- Sawalha A, Webb R, Han S, Kelly J, Kaufman K, Kimberly R, et al. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE. 2008;3:e1727 pubmed publisher..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE. ..
- Sawalha A, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007;37:1407-13 pubmed..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice. ..
- Sawalha A, Kaufman K, Kelly J, Adler A, Aberle T, Kilpatrick J, et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 2008;67:458-61 pubmed..025). Our findings indicate that IL-21 polymorphism is a candidate association with SLE. The functional effects of this association, when revealed, might improve our understanding of the disease and provide new therapeutic targets. ..
- Sawalha A, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, et al. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008;9:368-78 pubmed publisher..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity. ..