Thomas Schaer

Summary

Affiliation: U of Penn School of Veterinary Medicine
Location: Kennett Square, USA
Summary:
Dr. Thomas Schaer is the Director of the Comparative Orthopaedic Research Laboratory in the Department of Clinical Studies at the University Of Pennsylvania School Of Veterinary Medicine. Dr. Schaer trained in both human and
veterinary medicine, and completed an internship, residency and lectureship in large animal/equine surgery. He is a
member of the UPENN ULAR Veterinary Care Advisory Board as well as the UPENN IACUC, and is very involved in animal welfare and regulatory issues at the University level. His primary interests are in clinical orthopaedic trauma,
joints, spine, and CMF with a particular interest in the application of novel materials for functional restoration of the musculoskeletal system. In 2005 he started to develop a training program to provide an incubator environment across traditional academic boundaries for undergraduate and graduate education in orthopedic translational and regulatory R&D. He has developed an expertise in large animal surgical models for device development and evaluation, musculoskeletal tissue replacement and repair. These animal models have been developed through numerous funding sources, including both private industry and federal funding agencies. He has a significant amount of experience with developing animal models through discussions with cross-functional groups in the orthopedic biotech arena. Dr. Schaer continues to develop and refine large animal models to improve the predictability of clinical outcome in orthopedic large
animal models as novel therapies are being translated from bench-to-bedside. He has worked as a study director/project manager for over six years, designing and writing preclinical protocols to match the requirements of
multidisciplinary core teams. He has interfaced with regulatory colleagues in the submission of GLP (21CFR58 &
21CFR11)/Pivotal studies to the FDA and coordinated the preclinical requirements of these submissions in GLP/Pivotal
studies.

Publications

  1. ncbi Digitoxin metabolism by rat liver microsomes
    A Schmoldt
    Biochem Pharmacol 24:1639-41. 1975
  2. ncbi Meniscus tissue engineering on the nanoscale: from basic principles to clinical application
    Brendon M Baker
    McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, United States
    J Knee Surg 22:45-59. 2009
  3. ncbi Comparison of the analgesic properties of transdermally administered fentanyl and intramuscularly administered buprenorphine during and following experimental orthopedic surgery in sheep
    Benjamin J Ahern
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 70:418-22. 2009
  4. ncbi Orthopedic infections in equine long bone fractures and arthrodeses treated by internal fixation: 192 cases (1990-2006)
    Benjamin J Ahern
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Vet Surg 39:588-93. 2010
  5. ncbi Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord
    Makarand V Risbud
    Department of Orthopedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 239:2141-8. 2010
  6. ncbi Evaluation of a fiber reinforced drillable bone cement for screw augmentation in a sheep model--mechanical testing
    Benjamin J Ahern
    Comparative Orthopedic Research Laboratory, Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA
    Clin Transl Sci 3:112-5. 2010
  7. ncbi Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep
    Benjamin J Ahern
    Department of Clinical Studies New Bolton Center, Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 71:1127-32. 2010
  8. ncbi Evaluation of equine peripheral blood apheresis product, bone marrow, and adipose tissue as sources of mesenchymal stem cells and their differentation potential
    Benjamin J Ahern
    Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 72:127-33. 2011
  9. ncbi Perioperative ruminal pH changes in domestic sheep (Ovis aries) housed in a biomedical research setting
    Bambi H Jasmin
    University Laboratory Animal Resources, Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
    J Am Assoc Lab Anim Sci 50:27-32. 2011
  10. ncbi Intravenous technetium-99m labelled PEG-liposomes in horses: a safety and biodistribution study
    C Underwood
    Department of Clinical Studies New Bolton Center, Kennett Square, University of Pennsylvania, School of Veterinary Medicine, PA, USA
    Equine Vet J 44:196-202. 2012

Collaborators

Detail Information

Publications25

  1. ncbi Digitoxin metabolism by rat liver microsomes
    A Schmoldt
    Biochem Pharmacol 24:1639-41. 1975
  2. ncbi Meniscus tissue engineering on the nanoscale: from basic principles to clinical application
    Brendon M Baker
    McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, United States
    J Knee Surg 22:45-59. 2009
    ..This review details our progress and outlines the remaining hurdles that must be addressed to translate this work into clinical implementation...
  3. ncbi Comparison of the analgesic properties of transdermally administered fentanyl and intramuscularly administered buprenorphine during and following experimental orthopedic surgery in sheep
    Benjamin J Ahern
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 70:418-22. 2009
    ..To evaluate the analgesic properties of transdermally administered fentanyl and IM administered buprenorphine in sheep undergoing unilateral tibial osteotomy...
  4. ncbi Orthopedic infections in equine long bone fractures and arthrodeses treated by internal fixation: 192 cases (1990-2006)
    Benjamin J Ahern
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Vet Surg 39:588-93. 2010
    ..To determine the rate of postoperative infection (POI) for internal fixation repaired equine long bone fractures and arthrodeses and identify associated risk factors...
  5. ncbi Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord
    Makarand V Risbud
    Department of Orthopedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 239:2141-8. 2010
    ..Thus, the most critical choice for a suitable animal model should relate more to the anatomical and mechanical characteristics of the motion segment than concerns of cell loss and replacement by non-notochordal cells...
  6. ncbi Evaluation of a fiber reinforced drillable bone cement for screw augmentation in a sheep model--mechanical testing
    Benjamin J Ahern
    Comparative Orthopedic Research Laboratory, Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA
    Clin Transl Sci 3:112-5. 2010
    ..9% for 4.5 and 8 mm defects, respectively, when compared to t= 0 testing. Fiber reinforced calcium phosphate bone cement can be drilled and tapped to support orthopedic hardware for trauma applications...
  7. ncbi Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep
    Benjamin J Ahern
    Department of Clinical Studies New Bolton Center, Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 71:1127-32. 2010
    ..To investigate the pharmacokinetics of fentanyl administered transdermally and IV in sheep...
  8. ncbi Evaluation of equine peripheral blood apheresis product, bone marrow, and adipose tissue as sources of mesenchymal stem cells and their differentation potential
    Benjamin J Ahern
    Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 72:127-33. 2011
    ..To evaluate effects of apheresis on mesenchymal stem cells (MSCs) and compare those MSCs with MSCs obtained from adipose tissue or bone marrow (BM)...
  9. ncbi Perioperative ruminal pH changes in domestic sheep (Ovis aries) housed in a biomedical research setting
    Bambi H Jasmin
    University Laboratory Animal Resources, Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
    J Am Assoc Lab Anim Sci 50:27-32. 2011
    ....
  10. ncbi Intravenous technetium-99m labelled PEG-liposomes in horses: a safety and biodistribution study
    C Underwood
    Department of Clinical Studies New Bolton Center, Kennett Square, University of Pennsylvania, School of Veterinary Medicine, PA, USA
    Equine Vet J 44:196-202. 2012
    ..They have potential in equine medicine for targeted drug delivery and diagnostic imaging of infectious, inflammatory and neoplastic lesions...
  11. ncbi Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection
    Thomas P Schaer
    Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348, USA
    Biomaterials 33:1245-54. 2012
    ..Functionalizing orthopedic hardware with hydrophobic polycations thus holds promise in supporting bone healing in the presence of infection in veterinary and human orthopedic patients...
  12. ncbi Preclinical animal models in single site cartilage defect testing: a systematic review
    B J Ahern
    Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    Osteoarthritis Cartilage 17:705-13. 2009
    ..Review the literature for single site cartilage defect research and evaluate the respective strengths and weaknesses of different preclinical animal models...
  13. ncbi Percutaneous endovascular retrieval of an intravascular foreign body in five dogs, a goat, and a horse
    William T N Culp
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 232:1850-6. 2008
    ....
  14. ncbi Comparison of animal discs used in disc research to human lumbar disc: axial compression mechanics and glycosaminoglycan content
    Jesse C Beckstein
    McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104 6081, USA
    Spine (Phila Pa 1976) 33:E166-73. 2008
    ..Experimental measurement and normalization of in vitro disc axial compression mechanics and glycosaminoglycan and water content for several animal species used in intervertebral disc research...
  15. ncbi Review of drug treatment for Down's syndrome persons
    J B Share
    Am J Ment Defic 80:388-93. 1976
    ..There have not been any drugs that have demonstrated remarkable improvement in the status of Down's syndrome individuals that have been widely accepted as effective...
  16. ncbi Proximal interphalangeal arthrodesis in 22 horses
    T P Schaer
    Rood and Riddle Equine Hospital, Lexington, Kentucky, USA
    Equine Vet J 33:360-5. 2001
    ....
  17. ncbi Clostridium perfringens urachitis and uroperitoneum in 2 neonatal foals
    Sallie S Hyman
    Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348, USA
    J Vet Intern Med 16:489-93. 2002
  18. ncbi Conservative management of 17 horses with nonarticular fractures of the tibial tuberosity
    C E Arnold
    Department of Clinical Sciences, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, 382 West Street Road, Kennett Square, Pennsylvania 19348, USA
    Equine Vet J 35:202-6. 2003
    ..POTENTIAL CLINICAL RELEVANCE: This retrospective study suggests that the conservative management of nonarticular FTT is a viable treatment modality in managing athletic equine patients presenting with these fractures...
  19. ncbi Rupture of the gastrocnemius muscle in six foals
    Sophy A Jesty
    Department of Clinical Studies, Section of Medicine, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Am Vet Med Assoc 227:1965-8, 1929. 2005
    ..Moderate to severe gastrocnemius muscle injury is difficult to treat successfully, and the long-term prognosis for athletic function should be regarded as guarded...
  20. ncbi Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment
    Makarand V Risbud
    Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107
    J Cell Biochem 98:152-9. 2006
    ..The study confirmed that HIF-1alpha can be used as a phenotypic marker of nucleus pulposus cells...
  21. ncbi Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: a proof-of-concept study
    Suzanne Stewart
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Bone Joint Surg Am 94:1406-15. 2012
    ..We hypothesized that surface modification of titanium fracture hardware with vancomycin would support bone-healing and prevent bacterial colonization of the implant in a large-animal model...