J R Sawyer

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Translocation (1;19)(q21;q13.3) is a recurrent reciprocal translocation in meningioma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 134:88-90. 2002
  2. doi request reprint Metaphase cytogenetic techniques in multiple myeloma
    Jeffrey R Sawyer
    Department of Pathology, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Methods Mol Biol 730:149-58. 2011
  3. ncbi request reprint A novel t(X;2)(q13;q35) in clear cell sugar tumor of bone
    Jeffrey R Sawyer
    Cytogenetics Laboratory, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Cancer Genet Cytogenet 154:77-80. 2004
  4. ncbi request reprint Genomic instability in multiple myeloma: evidence for jumping segmental duplications of chromosome arm 1q
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Genes Chromosomes Cancer 42:95-106. 2005
  5. ncbi request reprint A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis
    Jeffrey R Sawyer
    Department of Pathology, Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Freeway Medical, Suite 200, 5800 West 10th Street, Little Rock, AR 72204, USA
    Cancer Genet Cytogenet 158:67-9. 2005
  6. ncbi request reprint Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone
    Jeffrey R Sawyer
    Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Little Rock, AR 72204, USA
    Cancer Genet Cytogenet 159:32-6. 2005
  7. ncbi request reprint Identification of isochromosome 1q as a recurring chromosome aberration in skull base chordomas: a new marker for aggressive tumors?
    J R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Neurosurg Focus 10:E6. 2001
  8. ncbi request reprint De novo proximal duplication of 1(q12q22) in a female infant with multiple congenital anomalies
    Jeffrey R Sawyer
    Cytogenetics Laboratory, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72204, USA
    Am J Med Genet A 143:338-42. 2007
  9. pmc Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage-fusion-bridge cycles of a 1q12 approximately 23 amplicon
    Jeffrey R Sawyer
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72204, USA
    Br J Haematol 147:484-94. 2009
  10. doi request reprint The prognostic significance of cytogenetics and molecular profiling in multiple myeloma
    Jeffrey R Sawyer
    Department of Pathology and Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cancer Genet 204:3-12. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Translocation (1;19)(q21;q13.3) is a recurrent reciprocal translocation in meningioma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 134:88-90. 2002
    ..3) as the sole cytogenetic aberration. We report a third case showing the t(1;19)(q21;q13.3) with additional unstable secondary aberrations of a dic(18;22)(p11;p11) and telomeric fusions...
  2. doi request reprint Metaphase cytogenetic techniques in multiple myeloma
    Jeffrey R Sawyer
    Department of Pathology, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Methods Mol Biol 730:149-58. 2011
    ..Regardless of the origin or quality of the specimen, some uninformative cytogenetic results may simply be due to insufficient number and type of cultures being initiated and subsequently examined...
  3. ncbi request reprint A novel t(X;2)(q13;q35) in clear cell sugar tumor of bone
    Jeffrey R Sawyer
    Cytogenetics Laboratory, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Cancer Genet Cytogenet 154:77-80. 2004
    ..We present what is to our knowledge the first reported case of a primary clear cell sugar tumor of bone displaying a novel t(X;2)(q13;q35) as the sole cytogenetic aberration...
  4. ncbi request reprint Genomic instability in multiple myeloma: evidence for jumping segmental duplications of chromosome arm 1q
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Genes Chromosomes Cancer 42:95-106. 2005
    ..We have designated this type of instability as a jumping segmental duplication...
  5. ncbi request reprint A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis
    Jeffrey R Sawyer
    Department of Pathology, Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Freeway Medical, Suite 200, 5800 West 10th Street, Little Rock, AR 72204, USA
    Cancer Genet Cytogenet 158:67-9. 2005
    ..We report a case of plantar fibromatosis with the novel finding of a t(2;7)(p13;p13) balanced reciprocal translocation as the sole cytogenetic abnormality...
  6. ncbi request reprint Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone
    Jeffrey R Sawyer
    Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Little Rock, AR 72204, USA
    Cancer Genet Cytogenet 159:32-6. 2005
    ..These findings support the concept that telomeric instability is responsible for a large degree of intratumor heterogeneity and serves as a precursor lesion to subsequent clonal structural aberrations of chromosome 11 in GCTB...
  7. ncbi request reprint Identification of isochromosome 1q as a recurring chromosome aberration in skull base chordomas: a new marker for aggressive tumors?
    J R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Neurosurg Focus 10:E6. 2001
    ..The authors conducted a study of 22 skull base chordomas...
  8. ncbi request reprint De novo proximal duplication of 1(q12q22) in a female infant with multiple congenital anomalies
    Jeffrey R Sawyer
    Cytogenetics Laboratory, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72204, USA
    Am J Med Genet A 143:338-42. 2007
    ....
  9. pmc Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage-fusion-bridge cycles of a 1q12 approximately 23 amplicon
    Jeffrey R Sawyer
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72204, USA
    Br J Haematol 147:484-94. 2009
    ..Our findings provide evidence for a novel BFB mechanism involving 1q12 pericentromeric breakage in the amplification of a large number of genes within a 1q12 approximately 23 amplicon...
  10. doi request reprint The prognostic significance of cytogenetics and molecular profiling in multiple myeloma
    Jeffrey R Sawyer
    Department of Pathology and Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cancer Genet 204:3-12. 2011
    ....
  11. ncbi request reprint Telomeric fusion as a mechanism for the loss of 1p in meningioma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 145:38-48. 2003
    ..The loss of 1p has possible diagnostic and prognostic implications in the management of meningioma...
  12. ncbi request reprint Constitutional t(16;22)(p13.3;q11.2 approximately 12) in a primitive neuroectodermal tumor of the pineal region
    Jeffrey R Sawyer
    Department of Pathology, Cytogenetics Laboratory, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202, USA
    Cancer Genet Cytogenet 142:73-6. 2003
    ..The finding of a 22q11.2 approximately 12 breakpoint in this patient suggests this constitutional translocation may somehow have predisposed the patient to the development of the tumor...
  13. ncbi request reprint Recurring breakpoints of 1p13 approximately p22 in osteochondroma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 Markham Street, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 138:102-6. 2002
    ..These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13 approximately p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma...
  14. ncbi request reprint Cyclin D1 and E2F-1 immunoreactivity in bone marrow biopsy specimens of multiple myeloma: relationship to proliferative activity, cytogenetic abnormalities and DNA ploidy
    C S Wilson
    University of Arkansas for Medical Sciences, Department of Pathology, Mail Slot 502, 4301 West Markham Street, Little Rock, AR 72205, USA
    Br J Haematol 112:776-82. 2001
    ..We conclude that in low to intermediately proliferative MM cases, cyclin D1 is probably upregulated by t(11;14), but an alternative mechanism is more probable in highly proliferative MM...
  15. ncbi request reprint Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma
    J R Sawyer
    Myeloma and Transplantation Research Center, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Br J Haematol 112:167-74. 2001
    ..The chromosome instability identified here demonstrates that the loss of 8p can occur by multiple whole-arm translocations, indicating a new pathway for the loss of a specific chromosome region in MM...
  16. ncbi request reprint Secondary acute myelogenous leukemia following safe exposure to etoposide
    K C Stine
    Department of Pediatrics, University of Arkansas for Medical Sciences Arkansas Children s Hospital, Little Rock 72202, USA
    J Clin Oncol 15:1583-6. 1997
    ..To present two patients as illustrations of the risk of developing secondary acute myelogenous leukemia (sAML) when theoretically safe doses of etoposide (VP-16) are used...
  17. pmc Mitochondrial DNA determines androgen dependence in prostate cancer cell lines
    M Higuchi
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Oncogene 25:1437-45. 2006
    ..The accumulation of large deletion and depletion of mitochondrial DNA may thus play a role in the development of androgen independence, leading to progression of prostate cancers...
  18. ncbi request reprint A reciprocal t(4;9)(q31;p22) in a solitary neurofibroma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 156:172-4. 2005
    ..We report the first case of a solitary circumscribed neurofibroma with a (4;9)(q31;p22) balanced reciprocal translocation as the sole cytogenetic abnormality...
  19. ncbi request reprint Cytogenetic distinction among benign fibro-osseous lesions of bone in children and adolescents: value of karyotypic findings in differential diagnosis
    David M Parham
    Department of Pathology, Arkansas Children Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:148-58. 2004
    ..Our current and published results indicate that cytogenetics might be of ancillary use in the diagnosis of BFOL and that a characteristic chromosomal arrangement is associated with ossifying fibroma...
  20. pmc Bone marrow transplant engraftment analysis with loss of an informative allele
    Steven A Schichman
    Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock 72205, USA
    J Mol Diagn 4:230-2. 2002
    ..This circumstance is a potential source of error in the interpretation of engraftment analysis, especially if only one informative allele is used to monitor engraftment...
  21. ncbi request reprint Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13)
    Dale A Ellison
    Department of Pathology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 10:46-9. 2007
    ..Soft-tissue ABC is a rare, benign lesion that can have a similar radiologic appearance to myositis ossificans but has a histologic appearance identical to that of its intraosseus counterpart...
  22. ncbi request reprint Cytogenetic findings in pediatric T-lymphoblastic lymphomas: one institution's experience and a review of the literature
    Dale A Ellison
    Department of Pathology, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, Arkansas 72202, USA
    Pediatr Dev Pathol 8:550-6. 2005
    ..The cytogenetic features of LL may be helpful in the diagnosis of pediatric lymphomas and undifferentiated neoplasms...
  23. ncbi request reprint Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings
    Ossama Al-Mefty
    Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurosurg 101:210-8. 2004
    ..In this study, the authors examined the data obtained in a group of patients with meningiomas that showed clear histopathological progression toward a higher grade of malignancy and then analyzed the underlying cytogenetic findings...
  24. ncbi request reprint Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics
    Ossama Al-Mefty
    University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosurg 100:1002-13. 2004
    ..Radiation-induced meningiomas are known to occur after high- and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas...
  25. ncbi request reprint Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes
    J R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock
    Cancer Genet Cytogenet 57:181-6. 1991
    ..The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis...
  26. ncbi request reprint Soft tissue masses in patients with multiple myeloma: a fine-needle aspiration study of 30 cases with flow cytometry and clinical correlation
    P Mukunyadzi
    Department of Pathology, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Cancer 93:257-62. 2001
    ..The objective of the current study was to examine ST masses in MM patients using FNA and to classify and determine the prognostic significance of MM in these lesions based on cytologic features...
  27. pmc Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantatio
    Ichiro Hanamura
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, 4301 W Markham St 776, Little Rock, AR 72205, USA
    Blood 108:1724-32. 2006
    ..027). The proportion of cells with Amp1q21 and the copy number of 1q21 tended to increase at relapse compared with diagnosis. Our data suggest that Amp1q21 is associated with both disease progression and poor prognosis...
  28. ncbi request reprint High resolution mid-prophase human chromosomes induced by echinomycin and ethidium bromide
    J R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, Arkansas Children s Hospital, Little Rock 72202
    Hum Genet 95:49-55. 1995
    ..With this combination of drugs, trypsin G-banded chromosomes showed over 1200 bands per haploid set in cells having a mid-prophase length of decondensation...
  29. ncbi request reprint Multicolor spectral karyotyping of the L5178Y Tk+/- -3.7.2C mouse lymphoma cell line
    Jeffrey R Sawyer
    Cytogenetics Laboratory, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Environ Mol Mutagen 47:127-31. 2006
    ..This analysis provides an updated standard reference for the karyotype of the L5178Y/Tk+/- -3.7.2C cell line used in the in vitro mouse lymphoma mutation assay...
  30. ncbi request reprint Multicolor spectral karyotyping in multiple myeloma
    Jeffrey R Sawyer
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AK, USA
    Methods Mol Med 113:49-58. 2005
    ....
  31. ncbi request reprint Evi27 encodes a novel membrane protein with homology to the IL17 receptor
    E Tian
    Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Oncogene 19:2098-109. 2000
    ....
  32. pmc Establishment and exploitation of hyperdiploid and non-hyperdiploid human myeloma cell lines
    Xin Li
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 138:802-11. 2007
    ..These myeloma cell lines and the procedures used for their establishment provide essential tools for studying myeloma biology and therapy...
  33. pmc Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors
    Ana Gabrea
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Genes Chromosomes Cancer 47:573-90. 2008
    ..We conclude that IG light chain and MYC rearrangements, as well as secondary IGH rearrangements, make similar contributions to the progression of both HRD and NHRD MM tumors...
  34. ncbi request reprint Adult T-cell leukemia/lymphoma with a complex karyotype and central nervous system involvement
    Myung Geun Shin
    Cancer Genet Cytogenet 177:78-80. 2007
  35. ncbi request reprint MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage
    Hsin Ling Hsu
    National Health Research Institutes, No 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC
    DNA Repair (Amst) 6:1319-32. 2007
    ..In conclusion, MCT-1 deregulates p53-p21 network and impairs the damage checkpoints those are robustly connected to oncogenic chromosomal abnormalities...
  36. ncbi request reprint Unusual type of TLS/FUS-ERG chimeric transcript in a pediatric acute myelocytic leukemia with 47,XX,+10,t(16;21)(p11;q22)
    Hyun Woo Choi
    Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Ilsimri 160, Hwasun eup, Hwasun Gun, South Korea 519 809
    Cancer Genet Cytogenet 167:172-6. 2006
    ..After achieving a complete remission with two cycles of induction chemotherapy, the patient received an umbilical cord blood transplantation...