A H Sawalha

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Clinical problem-solving. Still consider the source
    Amr H Sawalha
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    N Engl J Med 353:1503-7. 2005
  2. pmc Common variants within MECP2 confer risk of systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    PLoS ONE 3:e1727. 2008
  3. doi request reprint Epigenetics and T-cell immunity
    Amr H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
    Autoimmunity 41:245-52. 2008
  4. pmc An update on belimumab for the treatment of lupus
    Aikaterini Thanou-Stavraki
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Biologics 5:33-43. 2011
  5. pmc Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Autoimmun 38:J216-22. 2012
  6. pmc Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus
    Travis Hughes
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 71:694-9. 2012
  7. pmc Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    A H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
    Genes Immun 9:368-78. 2008
  8. pmc Dehydroepiandrosterone in systemic lupus erythematosus
    Amr H Sawalha
    Curr Rheumatol Rep 10:286-91. 2008
  9. ncbi request reprint Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    A H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 67:458-61. 2008
  10. ncbi request reprint Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice
    Amr H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, USA
    Eur J Immunol 37:1407-13. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Clinical problem-solving. Still consider the source
    Amr H Sawalha
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    N Engl J Med 353:1503-7. 2005
  2. pmc Common variants within MECP2 confer risk of systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    PLoS ONE 3:e1727. 2008
    ..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE...
  3. doi request reprint Epigenetics and T-cell immunity
    Amr H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
    Autoimmunity 41:245-52. 2008
    ..In this review, we focus on epigenetics in T helper cell differentiation, regulatory T-cell function, and IL-2 production...
  4. pmc An update on belimumab for the treatment of lupus
    Aikaterini Thanou-Stavraki
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Biologics 5:33-43. 2011
    ..In this review, we discuss basic aspects of B-cell and BLyS biology in SLE and summarize the evidence supporting a role of belimumab in SLE, from animal studies to phase III clinical trials...
  5. pmc Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Autoimmun 38:J216-22. 2012
    ....
  6. pmc Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus
    Travis Hughes
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 71:694-9. 2012
    ..The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genetic effects among SLE susceptibility loci...
  7. pmc Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    A H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA
    Genes Immun 9:368-78. 2008
    ..This model supports the contention that ERK pathway signaling defects in T cells contribute to the development of autoimmunity...
  8. pmc Dehydroepiandrosterone in systemic lupus erythematosus
    Amr H Sawalha
    Curr Rheumatol Rep 10:286-91. 2008
    ..Long-term safety studies are required in light of the reported effect of DHEA supplementation in lowering high-density lipoprotein cholesterol in lupus patients...
  9. ncbi request reprint Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    A H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 67:458-61. 2008
    ..The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell responses make IL-21 an attractive candidate gene for SLE...
  10. ncbi request reprint Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice
    Amr H Sawalha
    US Department of Veterans Affairs Medical Center, Oklahoma City, USA
    Eur J Immunol 37:1407-13. 2007
    ..Our data indicate that decreased expression of Dnmt1 and the corresponding T cell DNA hypomethylation correlate with the development of age-dependent autoimmunity in MRL/lpr mice...
  11. pmc A putative functional variant within the UBAC2 gene is associated with increased risk of Behçet's disease
    Amr H Sawalha
    University of Oklahoma Health Sciences Center, Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA
    Arthritis Rheum 63:3607-12. 2011
    ..We undertook this study to establish the genetic effect within the UBAC2 gene, in the course of which we replicated this genetic association and identified a functional variant within this locus...
  12. ncbi request reprint Clinical problem-solving. Step by step
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    N Engl J Med 349:2253-7. 2003
  13. doi request reprint Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective
    M Jeffries
    College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Lupus 17:739-43. 2008
    ..The presence of haemolytic anaemia is associated with a subset of lupus characterized by a younger age of disease onset, and a more severe disease with a higher likelihood of renal involvement, seizures, serositis and other cytopenias...
  14. doi request reprint Epigenetic regulation and the pathogenesis of systemic lupus erythematosus
    Yujun Pan
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Transl Res 153:4-10. 2009
    ..Herein, we discuss how defective epigenetic regulation is involved in the pathogenesis of lupus, which includes both DNA methylation and histone modification changes...
  15. ncbi request reprint Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients
    S Malik
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Lupus 16:863-6. 2007
    ..3% versus 27.4%, OR = 0.31, P = 0.0075). In conclusion, anti-La autoantibody is associated with less severe lupus. Patients with anti-La have a lower risk of renal involvement and seizures compared with anti-La negative lupus patients...
  16. pmc Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus
    Ryan Webb
    Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Arthritis Rheum 60:1076-84. 2009
    ....
  17. ncbi request reprint Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern
    A H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, OK, USA
    Genes Immun 3:S31-4. 2002
    ..In conclusion, an important SLE susceptibility gene, SLEH1 at 11q14, is identified in African-Americans when stratifying pedigrees by antinucleolar autoantibodies...
  18. doi request reprint Sulpha allergy in lupus patients: a clinical perspective
    M Jeffries
    College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Lupus 17:202-5. 2008
    ..0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005)...
  19. pmc Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus
    Amit K Maiti
    Oklahoma Medical Research Foundation, Oklahoma City, OK73104, USA
    Arthritis Rheum 62:323-9. 2010
    ....
  20. pmc Current status of lupus genetics
    Andrea L Sestak
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Arthritis Res Ther 9:210. 2007
    ..In this review we will present what is known, what is disputed, and what remains to be discovered in the world of lupus genetics...
  21. pmc DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks
    T Hughes
    Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    Genes Immun 11:554-60. 2010
    ..TSS in the majority of genes with permissive DNA methylation peaks is in DNase I hypersensitive sites, indicating a failure of DNA methylation to induce chromatin inaccessibility in these loci...
  22. ncbi request reprint Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:5553-63. 2007
    ..These results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation...
  23. pmc Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study
    Yiping Fei
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Arthritis Res Ther 11:R66. 2009
    ..Behçet's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Behçet's disease...
  24. pmc Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes
    Amr H Sawalha
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Autoimmun 33:31-4. 2009
    ..On the other hand, a gene dose effect could also be mediated by a gene without an SLE-associated polymorphism in that a gene that avoids X inactivation will have a higher level of expression in persons with two X chromosomes...
  25. pmc A polymorphism within IL21R confers risk for systemic lupus erythematosus
    Ryan Webb
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Arthritis Rheum 60:2402-7. 2009
    ..The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE...
  26. doi request reprint Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress
    L Tran
    Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Psychoneuroendocrinology 38:898-906. 2013
    ....
  27. ncbi request reprint Association between systemic lupus erythematosus and Helicobacter pylori seronegativity
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Rheumatol 31:1546-50. 2004
    ..pylori. We investigated the prevalence of H. pylori seropositivity as part of a larger serologic survey in a group of 466 patients with systemic lupus erythematosus (SLE) and 466 controls...
  28. pmc Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients
    Ryan Webb
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 70:151-6. 2011
    ..Systemic lupus erythematosus (SLE) is a chronic, multiorgan, autoimmune disease that affects people of all ages and ethnicities...
  29. doi request reprint Uric acid directly promotes human T-cell activation
    Ryan Webb
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Am J Med Sci 337:23-7. 2009
    ..We hypothesize that uric acid can also stimulate T cells directly and in the absence of antigen presentation...
  30. ncbi request reprint Antinuclear autoantibodies in systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Curr Opin Rheumatol 16:534-40. 2004
    ..In this review, we will discuss the various antinuclear autoantibodies detected in lupus patients, their potential pathogenic role, and their usefulness in clinical practice...
  31. ncbi request reprint The genetics of primary Sjögren's syndrome
    Amr H Sawalha
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Curr Rheumatol Rep 5:324-32. 2003
    ..No doubt a much more comprehensive description of the genetics of this disorder will soon emerge...
  32. doi request reprint MEK/ERK pathway inhibitors as a treatment for inflammatory arthritis might result in the development of lupus: comment on the article by Thiel et al
    Amr H Sawalha
    Arthritis Rheum 58:1203-4; author reply 1204. 2008
  33. ncbi request reprint Horizons in Sjögren's syndrome genetics
    Pamela H Williams
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Clin Rev Allergy Immunol 32:201-9. 2007
    ..Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren's syndrome...