A H Sawalha

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. Sawalha A, Webb R, Han S, Kelly J, Kaufman K, Kimberly R, et al. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE. 2008;3:e1727 pubmed publisher
    ..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE. ..
  2. request reprint
    Sawalha A, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007;37:1407-13 pubmed
    ..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice. ..
  3. request reprint
    Sawalha A, Kaufman K, Kelly J, Adler A, Aberle T, Kilpatrick J, et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:458-61 pubmed
    ..025). Our findings indicate that IL-21 polymorphism is a candidate association with SLE. The functional effects of this association, when revealed, might improve our understanding of the disease and provide new therapeutic targets. ..
  4. Sawalha A, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, et al. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008;9:368-78 pubmed publisher
    ..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity. ..

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Collaborators

Detail Information

Publications4

  1. Sawalha A, Webb R, Han S, Kelly J, Kaufman K, Kimberly R, et al. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE. 2008;3:e1727 pubmed publisher
    ..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE. ..
  2. request reprint
    Sawalha A, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007;37:1407-13 pubmed
    ..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice. ..
  3. request reprint
    Sawalha A, Kaufman K, Kelly J, Adler A, Aberle T, Kilpatrick J, et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:458-61 pubmed
    ..025). Our findings indicate that IL-21 polymorphism is a candidate association with SLE. The functional effects of this association, when revealed, might improve our understanding of the disease and provide new therapeutic targets. ..
  4. Sawalha A, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, et al. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008;9:368-78 pubmed publisher
    ..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity. ..