J R Sawyer
Affiliation: University of Arkansas for Medical Sciences
- Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myelomaJ R Sawyer
Myeloma and Transplantation Research Center, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Br J Haematol 112:167-74. 2001..The chromosome instability identified here demonstrates that the loss of 8p can occur by multiple whole-arm translocations, indicating a new pathway for the loss of a specific chromosome region in MM...
- Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutesJ R Sawyer
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock
Cancer Genet Cytogenet 57:181-6. 1991..The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis...
- Cyclin D1 and E2F-1 immunoreactivity in bone marrow biopsy specimens of multiple myeloma: relationship to proliferative activity, cytogenetic abnormalities and DNA ploidyC S Wilson
University of Arkansas for Medical Sciences, Department of Pathology, Mail Slot 502, 4301 West Markham Street, Little Rock, AR 72205, USA
Br J Haematol 112:776-82. 2001..We conclude that in low to intermediately proliferative MM cases, cyclin D1 is probably upregulated by t(11;14), but an alternative mechanism is more probable in highly proliferative MM...
- Mitochondrial DNA determines androgen dependence in prostate cancer cell linesM Higuchi
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Oncogene 25:1437-45. 2006..The accumulation of large deletion and depletion of mitochondrial DNA may thus play a role in the development of androgen independence, leading to progression of prostate cancers...