Katherine L Schaefer

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 120:702-13. 2007
  2. doi request reprint The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin
    Gianni Harris
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 388:345-9. 2009
  3. pmc Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 287:5928-41. 2012
  4. ncbi request reprint Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
    Cancer Res 65:2251-9. 2005
  5. ncbi request reprint PPAR-gamma inhibitors as novel tubulin-targeting agents
    Katherine L Schaefer
    Expert Opin Investig Drugs 16:923-6. 2007
  6. ncbi request reprint Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms
    Katherine L Schaefer
    Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Inflamm Bowel Dis 11:244-52. 2005

Collaborators

Detail Information

Publications6

  1. ncbi request reprint PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 120:702-13. 2007
    ..These results suggest that PPARgamma inhibitors are a novel potential antimicrotubule therapy for CRC that acts by directly reducing microtubule precursors...
  2. doi request reprint The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin
    Gianni Harris
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 388:345-9. 2009
    ..We conclude that T0070907-induced tubulin degradation proceeds through a proteasome-dependent pathway...
  3. pmc Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi
    Nayden G Naydenov
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 287:5928-41. 2012
    ..These results reveal a novel role for αSNAP in promoting epithelial cell survival by unique mechanisms involving regulation of Bcl-2 expression and Golgi biogenesis...
  4. ncbi request reprint Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
    Cancer Res 65:2251-9. 2005
    ..Inhibition of PPARgamma function causes HCC cell death by preventing adhesion and inducing anoikis-mediated apoptosis. PPARgamma inhibitors represent a potential novel treatment approach to HCC...
  5. ncbi request reprint PPAR-gamma inhibitors as novel tubulin-targeting agents
    Katherine L Schaefer
    Expert Opin Investig Drugs 16:923-6. 2007
    ..This observation suggests the possible development of antimicrotubule drugs that target tubulin itself, rather than the equilibrium between tubulin and microtubules...
  6. ncbi request reprint Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms
    Katherine L Schaefer
    Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Inflamm Bowel Dis 11:244-52. 2005
    ..These findings imply the existence of a novel posttranscriptional regulatory antiinflammatory mechanism by TZDs that is not associated with reductions in nuclear factor-kappaB activation...