmentAna L Coelho
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Immunol 179:5474-82. 2007..Thus, CCL6 attenuates the immune failure during sepsis, in part, through a protective type 1-cytokine mediated mechanism... - Identification of key processes that control tumor necrosis factor availability in a tuberculosis granulomaMohammad Fallahi-Sichani
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA
PLoS Comput Biol 6:e1000778. 2010..Ultimately, these modeling and experimental results can help identify new strategies for TB disease control/therapy...