MICHAEL SAXTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Modeling 2D and 3D diffusion
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, USA
    Methods Mol Biol 400:295-321. 2007
  2. pmc Fluorescence corralation spectroscopy
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    Biophys J 89:3678-9. 2005
  3. pmc Anomalous diffusion due to binding: a Monte Carlo study
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Biophys J 70:1250-62. 1996
  4. ncbi request reprint Single-particle tracking: applications to membrane dynamics
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Annu Rev Biophys Biomol Struct 26:373-99. 1997
  5. pmc A biological interpretation of transient anomalous subdiffusion. I. Qualitative model
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    Biophys J 92:1178-91. 2007
  6. pmc Wanted: a positive control for anomalous subdiffusion
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California, USA
    Biophys J 103:2411-22. 2012
  7. pmc Two-dimensional continuum percolation threshold for diffusing particles of nonzero radius
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA
    Biophys J 99:1490-9. 2010
  8. pmc A biological interpretation of transient anomalous subdiffusion. II. Reaction kinetics
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA
    Biophys J 94:760-71. 2008
  9. pmc Anomalous subdiffusion in fluorescence photobleaching recovery: a Monte Carlo study
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis, California 95616, USA
    Biophys J 81:2226-40. 2001
  10. pmc Single-particle tracking: the distribution of diffusion coefficients
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Biophys J 72:1744-53. 1997

Collaborators

  • R W Breidenbach
  • Yuen Keng Ng
  • Weiping Han
  • Alexandra Gulacsi
  • Xinghua Lu
  • Edwin S Levitan

Detail Information

Publications13

  1. ncbi request reprint Modeling 2D and 3D diffusion
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, USA
    Methods Mol Biol 400:295-321. 2007
    ..Random number generation is reviewed in the context of random walk simulations. Programming techniques and event-driven algorithms are discussed as ways to speed simulations...
  2. pmc Fluorescence corralation spectroscopy
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    Biophys J 89:3678-9. 2005
  3. pmc Anomalous diffusion due to binding: a Monte Carlo study
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Biophys J 70:1250-62. 1996
    ..Thermal equilibration leads to normal diffusion, or to diffusion as normal as the obstacles allow...
  4. ncbi request reprint Single-particle tracking: applications to membrane dynamics
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Annu Rev Biophys Biomol Struct 26:373-99. 1997
    ..The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics...
  5. pmc A biological interpretation of transient anomalous subdiffusion. I. Qualitative model
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    Biophys J 92:1178-91. 2007
    ..This physical model is translated directly into a plausible biological model testable by single-particle tracking...
  6. pmc Wanted: a positive control for anomalous subdiffusion
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California, USA
    Biophys J 103:2411-22. 2012
    ....
  7. pmc Two-dimensional continuum percolation threshold for diffusing particles of nonzero radius
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA
    Biophys J 99:1490-9. 2010
    ..To our knowledge, such a strong dependence has so far not been reported for the plasma membrane, suggesting that percolation is not the factor controlling lateral diffusion. A definitive experiment is proposed...
  8. pmc A biological interpretation of transient anomalous subdiffusion. II. Reaction kinetics
    Michael J Saxton
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA
    Biophys J 94:760-71. 2008
    ..This analysis predicts the distribution function for a lattice with perfect mixing; deviations reflect imperfect mixing in an ordinary random walk...
  9. pmc Anomalous subdiffusion in fluorescence photobleaching recovery: a Monte Carlo study
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis, California 95616, USA
    Biophys J 81:2226-40. 2001
    ..The extreme fluctuations in the recovery curves at and near the percolation threshold result from extreme fluctuations in the geometry of the percolation cluster...
  10. pmc Single-particle tracking: the distribution of diffusion coefficients
    M J Saxton
    Institute of Theoretical Dynamics, University of California, Davis 95616, USA
    Biophys J 72:1744-53. 1997
    ..To aid in the analysis of single-particle tracking measurements, the distribution of D is examined for various definitions of D and for various trajectory lengths...
  11. pmc Heat generation and dissipation in plants: can the alternative oxidative phosphorylation pathway serve a thermoregulatory role in plant tissues other than specialized organs?
    R W Breidenbach
    Thermalytics, Inc, West Sacramento, California 95691, USA
    Plant Physiol 114:1137-40. 1997
    ..1992), adapted to a large range of temperature climates. This results is consistent with the general relation between the apparent alternative oxidase activity and the climate of origin of the species...
  12. pmc Unexpected mobility variation among individual secretory vesicles produces an apparent refractory neuropeptide pool
    Yuen Keng Ng
    Department of Pharmacology, E1351 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biophys J 84:4127-34. 2003
    ..This unexpected variation, which could reflect heterogeneity among vesicles or in their medium, is shown to generate the appearance of a regulated refractory neuropeptide pool...
  13. doi request reprint Single-particle tracking: connecting the dots
    Michael J Saxton
    Nat Methods 5:671-2. 2008

Research Grants20

  1. Lateral Diffusion in an Archipelago: Monte Carlo Studies
    Michael J Saxton; Fiscal Year: 2010
    ..physical basis for this communication, asking: How is the cell surface organized for signaling? How do proteins and protein complexes move and find their biological targets in the crowded environments of the cell surface and interior? ..
  2. LATERAL DIFFUSION IN AN ARCHIPELAGO--MONTE CARLO STUDIES
    MICHAEL SAXTON; Fiscal Year: 2001
    ..Additional work will consider the effect of obstruction on three-dimensional diffusion in cytoplasm. ..
  3. LATERAL DIFFUSION IN AN ARCHIPELAGO: MONTE CARLO STUDIES
    MICHAEL SAXTON; Fiscal Year: 2003
    ..Other 3d work will model diffusion obstructed by the simplest geometric model of the cytoskeleton, and SPT of Cajal bodies in the nucleus. ..
  4. LATERAL DIFFUSION IN AN ARCHIPELAGO: MONTE CARLO STUDIES
    MICHAEL SAXTON; Fiscal Year: 2006
    ..Other 3d work will model diffusion obstructed by the simplest geometric model of the cytoskeleton, and SPT of Cajal bodies in the nucleus. ..
  5. LATERAL DIFFUSION IN AN ARCHIPELAGO: MONTE CARLO STUDIES
    MICHAEL SAXTON; Fiscal Year: 1992
    ..The results can be used to model the effects of missing or defective spectrin, as in hereditary hemolytic anemia, and to model the changes in diffusion and elasticity as the membrane skeleton is assembled during cell development...
  6. LATERAL DIFFUSION IN AN ARCHIPELAGO--MONTE CARLO STUDIES
    MICHAEL SAXTON; Fiscal Year: 1993
    ..The model will be further extended to three dimensions to examine the consequences of damage to the cytoskeleton in a wide variety of disorders...