PHILIP SCARPACE

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. request reprint
    Scarpace P, Matheny M, Zolotukhin S, Tumer N, Zhang Y. Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology. 2003;45:211-9 pubmed
    ..We suggest that defective endogenous melanocortin activation may represent one element of leptin resistance, leading to compensatory hypersensitivity of the melanocortin pathway. ..
  2. Anton S, Woods A, Ashizawa T, Barb D, Buford T, Carter C, et al. Successful aging: Advancing the science of physical independence in older adults. Ageing Res Rev. 2015;24:304-27 pubmed publisher
    ..With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults. ..
  3. request reprint
    Scarpace P, Matheny M, Zhang Y, Cheng K, Tumer N. Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance. J Pharmacol Exp Ther. 2007;320:706-12 pubmed
    ..These data reveal an uncoupling between leptin receptor activation and metabolic responses with central leptin resistance. ..
  4. Scarpace P, Matheny M, Zhang Y. Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area. Physiol Behav. 2010;100:173-9 pubmed publisher
    ..Moreover, WR enhances leptin signaling specifically in the VTA, suggestive of a WR-evoked mechanism of heightened leptin function in the VTA to curb the drive to consume palatable HF foods. ..
  5. Scarpace P, Matheny M, Strehler K, Toklu H, Kirichenko N, Carter C, et al. Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats. J Gerontol A Biol Sci Med Sci. 2016;71:891-9 pubmed publisher
    ..This coupled with potential peripheral mechanism serves to decrease adiposity and synthesis of leptin. ..
  6. Strehler K, Matheny M, Kirichenko N, Sakarya Y, Bruce E, Toklu H, et al. Onset of leptin resistance shows temporal differences related to dose or pulsed treatment. Eur J Pharmacol. 2016;779:177-85 pubmed publisher
    ..The positive benefit for pulsed delivery remains speculative, yet potentially may provide an alternative mode of leptin therapy. ..
  7. Toklu H, Muller Delp J, Sakaraya Y, Oktay S, Kirichenko N, Matheny M, et al. High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function. J Physiol Pharmacol. 2016;67:205-16 pubmed
    ..These data suggest that the presence of high fructose in a HF diet does not exacerbate the detrimental consequences of a HF diet on basilar artery function. ..
  8. request reprint
    Scarpace P, Matheny M, Zhang Y, Shek E, Prima V, Zolotukhin S, et al. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology. 2002;143:3026-35 pubmed
    ..We propose that both elevated leptin and obesity may be necessary for the development of leptin resistance. ..
  9. request reprint
    Scarpace P, Matheny M, Tumer N, Cheng K, Zhang Y. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia. 2005;48:1075-83 pubmed
    ..This, coupled with potential hypersensitivity to insulin, creates a milieu favouring fat deposition. Our data suggest that leptin resistance is both a consequence and cause of obesity. ..

More Information

Publications12

  1. Scarpace P, Matheny M, Kirichenko N, Gao Y, Tümer N, Zhang Y. Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes. Neuropharmacology. 2013;65:90-100 pubmed publisher
  2. Côté I, Sakarya Y, Green S, Morgan D, Carter C, Tumer N, et al. iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00219.2017 pubmed publisher
    ..In summary, iBAT denervation did not prevent body weight loss following central leptin gene delivery. The present data shows that sympathetic innervation of iBAT is not essential for leptin-induced body weight loss...
  3. Côté I, Green S, Morgan D, Carter C, Tumer N, Scarpace P. Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction. Can J Physiol Pharmacol. 2018;96:308-312 pubmed publisher
    ..In summary, it can be concluded that activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction. ..