Sanjaya Saxena

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:522-32. 2003
  2. ncbi Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:250-61. 2002
  3. ncbi Obsessive-compulsive hoarding: symptom severity and response to multimodal treatment
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
    J Clin Psychiatry 63:21-7. 2002
  4. ncbi Cerebral glucose metabolism in obsessive-compulsive hoarding
    Sanjaya Saxena
    UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1038-48. 2004
  5. ncbi Treatment of compulsive hoarding
    Sanjaya Saxena
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90095, USA
    J Clin Psychol 60:1143-54. 2004
  6. ncbi Brain-behavior relationships in obsessive-compulsive disorder
    S Saxena
    UCLA Obsessive Compulsive Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Semin Clin Neuropsychiatry 6:82-101. 2001
  7. ncbi A retrospective review of clinical characteristics and treatment response in body dysmorphic disorder versus obsessive-compulsive disorder
    S Saxena
    Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
    J Clin Psychiatry 62:67-72; quiz 73. 2001
  8. ncbi Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
    S Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    Psychiatr Clin North Am 23:563-86. 2000
  9. pmc Effect of a history of major depressive disorder on smoking-induced dopamine release
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 66:898-901. 2009
  10. pmc Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 34:282-9. 2009

Detail Information

Publications40

  1. ncbi Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:522-32. 2003
    ....
  2. ncbi Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:250-61. 2002
    ....
  3. ncbi Obsessive-compulsive hoarding: symptom severity and response to multimodal treatment
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
    J Clin Psychiatry 63:21-7. 2002
    ....
  4. ncbi Cerebral glucose metabolism in obsessive-compulsive hoarding
    Sanjaya Saxena
    UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1038-48. 2004
    ..The authors sought to identify cerebral metabolic patterns specifically associated with the compulsive hoarding syndrome using positron emission tomography (PET)...
  5. ncbi Treatment of compulsive hoarding
    Sanjaya Saxena
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90095, USA
    J Clin Psychol 60:1143-54. 2004
    ..New insights into the neurobiological characteristics of compulsive hoarding that might direct future treatment development are also presented...
  6. ncbi Brain-behavior relationships in obsessive-compulsive disorder
    S Saxena
    UCLA Obsessive Compulsive Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Semin Clin Neuropsychiatry 6:82-101. 2001
    ....
  7. ncbi A retrospective review of clinical characteristics and treatment response in body dysmorphic disorder versus obsessive-compulsive disorder
    S Saxena
    Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
    J Clin Psychiatry 62:67-72; quiz 73. 2001
    ..Although BDD and OCD respond to similar medications and cognitive-behavioral therapy (CBT), their response to treatment has never been directly compared...
  8. ncbi Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
    S Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    Psychiatr Clin North Am 23:563-86. 2000
    ..Ongoing studies of 5-HT synthesis in the brains of patients with OCD may shed light on this question...
  9. pmc Effect of a history of major depressive disorder on smoking-induced dopamine release
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 66:898-901. 2009
    ..We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)])...
  10. pmc Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 34:282-9. 2009
    ..Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release...
  11. ncbi Neurobiology and treatment of compulsive hoarding
    Sanjaya Saxena
    Obsessive Compulsive Disorders Program, University of California, San Diego, CA 92037, USA
    CNS Spectr 13:29-36. 2008
    ..More research will be required to determine the etiology and pathophysiology of compulsive hoarding, and to develop better treatments for this disorder...
  12. ncbi Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial
    Alexander Bystritsky
    Department of Psychiatry and Biobehavioral Sciences, Anxiety Disorders Program, University of California Los Angeles School of Medicine, Neuropsychiatric Institute and Hospital, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    J Clin Psychiatry 65:565-8. 2004
    ..The purpose of this study was to explore the efficacy of adding an atypical antipsychotic, olanzapine, to a serotonin reuptake inhibitor (SRI) in treatment-refractory obsessive-compulsive disorder (OCD)...
  13. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
    ..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release...
  14. ncbi Brain metabolic changes associated with symptom factor improvement in major depressive disorder
    A L Brody
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Psychiatry 50:171-8. 2001
    ..CONCLUSIONS: Brain regions that show significant relationships with symptom provocation in normal control subjects have similar relationships with MDD symptoms as they improve with treatment...
  15. pmc Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, CA 90024, USA
    J Psychiatr Res 47:494-504. 2013
    ..Comorbid depressive symptoms in OCD patients may have contributed to metabolite effects, although baseline and post-CBT change in depression ratings varied with choline-compounds and myo-inositol rather than Glx or tNAA...
  16. pmc Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
    Psychiatry Res 130:269-81. 2004
    ..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission...
  17. ncbi Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently
    S Saxena
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Psychiatry 50:159-70. 2001
    ..Depressive episodes occurring in OCD patients may be mediated by different basal ganglia-thalamic abnormalities than in primary MDD patients...
  18. ncbi Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
    ..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues...
  19. pmc Executive functioning in older adults with hoarding disorder
    Catherine R Ayers
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA Department of Psychiatry, University of California, San Diego, CA, USA
    Int J Geriatr Psychiatry 28:1175-81. 2013
    ..Midlife HD patients have been found to have neurocognitive impairment, particularly in areas of executive functioning, but the extent to which this is due to comorbid psychiatric disorders has not been clear...
  20. ncbi Differential efficacy of memantine for obsessive-compulsive disorder vs. generalized anxiety disorder: an open-label trial
    Jamie D Feusner
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Psychopharmacol Bull 42:81-93. 2009
    ..The objective of this study was to compare the efficacy and safety of memantine in OCD and GAD, and to probe relative effects on OCD and anxiety symptoms...
  21. pmc Age at onset and clinical features of late life compulsive hoarding
    Catherine R Ayers
    Department of Psychiatry, University of California, San Diego, CA, USA
    Int J Geriatr Psychiatry 25:142-9. 2010
    ..The objectives of this study were to determine the onset and illustrate the course and clinical features of late life compulsive hoarding, including psychiatric and medical comorbidities...
  22. ncbi FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
    Psychiatry Res 84:1-6. 1998
    ..35, P = 0.04), but worse outcome (tau = -0.57, P = 0.03) in the fluoxetine-treated group. These results suggest that subjects with differing patterns of metabolism preferentially respond to BT vs. medication...
  23. pmc Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
    G W Small
    Center on Aging and Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 97:6037-42. 2000
    ..These results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments...
  24. pmc Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder
    S Saxena
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92161, USA
    Mol Psychiatry 14:197-205. 2009
    ....
  25. ncbi Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele
    G W Small
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024 1759, USA
    Am J Psychiatry 156:1035-8. 1999
    ....
  26. ncbi Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetine
    A L Brody
    University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences, USA
    J Clin Psychiatry 61:349-55. 2000
    ..We also sought to determine whether or not these personality changes were associated with disease state (MDD vs. OCD) or treatment response (responders vs. nonresponders)...
  27. ncbi Prefrontal-subcortical and limbic circuit mediation of major depressive disorder
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
    Semin Clin Neuropsychiatry 6:102-12. 2001
    ....
  28. ncbi Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings
    A L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, CA, USA
    Arch Gen Psychiatry 58:631-40. 2001
    ..We also performed a preliminary comparison of regional changes with 2 distinct forms of treatment (paroxetine and interpersonal psychotherapy)...
  29. ncbi Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer's disease
    G W Small
    Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California at Los Angeles, 90024, USA
    Int J Geriatr Psychiatry 16:1071-7. 2001
    ..No previous study has focused on subjective memory complaints and depressive symptoms in the same subject population at genetic risk for Alzheimer's disease...
  30. ncbi Social functioning and quality of life comparisons between obsessive-compulsive and schizophrenic disorders
    A Bystritsky
    UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Los Angeles, California 90095, USA
    Depress Anxiety 14:214-8. 2001
    ..We concluded that patients with severe OCD and patients with schizophrenia are equally socially impaired. However, OCD patients experience greater significant functional improvement with multimodal treatment...
  31. ncbi Quality-of-life changes among patients with obsessive-compulsive disorder in a partial hospitalization program
    A Bystritsky
    University of California, Los Angeles, Neuropsychiatric Institute and Hospital, 90024, USA
    Psychiatr Serv 50:412-4. 1999
    ..No significant association between changes in YBOCS scores and QOL scores was found...
  32. ncbi Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine
    A L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
    Psychiatry Res 91:127-39. 1999
    ..These findings implicate ventral prefrontal-subcortical brain circuitry in the mediation of response to serotonin reuptake inhibitors in MDD...
  33. pmc Therapist and patient perspectives on cognitive-behavioral therapy for older adults with hoarding disorder: a collective case study
    Catherine R Ayers
    Research Service, VA San Diego Healthcare System, San Diego, CA, USA
    Aging Ment Health 16:915-21. 2012
    ....
  34. pmc The pathophysiology of body dysmorphic disorder
    Jamie D Feusner
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, David Geffen School of Medicine at UCLA, CA, USA
    Body Image 5:3-12. 2008
    ..An improved understanding of the pathophysiology of BDD will be crucial to guide the development of better treatments...
  35. ncbi Obsessive-compulsive disorder: boundary issues
    Naomi A Fineberg
    Postgraduate School of Medicine, University of Hertfordshire, Gueen Elizabeth II Hospital, Welwyn Garden City, UK
    CNS Spectr 12:359-64, 367-375. 2007
    ..Studies designed to delineate the cause, consequences, and common factors are a challenging but essential goal for future research in this area...
  36. ncbi Secondary obsessive-compulsive disorder related to diaschisis after pontine infarction, successfully treated with paroxetine
    Tokuzo Matsui
    Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Psychiatry Clin Neurosci 61:186-9. 2007
    ..This case suggests that brainstem infarction and decreased temporal lobe perfusion can lead to secondary obsessive-compulsive disorder...
  37. ncbi Is compulsive hoarding a genetically and neurobiologically discrete syndrome? Implications for diagnostic classification
    Sanjaya Saxena
    Am J Psychiatry 164:380-4. 2007
  38. pmc Paroxetine treatment of compulsive hoarding
    Sanjaya Saxena
    UCSD Department of Psychiatry, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Psychiatr Res 41:481-7. 2007
    ..We sought to determine whether compulsive hoarders would respond as well as non-hoarding OCD patients to the SRI, paroxetine...
  39. ncbi Refractory obsessive-compulsive disorder: state-of-the-art treatment
    Eric Hollander
    Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 63:20-9. 2002
    ..The authors synthesize state-of-the-art treatment and give practical advice for clinicians...
  40. ncbi Predicting treatment response in obsessive-compulsive disorder
    Robin A Hurley
    Mental Health Care Line, Houston Veterans Affairs Medical Center, Houston, Texas, USA
    J Neuropsychiatry Clin Neurosci 14:249-53. 2002