Research Topics
| A H SawalhaSummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Detail Information
Publications
Clinical problem-solving. Still consider the sourceAmr H Sawalha
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
N Engl J Med 353:1503-7. 2005
Common variants within MECP2 confer risk of systemic lupus erythematosusAmr H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
PLoS ONE 3:e1727. 2008..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE...
Epigenetics and T-cell immunityAmr H Sawalha
US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
Autoimmunity 41:245-52. 2008..In this review, we focus on epigenetics in T helper cell differentiation, regulatory T-cell function, and IL-2 production...- Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severityAmr H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Autoimmun 38:J216-22. 2012.... - Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosusTravis Hughes
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Ann Rheum Dis 71:694-9. 2012..The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genetic effects among SLE susceptibility loci... - A putative functional variant within the UBAC2 gene is associated with increased risk of Behçet's diseaseAmr H Sawalha
University of Oklahoma Health Sciences Center, Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA
Arthritis Rheum 63:3607-12. 2011..We undertook this study to establish the genetic effect within the UBAC2 gene, in the course of which we replicated this genetic association and identified a functional variant within this locus... - Dehydroepiandrosterone in systemic lupus erythematosusAmr H Sawalha
Curr Rheumatol Rep 10:286-91. 2008..Long-term safety studies are required in light of the reported effect of DHEA supplementation in lowering high-density lipoprotein cholesterol in lupus patients... - Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patientsA H Sawalha
US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
Genes Immun 9:368-78. 2008..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity... - Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosusA H Sawalha
US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA
Ann Rheum Dis 67:458-61. 2008..The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell responses make IL-21 an attractive candidate gene for SLE... - Clinical problem-solving. Step by stepAmr H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
N Engl J Med 349:2253-7. 2003 - Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone miceAmr H Sawalha
US Department of Veterans Affairs Medical Center, Oklahoma City, USA
Eur J Immunol 37:1407-13. 2007..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice... - Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspectiveM Jeffries
College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Lupus 17:739-43. 2008..The presence of haemolytic anaemia is associated with a subset of lupus characterized by a younger age of disease onset, and a more severe disease with a higher likelihood of renal involvement, seizures, serositis and other cytopenias... - Epigenetic regulation and the pathogenesis of systemic lupus erythematosusYujun Pan
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Transl Res 153:4-10. 2009..Herein, we discuss how defective epigenetic regulation is involved in the pathogenesis of lupus, which includes both DNA methylation and histone modification changes... - Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patientsS Malik
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Lupus 16:863-6. 2007..3% versus 27.4%, OR = 0.31, P = 0.0075). In conclusion, anti-La autoantibody is associated with less severe lupus. Patients with anti-La have a lower risk of renal involvement and seizures compared with anti-La negative lupus patients... - Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosusRyan Webb
Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City, USA
Arthritis Rheum 60:1076-84. 2009.... - Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody patternA H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, OK, USA
Genes Immun 3:S31-4. 2002..In conclusion, an important SLE susceptibility gene, SLEH1 at 11q14, is identified in African-Americans when stratifying pedigrees by antinucleolar autoantibodies... - Sulpha allergy in lupus patients: a clinical perspectiveM Jeffries
College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Lupus 17:202-5. 2008..0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005)... - Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locusAmit K Maiti
Oklahoma Medical Research Foundation, Oklahoma City, OK73104, USA
Arthritis Rheum 62:323-9. 2010.... - Current status of lupus geneticsAndrea L Sestak
Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
Arthritis Res Ther 9:210. 2007..In this review we will present what is known, what is disputed, and what remains to be discovered in the world of lupus genetics... - DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaksT Hughes
Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
Genes Immun 11:554-60. 2010..TSS in the majority of genes with permissive DNA methylation peaks is in DNase I hypersensitive sites, indicating a failure of DNA methylation to induce chromatin inaccessibility in these loci... - Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupusGabriela Gorelik
Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 179:5553-63. 2007..These results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation... - Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association studyYiping Fei
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Arthritis Res Ther 11:R66. 2009..Behçet's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Behçet's disease... - Autoimmunity and Klinefelter's syndrome: when men have two X chromosomesAmr H Sawalha
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Autoimmun 33:31-4. 2009..On the other hand, a gene dose effect could also be mediated by a gene without an SLE-associated polymorphism in that a gene that avoids X inactivation will have a higher level of expression in persons with two X chromosomes... - A polymorphism within IL21R confers risk for systemic lupus erythematosusRyan Webb
Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Arthritis Rheum 60:2402-7. 2009..The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE... - Association between systemic lupus erythematosus and Helicobacter pylori seronegativityAmr H Sawalha
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
J Rheumatol 31:1546-50. 2004..These findings suggest that there is a possible protective role for H. pylori infection against the development of SLE or that immunoregulatory events leading to H. pylori seropositivity are inversely related to the risk of SLE... - Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patientsRyan Webb
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Ann Rheum Dis 70:151-6. 2011..Systemic lupus erythematosus (SLE) is a chronic, multiorgan, autoimmune disease that affects people of all ages and ethnicities... - The genetics of primary Sjögren's syndromeAmr H Sawalha
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Curr Rheumatol Rep 5:324-32. 2003..No doubt a much more comprehensive description of the genetics of this disorder will soon emerge... - Uric acid directly promotes human T-cell activationRyan Webb
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Am J Med Sci 337:23-7. 2009..We hypothesize that uric acid can also stimulate T cells directly and in the absence of antigen presentation... - Antinuclear autoantibodies in systemic lupus erythematosusAmr H Sawalha
Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Curr Opin Rheumatol 16:534-40. 2004..In this review, we will discuss the various antinuclear autoantibodies detected in lupus patients, their potential pathogenic role, and their usefulness in clinical practice... - MEK/ERK pathway inhibitors as a treatment for inflammatory arthritis might result in the development of lupus: comment on the article by Thiel et alAmr H Sawalha
Arthritis Rheum 58:1203-4; author reply 1204. 2008 - Horizons in Sjögren's syndrome geneticsPamela H Williams
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Clin Rev Allergy Immunol 32:201-9. 2007..Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren's syndrome...