Research Topics
Genomes and GenesSpecies | Sanjaya SaxenaSummaryAffiliation: University of California Country: USA Publications
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Publications
Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorderS Saxena
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92161, USA
Mol Psychiatry 14:197-205. 2009....
Recent advances in compulsive hoardingSanjaya Saxena
Department of Psychiatry, University of California at San Diego, 8950 Villa La Jolla Village Drive, Suite C 207, San Diego, CA 92037, USA
Curr Psychiatry Rep 10:297-303. 2008..Effective treatments include pharmacotherapy and cognitive-behavioral therapy. More research will be required to determine the prevalence, etiology, and pathophysiology of compulsive hoarding and to develop better treatments...- Neurobiology and treatment of compulsive hoardingSanjaya Saxena
Obsessive Compulsive Disorders Program, University of California, San Diego, CA 92037, USA
CNS Spectr 13:29-36. 2008..More research will be required to determine the etiology and pathophysiology of compulsive hoarding, and to develop better treatments for this disorder... 
Pharmacotherapy of compulsive hoardingSanjaya Saxena
University of California San Diego, Department of Psychiatry, 140 Arbor Drive, San Diego, CA 92103, USA
J Clin Psychol 67:477-84. 2011..However, the combination of pharmacotherapy and CBT for compulsive hoarding is likely more effective than either treatment alone...- Quality of life and functional impairment in compulsive hoardingSanjaya Saxena
Department of Psychiatry, University of California at San Diego, 140 Arbor Drive, San Diego, CA 92103, United States
J Psychiatr Res 45:475-80. 2011..Psychosocial rehabilitation that focuses on problems with victimization, safety, employment, and financial areas may be a beneficial augmentation to treatment for compulsive hoarding... - Effect of a history of major depressive disorder on smoking-induced dopamine releaseArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Biol Psychiatry 66:898-901. 2009..We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)])... - Paroxetine treatment of compulsive hoardingSanjaya Saxena
UCSD Department of Psychiatry, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Psychiatr Res 41:481-7. 2007..We sought to determine whether compulsive hoarders would respond as well as non-hoarding OCD patients to the SRI, paroxetine... - Age at onset and clinical features of late life compulsive hoardingCatherine R Ayers
Department of Psychiatry, University of California, San Diego, CA, USA
Int J Geriatr Psychiatry 25:142-9. 2010..The objectives of this study were to determine the onset and illustrate the course and clinical features of late life compulsive hoarding, including psychiatric and medical comorbidities... - Cognitive-behavioral therapy for geriatric compulsive hoardingCatherine R Ayers
Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA
Behav Res Ther 49:689-94. 2011..No participants dropped out, but homework compliance was variable and correlated with decreases in hoarding severity. Findings suggest that older adults with compulsive hoarding may require an enhanced or alternative treatment... - Refractory obsessive-compulsive disorder: state-of-the-art treatmentEric Hollander
Department of Psychiatry, Compulsive, Impulsive, and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 63:20-9. 2002..The authors synthesize state-of-the-art treatment and give practical advice for clinicians... - Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbensArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 63:808-16. 2006..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release... - Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depressionSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 59:250-61. 2002.... - Therapist and patient perspectives on cognitive-behavioral therapy for older adults with hoarding disorder: a collective case studyCatherine R Ayers
Research Service, VA San Diego Healthcare System, San Diego, CA, USA
Aging Ment Health 16:915-21. 2012.... - Differential efficacy of memantine for obsessive-compulsive disorder vs. generalized anxiety disorder: an open-label trialJamie D Feusner
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Psychopharmacol Bull 42:81-93. 2009..The objective of this study was to compare the efficacy and safety of memantine in OCD and GAD, and to probe relative effects on OCD and anxiety symptoms... - Obsessive-compulsive disorder: boundary issuesNaomi A Fineberg
Postgraduate School of Medicine, University of Hertfordshire, Gueen Elizabeth II Hospital, Welwyn Garden City, UK
CNS Spectr 12:359-64, 367-375. 2007..Studies designed to delineate the cause, consequences, and common factors are a challenging but essential goal for future research in this area... - Obsessive-compulsive hoarding: symptom severity and response to multimodal treatmentSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
J Clin Psychiatry 63:21-7. 2002.... - Treatment of compulsive hoardingSanjaya Saxena
UCLA Neuropsychiatric Institute, Los Angeles, CA 90095, USA
J Clin Psychol 60:1143-54. 2004..New insights into the neurobiological characteristics of compulsive hoarding that might direct future treatment development are also presented... - Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depressionSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Psychiatry 160:522-32. 2003.... - Secondary obsessive-compulsive disorder related to diaschisis after pontine infarction, successfully treated with paroxetineTokuzo Matsui
Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan
Psychiatry Clin Neurosci 61:186-9. 2007..This case suggests that brainstem infarction and decreased temporal lobe perfusion can lead to secondary obsessive-compulsive disorder... - Predicting treatment response in obsessive-compulsive disorderRobin A Hurley
Mental Health Care Line, Houston Veterans Affairs Medical Center, Houston, Texas, USA
J Neuropsychiatry Clin Neurosci 14:249-53. 2002 - Brain metabolic changes during cigarette cravingArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
Arch Gen Psychiatry 59:1162-72. 2002..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues... - Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trialAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, Anxiety Disorders Program, University of California Los Angeles School of Medicine, Neuropsychiatric Institute and Hospital, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
J Clin Psychiatry 65:565-8. 2004..The purpose of this study was to explore the efficacy of adding an atypical antipsychotic, olanzapine, to a serotonin reuptake inhibitor (SRI) in treatment-refractory obsessive-compulsive disorder (OCD)... - Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary studyArthur L Brody
Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
Psychiatry Res 130:269-81. 2004..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission... - Cerebral glucose metabolism in obsessive-compulsive hoardingSanjaya Saxena
UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Psychiatry 161:1038-48. 2004..The authors sought to identify cerebral metabolic patterns specifically associated with the compulsive hoarding syndrome using positron emission tomography (PET)... - Is compulsive hoarding a genetically and neurobiologically discrete syndrome? Implications for diagnostic classificationSanjaya Saxena
Am J Psychiatry 164:380-4. 2007
Research Grants
- NEUROANATOMY AND PHARMACOTHERAPY OF OCD AND MAJOR DEPRESSanjaya Saxena; Fiscal Year: 2003This application proposes Sanjaya Saxena, M.D. for a Mentored Patient-Oriented Research Career Development Award...
- Neurobiology of Obsessive-Compulsive HoardingSanjaya Saxena; Fiscal Year: 2007..The long-term goal is to develop more effective treatments for compulsive hoarding, based on an improved understanding of its pathophysiology. ..