J L Saver

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Food and Drug Administration public hearing on the conduct of emergency clinical research: testimony of the American Stroke Association
    Jeffrey L Saver
    Geffen School of Medicine at UCLA and UCLA Stroke Center, Los Angeles, CA, USA
    Acad Emerg Med 14:e57-8. 2007
  2. ncbi request reprint Cryptogenic stroke in patients with patent foramen ovale
    Jeffrey L Saver
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 9:319-25. 2007
  3. doi request reprint Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: a systematic, comparative analysis
    Richa D Patel
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 44:94-8. 2013
  4. doi request reprint Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial
    Jeffrey L Saver
    Department of Neurology and Stroke Center, University of California, Los Angeles, CA 90095, USA
    Lancet 380:1241-9. 2012
  5. pmc Relationship between neurologic deficit severity and final functional outcome shifts and strengthens during first hours after onset
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Stroke 43:1537-41. 2012
  6. pmc Standardizing the structure of stroke clinical and epidemiologic research data: the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) project
    Jeffrey L Saver
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 43:967-73. 2012
  7. pmc Thrombus branching and vessel curvature are important determinants of middle cerebral artery trunk recanalization with Merci thrombectomy devices
    Liangfu Zhu
    Department of Neurology, Henan Provincial People s Hospital, Zhengzhou, China
    Stroke 43:787-92. 2012
  8. ncbi request reprint Hemorrhage after thrombolytic therapy for stroke: the clinically relevant number needed to harm
    Jeffrey L Saver
    UCLA Stroke Center, Los Angeles, CA 90095, USA
    Stroke 38:2279-83. 2007
  9. pmc The "golden hour" and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset
    Jeffrey L Saver
    Department of Neurology, University of California, Los Angeles, Calif 90095, USA
    Stroke 41:1431-9. 2010
  10. doi request reprint Targeting the brain: neuroprotection and neurorestoration in ischemic stroke
    Jeffrey L Saver
    UCLA Stroke Center and Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Pharmacotherapy 30:62S-9S. 2010

Research Grants

  1. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
  2. Field Administration of Stroke Therapy - Magnesium Trial
    Jeffrey Saver; Fiscal Year: 2007
  3. UCLA SPOTRIAS Center Application
    Jeffrey Saver; Fiscal Year: 2007

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint Food and Drug Administration public hearing on the conduct of emergency clinical research: testimony of the American Stroke Association
    Jeffrey L Saver
    Geffen School of Medicine at UCLA and UCLA Stroke Center, Los Angeles, CA, USA
    Acad Emerg Med 14:e57-8. 2007
  2. ncbi request reprint Cryptogenic stroke in patients with patent foramen ovale
    Jeffrey L Saver
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 9:319-25. 2007
    ....
  3. doi request reprint Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: a systematic, comparative analysis
    Richa D Patel
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 44:94-8. 2013
    ..However, the cervicocephalic circulatory bed offers more challenges to recanalization interventions. The historical development of reperfusion interventions has not previously been systematically compared...
  4. doi request reprint Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial
    Jeffrey L Saver
    Department of Neurology and Stroke Center, University of California, Los Angeles, CA 90095, USA
    Lancet 380:1241-9. 2012
    ..We compared the efficacy and safety of Solitaire with the standard, predicate mechanical thrombectomy device, the Merci Retrieval System...
  5. pmc Relationship between neurologic deficit severity and final functional outcome shifts and strengthens during first hours after onset
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Stroke 43:1537-41. 2012
    ..Early neurological deficit severity is the most important determinant of final functional outcome in acute ischemic stroke. However, deficit severity frequently changes during the first hours and days postonset...
  6. pmc Standardizing the structure of stroke clinical and epidemiologic research data: the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) project
    Jeffrey L Saver
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 43:967-73. 2012
    ..Standardizing data elements in translational, clinical, and population research in cerebrovascular disease could decrease study start-up time, facilitate data sharing, and promote well-informed clinical practice guidelines...
  7. pmc Thrombus branching and vessel curvature are important determinants of middle cerebral artery trunk recanalization with Merci thrombectomy devices
    Liangfu Zhu
    Department of Neurology, Henan Provincial People s Hospital, Zhengzhou, China
    Stroke 43:787-92. 2012
    ..Although the amount of thrombotic material to be digested is an important consideration for chemical lysis, mechanical debulking may be more greatly influenced by other target lesion characteristics...
  8. ncbi request reprint Hemorrhage after thrombolytic therapy for stroke: the clinically relevant number needed to harm
    Jeffrey L Saver
    UCLA Stroke Center, Los Angeles, CA 90095, USA
    Stroke 38:2279-83. 2007
    ..A clinically relevant number needed to harm for tissue plasminogen activator (tPA)-related symptomatic intracerebral hemorrhage (SICH) would greatly assist therapeutic decision-making...
  9. pmc The "golden hour" and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset
    Jeffrey L Saver
    Department of Neurology, University of California, Los Angeles, Calif 90095, USA
    Stroke 41:1431-9. 2010
    ..The benefit of intravenous thrombolytic therapy in acute brain ischemia is strongly time dependent...
  10. doi request reprint Targeting the brain: neuroprotection and neurorestoration in ischemic stroke
    Jeffrey L Saver
    UCLA Stroke Center and Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Pharmacotherapy 30:62S-9S. 2010
    ..Therapies that target the brain in patients with stroke will increasingly complement and enhance traditional vasotherapeutics...
  11. ncbi request reprint Time is brain--quantified
    Jeffrey L Saver
    The Stroke Center, Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Stroke 37:263-6. 2006
    ..Recent advances in quantitative neurostereology and stroke neuroimaging permit calculation of just how much brain is lost per unit time in acute ischemic stroke...
  12. pmc Treatment effects for which shift or binary analyses are advantageous in acute stroke trials
    Jeffrey L Saver
    UCLA Stroke Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurology 72:1310-5. 2009
    ..The conditions under which shift or binary analysis will be more efficient have not been previously well delineated...
  13. pmc Improving the reliability of stroke disability grading in clinical trials and clinical practice: the Rankin Focused Assessment (RFA)
    Jeffrey L Saver
    Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA
    Stroke 41:992-5. 2010
    ..However, substantial interobserver variability in modified Rankin Scale scoring has been reported. This study sought to develop and validate a short, practicable structured assessment that would enhance interrater reliability...
  14. ncbi request reprint Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 38:3055-62. 2007
    ..Choice of primary end point analytic technique should be tailored to the study population, expected treatment response, and study purpose. Shift analysis generally provides the most comprehensive index of a treatment's clinical impact...
  15. doi request reprint Proposal for a universal definition of cerebral infarction
    Jeffrey L Saver
    Stroke Center and the Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 39:3110-5. 2008
    ..Cerebral infarction is a leading cause of disability and death worldwide but has no uniform international definition...
  16. ncbi request reprint Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial
    Jeffrey L Saver
    UCLA Stroke Center, Geffen School of Medicine of the University of California, Los Angeles 90095, USA
    Stroke 35:e106-8. 2004
    ..To demonstrate that paramedic initiation of intravenous magnesium sulfate (Mg) in the field in focal stroke patients is feasible, safe, and yields significant time-savings compared with in-hospital initiation of neuroprotective therapy...
  17. ncbi request reprint Number needed to treat estimates incorporating effects over the entire range of clinical outcomes: novel derivation method and application to thrombolytic therapy for acute stroke
    Jeffrey L Saver
    Department of Neurology, and UCLA Stroke Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 61:1066-70. 2004
    ..However, NNT estimates for treatments for neurologic conditions have previously been generated only for dichotomized functional outcomes, which may underestimate clinically relevant treatment effects...
  18. pmc Graphic reanalysis of the two NINDS-tPA trials confirms substantial treatment benefit
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Calif 90095, USA
    Stroke 41:2381-90. 2010
    ....
  19. pmc Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window: joint outcome table analysis of the ECASS 3 trial
    Jeffrey L Saver
    UCLA Stroke Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 40:2433-7. 2009
    ..5-hour window, but an effect size estimate incorporating benefit and harm across all levels of poststroke disability has not previously been derived...
  20. pmc Optimal end points for acute stroke therapy trials: best ways to measure treatment effects of drugs and devices
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Stroke 42:2356-62. 2011
    ..Over the past decade, analysis of completed actual trials, model population studies, and theoretical work have improved approaches to selecting and analyzing end points in acute stroke treatment trials...
  21. ncbi request reprint Combination therapies and the theoretical limits of evidence-based medicine
    J L Saver
    Neurobehavior Program, University of California, Los Angeles, Calif, USA
    Neuroepidemiology 20:57-64. 2001
    ..Consequently, determining the optimum combination of therapies for a condition is a burgeoning challenge to clinical trialists and practicing physicians...
  22. ncbi request reprint Does the Merci Retriever work? For
    Jeffrey L Saver
    Stroke Center, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Stroke 37:1340-1; discussion 1342-3. 2006
  23. ncbi request reprint Clinical impact of NXY-059 demonstrated in the SAINT I trial: derivation of number needed to treat for benefit over entire range of functional disability
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 38:1515-8. 2007
    ..Derivation of an NNT value reflecting the treatment's benefit over the entire range of the mRS is required to describe the clinical import of the trial results...
  24. ncbi request reprint Physician-investigator phone elicitation of consent in the field: a novel method to obtain explicit informed consent for prehospital clinical research
    Jeffrey L Saver
    Stroke Center, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Prehosp Emerg Care 10:182-5. 2006
    ..To describe and report the feasibility of a novel field telephonic strategy to elicit explicit informed consent in prehospital trials for conditions in which patients retain decision-making capacity...
  25. ncbi request reprint Can acute MRI predict outcome following transient ischemic attack and minor stroke?
    Jeffrey L Saver
    UCLA Stroke Center, Los Angeles, CA 90095, USA
    Nat Clin Pract Neurol 2:14-5. 2006
  26. doi request reprint Improving reperfusion therapy for acute ischaemic stroke
    J L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    J Thromb Haemost 9:333-43. 2011
    ..The first generation of clinical reperfusion treatment, intravenous (IV) fibrinolysis with tissue plasminogen activator (tPA), was a transformative breakthrough in stroke care, but is far from ideal...
  27. ncbi request reprint Confirmation of tPA treatment effect by baseline severity-adjusted end point reanalysis of the NINDS-tPA stroke trials
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Stroke 38:414-6. 2007
    ....
  28. ncbi request reprint Intra-arterial thrombolysis for acute stroke in patients 80 and older: a comparison of results in patients younger than 80 years
    D Kim
    University of California at Los Angeles Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    AJNR Am J Neuroradiol 28:159-63. 2007
    ..The purpose of this study was to compare the baseline characteristics, complications, and outcomes between intra-arterially treated ischemic stroke patients aged > or = 80 years and their younger counterparts...
  29. ncbi request reprint Statin enhancement of collateralization in acute stroke
    B Ovbiagele
    Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Neurology 68:2129-31. 2007
    ..After adjusting for covariates, the statin-treated group had significantly higher collateral scores than non-statin users, suggesting an association between statin use and better collateralization during acute stroke...
  30. ncbi request reprint Anticoagulants and antiplatelet agents in acute ischemic stroke: report of the Joint Stroke Guideline Development Committee of the American Academy of Neurology and the American Stroke Association (a division of the American Heart Association)
    B M Coull
    Department of Neurology, Arizona Health Science Center, Tucson, Ariz, USA
    Stroke 33:1934-42. 2002
  31. doi request reprint The risk of acute radiocontrast-mediated kidney injury following endovascular therapy for acute ischemic stroke is low
    Y Loh
    Division of Neurosurgery, David Geffen School of Medicine at the University of California at Los Angeles, CA, USA
    AJNR Am J Neuroradiol 31:1584-7. 2010
    ..The risk of RCM-mediated AKI following endovascular therapy for AIS may be different from that following coronary interventions because patients may not have identical risk factors...
  32. pmc Angiography reveals that fluid-attenuated inversion recovery vascular hyperintensities are due to slow flow, not thrombus
    N Sanossian
    Stroke Center and Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
    AJNR Am J Neuroradiol 30:564-8. 2009
    ..We studied the pathophysiologic and hemodynamic correlates of FVH on conventional angiography and concurrent MR imaging sequences...
  33. doi request reprint Partial recanalization of concomitant internal carotid-middle cerebral arterial occlusions promotes distal recanalization of residual thrombus within 24 h
    Y Loh
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurointerv Surg 3:38-42. 2011
    ..Successful recanalization of the proximal aspect of the occlusion may allow for endogenous thrombolysis and facilitate further endogenous recanalization of any residual MCA occlusion...
  34. doi request reprint Higher rates of mortality but not morbidity follow intracranial mechanical thrombectomy in the elderly
    Yince Loh
    Division of Neurosurgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    AJNR Am J Neuroradiol 31:1181-5. 2010
    ..Mechanical thrombectomy is a promising means of recanalizing acute cerebrovascular occlusions in certain situations. We sought to determine if increasing age adversely affects prognosis...
  35. ncbi request reprint Use of multimodal MRI and novel endovascular therapies in a patient ineligible for intravenous tissue plasminogen activator
    Shuichi Suzuki
    Department of Radiology, UCLA Medical Center, Los Angeles, California, USA
    Stroke 36:e77-9. 2005
    ..We report a patient who twice benefited from this management approach, in the setting of hemorrhagic risk following successive ischemic strokes...
  36. ncbi request reprint Early MRI and outcomes of untreated patients with mild or improving ischemic stroke
    V Rajajee
    UCLA Medical Center, Los Angeles, CA, USA
    Neurology 67:980-4. 2006
    ....
  37. ncbi request reprint Diffusion-perfusion MRI characterization of post-recanalization hyperperfusion in humans
    C S Kidwell
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, CA 90095, USA
    Neurology 57:2015-21. 2001
    ..Animal and human studies have demonstrated that postischemic hyperperfusion may occur both early and late timepoints following acute cerebral ischemia...
  38. ncbi request reprint Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage
    C S Kidwell
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Neurology 57:1611-7. 2001
    ..Diffusion-perfusion MRI provides a novel means of assessing injury in perihematomal regions in patients with ICH...
  39. ncbi request reprint Trends in acute ischemic stroke trials through the 20th century
    C S Kidwell
    University of California at Los Angeles UCLA Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Stroke 32:1349-59. 2001
    ..The objective of this study was to quantitatively characterize developments in clinical trial methodology over time in the field of acute ischemic stroke...
  40. ncbi request reprint Design and retrospective analysis of the Los Angeles Prehospital Stroke Screen (LAPSS)
    C S Kidwell
    UCLA Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, California 90095, USA
    Prehosp Emerg Care 2:267-73. 1998
    ..Further, the study evaluated the potential time savings that could be achieved by paramedic administration of neuroprotective agents in the field...
  41. ncbi request reprint Endovascular mechanical clot retrieval in a broad ischemic stroke cohort
    D Kim
    University of California at Los Angeles Stroke Center, Los Angeles, CA, USA
    AJNR Am J Neuroradiol 27:2048-52. 2006
    ..Our aim was to describe an expanded experience with endovascular mechanical embolectomy in a broad group of patients, including those not meeting entry criteria for the MERCI multicenter trials...
  42. ncbi request reprint Are elevated admission calcium levels associated with better outcomes after ischemic stroke?
    B Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, USA
    Neurology 67:170-3. 2006
    ..After adjusting for covariates, higher admission Ca(2+) was significantly associated with lesser stroke severity and better discharge functional outcome. Admission Mg(2+) was not an independent clinical outcome prognosticator...
  43. ncbi request reprint Angiotensin 2 type 2 receptor activity and ischemic stroke severity
    B Ovbiagele
    Stroke Center, Department of Neurology, Olive View UCLA Medical Center, Los Angeles, CA, USA
    Neurology 65:851-4. 2005
    ....
  44. ncbi request reprint Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke
    S H Shah
    Department of Neurology, UCLA Medical Center, USA
    Neurology 66:1745-6. 2006
    ....
  45. ncbi request reprint Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue
    Ludy C Shih
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, Calif, USA
    Stroke 34:1425-30. 2003
    ..Pretreatment perfusion MRI offers promise as a means to differentiate core from penumbral tissues...
  46. ncbi request reprint Premorbid antiplatelet use and ischemic stroke outcomes
    N Sanossian
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Neurology 66:319-23. 2006
    ..To evaluate the independent effect of premorbid antiplatelet use on incident ischemic stroke severity and outcome at discharge...
  47. ncbi request reprint Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial
    Wade S Smith
    Department of Neurology, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 36:1432-8. 2005
    ..An alternative strategy for opening intracranial vessels during stroke is mechanical embolectomy, especially for patients ineligible for intravenous tPA...
  48. ncbi request reprint Magnesium sulfate neither potentiates nor inhibits tissue plasminogen activator-induced thrombolysis
    D Stewart
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Thromb Haemost 4:1575-9. 2006
    ..Increasing circulating magnesium concentrations to 2-fold over normal baseline may afford a neuroprotective effect in patients with acute cerebral ischemia...
  49. ncbi request reprint Statin treatment and adherence to national cholesterol guidelines after ischemic stroke
    B Ovbiagele
    Stroke Center, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Neurology 66:1164-70. 2006
    ..The authors aimed to determine the rate of statin use, its predictors, and the achievement of national guideline target lipid goals among ischemic stroke survivors...
  50. ncbi request reprint PROTECT: a coordinated stroke treatment program to prevent recurrent thromboembolic events
    B Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Neurology 63:1217-22. 2004
    ..To assess the impact of the Preventing Recurrence of Thromboembolic Events through Coordinated Treatment (PROTECT) Program on achievement of its eight secondary prevention goals at the time of discharge...
  51. ncbi request reprint Validation of computed tomographic middle cerebral artery "dot"sign: an angiographic correlation study
    Megan C Leary
    Department of Neurology, Division of Stroke and Cerebrovascular Disease, Palmer 125, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
    Stroke 34:2636-40. 2003
    ..The MCA dot sign has not been validated previously against the gold standard of conventional cerebral angiography...
  52. doi request reprint Basal ganglionic infarction before mechanical thrombectomy predicts poor outcome
    Yince Loh
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
    Stroke 40:3315-20. 2009
    ..Use of mechanical thrombectomy for acute cerebrovascular occlusions is increasing. Preintervention MRI patterns may be helpful in predicting prognosis...
  53. pmc Association of serum bilirubin with ischemic stroke outcomes
    Sandra Pineda
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, CA 90095, USA
    J Stroke Cerebrovasc Dis 17:147-52. 2008
    ..Little is known about the role of bilirubin in stroke. We assessed the relation of serum bilirubin levels with clinical presentation and outcomes among patients hospitalized with ischemic stroke...
  54. ncbi request reprint Correlation of aphasia and/or neglect with cortical infarction in a subpopulation of RANTTAS
    B B Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Cerebrovasc Dis 11:257-64. 2001
    ..If selective neuroprotection is envisioned for acute stroke patients, more accurate markers of cortical infarction may be needed...
  55. ncbi request reprint Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort
    J M Ringman
    Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza, Suite 2 238, Los Angeles, CA 90095 1769, USA
    Neurology 63:468-74. 2004
    ..To delineate the frequency, course, risk factors, and neuroanatomy of hemispatial neglect in a large stroke cohort...
  56. ncbi request reprint Diffusion MRI in patients with transient ischemic attacks
    C S Kidwell
    University of California at Los Angeles, CA, USA
    Stroke 30:1174-80. 1999
    ..Diffusion MRI has established value in patients with ischemic stroke but has not been systematically investigated in patients with transient ischemic attack (TIA)...
  57. ncbi request reprint Detection of early CT signs of >1/3 middle cerebral artery infarctions : interrater reliability and sensitivity of CT interpretation by physicians involved in acute stroke care
    M A Kalafut
    Scripps Clinic, Division of Neurology, La Jolla, CA, USA
    Stroke 31:1667-71. 2000
    ..The American Academy of Neurology and the American Heart Association recommend avoiding thrombolysis if early signs of major infarction are present...
  58. ncbi request reprint Hemispheric asymmetry of gaze deviation and relationship to neglect in acute stroke
    J M Ringman
    Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
    Neurology 65:1661-2. 2005
    ..There was no difference in its rate of co-occurrence with neglect between right- and nonright-handed patients...
  59. pmc Dispatcher recognition of stroke using the National Academy Medical Priority Dispatch System
    Brian H Buck
    University of California at Los Angeles Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Stroke 40:2027-30. 2009
    ..1 of the National Academy Medical Priority Dispatch System)...
  60. doi request reprint In-hospital initiation of secondary prevention is associated with improved vascular outcomes at 3 months
    Abdul Rahiman
    Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Stroke Cerebrovasc Dis 17:5-8. 2008
    ..We evaluated the impact of the PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program on short-term vascular risk...
  61. doi request reprint Indices of kidney dysfunction and discharge outcomes in hospitalized stroke patients without known renal disease
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, University of Southern California, 710 Westwood Plaza, Los Angeles, CA 90095, USA ovibes mednet ucla edu
    Cerebrovasc Dis 28:582-8. 2009
    ..We determined whether various indices of CKD would predict discharge outcomes in persons hospitalized with a recent ischemic stroke...
  62. doi request reprint Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke
    Chelsea S Kidwell
    Department of Neurology, Georgetown University, Washington, DC 20010, USA
    Cerebrovasc Dis 25:338-43. 2008
    ..Early barrier opening caused by focal cerebral ischemia in human stroke can be assessed by the presence of gadolinium enhancement of cerebrospinal fluid, termed 'Hyperintense Acute Injury Marker' (HARM)...
  63. doi request reprint Identifying patients at high risk for poor outcome after intra-arterial therapy for acute ischemic stroke
    Hen Hallevi
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 40:1780-5. 2009
    ..Despite high rates of recanalization, the outcome is variable. We attempted to identify predictors of outcome that will enable better patient selection for IAT...
  64. ncbi request reprint Thrombolytic therapy of acute ischemic stroke during pregnancy
    A Murugappan
    Stroke Program, Department of Neurology, Wayne State University, School of Medicine, Detroit, MI, USA
    Neurology 66:768-70. 2006
    ..Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed...
  65. doi request reprint Recanalization rates decrease with increasing thrombectomy attempts
    Y Loh
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    AJNR Am J Neuroradiol 31:935-9. 2010
    ..We sought to determine whether there is an optimum number of retrieval attempts that yields the highest recanalization rates and after which the probability of success decreases...
  66. pmc Gradient echo MRI: implementation of a training tutorial for intracranial hemorrhage diagnosis
    B R Copenhaver
    Department of Neurology, Georgetown University, Washington, DC, USA
    Neurology 72:1576-81. 2009
    ..However, many physicians who currently read acute stroke imaging studies may be unfamiliar with interpretation of GRE images...
  67. pmc Presence of baseline prehypertension and risk of incident stroke: a meta-analysis
    M Lee
    Stroke Center, University of California, San Diego, La Jolla, CA 92093 9127, USA
    Neurology 77:1330-7. 2011
    ..To qualitatively and quantitatively assess the association of prehypertension with incident stroke through a meta-analysis of prospective cohort studies...
  68. ncbi request reprint Annual incidence of first silent stroke in the United States: a preliminary estimate
    Megan C Leary
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cerebrovasc Dis 16:280-5. 2003
    ....
  69. ncbi request reprint The Los Angeles Motor Scale (LAMS): a new measure to characterize stroke severity in the field
    Jennifer N Llanes
    UCLA Stroke Center, 90095, USA
    Prehosp Emerg Care 8:46-50. 2004
    ..To develop and retrospectively analyze an instrument that rapidly characterizes pretreatment stroke severity for use in prehospital acute stroke clinical trials...
  70. ncbi request reprint Association of serum lipid indices with large artery atherosclerotic stroke
    O Y Bang
    Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurology 70:841-7. 2008
    ..We evaluated the relationship between several measures of the classically obtained serum lipid panel and the occurrence of large artery atherosclerotic stroke...
  71. ncbi request reprint Safety and cost of low-molecular-weight heparin as bridging anticoagulant therapy in subacute cerebral ischemia
    M A Kalafut
    Division of Neurology, Scripps Clinic, La Jolla, CA, USA
    Stroke 31:2563-8. 2000
    ....
  72. ncbi request reprint Advances in neuroimaging of acute stroke
    C S Kidwell
    University of California, Los Angeles, Stroke Center, 710 Westwood Plaza, UCLA Medical Center, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 2:126-35. 2000
    ....
  73. ncbi request reprint Cranial computed tomography interpretation in acute stroke: physician accuracy in determining eligibility for thrombolytic therapy
    D L Schriger
    Emergency Medicine Center, University of California at Los Angeles, USA
    JAMA 279:1293-7. 1998
    ..Intracranial hemorrhage must be excluded prior to administration of thrombolytic agents in acute stroke...
  74. pmc Disability status at 1 month is a reliable proxy for final ischemic stroke outcome
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurology 75:688-92. 2010
    ..We assessed whether day 30 global disability status reliably predicts final 3-month disability outcome among acute stroke patients...
  75. ncbi request reprint The smoking-thrombolysis paradox and acute ischemic stroke
    Bruce Ovbiagele
    Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Neurology 65:293-5. 2005
    ..After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year...
  76. doi request reprint Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices
    Sean I Savitz
    Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 26:156-62. 2008
    ..Recent studies have introduced more sensitive outcome measures such as the shift analysis to detect a treatment effect in AIS trials and are also including imaging as a surrogate of injury...
  77. doi request reprint Serum calcium as prognosticator in ischemic stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:2231-6. 2008
    ..Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke...
  78. doi request reprint Day-90 acute ischemic stroke outcomes can be derived from early functional activity level
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, and Department of Neurology, Olive View UCLA Medical Center, Los Angeles, CA 90095, USA
    Cerebrovasc Dis 29:50-6. 2010
    ..We assessed whether day-7/10 functional outcome predicted day-90 functional outcome among acute ischemic stroke patients...
  79. ncbi request reprint Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack
    Bruce Ovbiagele
    UCLA Stroke Center, Department of Neurology, UCLA Medical Center, 90095, USA
    Stroke 34:919-24. 2003
    ..The objective of this study was to characterize the epidemiological impact of adopting a tissue-based definition of TIA...
  80. pmc Simultaneous ring voice-over-Internet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials
    Nerses Sanossian
    Department of Neurology, University of Southern California, 1200 N State St, Los Angeles, CA 90033, USA
    Cerebrovasc Dis 28:539-44. 2009
    ....
  81. ncbi request reprint Late secondary ischemic injury in patients receiving intraarterial thrombolysis
    Chelsea S Kidwell
    Stroke Center, UCLA Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Ann Neurol 52:698-703. 2002
    ..In the future, late secondary tissue injury may become an important therapeutic target for postreperfusion neuroprotective therapies, with treatment efficacy monitored by serial diffusion magnetic resonance imaging...
  82. pmc Impact of reperfusion after 3 hours of symptom onset on tissue fate in acute cerebral ischemia
    Oh Young Bang
    Department of Neurology, University of California, Los Angeles, CA, USA
    J Neuroimaging 19:317-22. 2009
    ..However, there has been only sparse direct evidence that reperfusion after 3 hours prevents infarct growth...
  83. ncbi request reprint In-hospital initiation of secondary stroke prevention therapies yields high rates of adherence at follow-up
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 35:2879-83. 2004
    ..The objective of this study was to determine if the high utilization rates previously demonstrated at hospital discharge were maintained at 90 days after discharge...
  84. pmc Impact of hyperlipidemia and statins on ischemic stroke outcomes after intra-arterial fibrinolysis and percutaneous mechanical embolectomy
    Lucas Restrepo
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Cerebrovasc Dis 28:384-90. 2009
    ..The determinants of the final clinical outcome after endovascular treatment have been understudied. We investigated the effects of hyperlipidemia and statins on acute ischemic stroke outcomes after endovascular procedures...
  85. doi request reprint Impact of baseline tissue status (diffusion-weighted imaging lesion) versus perfusion status (severity of hypoperfusion) on hemorrhagic transformation
    Jong Hun Kim
    Department of Neurology, Stroke Center, Samsung Medical Center, Seoul, South Korea
    Stroke 41:e135-42. 2010
    ..We investigated the factors associated with HTs and the influence of the HTs observed on gradient echo imaging on the early course after a stroke...
  86. ncbi request reprint Acute basilar artery occlusion: diffusion-perfusion MRI characterization of tissue salvage in patients receiving intra-arterial stroke therapies
    Jill L Ostrem
    Department of Neurology, UCLA Medical Center, USA
    Stroke 35:e30-4. 2004
    ..Diffusion-perfusion MRI in patients with anterior circulation occlusions has demonstrated salvage of threatened tissue after thrombolytic therapy. Similar studies have not been reported with posterior circulation occlusions...
  87. doi request reprint Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage
    Chad M Miller
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Surg Neurol 69:441-6; discussion 446. 2008
    ..Image-guided stereotactic endoscopic hematoma evacuation is a promising minimally invasive approach designed to limit operative injury and maximize hematoma removal...
  88. doi request reprint Outpatient practice patterns after stroke hospitalization among neurologists
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:1850-4. 2008
    ..However, not much is known about poststroke practice patterns among neurologists. Such knowledge may help direct specific efforts to improve the impact of practicing neurologists on clinical outcomes after stroke...
  89. ncbi request reprint Antihypertensive medications prescribed at discharge after an acute ischemic cerebrovascular event
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Stroke 36:1944-7. 2005
    ..We aimed to evaluate the discharge antihypertensive prescription patterns in patients hospitalized for an ischemic cerebrovascular event and to determine factors associated with treatment utilization...
  90. ncbi request reprint Secondary-prevention drug prescription in the very elderly after ischemic stroke or TIA
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, San Francisco, CA, USA
    Neurology 66:313-8. 2006
    ..An age bias may exist in the prescription of important secondary-preventive therapies in the elderly...
  91. ncbi request reprint Impact of metabolic syndrome on prognosis of symptomatic intracranial atherostenosis
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Neurology 66:1344-9. 2006
    ..The authors evaluated the prevalence and prognosis of the MetS among individuals with symptomatic intracranial arterial stenosis...
  92. ncbi request reprint Evolving paradigms in neuroimaging of the ischemic penumbra
    Chelsea S Kidwell
    UCLA Stroke Center, 710 Westwood Plaza, UCLA Medical Center, Los Angeles, CA 9009, USA5
    Stroke 35:2662-5. 2004
    ....
  93. doi request reprint Characteristics, performance measures, and in-hospital outcomes of the first one million stroke and transient ischemic attack admissions in get with the guidelines-stroke
    Gregg C Fonarow
    University of California, Los Angeles, USA
    Circ Cardiovasc Qual Outcomes 3:291-302. 2010
    ....
  94. ncbi request reprint Cerebral white matter hyperintensities on MRI: Current concepts and therapeutic implications
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, Los Angeles, CA 90095, USA
    Cerebrovasc Dis 22:83-90. 2006
    ..This review provides an overview of current knowledge on vascular WMH, and describes some pharmacological agents that may have a role in mitigating this condition...
  95. ncbi request reprint Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke
    Victor J Marder
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles Orthopaedic Hospital, 2400 S Flower St, Los Angeles, California 90007, USA
    Stroke 37:2086-93. 2006
    ..Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management...
  96. ncbi request reprint Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients
    Bruce Ovbiagele
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, CA 90095, USA
    Cerebrovasc Dis 22:378-83. 2006
    ..We evaluated risk factors for these microangiopathic lesions in a cohort of stroke and transient ischemic attack patients...
  97. ncbi request reprint Ensuring management of vascular risk factors after stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, Los Angeles, CA, USA
    Rev Neurol Dis 3:93-100. 2006
    ..Available evidence suggests that hospital-based systems can markedly improve medical care and education of hospitalized ischemic stroke patients, and increase longer-term patient adherence in the community...
  98. ncbi request reprint Leukocyte count and vascular risk in symptomatic intracranial atherosclerosis
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Cerebrovasc Dis 24:283-8. 2007
    ..We investigated the relationship between WBC count and vascular risk in patients with symptomatic intracranial atherosclerotic disease enrolled in the Warfarin-Aspirin Symptomatic Intracranial Disease(WASID) study...
  99. ncbi request reprint Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis
    Chelsea S Kidwell
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, Calif 90095, USA
    Stroke 33:717-24. 2002
    ..Hemorrhagic transformation (HT) is a major complication of intra-arterial (IA) thrombolytic therapy. Identifying significant predictors of hemorrhage after thrombolysis would be useful in guiding patient selection for IA treatment...
  100. doi request reprint Recent nationwide trends in discharge statin treatment of hospitalized patients with stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, Ronald Reagan UCLA Medical Center, Los Angeles, Calif, USA
    Stroke 41:1508-13. 2010
    ..In this study, we assessed recent nationwide trends in discharge statin treatment after acute stroke and the influence of SPARCL on clinical practice...
  101. ncbi request reprint Lipid assessment and treatment patterns in hospitalized TIA and ischemic stroke patients
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, California 90095, USA
    J Hosp Med 1:214-20. 2006
    ..We aimed to study the frequency and predictors of lipid assessment and discharge utilization of lipid-lowering therapies among patients hospitalized for stroke and TIA...

Research Grants5

  1. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..abstract_text> ..
  2. Field Administration of Stroke Therapy - Magnesium Trial
    Jeffrey Saver; Fiscal Year: 2007
    ..abstract_text> ..
  3. UCLA SPOTRIAS Center Application
    Jeffrey Saver; Fiscal Year: 2007
    ..Five Cores will support the Projects: A) Patient Access, B) Blood / Tissue Specimen, C) Biostatistics / Data Management, D) Neuroimaging, E) Career Development. ..