Katherine L Schaefer
Affiliation: University of Rochester
- PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cellsKatherine L Schaefer
Section of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Cancer 120:702-13. 2007..These results suggest that PPARgamma inhibitors are a novel potential antimicrotubule therapy for CRC that acts by directly reducing microtubule precursors...
- The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulinGianni Harris
Department of Medicine, Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Biochem Biophys Res Commun 388:345-9. 2009..We conclude that T0070907-induced tubulin degradation proceeds through a proteasome-dependent pathway...
- Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the GolgiNayden G Naydenov
Department of Medicine, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 287:5928-41. 2012..These results reveal a novel role for αSNAP in promoting epithelial cell survival by unique mechanisms involving regulation of Bcl-2 expression and Golgi biogenesis...
- Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cellsKatherine L Schaefer
Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
Cancer Res 65:2251-9. 2005..Inhibition of PPARgamma function causes HCC cell death by preventing adhesion and inducing anoikis-mediated apoptosis. PPARgamma inhibitors represent a potential novel treatment approach to HCC...
- PPAR-gamma inhibitors as novel tubulin-targeting agentsKatherine L Schaefer
Expert Opin Investig Drugs 16:923-6. 2007..This observation suggests the possible development of antimicrotubule drugs that target tubulin itself, rather than the equilibrium between tubulin and microtubules...
- Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanismsKatherine L Schaefer
Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts 02118, USA
Inflamm Bowel Dis 11:244-52. 2005..These findings imply the existence of a novel posttranscriptional regulatory antiinflammatory mechanism by TZDs that is not associated with reductions in nuclear factor-kappaB activation...