Tor C Savidge

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi Role of enteric glial cells in inflammatory bowel disease
    Julie Cabarrocas
    Institut National de la Santé et de la Recherche Médicale U546, Pitie Salpetriere Hospital, Paris, France
    Glia 41:81-93. 2003
  2. ncbi Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen
    Willemijntje A Hoogerwerf
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Gastroenterology 133:1250-60. 2007
  3. pmc S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother
    Tor C Savidge
    Division of Gastroenterology and Hepatology, The University of Texas Medical Branch Galveston, TX, USA
    Front Neurosci 5:31. 2011
  4. ncbi MIND the gap: an astroglial perspective on barrier regulation
    Tor C Savidge
    Division of Gastroenterology and Hepatology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Neuron Glia Biol 3:191-7. 2007
  5. pmc Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins
    Tor C Savidge
    Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA
    Nat Med 17:1136-41. 2011
  6. ncbi Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    Tor C Savidge
    Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
    Gastroenterology 132:1344-58. 2007
  7. ncbi Starring roles for astroglia in barrier pathologies of gut and brain
    Tor C Savidge
    Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Lab Invest 87:731-6. 2007
  8. pmc Clostridial toxins: sensing a target in a hostile gut environment
    Numan Oezguen
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
    Gut Microbes 3:35-41. 2012
  9. doi Recent insights into Clostridium difficile pathogenesis
    Alex G Peniche
    Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
    Curr Opin Infect Dis 26:447-53. 2013
  10. pmc Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies
    John E Wiktorowicz
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 50:5601-14. 2011

Collaborators

Detail Information

Publications12

  1. ncbi Role of enteric glial cells in inflammatory bowel disease
    Julie Cabarrocas
    Institut National de la Santé et de la Recherche Médicale U546, Pitie Salpetriere Hospital, Paris, France
    Glia 41:81-93. 2003
    ..Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation...
  2. ncbi Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen
    Willemijntje A Hoogerwerf
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Gastroenterology 133:1250-60. 2007
    ..We hypothesized that clock genes are present in the gastrointestinal tract and that they are part of a functional molecular clock that coordinates rhythmic physiologic functions...
  3. pmc S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother
    Tor C Savidge
    Division of Gastroenterology and Hepatology, The University of Texas Medical Branch Galveston, TX, USA
    Front Neurosci 5:31. 2011
    ..Thus, S-nitrosylation may mediate previously underappreciated NO-derived signals in the enteric nervous system that regulate homeostatic gut functions and disease susceptibility...
  4. ncbi MIND the gap: an astroglial perspective on barrier regulation
    Tor C Savidge
    Division of Gastroenterology and Hepatology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Neuron Glia Biol 3:191-7. 2007
    ..A better understanding of such universal mechanisms for barrier regulation will facilitate novel therapeutic strategies that target permeability disorders at CNS and mucosal tissue interfaces...
  5. pmc Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins
    Tor C Savidge
    Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA
    Nat Med 17:1136-41. 2011
    ..difficile infection. Allostery in bacterial proteins has thus been successfully exploited in the evolutionary development of nitrosothiol-based innate immunity and may provide an avenue to new therapeutic approaches...
  6. ncbi Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    Tor C Savidge
    Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
    Gastroenterology 132:1344-58. 2007
    ..Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not known...
  7. ncbi Starring roles for astroglia in barrier pathologies of gut and brain
    Tor C Savidge
    Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Lab Invest 87:731-6. 2007
    ....
  8. pmc Clostridial toxins: sensing a target in a hostile gut environment
    Numan Oezguen
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
    Gut Microbes 3:35-41. 2012
    ..difficile infection. In this addendum article, we provide a continued perspective of this antitoxin mechanism and consider the broader implications of therapeutic allostery in combating gut microbial pathogenesis...
  9. doi Recent insights into Clostridium difficile pathogenesis
    Alex G Peniche
    Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
    Curr Opin Infect Dis 26:447-53. 2013
    ..The aim of this review is to summarize and highlight recent advances focused on CDI pathogenic mechanisms...
  10. pmc Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies
    John E Wiktorowicz
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biochemistry 50:5601-14. 2011
    ..Thus, both examples demonstrate the technique's power in confirming the widespread involvement of S-nitrosylation in hypoxia-ischemia/reperfusion injury and in antimicrobial host responses...
  11. ncbi Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine
    Tor C Savidge
    Developmental Gastroenterology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, USA
    Gastroenterology 125:413-20. 2003
    ..However, toxin A-negative/toxin B-positive strains of C. difficile recently were isolated from patients with antibiotic-associated diarrhea and colitis, indicating that toxin B also may be pathogenic in humans...
  12. ncbi Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestine
    Dingwei Dai
    Shanghai Institute for Pediatric Research, Xinhua Hospital and Shanghai Second Medical University, Shanghai, People s Republic of China 200092
    Am J Physiol Gastrointest Liver Physiol 282:G480-90. 2002
    ..globlet cells. These age-dependent and region-specific differences in sialyl alpha-2,6 glycoconjugates may be mediated in part by altered alpha-2,6-ST gene expression regulated by trophic factors such as glucocorticoids...