J Schacht

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention
    Jochen Schacht
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 5616, USA
    Anat Rec (Hoboken) 295:1837-50. 2012
  2. ncbi request reprint Sketches of otohistory. Part 6: Gustaf Retzius
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48105 0506, USA
    Audiol Neurootol 10:65-8. 2005
  3. ncbi request reprint Sketches of otohistory. Part 9: presby[a]cusis
    Jochen Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48109 0506, USA
    Audiol Neurootol 10:243-7. 2005
  4. ncbi request reprint Biochemistry and pharmacology of aminoglycoside-induced hearing loss
    J Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109, USA
    Acta Physiol Pharmacol Ther Latinoam 49:251-6. 1999
  5. ncbi request reprint Antioxidant therapy attenuates aminoglycoside-induced hearing loss
    J Schacht
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0506, USA
    Ann N Y Acad Sci 884:125-30. 1999
  6. ncbi request reprint Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss
    Jochen Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, 48109, USA
    Audiol Neurootol 11:1-6. 2006
  7. ncbi request reprint Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea
    Yoshimitsu Ohinata
    Kresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, Michigan, MI 48109 0506, USA
    Brain Res 966:265-73. 2003
  8. ncbi request reprint NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 79:644-51. 2005
  9. ncbi request reprint Sketches of otohistory. Part 10: noise-induced hearing loss
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Audiol Neurootol 10:305-9. 2005
  10. pmc A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss
    M Angeles Vicente-Torres
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    J Neurosci Res 83:1564-72. 2006

Research Grants

  1. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2007
  2. Administration Structure
    Jochen Schacht; Fiscal Year: 2007
  3. Oxidative Stress Pathways in Noise Induced Hearing Loss
    Jochen Schacht; Fiscal Year: 2005
  4. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2002
  5. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2010

Collaborators

Detail Information

Publications45

  1. pmc Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention
    Jochen Schacht
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 5616, USA
    Anat Rec (Hoboken) 295:1837-50. 2012
    ..Finally, based on an understanding the mechanisms of ototoxicity pharmaceutical ways of protection of the cochlea are presented...
  2. ncbi request reprint Sketches of otohistory. Part 6: Gustaf Retzius
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48105 0506, USA
    Audiol Neurootol 10:65-8. 2005
  3. ncbi request reprint Sketches of otohistory. Part 9: presby[a]cusis
    Jochen Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48109 0506, USA
    Audiol Neurootol 10:243-7. 2005
  4. ncbi request reprint Biochemistry and pharmacology of aminoglycoside-induced hearing loss
    J Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109, USA
    Acta Physiol Pharmacol Ther Latinoam 49:251-6. 1999
    ..The review concludes with recent advances that have demonstrated free-radical reactions as the underlying mechanism and intervention with antioxidant/chelation therapy to prevent aminoglycoside ototoxicity...
  5. ncbi request reprint Antioxidant therapy attenuates aminoglycoside-induced hearing loss
    J Schacht
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0506, USA
    Ann N Y Acad Sci 884:125-30. 1999
    ..This finding may lead to a safe and effective way to eliminate the threat of ototoxicity of this commonly used class of antibiotics...
  6. ncbi request reprint Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss
    Jochen Schacht
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, 48109, USA
    Audiol Neurootol 11:1-6. 2006
  7. ncbi request reprint Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea
    Yoshimitsu Ohinata
    Kresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, Michigan, MI 48109 0506, USA
    Brain Res 966:265-73. 2003
    ..NMDA receptors and, to some extent, NOS may be involved in noise-induced ROS formation. The data also indicate that lipid peroxidation in the lateral wall tissues does not influence permanent threshold shifts...
  8. ncbi request reprint NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 79:644-51. 2005
    ..These results suggest that changes in the redox state of the cochlea stimulate the activation of NF-kappaB and that this activation is cell protective...
  9. ncbi request reprint Sketches of otohistory. Part 10: noise-induced hearing loss
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Audiol Neurootol 10:305-9. 2005
  10. pmc A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss
    M Angeles Vicente-Torres
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
    J Neurosci Res 83:1564-72. 2006
    ..The translocation of BAD to the mitochondria in degenerating cells is indicative of the activation of its proapoptotic capacity, whereas up-regulation of phospho-BAD is consistent with a nonapoptotic role of BAD in less vulnerable cells...
  11. pmc Creatine and tempol attenuate noise-induced hearing loss
    Shujiro B Minami
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Brain Res 1148:83-9. 2007
    ..Our results indicate that the maintenance of ATP levels is important in attenuating both temporary and permanent NIHL, while the scavenging of free radicals provides protection from permanent NIHL...
  12. ncbi request reprint Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss
    S H Sha
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Mich 48109-0506, USA
    Audiol Neurootol 6:117-23. 2001
    ..The results also suggest transgenic animals as suitable models to investigate the underlying mechanisms and possible strategies for prevention...
  13. ncbi request reprint Sketches of otohistory part 4: a cell by any other name: cochlear eponyms
    Jochen Schacht
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Audiol Neurootol 9:317-27. 2004
  14. ncbi request reprint Antioxidant protection in a new animal model of cisplatin-induced ototoxicity
    Shujiro B Minami
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Hear Res 198:137-43. 2004
    ..The results also support the notion that reactive oxygen species are involved in cisplatin ototoxicity and show the potential usefulness of antioxidant treatment...
  15. ncbi request reprint Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat
    W J Wu
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA
    Hear Res 158:165-78. 2001
    ..Pigmentation, however, paralleled this rank order suggesting an influence of melanin on cochlear antioxidant status...
  16. ncbi request reprint Sketches of otohistory. Part 8: The emergence of vestibular science
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Audiol Neurootol 10:185-90. 2005
  17. pmc Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA
    J Neurosci Res 83:1544-51. 2006
    ..These changes will ultimately contribute to aminoglycoside-induced loss of hair cells...
  18. pmc Oxidative imbalance in the aging inner ear
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Neurobiol Aging 28:1605-12. 2007
    ..An imbalance of redox status may be a component of age-related hearing loss...
  19. ncbi request reprint Biochemical basis of aminoglycoside ototoxicity
    J Schacht
    Kresge Hearing Research Institute, University of Michigan School of Medicine, Ann Arbor
    Otolaryngol Clin North Am 26:845-56. 1993
    ....
  20. ncbi request reprint Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
    S H Sha
    Kresge Hearing Research Institute, University of Michigan, MI 48109-0506, USA
    Hear Res 155:1-8. 2001
    ..The results support an intrinsic susceptibility to free radicals that differs among cochlear cell populations. This differential provides a rational explanation for base-to-apex gradients observed in various forms of cochlear pathology...
  21. ncbi request reprint Sketches of otohistory. Part 7: The nineteenth-century rise of laryngology
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Audiol Neurootol 10:130-3. 2005
  22. ncbi request reprint Calcineurin activation contributes to noise-induced hearing loss
    Shujiro B Minami
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    J Neurosci Res 78:383-92. 2004
    ..The results suggest that calcineurin inhibitors are of potential therapeutic value for long-term protection of the morphologic integrity and function of the organ of Corti against noise trauma...
  23. pmc Age-related auditory pathology in the CBA/J mouse
    Su Hua Sha
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 5616, USA
    Hear Res 243:87-94. 2008
    ..The superimposed early hearing loss at low frequencies, which is not seen in animals bred in-house, may complicate the use of these animals as a presbycusis model...
  24. pmc PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse
    Su Hua Sha
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Hear Res 264:86-92. 2010
    ..The results suggest a decline of the survival capacity of aging outer hair cells due to a decrease in PIP(3)/Akt signaling caused by an increase of PTEN...
  25. ncbi request reprint 8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow
    Josef M Miller
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    Audiol Neurootol 8:207-21. 2003
    ..Prevention of isoprostane-mediated vasoconstriction may have clinical utility in the protection from noise-induced hearing loss...
  26. pmc Activation of cell death pathways in the inner ear of the aging CBA/J mouse
    Su Hua Sha
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109, USA
    Hear Res 254:92-9. 2009
    ..The results suggest that multiple cell death pathways, all potentially linked to oxidative stress, are activated in hair cells of the auditory organ in aging mice...
  27. pmc Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo
    Ai Mei Wang
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    Antimicrob Agents Chemother 47:1836-41. 2003
    ..Such traditional medicines are widely used in many developing countries and could become an easily accepted and inexpensive protective therapy...
  28. ncbi request reprint Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest alpha9-like receptors
    T Matsunobu
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 49109-0506, USA
    J Neurosci Res 63:252-6. 2001
    ..Nicotine was an ineffective agonist. The pharmacologic profile and the kinetics of the calcium response suggest an alpha9-like ACh receptor on Deiters' cells similar but not identical to that on the outer hair cells...
  29. ncbi request reprint Sketches of otohistory. Part 3: Alfonso Corti
    Joseph E Hawkins
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48109, USA
    Audiol Neurootol 9:259-64. 2004
  30. ncbi request reprint AIF and EndoG in noise-induced hearing loss
    Daisuke Yamashita
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Neuroreport 15:2719-22. 2004
    ..These findings indicate that EndoG is a factor in noise-induced caspase-independent apoptosis. In contrast, AIF may not be involved in cell death, but act as a redox factor in response to noise-induced oxidant stress...
  31. ncbi request reprint Pharmacokinetics of aminoglycoside antibiotics in blood, inner-ear fluids and tissues and their relationship to ototoxicity
    C M Henley
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor
    Audiology 27:137-46. 1988
    ..A sequence of biochemical events that may lead to the development of toxicity at the molecular level is briefly described...
  32. ncbi request reprint Sketches of otohistory: part 5: Prosper Ménière: physician, botanist, classicist, diarist and historian
    Joseph E Hawkins
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Audiol Neurootol 10:1-5. 2005
  33. ncbi request reprint Sketches of otohistory. Part 2: origins of otology in the British Isles: Wilde And Toynbee
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48109 0506, USA
    Audiol Neurootol 9:129-34. 2004
  34. ncbi request reprint Sketches of otohistory. Part 1: otoprehistory: how it all began
    Joseph E Hawkins
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich, USA
    Audiol Neurootol 9:66-71. 2004
  35. ncbi request reprint Recent advances in understanding aminoglycoside ototoxicity and its prevention
    Wei jing Wu
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Mich, USA
    Audiol Neurootol 7:171-4. 2002
    ....
  36. pmc Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea
    Fu Quan Chen
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, USA
    J Neurochem 108:1226-36. 2009
    ..The results are consistent with an involvement of deficient histone acetylation in aminoglycoside-induced hair cell death and point to the potential value of HDAC-inhibitors in protection from the side effects of these drugs...
  37. ncbi request reprint Delayed production of free radicals following noise exposure
    Daisuke Yamashita
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
    Brain Res 1019:201-9. 2004
    ..The late formation of free radicals may provide a window of opportunity for pharmacological rescue immediately following exposure, requiring both ROS and RNS scavengers...
  38. ncbi request reprint Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action
    Geming Li
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
    Lab Invest 82:585-96. 2002
    ..The results suggest that administration of salicylate may become the basis of an effective therapeutic intervention against the ototoxic and nephrotoxic side effects associated with CDDP chemotherapy...
  39. pmc ATP and nitric oxide modulate intracellular calcium in isolated pillar cells of the guinea pig cochlea
    J W Chung
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506, USA
    J Assoc Res Otolaryngol 2:399-407. 2001
    ..The results indicate the involvement of purinergic mechanisms and the nitric oxide/cyclic GMP/protein kinase G pathway in the regulation of [Ca2+]i in cochlear pillar cells...
  40. pmc Caspase-independent pathways of hair cell death induced by kanamycin in vivo
    H Jiang
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Cell Death Differ 13:20-30. 2006
    ..These results provide a better understanding of the toxic effects of aminoglycosides and are relevant to design protection from aminoglycoside-induced hearing loss...
  41. ncbi request reprint Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA
    J Neurochem 99:269-76. 2006
    ..These actions may contribute to the death of outer hair cells, which is a consequence of chronic kanamycin treatment...
  42. pmc Emerging treatments for noise-induced hearing loss
    Naoki Oishi
    Kresge Hearing Research Institute, Medical Sciences Bldg I, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5616, USA
    Expert Opin Emerg Drugs 16:235-45. 2011
    ..This review discusses pharmacological strategies to attenuate NIHL that have been developed in animal models and that are now beginning to be tested in field trials...
  43. ncbi request reprint Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity
    Wojciech Lesniak
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109, USA
    Inorg Chem 42:1420-9. 2003
    ..Further, once introduced into aqueous solution, histidine replaces gentamicin in Cu(II)-gentamicin complexes. Therefore, Cu(II)-gentamicin complexes might not exist under physiological conditions...
  44. ncbi request reprint An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern
    Wojciech Lesniak
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, 1331 E Ann, Ann Arbor, MI 48109 0506, USA
    Carbohydr Res 338:2853-62. 2003
    ..The protonation pattern of the separated gentamicins was determined by potentiometry and 15N and 1H NMR. The full proton NMR assignment for gentamicin C-1 was obtained through the use of 1H 1D and 2D 1H-1H COSY measurements...
  45. ncbi request reprint Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species
    Wojciech Lesniak
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Chem Res Toxicol 18:357-64. 2005
    ..Arachidonic acid also forms a ternary complex with Fe(2+/3+)-gentamicin, confirmed by ESI-MS, that reacts with lipid peroxides and molecular oxygen, leading to the propagation of arachidonic acid peroxidation...

Research Grants20

  1. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2007
    ..The attenuation or prevention of adverse effects of aminoglycosides will have far reaching implications for the continued but safe use of a family of drugs whose primary efficacy is unquestioned. ..
  2. Administration Structure
    Jochen Schacht; Fiscal Year: 2007
    ..carry out or facilitate contacts with University of Michigan administration and granting agencies; 5. coordinate the submission of progress reports and renewal grant applications. ..
  3. Oxidative Stress Pathways in Noise Induced Hearing Loss
    Jochen Schacht; Fiscal Year: 2005
    ..abstract_text> ..
  4. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2002
    ..The prevention or amelioration of adverse effects of aminoglycoside antibiotics will have far reaching implications for the continued but safe use of a family of drugs whose primary efficacy is unquestioned. ..
  5. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2010
    ..They do, however, cause hearing loss in 15-20% of patients, and will provide novel insights into the molecular mechanisms of their toxicity and aid in the design of new and effective therapeutic protection. ..