Affiliation: University of Minnesota
- Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infectionT Schacker
Dept of Medicine Infectious Diseases, University of Minnesota, Box 250 UMHC, 516 Delaware St SE, Minneapolis, MN 55455, USA
J Infect Dis 183:555-62. 2001..Despite the relatively high frequency of productively infected cells in LT, the impact on the size of the T cell population in LT at this stage was minor...
- Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppressionTimothy Schacker
Department of Medicine, University of Minnesota, Minneapolis, 55455, USA
J Infect Dis 186:1718-25. 2002..These data indicate that frequent mucosal HSV reactivation influences HIV replication in vivo and daily HSV suppression may be important in the management of HSV-positive/HIV-positive persons...
- Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapyT Schacker
Department of Medicine Infectious Diseases, University of Minnesota, 216 Delaware St, Minneapolis, MN 55455, USA
J Infect Dis 181:354-7. 2000....
- Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected menT Schacker
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
J Infect Dis 178:1616-22. 1998..Thus, subclinical HSV-2 reactivation is an important opportunistic infection in persons with HIV infection. Further studies are necessaryto determine the impact of subclinical HSV-2 reactivation on the natural history of HIV infection...
- The role of HSV in the transmission and progression of HIVT Schacker
Department of Medicine, University of Minnesota, Division of Infectious Diseases, Box 250, 516 Delaware Street, Minneapolis, MN 55055, USA
Herpes 8:46-9. 2001....
- Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDSM M Berrey
Department of Medicine, University of Washington, Seattle, WA, USA
J Infect Dis 183:1466-75. 2001..Combination antiretroviral therapy during primary HIV-1 infection demonstrated a decreased frequency of minor opportunistic infections, mucocutaneous disorders, and respiratory infections and reduced progression to AIDS...
- Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infectionU Malhotra
Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
J Infect Dis 181:121-31. 2000..The amplified HIV-1-specific T-cell responses may help maintain cytotoxic activities...
- Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell countTimothy W Schacker
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
AIDS 19:2169-71. 2005..001). This suggests that collagen-targeted therapies might be of benefit...
- Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjectsMitchell D Krathwohl
Department of Medicine, University of Minnesota, Minneapolis, USA
J Infect Dis 193:494-504. 2006..We conclude that HIV infection correlates with the presence of semimature DCs that stimulate T cell tolerance rather than immunity. These regulatory T cells may contribute to the lack of effective HIV immune responses...
- Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infectionTimothy W Schacker
Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, MN 55455, USA
Clin Vaccine Immunol 13:556-60. 2006....
- Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
- Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infectionQingsheng Li
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
J Infect Dis 192:1269-76. 2005....
- CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
J Exp Med 200:749-59. 2004....
- Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjectsEdwin DeJesus
Infectious Disease Consultants, Altamonte Springs, Florida 32701, USA
J Infect Dis 188:1009-16. 2003..There were no episodes of thrombotic microangiopathy. Valacyclovir was safe and effective for the suppression of recurrent genital herpes infection in HIV-infected individuals...
- Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasisTimothy W Schacker
Department of Medicine Infectious Diseases, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis, Minnesota 55455, USA
J Clin Invest 110:1133-9. 2002....
- Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapyTimothy W Schacker
Department of Medicine, University of Minnesota, MMC 250, 516 Delaware Street, Minneapolis MN 55455, USA
J Infect Dis 186:1092-7. 2002....
- Imiquimod 5-percent cream does not alter the natural history of recurrent herpes genitalis: a phase II, randomized, double-blind, placebo-controlled studyTimothy W Schacker
University of Minnesota, Minneapolis 55455, USA
Antimicrob Agents Chemother 46:3243-8. 2002....
- Concentration-controlled compared with conventional antiretroviral therapy for HIV infectionCourtney V Fletcher
Department of Experimental and Clinical Pharmacology, University of Minnesota Academic Health Sciences Center, Minneapolis, MN, USA
AIDS 16:551-60. 2002..To demonstrate the feasibility of a concentration-controlled approach to combination antiretroviral therapy, and to compare the virological responses and safety of this strategy versus conventional fixed-dose therapy...
- Collagen deposition limits immune reconstitution in the gutJacob Estes
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Infect Dis 198:456-64. 2008....
- Ex vivo modeling of oral HIV transmission in human palatine tonsilDiane M Maher
Department of Microbiology, MMC 196, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Histochem Cytochem 53:631-42. 2005....
- Inguinal lymph node biopsy in patients infected with the human immunodeficiency virus is safeDavid E Skarda
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Surg Infect (Larchmt) 8:173-8. 2007..Additionally, we monitored the rates of other complications, namely, hematoma, dorsal vein thrombosis, epididymitis, lymphocele, and suture extrusion...
- Accuracy of herpes simplex virus detection in liquid-based (SurePath) Papanicolaou tests: a comparison with polymerase chain reactionDeniz L Aslan
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Fairview University Medical Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Diagn Cytopathol 36:94-103. 2008..Real-time PCR was positive in 8 of 8 cases diagnosed as HSV and none of the 32 controls. We conclude that LBPT allows an increased detection of HSV that is highly accurate...