Tor C Savidge
Affiliation: University of Texas Medical Branch
- Role of enteric glial cells in inflammatory bowel diseaseJulie Cabarrocas
Institut National de la Santé et de la Recherche Médicale U546, Pitie Salpetriere Hospital, Paris, France
Glia 41:81-93. 2003..Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation...
- Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimenWillemijntje A Hoogerwerf
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
Gastroenterology 133:1250-60. 2007..We hypothesized that clock genes are present in the gastrointestinal tract and that they are part of a functional molecular clock that coordinates rhythmic physiologic functions...
- S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brotherTor C Savidge
Division of Gastroenterology and Hepatology, The University of Texas Medical Branch Galveston, TX, USA
Front Neurosci 5:31. 2011..Thus, S-nitrosylation may mediate previously underappreciated NO-derived signals in the enteric nervous system that regulate homeostatic gut functions and disease susceptibility...
- MIND the gap: an astroglial perspective on barrier regulationTor C Savidge
Division of Gastroenterology and Hepatology, The University of Texas Medical Branch, Galveston, TX 77555, USA
Neuron Glia Biol 3:191-7. 2007..A better understanding of such universal mechanisms for barrier regulation will facilitate novel therapeutic strategies that target permeability disorders at CNS and mucosal tissue interfaces...
- Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxinsTor C Savidge
Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, USA
Nat Med 17:1136-41. 2011..difficile infection. Allostery in bacterial proteins has thus been successfully exploited in the evolutionary development of nitrosothiol-based innate immunity and may provide an avenue to new therapeutic approaches...
- Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathioneTor C Savidge
Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
Gastroenterology 132:1344-58. 2007..Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not known...
- Starring roles for astroglia in barrier pathologies of gut and brainTor C Savidge
Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
Lab Invest 87:731-6. 2007....
- Clostridial toxins: sensing a target in a hostile gut environmentNuman Oezguen
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
Gut Microbes 3:35-41. 2012..difficile infection. In this addendum article, we provide a continued perspective of this antitoxin mechanism and consider the broader implications of therapeutic allostery in combating gut microbial pathogenesis...
- Recent insights into Clostridium difficile pathogenesisAlex G Peniche
Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
Curr Opin Infect Dis 26:447-53. 2013..The aim of this review is to summarize and highlight recent advances focused on CDI pathogenic mechanisms...
- Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studiesJohn E Wiktorowicz
Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
Biochemistry 50:5601-14. 2011..Thus, both examples demonstrate the technique's power in confirming the widespread involvement of S-nitrosylation in hypoxia-ischemia/reperfusion injury and in antimicrobial host responses...
- Clostridium difficile toxin B is an inflammatory enterotoxin in human intestineTor C Savidge
Developmental Gastroenterology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, USA
Gastroenterology 125:413-20. 2003..However, toxin A-negative/toxin B-positive strains of C. difficile recently were isolated from patients with antibiotic-associated diarrhea and colitis, indicating that toxin B also may be pathogenic in humans...
- Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestineDingwei Dai
Shanghai Institute for Pediatric Research, Xinhua Hospital and Shanghai Second Medical University, Shanghai, People s Republic of China 200092
Am J Physiol Gastrointest Liver Physiol 282:G480-90. 2002..globlet cells. These age-dependent and region-specific differences in sialyl alpha-2,6 glycoconjugates may be mediated in part by altered alpha-2,6-ST gene expression regulated by trophic factors such as glucocorticoids...