F Q Schafer

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
  2. pmc Iron and free radical oxidations in cell membranes
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City 52242 1101, USA
    Cell Mol Biol (Noisy-le-grand) 46:657-62. 2000
  3. ncbi request reprint Acidic pH amplifies iron-mediated lipid peroxidation in cells
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 28:1175-81. 2000
  4. ncbi request reprint Singlet oxygen toxicity is cell line-dependent: a study of lipid peroxidation in nine leukemia cell lines
    F Q Schafer
    Free Radical Research Institute and ESR Facility, University of Iowa, Iowa City 52242 1101, USA
    Photochem Photobiol 70:858-67. 1999
  5. ncbi request reprint Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy
    H P Wang
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, The University of Iowa, Iowa City, 52242-1101, USA
    Free Radic Biol Med 30:825-35. 2001

Collaborators

  • H P Wang
  • F E Domann
  • L W Oberley
  • S Y Qian
  • G R Buettner

Detail Information

Publications5

  1. ncbi request reprint Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
    ..These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress...
  2. pmc Iron and free radical oxidations in cell membranes
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City 52242 1101, USA
    Cell Mol Biol (Noisy-le-grand) 46:657-62. 2000
    ..These data suggest that iron-oxygen complexes are the primary route to the initiation of biological free radical oxidations. This model proposes a mechanism to explain how catalytic iron in brain tissue can be so destructive...
  3. ncbi request reprint Acidic pH amplifies iron-mediated lipid peroxidation in cells
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 28:1175-81. 2000
    ..These data demonstrate that lipid peroxidation processes, mediated by iron, are enhanced with decreasing extracellular pH. Thus, acidic pH not only releases iron from "safe" sites, but this iron will also be more damaging...
  4. ncbi request reprint Singlet oxygen toxicity is cell line-dependent: a study of lipid peroxidation in nine leukemia cell lines
    F Q Schafer
    Free Radical Research Institute and ESR Facility, University of Iowa, Iowa City 52242 1101, USA
    Photochem Photobiol 70:858-67. 1999
    ..This suggests that cellular proteins are a key target for 1O2-mediated toxicity. A remarkable observation is that cell size correlates inversely with ability of cells to cope with a given flux of 1O2...
  5. ncbi request reprint Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy
    H P Wang
    Free Radical and Radiation Biology Program, Department of Radiology, College of Medicine, The University of Iowa, Iowa City, 52242-1101, USA
    Free Radic Biol Med 30:825-35. 2001
    ..Thus, PhGPx activity could contribute to the resistance of tumor cells to PDT...