A H Sawalha
Affiliation: University of Oklahoma Health Sciences Center
Sawalha A, Webb R, Han S, Kelly J, Kaufman K, Kimberly R, et al
. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE. 2008;3:e1727 pubmed publisher
..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE. ..
Sawalha A, Hughes T, Nadig A, Yilmaz V, Aksu K, Keser G, et al
. A putative functional variant within the UBAC2 gene is associated with increased risk of Behçet's disease. Arthritis Rheum. 2011;63:3607-12 pubmed publisher
..We identified the minor allele in rs7999348 as a disease-risk allele that tags altered UBAC2 expression. ..
Sawalha A, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007;37:1407-13 pubmed
..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice. ..
Sawalha A, Kaufman K, Kelly J, Adler A, Aberle T, Kilpatrick J, et al
. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:458-61 pubmed
..025). Our findings indicate that IL-21 polymorphism is a candidate association with SLE. The functional effects of this association, when revealed, might improve our understanding of the disease and provide new therapeutic targets. ..
Sawalha A, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, et al
. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008;9:368-78 pubmed publisher
..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity. ..