J Saxton

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi Memantine and functional communication in Alzheimer's disease: results of a 12-week, international, randomized clinical trial
    Judith Saxton
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213 2536, USA
    J Alzheimers Dis 28:109-18. 2012
  2. pmc Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimer's disease
    Steven H Ferris
    Alzheimer Disease Center, Centre of Excellence on Brain Aging, New York University Langone Medical Center, 145 East 32nd Street, New York, NY 10016, USA
    Alzheimers Res Ther 3:22. 2011
  3. pmc Computer assessment of mild cognitive impairment
    Judith Saxton
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Postgrad Med 121:177-85. 2009
  4. pmc Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia
    J Saxton
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 80:737-43. 2009
  5. ncbi Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
  6. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
  7. ncbi Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
  8. ncbi Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset
    J Saxton
    University of Pittsburgh, Oxford Building, Room 738, Pittsburgh, PA 15213, USA
    Neurology 63:2341-7. 2004
  9. ncbi Cognitive test performance and presence of subclinical cardiovascular disease in the cardiovascular health study
    J Saxton
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroepidemiology 19:312-9. 2000
  10. ncbi Normative data on the Boston Naming Test and two equivalent 30-item short forms
    J Saxton
    Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    Clin Neuropsychol 14:526-34. 2000

Research Grants

Detail Information

Publications30

  1. doi Memantine and functional communication in Alzheimer's disease: results of a 12-week, international, randomized clinical trial
    Judith Saxton
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213 2536, USA
    J Alzheimers Dis 28:109-18. 2012
    ..5; p = 0.022), compared with placebo-treated patients (n = 124). Memantine had a low incidence of adverse events. In patients with moderate AD, memantine treatment improved functional communication, as recognized by caregivers...
  2. pmc Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimer's disease
    Steven H Ferris
    Alzheimer Disease Center, Centre of Excellence on Brain Aging, New York University Langone Medical Center, 145 East 32nd Street, New York, NY 10016, USA
    Alzheimers Res Ther 3:22. 2011
    ....
  3. pmc Computer assessment of mild cognitive impairment
    Judith Saxton
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Postgrad Med 121:177-85. 2009
    ..In contrast, the CAMCI was highly sensitive (86%) and specific (94%) for the identification of MCI in a population of community-dwelling nondemented elderly individuals...
  4. pmc Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia
    J Saxton
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 80:737-43. 2009
    ..To compare rates of mild cognitive impairment (MCI) and rates of progression to dementia using different MCI diagnostic systems...
  5. ncbi Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  6. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  7. ncbi Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
    ....
  8. ncbi Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset
    J Saxton
    University of Pittsburgh, Oxford Building, Room 738, Pittsburgh, PA 15213, USA
    Neurology 63:2341-7. 2004
    ..To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset...
  9. ncbi Cognitive test performance and presence of subclinical cardiovascular disease in the cardiovascular health study
    J Saxton
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroepidemiology 19:312-9. 2000
    ..These results add to the evidence that, in addition to other health implications, cardiovascular disease is related to cognitive functioning in the elderly even at subclinical levels...
  10. ncbi Normative data on the Boston Naming Test and two equivalent 30-item short forms
    J Saxton
    Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    Clin Neuropsychol 14:526-34. 2000
    ..Age and education norms are presented using an overlapping midpoint interval strategy...
  11. ncbi Functional neuroimaging indicators of successful executive control in the oldest old
    C Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15260, USA
    Neuroimage 28:881-9. 2005
    ..Older adults who are able to perform executive control tasks as well as young adults, also seem to implement speed-accuracy trade-off strategies which may rely on increased parietal activation...
  12. pmc Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 19:169-75. 2011
    ....
  13. pmc Temporal stability of receptiveness to clinical research on Alzheimer disease
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA
    Alzheimer Dis Assoc Disord 24:S30-4. 2010
    ..This finding has relevance for the policy debate around research advance directives, an approach which assumes that preferences with regard to research participation are consistent over time...
  14. pmc Cognitive test performance predicts change in functional status at the population level: the MYHAT Project
    Mary Ganguli
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Int Neuropsychol Soc 16:761-70. 2010
    ..At the population level, changes in both directions are observable in functional status, with different neuropsychological measures predicting the direction of change...
  15. pmc Age and education effects and norms on a cognitive test battery from a population-based cohort: the Monongahela-Youghiogheny Healthy Aging Team
    Mary Ganguli
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Aging Ment Health 14:100-7. 2010
    ..Performance on cognitive tests can be affected by age, education, and also selection bias. We examined the distribution of scores on several cognitive screening tests by age and educational levels in a population-based cohort...
  16. pmc High medical co-morbidity and family history of dementia is associated with lower cognitive function in older patients
    Lisa A Morrow
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Fam Pract 26:339-43. 2009
    ..Risk factors for cognitive decline in ageing are multifactorial, including medical co-morbidities and familial genetic risk...
  17. pmc Subjective memory complaints and concurrent memory performance in older patients of primary care providers
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Int Neuropsychol Soc 14:1004-13. 2008
    ....
  18. ncbi The association between congestive heart failure and cognitive performance in a primary care population of elderly adults: the Steel Valley Seniors Survey
    Laurie Lavery
    Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int Psychogeriatr 19:215-25. 2007
    ..We examined the association between CHF and cognitive performance in stable outpatients recruited from primary care...
  19. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  20. ncbi The relation of white matter hyperintensities to cognitive performance in the normal old: education matters
    Robert D Nebes
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006
    ..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies...
  21. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  22. pmc Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease
    O L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurol Neurosurg Psychiatry 72:310-4. 2002
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD)...
  23. ncbi Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-MadriƱan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  24. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  25. ncbi The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
    ....
  26. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
    ....
  27. pmc Factors associated with adherence to medication regimens in older primary care patients: the Steel Valley Seniors Survey
    Gary P Stoehr
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Pharmacother 6:255-63. 2008
    ..The aim of this study was to explore associations between 2 specific cognitive domains and aspects of medication management among older primary care patients...
  28. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  29. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  30. pmc Cognitive domains and trajectories of functional independence in nondemented elderly persons
    Hiroko H Dodge
    Department of Public Health, Oregon State University, Corvallis, OR 97331, USA
    J Gerontol A Biol Sci Med Sci 61:1330-7. 2006
    ..Cognitive impairment in general is known to predict functional disability, but it is not clear whether performance on specific cognitive domains predicts future disability trends among nondemented elderly persons...

Research Grants6

  1. Cognitive Assessment of Elderly Primary Care Patients
    Judith Saxton; Fiscal Year: 2007
    ..Second, this study will help prepare PCP's to identify and manage older patients with cognitive decline as improved treatments for AD and other cognitive disorders become available over the next three-five years. ..
  2. Cognitive Assessment of Elderly Primary Care Patients
    Judith Saxton; Fiscal Year: 2009
    ..Second, this study will help prepare PCP's to identify and manage older patients with cognitive decline as improved treatments for AD and other cognitive disorders become available over the next three-five years. ..
  3. Cognitive Assessment of Elderly Primary Care Patients.
    Judith A Saxton; Fiscal Year: 2010
    ..We will determine whether a brief Computer Assessment of MCI works as well as traditional neuropsychological testing. We will also investigate lifestyle and medical factors associated with instability in the MCI diagnosis. ..